Pierpaolo Trimboli
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View article: Searching for optimized follow-up timing after radiofrequency ablation of benign thyroid nodules: Systematic review and Meta-analysis
Searching for optimized follow-up timing after radiofrequency ablation of benign thyroid nodules: Systematic review and Meta-analysis Open
View article: Variability of ChatGPT in Interpreting the Lexicon of ACR-TIRADS, EU-TIRADS, and K-TIRADS
Variability of ChatGPT in Interpreting the Lexicon of ACR-TIRADS, EU-TIRADS, and K-TIRADS Open
Background: There is an ongoing project to create an international Thyroid Imaging Reporting And Data System (I-TIRADS) to harmonize the terminology of guidelines for reporting thyroid ultrasonography. As artificial intelligence (AI) has b…
View article: Classification system of ultrasound patterns of non-nodular thyroid diseases
Classification system of ultrasound patterns of non-nodular thyroid diseases Open
View article: A subtle initial clinical presentation of a TSH-secreting PitNET
A subtle initial clinical presentation of a TSH-secreting PitNET Open
Summary Thyroid stimulating hormone (TSH)-secreting PitNETs, also called TSHomas, are rare benign pituitary tumors with an incidence of 1.0 per million population. They are generally diagnosed in the context of central hyperthyroidism and/…
View article: EndoCompass project: research roadmap for thyroid endocrinology
EndoCompass project: research roadmap for thyroid endocrinology Open
Background Endocrine science remains underrepresented in European Union research programs despite the fundamental role of hormone health in human well-being. Analysis of the CORDIS database reveals a persistent gap between the societal imp…
View article: Minimal or absent tumor desmoplasia predicts lower recurrence risk in papillary thyroid carcinoma
Minimal or absent tumor desmoplasia predicts lower recurrence risk in papillary thyroid carcinoma Open
Background Papillary thyroid carcinoma (PTC) has an excellent prognosis, yet recurrence remains a clinical concern. Patients at intermediate risk may benefit from additional prognostic markers. We aimed to evaluate whether tumor desmoplasi…
View article: P13 - Quality of life in patients with cystic thyroid nodules undergoing percutaneous ethanol injection: impact of treatment response after one year of follow-up
P13 - Quality of life in patients with cystic thyroid nodules undergoing percutaneous ethanol injection: impact of treatment response after one year of follow-up Open
Background/Introduction Little attention has been paid to the impact of percutaneous ethanol injection (PEI) of cystic thyroid nodules (CTNs) on health- related quality of life (HRQoL). Purpose To evaluate thyroid-related and generic HRQoL…
View article: Calibrating Dexcom G7 improves its performance in the context of repetitive recreational scuba diving in people with type 1 diabetes
Calibrating Dexcom G7 improves its performance in the context of repetitive recreational scuba diving in people with type 1 diabetes Open
Background The use of continuous glucose monitors (CGM) in scuba diving for patients with type 1 diabetes (T1DM) shows potential but faces challenges related to accuracy. Previous research has highlighted the poor accuracy of the Dexcom G7…
View article: Quality of Life After Ethanol Ablation of Thyroid Nodules: A 1-Year Follow-Up Study
Quality of Life After Ethanol Ablation of Thyroid Nodules: A 1-Year Follow-Up Study Open
EA of symptomatic and benign CTNs is associated with a great improvement of HRQoL scores of ThyPRO-39 and SF-36 at 6-month and 12-month follow-ups. Both physical and mental domains of HRQoL are positively affected by EA of CTNs. Risk facto…
View article: Correction: Ultrasound detection of normal parathyroid glands: detection rate, topographic anatomy and the role of underlying thyroid disease
Correction: Ultrasound detection of normal parathyroid glands: detection rate, topographic anatomy and the role of underlying thyroid disease Open
[This corrects the article DOI: 10.3389/fendo.2025.1595940.].
