Piergiuseppe Colombo
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View article: Predicting immune checkpoint inhibitors response via fluorescence lifetime imaging microscopy: a systematic review
Predicting immune checkpoint inhibitors response via fluorescence lifetime imaging microscopy: a systematic review Open
Introduction Fluorescence Lifetime Imaging Microscopy (FLIM) is an imaging technique that allows for the visualization of the cellular microenvironment by measuring the decay time of endogenous fluorescent molecules. Its advent has allowed…
View article: Exploring the metastatic potential of isolated tumour cells and clusters-cords patterns of ISUP Grade 5 acinar adenocarcinoma of the prostate: a comprehensive morphological analysis
Exploring the metastatic potential of isolated tumour cells and clusters-cords patterns of ISUP Grade 5 acinar adenocarcinoma of the prostate: a comprehensive morphological analysis Open
Gleason pattern 5 (GP5) prostatic adenocarcinoma (PC) includes distinct morphologies: undifferentiated solid pattern (US), solid and cribriform with necrosis (CN), clusters and cords (CC), and isolated single tumour cells (ISTC). The role …
View article: Integrated design of multifunctional paraffin-impregnated porous ceramic metastructures for electromagnetic wave absorption and thermal management
Integrated design of multifunctional paraffin-impregnated porous ceramic metastructures for electromagnetic wave absorption and thermal management Open
To address the growing demand for radar and infrared stealth materials in complex application scenarios, this study develops an integrated multifunctional composite through a vacuum impregnation process that combines SiCN ceramics, porous …
View article: PV-1: a novel molecular prognostic marker of distant metastases in various solid tumors
PV-1: a novel molecular prognostic marker of distant metastases in various solid tumors Open
Identification of biomarkers for the hematogenous spreading of cancer cells is of paramount prognostic and therapeutic value. We showed that Plasmalemma Vesicle Associated Protein-1 (PV-1) serves as a marker of increased blood vessel perme…
View article: Chemosensor receptors are lipid-detecting regulators of macrophage function in cancer
Chemosensor receptors are lipid-detecting regulators of macrophage function in cancer Open
Infiltration of macrophages into tumors is a hallmark of cancer progression, and re-educating tumor-associated macrophages (TAMs) toward an antitumor status is a promising immunotherapy strategy. However, the mechanisms through which cance…
View article: Prostate-sparing conservative management of a solitary fibrous tumor of the prostate: A case report
Prostate-sparing conservative management of a solitary fibrous tumor of the prostate: A case report Open
Solitary fibrous tumors (SFTs) are rare mesenchymal neoplasms with variable malignancy potential. We report a 69-year-old man with elevated PSA and an asymptomatic pelvic solid mass (42 × 32 × 48 mm), found on imaging between the bl…
View article: Assessment of the Mechanisms of Action of Eribulin in Patients with Advanced Liposarcoma Through the Evaluation of Radiological, Functional, and Tissue Responses: A Prospective Monocentric Study (Malibu Study)
Assessment of the Mechanisms of Action of Eribulin in Patients with Advanced Liposarcoma Through the Evaluation of Radiological, Functional, and Tissue Responses: A Prospective Monocentric Study (Malibu Study) Open
Background: Liposarcoma (LPS) is one of the most frequent histotypes of soft tissue sarcoma (STS). Eribulin is a cytotoxic agent that has improved overall survival in patients with advanced LPS. Additionally, preclinical and clinical evide…
View article: Xpert Bladder Cancer Detection in Emergency Setting Assessment (XESA Project): A Prospective, Single-centre Trial
Xpert Bladder Cancer Detection in Emergency Setting Assessment (XESA Project): A Prospective, Single-centre Trial Open
Xpert Bladder Cancer Detection is a simple urine test that detects the presence of five genes associated with bladder cancer. We found that for patients visiting the emergency department because of blood in their urine, use of this test co…
View article: C/EBPβ-dependent autophagy inhibition hinders NK cell function in cancer
C/EBPβ-dependent autophagy inhibition hinders NK cell function in cancer Open
View article: Case report: STRN3-NTRK3 fusion in uterine sarcoma with spleen metastasis: a new variant in the spectrum of NTRK-rearranged tumors
Case report: STRN3-NTRK3 fusion in uterine sarcoma with spleen metastasis: a new variant in the spectrum of NTRK-rearranged tumors Open
