Piero Colli Franzone
YOU?
Author Swipe
View article: Transmural APD heterogeneity determines ventricular arrhythmogenesis in LQT8 syndrome: Insights from Bidomain computational modeling
Transmural APD heterogeneity determines ventricular arrhythmogenesis in LQT8 syndrome: Insights from Bidomain computational modeling Open
Long QT Syndrome type 8 (LQT8) is a cardiac arrhythmic disorder associated with Timothy Syndrome, stemming from mutations in the CACNA1C gene, particularly the G406R mutation. While prior studies hint at CACNA1C mutations’ role in ventricu…
View article: Unexpected impairment of INa underpins reentrant arrhythmias in a knock-in swine model of Timothy syndrome
Unexpected impairment of INa underpins reentrant arrhythmias in a knock-in swine model of Timothy syndrome Open
View article: A subgradient method with constant step-size for $$\ell _1$$-composite optimization
A subgradient method with constant step-size for $$\ell _1$$-composite optimization Open
Subgradient methods are the natural extension to the non-smooth case of the classical gradient descent for regular convex optimization problems. However, in general, they are characterized by slow convergence rates, and they require decrea…
View article: A subgradient method with constant step-size for $\ell_1$-composite optimization
A subgradient method with constant step-size for $\ell_1$-composite optimization Open
Subgradient methods are the natural extension to the non-smooth case of the classical gradient descent for regular convex optimization problems. However, in general, they are characterized by slow convergence rates, and they require decrea…
View article: Epicardial Dispersion of Repolarization Promotes the Onset of Reentry in Brugada Syndrome: A Numerical Simulation Study
Epicardial Dispersion of Repolarization Promotes the Onset of Reentry in Brugada Syndrome: A Numerical Simulation Study Open
The Brugada syndrome (BrS) is a cardiac arrhythmic disorder responsible for sudden cardiac death associated with the onset of ventricular arrhythmias, such as reentrant ventricular tachycardia and fibrillation. The mechanisms which lead to…
View article: Unexpected Impairment of INa current Underpins Reentrant Arrhythmias in a Knock-in Swine Model of Timothy Syndrome
Unexpected Impairment of INa current Underpins Reentrant Arrhythmias in a Knock-in Swine Model of Timothy Syndrome Open
Timothy Syndrome 1 (TS1) is a multiorgan form of Long QT Syndrome associated with life-threatening cardiac arrhythmias, the organ-level dynamics of which remain unclear. Here, we developed and characterized a novel porcine model of TS1 car…
View article: Role of Scar and Border Zone Geometry on the Genesis and Maintenance of Re-Entrant Ventricular Tachycardia in Patients With Previous Myocardial Infarction
Role of Scar and Border Zone Geometry on the Genesis and Maintenance of Re-Entrant Ventricular Tachycardia in Patients With Previous Myocardial Infarction Open
In patients with healed myocardial infarction, the left ventricular ejection fraction is characterized by low sensitivity and specificity in the prediction of future malignant arrhythmias. Thus, there is the need for new parameters in dail…
View article: A piecewise conservative method for unconstrained convex optimization
A piecewise conservative method for unconstrained convex optimization Open
View article: A clinical-in silico study on the effectiveness of multipoint bicathodic and cathodic-anodal pacing in cardiac resynchronization therapy
A clinical-in silico study on the effectiveness of multipoint bicathodic and cathodic-anodal pacing in cardiac resynchronization therapy Open
View article: Numerical evaluation of cardiac mechanical markers as estimators of the electrical activation time
Numerical evaluation of cardiac mechanical markers as estimators of the electrical activation time Open
Recent advances in the development of noninvasive cardiac imaging technologies have made it possible to measure longitudinal and circumferential strains at a high spatial resolution also at intramural level. Local mechanical activation tim…
View article: A Numerical Study of Scalable Cardiac Electro-Mechanical Solvers on HPC Architectures
A Numerical Study of Scalable Cardiac Electro-Mechanical Solvers on HPC Architectures Open
We introduce and study some scalable domain decomposition preconditioners for cardiac electro-mechanical 3D simulations on parallel HPC (High Performance Computing) architectures. The electro-mechanical model of the cardiac tissue is compo…
View article: Computational modeling of the electromechanical response of a ventricular fiber affected by eccentric hypertrophy
Computational modeling of the electromechanical response of a ventricular fiber affected by eccentric hypertrophy Open
The aim of this work is to study the effects of eccentric hypertrophy on the electromechanics of a single myocardial ventricular fiber by means of a one-dimensional finite-element strongly-coupled model. The electrical current ow model is …
View article: Effects of mechanical feedback on the stability of cardiac scroll waves: A bidomain electro-mechanical simulation study
Effects of mechanical feedback on the stability of cardiac scroll waves: A bidomain electro-mechanical simulation study Open
In this work, we investigate the influence of cardiac tissue deformation on re-entrant wave dynamics. We have developed a 3D strongly coupled electro-mechanical Bidomain model posed on an ideal monoventricular geometry, including fiber dir…