View article: Ultrasound Pattern of Indeterminate Thyroid Nodules with Prevalence of Oncocytes
Ultrasound Pattern of Indeterminate Thyroid Nodules with Prevalence of Oncocytes Open
Objectives: Oncocyte-rich indeterminate thyroid nodules (O-ITNs) present diagnostic and management challenges due to overlapping features between benign and malignant lesions and differing cytological classifications. This study aimed prim…
View article: Establishing the Adequate Levothyroxine Dose After Total Thyroidectomy: A Systematic Review With Meta-analysis
Establishing the Adequate Levothyroxine Dose After Total Thyroidectomy: A Systematic Review With Meta-analysis Open
Background Total thyroidectomy requires lifelong levothyroxine (LT4) therapy. Achieving optimal thyroid hormone replacement at the first postoperative follow-up might be harder than expected. Despite the various LT4 dose-choosing strategie…
View article: Ultrasound detection of normal parathyroid glands: detection rate, topographic anatomy, and the role of underlying thyroid disease
Ultrasound detection of normal parathyroid glands: detection rate, topographic anatomy, and the role of underlying thyroid disease Open
Introduction Visualizing normal parathyroid glands (PTGs) using ultrasound (US) has historically been challenging. This study aims to assess the detection rate of normal PTGs in thyroid patients and evaluate their echostructure, anatomical…
View article: ETA guidelines for the use of levothyroxine sodium preparations in monotherapy to optimize the treatment of hypothyroidism
ETA guidelines for the use of levothyroxine sodium preparations in monotherapy to optimize the treatment of hypothyroidism Open
Sodium levothyroxine (LT4) as a monotherapy represents the mainstay of treatment of hypothyroidism, and its use has increased over time. Nevertheless, it faces several potential barriers in its ‘real life’ utilization, and hence its clinic…
View article: Analysis of FNAC indication in thyroid nodules assessed as low risk according to various TIRADSs
Analysis of FNAC indication in thyroid nodules assessed as low risk according to various TIRADSs Open
Background Thyroid nodule (TN) is a common entity, and TNs assessed by Thyroid Imaging and Reporting Data Systems (TIRADSs) as low-risk lesions (TIRADS 3) can significantly impact the rate of unnecessary biopsy (UN-FNAC). This study review…
View article: Interobserver agreement between artificial intelligence models in the thyroid imaging and reporting data system (TIRADS) assessment of thyroid nodules
Interobserver agreement between artificial intelligence models in the thyroid imaging and reporting data system (TIRADS) assessment of thyroid nodules Open
Background As ultrasound (US) is the most accurate tool for assessing the thyroid nodule (TN) risk of malignancy (RoM), international societies have published various Thyroid Imaging and Reporting Data Systems (TIRADSs). With the recent ad…
View article: Meta-Analysis on the Prevalence and Significance of Incidental Findings in the Thyroid Gland Using Other PET Radiopharmaceuticals Beyond [18F]FDG
Meta-Analysis on the Prevalence and Significance of Incidental Findings in the Thyroid Gland Using Other PET Radiopharmaceuticals Beyond [18F]FDG Open
Background: Meta-analyses on the prevalence and significance of thyroid incidentalomas at PET (TIP) are available only about [18F]FDG. Focal TIP at [18F]FDG PET is not rare and may be malignant lesions in about one-third of cases. The aim …
View article: Correction: Thymic hyperplasia is accurate to detect new-onset Graves’ hyperthyroidism and resolves after restoring euthyroidism
Correction: Thymic hyperplasia is accurate to detect new-onset Graves’ hyperthyroidism and resolves after restoring euthyroidism Open
View article: Analysis of histological features and recurrence risk assessment of papillary thyroid carcinoma according to presurgery FNAC category
Analysis of histological features and recurrence risk assessment of papillary thyroid carcinoma according to presurgery FNAC category Open
Identifying preoperatively cases of more indolent papillary thyroid carcinoma (PTC)could be of high interest. The aim of this study was to verify previously published data on the prognostic value of fine needle aspiration cytology (FNAC)in…
View article: Complexity in the interpretation and application of multiple guidelines for thyroid nodules: the need for coordinated recommendations for “small” lesions
