Pierre Bouloux
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View article: Extracellular matrix protein anosmin-1 regulates Schwann cell-astrocyte interaction for regenerative axon targeting in dorsal root crush injury model
Extracellular matrix protein anosmin-1 regulates Schwann cell-astrocyte interaction for regenerative axon targeting in dorsal root crush injury model Open
Schwann cell (SC) transplantation is considered as a promising strategy for spinal cord injury. However, SCs show less capability in assisting the regenerative axons to penetrate through astrocyte (AS)-formed scar barrier. Anosmin-1, an ex…
View article: A core outcome set for pituitary surgery research: an international delphi consensus study
A core outcome set for pituitary surgery research: an international delphi consensus study Open
View article: Identifying research priorities for pituitary adenoma surgery: an international Delphi consensus statement
Identifying research priorities for pituitary adenoma surgery: an international Delphi consensus statement Open
Purpose Pituitary surgery is the mainstay treatment for most pituitary adenomas, but many questions remain about perioperative and long-term management and outcomes. This study aimed to identify the most pressing research priorities in pit…
View article: Non-functioning pituitary macroadenoma following surgery: long-term outcomes and development of an optimal follow-up strategy
Non-functioning pituitary macroadenoma following surgery: long-term outcomes and development of an optimal follow-up strategy Open
Objectives Recurrence and regrowth of non-functioning pituitary macroadenomas (NFPMs) after surgery are common but remain unpredictable. Therefore, the optimal timing and frequency of follow-up imaging remain to be determined. We sought to…
View article: Pituitary function at presentation and following therapy in patients with non-functional pituitary macroadenomas: a single centre retrospective cohort study
Pituitary function at presentation and following therapy in patients with non-functional pituitary macroadenomas: a single centre retrospective cohort study Open
View article: Pituitary Function at Presentation and Following Therapy in Patients with Non-functional Pituitary Adenomas: A Single Centre Retrospective Cohort Study
Pituitary Function at Presentation and Following Therapy in Patients with Non-functional Pituitary Adenomas: A Single Centre Retrospective Cohort Study Open
Background: Non-functioning pituitary macroadenomas (NFPMs) may present with hypopituitarism. Pituitary surgery and radiotherapy pose an additional risk to pituitary function. Objectives To assess the incidence of hypopituitarism at presen…
View article: A Comparison of the Blood Glucose, Growth Hormone, and Cortisol Responses to Two Doses of Insulin (0.15 U/kg vs. 0.10 U/kg) in the Insulin Tolerance Test: A Single-Centre Audit of 174 Cases
A Comparison of the Blood Glucose, Growth Hormone, and Cortisol Responses to Two Doses of Insulin (0.15 U/kg vs. 0.10 U/kg) in the Insulin Tolerance Test: A Single-Centre Audit of 174 Cases Open
Objective. The insulin tolerance test (ITT) is the gold standard endocrine test used to assess the integrity of the growth hormone (GH) and cortisol axes. The ITT has potential risks, and severe hypoglycaemia may necessitate intravenous gl…
View article: The management and outcome of hyponatraemia following transsphenoidal surgery: a retrospective observational study
The management and outcome of hyponatraemia following transsphenoidal surgery: a retrospective observational study Open
View article: MANAGEMENT OF ENDOCRINE DISEASE: Dysnatraemia in COVID-19: prevalence, prognostic impact, pathophysiology, and management
MANAGEMENT OF ENDOCRINE DISEASE: Dysnatraemia in COVID-19: prevalence, prognostic impact, pathophysiology, and management Open
This review examines the prevalence, aetiology, pathophysiology, prognostic value, and investigation of dysnatraemia in hospitalised COVID-19 patients, taking into account all relevant studies published in PubMed and Cochrane Library studi…
