Explanipedia

Characterization of near-complete hepatitis E virus genomes of genotype 1e and 4b detected from humans in Cameroon Open

Abdou Fatawou Modiyinji, Pierre Cappy, Arnaud Ly, Aristide Mounchili-Njifon, Moïse Henri Moumbeket-Yifomnjou , et al. · 2025

Hepatitis E virus (HEV) is an important public health concern, especially in developing countries. Complete genomes of HEV strains circulating in Cameroon are not available. Here, we report five nearly complete strains of HEV in Cameroon. …

Severe parvovirus B19 infection in patients with sickle cell disease hospitalized in intensive care units Open

Ségolène Gendreau, Louis-Marie Coupry, Pierre Cappy, Alexandra Beurton, Nicolas Verger , et al. · 2025

Parvovirus B19 infection can lead to severe complications in patients with chronic hemolysis. The aim of this study was to describe severe parvovirus B19 infections in adult patients with sickle cell disease (SCD). In this multicenter, ret…

Genomics-based approach for detection and characterization of SARS-CoV-2 co-infections and diverse viral populations Open

Bryan Jimenez-Araya, Aurélie Gourgeon, Mélissa N’Debi, Bruce Thompson, Vanessa Démontant , et al. · 2025

Due to the continuous genetic diversification of severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) over time, the co-circulation of two different lineages in the same region may lead to co-infections within a host, a situat…

Real-World Emergence of Nirsevimab Resistance in RSV-B Breakthrough Infections Open

Slim Fourati, Alawiya Reslan, Jérôme Bourret, Jean‐Sébastien Casalegno, Yannis Rahou , et al. · 2025

Multicenter benchmarking of short and long read wet lab protocols for clinical viral metagenomics Open

F. Xavier López‐Labrador, Michael Huber, Igor A. Sidorov, Julianne R. Brown, Lize Cuypers , et al. · 2024

Multicenter benchmarking of short and long read wet lab protocols for clinical viral metagenomics Open

F. Xavier López‐Labrador, Michael Huber, Igor A. Sidorov, Julianne R. Brown, Lize Cuypers , et al. · 2024

Metagenomics is gradually being implemented for diagnosing infectious diseases. However, in-depth protocol comparisons for viral detection have been limited to individual sets of experimental workflows and laboratories. In this study, we p…

Gynoid Fat Distribution and Adipocyte Trapping May Explain Virological Failure With Intramuscular Long-Acting Cabotegravir and Rilpivirine Open

Isabelle de Malliard, Anne-Laure Houist, Gilles Peytavin, Thomas L’Yavanc, Michel Bouvier , et al. · 2023

Intramuscular long-acting antiretroviral drugs can improve adherence to lifelong antiretroviral treatment. Nevertheless, adipose tissue thickness and distribution play a critical role with injectable drugs. We describe a virological failur…

Unknown Circovirus in Immunosuppressed Patient with Hepatitis, France, 2022 Open

Christophe Rodriguez, Laure Boizeau, Alexandre Soulier, Mélissa N’Debi, Vanessa Démontant , et al. · 2023

Hepatitis of undetermined origin can be caused by a wide variety of pathogens, sometimes emerging pathogens. We report the discovery, by means of routine shotgun metagenomics, of a new virus belonging to the family Circoviridae, genus Circ…

Insights on 21 Years of HBV Surveillance in Blood Donors in France Open

Pierre Cappy, Laure Boizeau, Daniel Candotti, Sophie Le Cam, Christophe Martinaud , et al. · 2022

Hepatitis B virus (HBV) infection is the most frequent viral infection found in blood donors (BDs) in France. We analyzed the epidemiological and sero-molecular data on HBV infection gathered over the past two decades by the French haemovi…

SARS-CoV-2 and post-donation information: a one-year experience of the French haemovigilance network. Open

Pierre Cappy, Saadia Legrain-Jbilou, Lila Chabli, Mélissa N’Debi, Pierre Gallian , et al. · 2022

SARS-CoV-2 RNA can be detected in a small fraction of blood donors with PDI, reporting very low levels of RNA. The corresponding plasma is probably not infectious. These findings highlight the value of haemovigilance and PDI to guide blood…

Effectiveness of the HCV blood screening strategy through eighteen years of surveillance of HCV infection in blood donors in France. Open

Pierre Cappy, Laure Boizeau, Daniel Candotti, Rémi Caparros, Quentin Lucas , et al. · 2022

The decline in HCV-NAT yield cases raises the question of the relevance of NAT. Conversely, the increase in Ab+/NAT-donors, suggesting a growing number of resolved infections, argue for Ab discontinuation. In our experience, at least 0.5% …

DGVRetroDon : contribution à l’évaluation du risque de transmission du SARS-CoV-2 par transfusion par un dépistage de l’ARN viral plasmatique dans des dons de sang en France Open

Sophie Le Cam, Céline Ricard, Céline Narboux, Valérie Barlet, Claude Maugard , et al. · 2021

SARS-CoV-2 and post-donation information: the one-year experience of the French Haemovigilance network Open