Neurotrophic tyrosine receptor kinase (NTRK) fusions are infrequent genetic events that can occur in various tumor types. Specifically, NTRK-rearranged sarcoma has been observed in pediatric mesenchymal tumors and, to a lesser extent, in a…
View article: P065 Early oncological outcomes of high-intensity focused ultrasound focal therapy for localized prostate cancer: A prospective cohort study utilizing advanced imaging modalities
P065 Early oncological outcomes of high-intensity focused ultrasound focal therapy for localized prostate cancer: A prospective cohort study utilizing advanced imaging modalities Open
View article: Ex Vivo Real-time Assessment of Detrusor Muscle Sampling via Confocal Microscopy During Endoscopic Resection of Bladder Tumor
Ex Vivo Real-time Assessment of Detrusor Muscle Sampling via Confocal Microscopy During Endoscopic Resection of Bladder Tumor Open
View article: A Propensity Score–matched Comparison of Micro-ultrasound–guided Transrectal and Magnetic Resonance Imaging/Transrectal Ultrasound Fusion-guided Transperineal Prostate Biopsies for Detection of Clinically Significant Prostate Cancer
A Propensity Score–matched Comparison of Micro-ultrasound–guided Transrectal and Magnetic Resonance Imaging/Transrectal Ultrasound Fusion-guided Transperineal Prostate Biopsies for Detection of Clinically Significant Prostate Cancer Open
We compared the ability of two different prostate biopsy approaches to detect clinically significant prostate cancer. We found that transrectal biopsy guided by micro-ultrasound had similar detection rates to transperineal biopsy guided by…
View article: Disruptions in antigen processing and presentation machinery on sarcoma
Disruptions in antigen processing and presentation machinery on sarcoma Open
Sarcomas exhibit a high degree of defects in APM components, with differences among histotypes and tumoral areas. The most commonly altered APM components were HLA Class I subunit β2-microglobulin, HLA Class I subunit α (HC10), and MHC I t…
View article: True Mitotic Count Prediction in Gastrointestinal Stromal Tumors: Bayesian Network Model and PROMETheus (Preoperative Mitosis Estimator Tool) Application Development
True Mitotic Count Prediction in Gastrointestinal Stromal Tumors: Bayesian Network Model and PROMETheus (Preoperative Mitosis Estimator Tool) Application Development Open
Background Gastrointestinal stromal tumors (GISTs) present a complex clinical landscape, where precise preoperative risk assessment plays a pivotal role in guiding therapeutic decisions. Conventional methods for evaluating mitotic count, s…
View article: Impact of disruptions in antigen processing and presentation machinery on sarcoma
Impact of disruptions in antigen processing and presentation machinery on sarcoma Open
Background: The antigen processing machinery (APM) plays a critical role in generating tumor-specific antigens that can be recognized and targeted by the immune system. The status of the APM in sarcomas is not well characterized. Methods: …
View article: Dataset related to article "Diagnostic performance of microUltrasound at MRI-guided confirmatory biopsy in patients under active surveillance for low-risk prostate cancer "
Dataset related to article "Diagnostic performance of microUltrasound at MRI-guided confirmatory biopsy in patients under active surveillance for low-risk prostate cancer " Open
<p>This record contains raw data related to article "Diagnostic performance of microUltrasound at MRI-guided confirmatory biopsy in patients under active surveillance for low-risk prostate cancer"</p>\n<p><strong>Ab…
View article: Dataset related to article "Prospective Validation of the ROL System in Substaging pT1 High-Grade Urothelial Carcinoma: Results from a Mono-Institutional Confirmatory Analysis in BCG Treated Patients"
Dataset related to article "Prospective Validation of the ROL System in Substaging pT1 High-Grade Urothelial Carcinoma: Results from a Mono-Institutional Confirmatory Analysis in BCG Treated Patients" Open
This record contains raw data related to article "Prospective Validation of the ROL System in Substaging pT1 High-Grade Urothelial Carcinoma: Results from a Mono-Institutional Confirmatory Analysis in BCG Treated Patients"Abstract<…
View article: Impact of disruptions in antigen processing and presentation machinery on sarcoma
Impact of disruptions in antigen processing and presentation machinery on sarcoma Open
Background The antigen processing machinery (APM) plays a critical role in generating tumor-specific antigens that can be recognized and targeted by the immune system. The status of the APM in sarcomas is not well characterized. Methods We…
