Pierpaolo Coni
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View article: They will be famous: Multipotent stem cells in breast milk
They will be famous: Multipotent stem cells in breast milk Open
Breast milk represents the gold standard for neonatal nutrition, especially for preterm and term infants with a low birthweight. This awareness is based not only on the nutritional properties of human milk, which is specifically designed f…
View article: Kojic Acid Derivative as an Antimitotic Agent That Selectively Kills Tumour Cells
Kojic Acid Derivative as an Antimitotic Agent That Selectively Kills Tumour Cells Open
Background/Objectives: The primary method used to pharmacologically arrest cancer development and its metastasis is to disrupt the cell division process. There are a few approaches that may be used to meet this objective, mainly through in…
View article: Thymosin β4 and β10 Expression in Human Organs during Development: A Review
Thymosin β4 and β10 Expression in Human Organs during Development: A Review Open
This review summarizes the results of a series of studies performed by our group with the aim to define the expression levels of thymosin β4 and thymosin β10 over time, starting from fetal development to different ages after birth, in diff…
View article: Stem cells of the maternal milk allow a better development of lactating newborns
Stem cells of the maternal milk allow a better development of lactating newborns Open
Recent findings of stem/progenitor cells in maternal milk and their ability to cross the intestinal barrier of lactating newborns and integrate into neonatal organs to promote optimal child development present a new challenge in perinatal …
View article: Human breast milk cells are positive for the pioneer transcription factor ISL1.
Human breast milk cells are positive for the pioneer transcription factor ISL1. Open
These preliminary results suggest that ISL1 could distinguish a readily available source of putative stem cells in human breast milk. These stem cells may complete the network created between the mother and the newborn during gestation, th…
View article: Cell starvation increases uptake of extracellular Thymosin β4 and its complexes with calcium
Cell starvation increases uptake of extracellular Thymosin β4 and its complexes with calcium Open
Cell metastasis is the main cause of cancer mortality. Inhibiting early events during cell metastasis and invasion could significantly improve cancer prognosis, but the initial mechanisms of cell transition and migration are barely known. …
View article: Exploring cell surface markers and cell-cell interactions of human breast milk stem cells
Exploring cell surface markers and cell-cell interactions of human breast milk stem cells Open
Background: Breakthrough studies have shown that pluripotent stem cells are present in human breast milk. The expression of pluripotency markers by breast milk cells is heterogeneous, relating to cellular hierarchy, from early-stage multi-…
View article: Toward the renal vesicle: Ultrastructural investigation of the cap mesenchyme splitting process in the developing kidney
Toward the renal vesicle: Ultrastructural investigation of the cap mesenchyme splitting process in the developing kidney Open
Background: A complex sequence of morphogenetic events leads to the development of the adult mouse kidney. In the present study, we investigated the morphological events that characterize the early stages of the mesenchymal-to-epithelial t…
View article: Generalized scleroderma‐like induration associated with D‐penicillamine <i>elastosis perforans serpiginosa</i> in Wilson's disease
Generalized scleroderma‐like induration associated with D‐penicillamine <i>elastosis perforans serpiginosa</i> in Wilson's disease Open
Wilson's disease is a rare autosomal recessive neurometabolic disorder of copper metabolism, whose treatment consists of metal ion excretion with the use of copper chelating agents, among which D-penicillamine is used most frequently.Skin …
View article: Thymosin β4 Is an Endogenous Iron Chelator and Molecular Switcher of Ferroptosis
Thymosin β4 Is an Endogenous Iron Chelator and Molecular Switcher of Ferroptosis Open
Thymosin β4 (Tβ4) was extracted forty years agofrom calf thymus. Since then, it has been identified as a G-actin binding protein involved in blood clotting, tissue regeneration, angiogenesis, and anti-inflammatory processes. Tβ4 has also b…
View article: Ultrastructural findings of lung injury due to Vaccine-induced Immune Thrombotic Thrombo- cytopenia (VITT) following COVID-19 vaccination: a scanning electron microscopic study.