View article: Outcome of Petrosal Venous Sampling in Consecutive 68 Patients From a Major Neurosurgical Center in the United Kingdom
Outcome of Petrosal Venous Sampling in Consecutive 68 Patients From a Major Neurosurgical Center in the United Kingdom Open
Background: Cushing’s disease is a challenging endocrine disorder caused by non-physiological cortisol excess from adrenocorticotropic hormone (ACTH) secreting pituitary adenoma. Inferior petrosal venous sampling (IPSS) is considered the g…
View article: The Management And Outcome of Hyponatraemia Following Transsphenoidal Surgery: A Retrospective Observational Study
The Management And Outcome of Hyponatraemia Following Transsphenoidal Surgery: A Retrospective Observational Study Open
Purpose: Hyponatraemia is a common complication following transsphenoidal surgery. However, there is sparse data on its optimal management and impact on clinical outcomes. The aim of this study was to evaluate the management and outcome of…
View article: Protracted ketonaemia in hyperglycaemic emergencies in COVID-19: a retrospective case series
Protracted ketonaemia in hyperglycaemic emergencies in COVID-19: a retrospective case series Open
View article: Significant Benefits of <i>AIP</i> Testing and Clinical Screening in Familial Isolated and Young-onset Pituitary Tumors
Significant Benefits of <i>AIP</i> Testing and Clinical Screening in Familial Isolated and Young-onset Pituitary Tumors Open
Context Germline mutations in the aryl hydrocarbon receptor-interacting protein (AIP) gene are responsible for a subset of familial isolated pituitary adenoma (FIPA) cases and sporadic pituitary neuroendocrine tumors (PitNETs). Objective T…
View article: Improving care and outcomes of inpatients with syndrome of inappropriate antidiuresis (SIAD): a prospective intervention study of intensive endocrine input vs. routine care
Improving care and outcomes of inpatients with syndrome of inappropriate antidiuresis (SIAD): a prospective intervention study of intensive endocrine input vs. routine care Open
View article: Neuroendocrine abnormalities in Parkinson's disease
Neuroendocrine abnormalities in Parkinson's disease Open
Neuroendocrine abnormalities are common in Parkinson's disease (PD) and include disruption of melatonin secretion, disturbances of glucose, insulin resistance and bone metabolism, and body weight changes. They have been associated with mul…
View article: Landscape of Familial Isolated and Young-Onset Pituitary Adenomas: Prospective Diagnosis in<i>AIP</i>Mutation Carriers
Landscape of Familial Isolated and Young-Onset Pituitary Adenomas: Prospective Diagnosis in<i>AIP</i>Mutation Carriers Open
A quarter of the AIPmut carriers screened were diagnosed with pituitary disease, justifying this screening and suggesting a variable clinical course for AIPmut-positive pituitary adenomas.
View article: Effects of long-term oral testosterone undecanoate therapy on urinary symptoms: data from a 1-year, placebo-controlled, dose-ranging trial in aging men with symptomatic hypogonadism
Effects of long-term oral testosterone undecanoate therapy on urinary symptoms: data from a 1-year, placebo-controlled, dose-ranging trial in aging men with symptomatic hypogonadism Open
Background: There has been a longstanding question as to whether testosterone therapy could precipitate or worsen urinary symptoms in aging men. We investigated the effects of 1-year oral testosterone undecanoate (TU) therapy on urinary sy…
View article: Dysfunctional SEMA3E signaling underlies gonadotropin-releasing hormone neuron deficiency in Kallmann syndrome
Dysfunctional SEMA3E signaling underlies gonadotropin-releasing hormone neuron deficiency in Kallmann syndrome Open
Individuals with an inherited deficiency in gonadotropin-releasing hormone (GnRH) have impaired sexual reproduction. Previous genetic linkage studies and sequencing of plausible gene candidates have identified mutations associated with inh…
View article: Inpatient hyponatraemia: adequacy of investigation and prevalence of endocrine causes
Inpatient hyponatraemia: adequacy of investigation and prevalence of endocrine causes Open