Complexity in the interpretation and application of multiple guidelines for thyroid nodules: the need for coordinated recommendations for “small” lesions Open
Multiple guidelines for thyroid nodule management have been developed by endocrinologists, often in collaboration with surgeons and radiologists. While there is now a lot of scientific information available to meet the needs of healthcare …
View article: [18F]Tetrafluoroborate, a new NIS PET/CT radiopharmaceutical: an overview focused on differentiated thyroid cancer
[18F]Tetrafluoroborate, a new NIS PET/CT radiopharmaceutical: an overview focused on differentiated thyroid cancer Open
Background In relapsing differentiated thyroid cancer (DTC), the in vivo evaluation of natrium–iodide symporter (NIS) expression is pivotal in the therapeutic planning and is achieved by 131/123 Iodine ( 131/123 I) whole body scan. However…
View article: PEG Precipitation to Detect Macro‐TSH in Clinical Practice: A Systematic Review
PEG Precipitation to Detect Macro‐TSH in Clinical Practice: A Systematic Review Open
Macro‐thyroid‐stimulating hormone (macro‐TSH) is a complex formed by monomeric TSH with anti‐TSH antibodies, causing falsely elevated TSH levels and potential misdiagnosis of hypothyroidism. Identification of macro‐TSH is essential for pro…
View article: Performance of computer scientists in the assessment of thyroid nodules using TIRADS lexicons
Performance of computer scientists in the assessment of thyroid nodules using TIRADS lexicons Open
Objectives Ultrasound (US) evaluation is recognized as pivotal in assessing the risk of malignancy (RoM) of thyroid nodules (TNs). Recently, various US-based risk-classification systems (Thyroid Imaging and Reporting Data Systems [TIRADSs]…
View article: Rebound effect of hypothalamic-pituitary thyreotropic activity: a new model to better understand hypothyroidism
Rebound effect of hypothalamic-pituitary thyreotropic activity: a new model to better understand hypothyroidism Open
View article: Refining the role of presurgical PET/4D‐CT in a large series of patients with primary hyperparathyroidism undergoing [<sup>18</sup>F]Fluorocholine PET/CT
Refining the role of presurgical PET/4D‐CT in a large series of patients with primary hyperparathyroidism undergoing [<sup>18</sup>F]Fluorocholine PET/CT Open
Background 4D‐CT has garnered attention as complementary imaging for patients with primary hyperparathyroidism (pHPT). Herein we evaluated a diagnostic strategy using [ 18 F]Fluorocholine Positron Emission Tomography/Computed Tomography (P…
View article: Assessment of Bone Mineral Density Over 1 Year in a Cross-Sectional Cohort of Migraine Patients Receiving Anti-CGRP Monoclonal Antibodies
Assessment of Bone Mineral Density Over 1 Year in a Cross-Sectional Cohort of Migraine Patients Receiving Anti-CGRP Monoclonal Antibodies Open
View article: Performance of ACR-TIRADS in assessing thyroid nodules does not vary according to patient age
Performance of ACR-TIRADS in assessing thyroid nodules does not vary according to patient age Open
Aims A few studies have evaluated the performance of the American College of Radiology Thyroid Imaging Reporting And Data System (ACR-TIRADS) in pediatric and elderly patients and found differences between the latter two age groups and mid…
View article: Risk of TIRADS-based inappropriate FNAC in autonomous thyroid nodules is clinically negligible
Risk of TIRADS-based inappropriate FNAC in autonomous thyroid nodules is clinically negligible Open
Objective Thyroid nodule (TN) is usually managed according to Thyroid Imaging And Reporting Data Systems (TIRADS) with the major aim to reduce as much as possible unnecessary fine-needle aspiration cytologies (UN-FNACs). Since the assessme…
View article: The value of ACR, European, Korean, and ATA ultrasound risk stratification systems combined with RAS mutations for detecting thyroid carcinoma in cytologically indeterminate and suspicious for malignancy thyroid nodules
The value of ACR, European, Korean, and ATA ultrasound risk stratification systems combined with RAS mutations for detecting thyroid carcinoma in cytologically indeterminate and suspicious for malignancy thyroid nodules Open
View article: [18F]Fluorocholine PET/CT as First-Line vs. Second-Line Imaging Method to localize parathyroid adenomas in primary hyperparathyroidism: “Game, Set, and Match”
[18F]Fluorocholine PET/CT as First-Line vs. Second-Line Imaging Method to localize parathyroid adenomas in primary hyperparathyroidism: “Game, Set, and Match” Open