Ultrastructural findings of lung injury due to Vaccine-induced Immune Thrombotic Thrombo- cytopenia (VITT) following COVID-19 vaccination: a scanning electron microscopic study. Open
Vaccine-induced immune thrombotic thrombocytopenia (VITT) is a rare new syndrome occurring after the ChAdOx1 nCoV-19 vaccine immunization. Patients with VITT are characterized by a variable clinical presentation, likewise also the outcome …
View article: Thyroid cancer in Sardinian pediatric patients: report of 63 cases and a review of the literature
Thyroid cancer in Sardinian pediatric patients: report of 63 cases and a review of the literature Open
8%), according to the last WHO classification.Autoimmune thyroid diseases were detected in the 29 PTCs (64% of PTCs).BRAF V600E mutation was found in 21 PTCs (47% of PTCs).Our study shows that thyroid cancer in Sardinian children and adole…
View article: Thymosin β4 and β10 are highly expressed at the deep infiltrative margins of colorectal cancer - A mass spectrometry analysis.
Thymosin β4 and β10 are highly expressed at the deep infiltrative margins of colorectal cancer - A mass spectrometry analysis. Open
The results obtained in the present investigation encouraged the hypothesis that the two thymosin are involved in colorectal cancer progression, and in promoting cancer invasion. Thus, they are good candidates to be diagnostic/prognostic b…
View article: Zinc as a Drug for Wilson’s Disease, Non-Alcoholic Liver Disease and COVID-19-Related Liver Injury
Zinc as a Drug for Wilson’s Disease, Non-Alcoholic Liver Disease and COVID-19-Related Liver Injury Open
Zinc is the second most abundant trace element in the human body, and it plays a fundamental role in human physiology, being an integral component of hundreds of enzymes and transcription factors. The discovery that zinc atoms may compete …
View article: Retrospective Comparative Analysis of KRAS G12C vs. Other KRAS Mutations in mCRC Patients Treated With First-Line Chemotherapy Doublet + Bevacizumab
Retrospective Comparative Analysis of KRAS G12C vs. Other KRAS Mutations in mCRC Patients Treated With First-Line Chemotherapy Doublet + Bevacizumab Open
Background KRAS mutations in metastatic colorectal cancer (mCRC) define a subset of tumors that have primary resistance to anti-EGFR-based therapy. Data concerning whether different KRAS mutations may also have a prognostic value are lacki…
View article: Thymosin β4 is an Endogenous Iron Chelator and Molecular Switcher of Ferroptosis
Thymosin β4 is an Endogenous Iron Chelator and Molecular Switcher of Ferroptosis Open
Thymosin β4 (Tβ4) was extracted forty years ago 1 from calf thymus. Since then, it has been identified as a G-actin binding protein involved in blood clothing, tissue regeneration, angiogenesis, and anti-inflammatory processes. Tβ4 has als…
View article: Immunohistochemical findings in the lungs of COVID-19 subjects: evidence of surfactant dysregulation.
Immunohistochemical findings in the lungs of COVID-19 subjects: evidence of surfactant dysregulation. Open
Our immunohistochemical data show the dysregulation of surfactant production in COVID-19 patients, particularly regarding SP-A expression. The increased presence of SP-A in condensed masses inside alveolar spaces could invalidate the thera…
View article: Undercover Toxic Ménage à Trois of Amylin, Copper (II) and Metformin in Human Embryonic Kidney Cells
Undercover Toxic Ménage à Trois of Amylin, Copper (II) and Metformin in Human Embryonic Kidney Cells Open
In recent decades, type 2 diabetes complications have been correlated with amylin aggregation, copper homeostasis and metformin side effects. However, each factor was analyzed separately, and only in some rare cases copper/amylin or copper…
View article: Intermediate Alpha-1 Antitrypsin Deficiency Can Play a Role in Pulmonary Exacerbation?