View article: Dataset related to article "Multidisciplinary management of adolescents and young adults (AYA) sarcoma: A successful effort of an adult high-volume cancer center"
Dataset related to article "Multidisciplinary management of adolescents and young adults (AYA) sarcoma: A successful effort of an adult high-volume cancer center" Open
This record contains raw data related to article "Multidisciplinary management of adolescents and young adults (AYA) sarcoma: A successful effort of an adult high-volume cancer center"AbstractIntroduction:…
View article: Multi-imaging model for local staging and targeted treatment of localized prostate cancer using high-intensity focused ultrasound (HIFU) focal therapy
Multi-imaging model for local staging and targeted treatment of localized prostate cancer using high-intensity focused ultrasound (HIFU) focal therapy Open
View article: Dataset related to article "Exploring the CXCR4/CXCR7/CXCL12 Axis in Primary Desmoid Tumors"
Dataset related to article "Exploring the CXCR4/CXCR7/CXCL12 Axis in Primary Desmoid Tumors" Open
<p>This record contains raw data related to article "Exploring the CXCR4/CXCR7/CXCL12 Axis in Primary Desmoid Tumors"</p><p><strong>Background: </strong>Desmoid tumors have an extremely variable natural histor…
View article: Dataset related to article "Stereotactic Body Radiation Therapy for Lung Metastases From Sarcoma in Oligometastatic Patients: A Phase 2 Study"
Dataset related to article "Stereotactic Body Radiation Therapy for Lung Metastases From Sarcoma in Oligometastatic Patients: A Phase 2 Study" Open
<p>This record contains raw data related to article "Stereotactic Body Radiation Therapy for Lung Metastases From Sarcoma in Oligometastatic Patients: A Phase 2 Study"</p><p>Abstract</p><p><strong>Purpos…
View article: Table of Contents
Table of Contents Open
early detection of prostate cancer Hormone treatment for biochemical recurrence following defi nitive therapy of prostate cancer
View article: Multidisciplinary management of adolescents and young adults (<scp>AYA</scp>) sarcoma: A successful effort of an adult high‐volume cancer center
Multidisciplinary management of adolescents and young adults (<span>AYA</span>) sarcoma: A successful effort of an adult high‐volume cancer center Open
Introduction The aim of this retrospective study was to investigate the clinicopathological characteristics of AYA sarcomas and their clinical outcomes at a high‐volume single center. Methods Demographic, clinicopathological data on the di…
View article: Clinical and pathological predictors of persistent T1 HG at second resection
Clinical and pathological predictors of persistent T1 HG at second resection Open
Background: T1 high-grade (HG) non-muscle invasive bladder cancer (NMIBC) has a significant risk of recurrence and progression, and the European Association of Urology recommends a second transurethral resection of the bladder (ReTUR). Sta…
View article: PROMETheus (PReOperative Mitosis Estimator Tool) – An App to Predict Mitotic Count on the Surgical Specimen in GIST (Preprint)
PROMETheus (PReOperative Mitosis Estimator Tool) – An App to Predict Mitotic Count on the Surgical Specimen in GIST (Preprint) Open
BACKGROUND Accurate preoperative risk stratification in Gastrointestinal Stromal Tumors (GISTs) is crucial for determining the need for neoadjuvant therapy. However, existing methods, such as biopsy-based mitotic count assessment, suffer …
View article: Evaluation of Semen Self-Sampling Yield Predictors and CTC Isolation by Multi-Color Flow Cytometry for Liquid Biopsy of Localized Prostate Cancer
Evaluation of Semen Self-Sampling Yield Predictors and CTC Isolation by Multi-Color Flow Cytometry for Liquid Biopsy of Localized Prostate Cancer Open
Liquid biopsy (LB) for prostate cancer (PCa) detection could represent an alternative to biopsy. Seminal fluid (SF) is a source of PCa-specific biomarkers, as 40% of ejaculate derives from the prostate. We tested the feasibility of an SF-b…
View article: Supplementary Figure Legends from Urokinase Receptor Promotes Skin Tumor Formation by Preventing Epithelial Cell Activation of Notch1
Supplementary Figure Legends from Urokinase Receptor Promotes Skin Tumor Formation by Preventing Epithelial Cell Activation of Notch1 Open
This file include Supplementary Figure Legends
View article: Supplementary Data from Urokinase Receptor Promotes Skin Tumor Formation by Preventing Epithelial Cell Activation of Notch1
Supplementary Data from Urokinase Receptor Promotes Skin Tumor Formation by Preventing Epithelial Cell Activation of Notch1 Open
This file include more detailed Material and Methods