Pierre Cappy · 2021

This dataset was gathered from February 18, 2020 and January 18, using the French haemovigilance network. Provided information are related to donations: date of donation, gender and age of the donor), and to post-donation information (PDI)…

No evidence of SARS-CoV-2 transfusion transmission despite RNA detection in blood donors showing symptoms after donation Open

Pierre Cappy, Daniel Candotti, Virginie Sauvage, Quentin Lucas, Laure Boizeau , et al. · 2020

The risk of transfusion-associated transmission of SARS-CoV-2 is unknown. Cappy and colleagues report on hemovigilance studies of 268 blood donations from individuals reporting symptoms shortly after donation. Of 268 samples, 3 tested posi…

NKNK: a New Essential Motif in the C-Terminal Domain of HIV-1 Group M Integrases Open

Marine Kanja, Pierre Cappy, Nicolas Lévy, Oyndamola Oladosu, Sylvie Schmidt , et al. · 2020

Intensive studies of HIV-1 have revealed its extraordinary ability to adapt to environmental and immunological challenges, an ability that is also at the basis of antiviral treatment escape. Here, by deconvoluting the different roles of th…

A Highly Prevalent Polymorphism in the Core Region Impairs Quantification of Hepatitis B Virus (HBV) by the cobas TaqMan HBV Assay Open

Laure Boizeau, Annabelle Servant‐Delmas, Alexandra Ducancelle, Stéphane Chevaliez, Vincent Thibault , et al. · 2020

The high genetic variability of hepatitis B virus (HBV) can impair DNA quantification. Here, we investigate a major underquantification of HBV by the cobas TaqMan HBV assay (CTM; Roche). In France, between 2005 and 2017, HBV DNA was detect…

Genetically flexible but conserved: a new essential motif in the C-ter domain of HIV-1 group M integrases Open

Marine Kanja, Pierre Cappy, Nicolas Lévy, Oyndamola Oladosu, Sylvie Schmidt , et al. · 2020

Using coevolution-network interference based on the comparison of two phylogenetically distantly related isolates, one from the main group M and the other from the minor group O of HIV-1, we identify, in the C-terminal domain (CTD) of inte…

In vivo emergence of an HIV-1/MO recombinant revealed undiagnosed HIV-1/M+O co-infection Open

Alice Moisan, Fabienne De Oliveira, Charlotte Pronier, Pierre Cappy, Anne Maillard , et al. · 2019

Detection of numerous HIV-1/MO recombinants in France Open

Fabienne De Oliveira, Pierre Cappy, Véronique Lemée, Alice Moisan, Charlotte Pronier , et al. · 2018

Our work highlights the fact that the continuous evolution of HIV can hinder diagnosis and complicate clinical practice. We stress that unexpected results during diagnosis or monitoring necessitate further serological and molecular explora…

Genetic Flexibility of the NKNK Motif in HIV-1 Integrases Allows Its Involvement in Multiple Functions During Infection Open

Marine Kanja, Pierre Cappy, Guillermo Blanco-Rodriguez, Nicolas Lévy, Oyndamola Oladosu , et al. · 2018

HIV-1 sequences in the epidemic suggest an alternative pathway for the generation of the Long Terminal Repeats Open

Pierre Cappy, Alice Moisan, Fabienne De Oliveira, Jean‐Christophe Plantier, Matteo Negroni · 2017

Evolution of HIV-1 groups M and O: genetic comparative analysis of 23 HIV-1/MO inter-group recombinant forms Open

Alice Moisan, Fabienne De Oliveira, Pierre Cappy, Paul-Alain Ngoupo, Richard Njouom , et al. · 2017

Analyse génétique comparée de 19 formes recombinantes VIH-1 inter-groupes M et O et impact évolutif Open

Audrey Moisan, F de Oliveira, Pierre Cappy, Paul Alain Tagnouokam‐Ngoupo, Aurélia Vessière , et al. · 2016

A Multiplex PCR Approach for Detecting Dual Infections and Recombinants Involving Major HIV Variants Open

Pierre Cappy, Fabienne De Oliveira, Marie Gueudin, Élodie Alessandri-Gradt, Jean‐Christophe Plantier · 2016

The cocirculation of different HIV types and groups can lead to dual infections and recombinants, which hinder diagnosis and therapeutic management. We designed two multiplex PCRs (mPCRs) coupled with capillary electrophoresis to facilitat…

HIV-1/M+O INTERGROUP DUAL INFECTIONS AND ASSOCIATED HIV-MO RECOMBINANTS IN FRANCE FROM 2004 TO 2014 Open

Pierre Cappy, Fabienne De Oliveira, Véronique Lemee, Jean‐Louis Gaillard, Laurence Bocquet , et al. · 2015

DUAL HIV-1/M+O INFECTIONS AND HIV-1/MO RECOMBINANTS IN FRANCE FROM 2004 TO 2014 Open

Pierre Cappy, Fabienne De Oliveira, Véronique Lemee, Jean‐Louis Gaillard, Laurence Bocquet , et al. · 2015

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