Intermediate Alpha-1 Antitrypsin Deficiency Can Play a Role in Pulmonary Exacerbation? Open
Background: Alpha-1 antitrypsin deficiency is generally suspected in young patients with pulmonary emphysema or chronic obstructive pulmonary disease (COPD). Patients often suffer from diagnostic delays or are misdiagnosed, for example, wi…
View article: Liver changes in Wilson's disease: the full spectrum. A report of 127 biopsies from 43 patients.
Liver changes in Wilson's disease: the full spectrum. A report of 127 biopsies from 43 patients. Open
Our data confirm the variability of the histological pattern in WD. However, the preferential localization of steatosis and balloon cells in periportal zone can be a useful clue for the diagnosis of WD.
View article: Liver changes in Wilson’s disease: the full spectrum. A report of 127 biopsies from 43 patients
Liver changes in Wilson’s disease: the full spectrum. A report of 127 biopsies from 43 patients Open
OBJECTIVE: Wilson’s Disease (WD) is an autosomal recessive copper overload. Several mutations of the copper pump named ATP7B have been involved. WD is difficult to diagnose mainly because of its heterogeneity of presentation. The histologi…
View article: Trace elements and the carotid plaque: the GOOD (Mg, Zn, Se), the UGLY (Fe, Cu), and the BAD (P, Ca)?
Trace elements and the carotid plaque: the GOOD (Mg, Zn, Se), the UGLY (Fe, Cu), and the BAD (P, Ca)? Open
Multiple epidemiological studies have suggested that industrialization and progressive urbanization should be considered one of the main factors responsible for the rising of atherosclerosis in the developing world. In this scenario, the r…
View article: Thymosin beta-4 prenatal administration improves fetal development and halts side effects due to preterm delivery.
Thymosin beta-4 prenatal administration improves fetal development and halts side effects due to preterm delivery. Open
Our study shows that TB4 administration during gestation may act as a powerful fetal growth promoter, by accelerating the development of newborn organs and tissues.
View article: Molecular pathways triggered by COVID-19 in different organs: ACE2 receptor-expressing cells under attack? A review.
Molecular pathways triggered by COVID-19 in different organs: ACE2 receptor-expressing cells under attack? A review. Open
The main pathways involved showed different pathological changes in multiple tissues and the different clinical presentations. Even if ACE2 is the main receptor of SARS-CoV-2 and the main entry point into cells for the virus, ACE2 expressi…
View article: Thymosin β4 cytoplasmic/nuclear translocation as a new marker of cellular stress. A Caco2 case study
Thymosin β4 cytoplasmic/nuclear translocation as a new marker of cellular stress. A Caco2 case study Open
Biomarkers of cell stress are important for proper diagnosis, and in studies of how cells respond to drug treatment.
View article: Oral human papilloma virus infection: an overview of clinical-laboratory diagnosis and treatment.
Oral human papilloma virus infection: an overview of clinical-laboratory diagnosis and treatment. Open
Dental care units are often the front line for a clinical evaluation of a possible HPV lesion in the oral cavity, which means that correct clinical governance could avoid a viral neoplastic progression of this disease with great advantages…
View article: Evaluation of accuracy of one-step nucleic acid amplification (OSNA) in diagnosis of lymph node metastases of papillary thyroid carcinoma. Diagnostic study
Evaluation of accuracy of one-step nucleic acid amplification (OSNA) in diagnosis of lymph node metastases of papillary thyroid carcinoma. Diagnostic study Open
OSNA is effective in detecting lymph node metastases of PTC. Considering the high risk of complications in CLND, and the uncertain prognostic value of lymph node metastases of PTC, OSNA seems to be a promising tool to identify intraoperati…
View article: BRAF-mutant colorectal cancer, a different breed evolving
BRAF-mutant colorectal cancer, a different breed evolving Open
BRAF mutant colorectal cancer (BRAF MT CRC) is a unique category of colorectal tumour with peculiar molecular, pathological and clinical features and poor prognosis; despite recent research, BRAF mutation predictive value and standard trea…