Jean‐Pierre Farmer
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View article: Ambulatory children with spastic cerebral palsy have smaller bone area and deficits in trabecular microarchitecture
Ambulatory children with spastic cerebral palsy have smaller bone area and deficits in trabecular microarchitecture Open
Cerebral palsy (CP) is a non-progressive neurological syndrome resulting in abnormal muscle tone, movement, and posture. It is unclear whether ambulatory children with CP have deficits in bone quantity or quality. Furthermore, the relation…
View article: Supplementary Data S1 from Clinical Characteristics and Outcomes of Central Nervous System Tumors Harboring NTRK Gene Fusions
Supplementary Data S1 from Clinical Characteristics and Outcomes of Central Nervous System Tumors Harboring NTRK Gene Fusions Open
Supplementary Data S1. Definition of response, Description of response criteria used by sites to evaluate tumor response, Definition of extend of resection, Definition of extend of resection used by sites.
View article: Supplementary Table S5 from Clinical Characteristics and Outcomes of Central Nervous System Tumors Harboring NTRK Gene Fusions
Supplementary Table S5 from Clinical Characteristics and Outcomes of Central Nervous System Tumors Harboring NTRK Gene Fusions Open
Supplementary Table S5. Method of NTRK fusion detection as reported by participating centers.
View article: Supplementary Table S4 from Clinical Characteristics and Outcomes of Central Nervous System Tumors Harboring NTRK Gene Fusions
Supplementary Table S4 from Clinical Characteristics and Outcomes of Central Nervous System Tumors Harboring NTRK Gene Fusions Open
Supplementary Table S4. Other molecular alterations reported.
View article: Supplementary Figure S1 from Clinical Characteristics and Outcomes of Central Nervous System Tumors Harboring NTRK Gene Fusions
Supplementary Figure S1 from Clinical Characteristics and Outcomes of Central Nervous System Tumors Harboring NTRK Gene Fusions Open
Supplementary Figure S1. Diagram of population patients.
View article: Supplementary Table S1 from Clinical Characteristics and Outcomes of Central Nervous System Tumors Harboring NTRK Gene Fusions
Supplementary Table S1 from Clinical Characteristics and Outcomes of Central Nervous System Tumors Harboring NTRK Gene Fusions Open
Supplementary Table S1. NTRK fusion type and histology.
View article: Supplementary Table S2 from Clinical Characteristics and Outcomes of Central Nervous System Tumors Harboring NTRK Gene Fusions
Supplementary Table S2 from Clinical Characteristics and Outcomes of Central Nervous System Tumors Harboring NTRK Gene Fusions Open
Supplementary Table S2. Responses based on clinical assessment for each line of therapy. Non-targeted therapy and TRKi given concurrently in a specific line were excluded.
View article: Data from Clinical Characteristics and Outcomes of Central Nervous System Tumors Harboring NTRK Gene Fusions
Data from Clinical Characteristics and Outcomes of Central Nervous System Tumors Harboring NTRK Gene Fusions Open
Purpose:Tropomyosin receptor kinase (TRK) fusions are detected in less than 2% of central nervous system tumors. There are limited data on the clinical course of affected patients.Experimental Design:We conducted an international retrospec…
View article: Supplementary Figure S2 from Clinical Characteristics and Outcomes of Central Nervous System Tumors Harboring NTRK Gene Fusions
Supplementary Figure S2 from Clinical Characteristics and Outcomes of Central Nervous System Tumors Harboring NTRK Gene Fusions Open
Supplementary Figure S2. A) Hazard ratio for progression or death according to clinical characteristics. B) Hazard ratio for death according to clinical characteristics. LGG: Low-grade glioma, HGG: High-grade glioma
View article: Supplementary Table S3 from Clinical Characteristics and Outcomes of Central Nervous System Tumors Harboring NTRK Gene Fusions
Supplementary Table S3 from Clinical Characteristics and Outcomes of Central Nervous System Tumors Harboring NTRK Gene Fusions Open
Supplementary Table S3. Survival outcome.
View article: Clinical Characteristics and Outcomes of Central Nervous System Tumors Harboring NTRK Gene Fusions
Clinical Characteristics and Outcomes of Central Nervous System Tumors Harboring NTRK Gene Fusions Open
Purpose: Tropomyosin receptor kinase (TRK) fusions are detected in less than 2% of central nervous system tumors. There are limited data on the clinical course of affected patients. Experimental Design: We conducted an international retros…
View article: mTOR Pathway Somatic Pathogenic Variants in Focal Malformations of Cortical Development
mTOR Pathway Somatic Pathogenic Variants in Focal Malformations of Cortical Development Open
The AAF of somatic pathogenic variants correlated with the topographic distribution, histopathology, and postsurgical outcomes. Moreover, cortical regions with absent histologic FCD features had negligible or undetectable pathogenic varian…
View article: Data from Genetic Aberrations Leading to MAPK Pathway Activation Mediate Oncogene-Induced Senescence in Sporadic Pilocytic Astrocytomas
Data from Genetic Aberrations Leading to MAPK Pathway Activation Mediate Oncogene-Induced Senescence in Sporadic Pilocytic Astrocytomas Open
Purpose: Oncogenic BRAF/Ras or NF1 loss can potentially trigger oncogene-induced senescence (OIS) through activation of the mitogen-activated protein kinase (MAPK) pathway. Somatic genetic abnormalities affecting this pathway occur …
View article: Data from Genetic Aberrations Leading to MAPK Pathway Activation Mediate Oncogene-Induced Senescence in Sporadic Pilocytic Astrocytomas
Data from Genetic Aberrations Leading to MAPK Pathway Activation Mediate Oncogene-Induced Senescence in Sporadic Pilocytic Astrocytomas Open
Purpose: Oncogenic BRAF/Ras or NF1 loss can potentially trigger oncogene-induced senescence (OIS) through activation of the mitogen-activated protein kinase (MAPK) pathway. Somatic genetic abnormalities affecting this pathway occur …
View article: Supplementary Data from Genetic Aberrations Leading to MAPK Pathway Activation Mediate Oncogene-Induced Senescence in Sporadic Pilocytic Astrocytomas
Supplementary Data from Genetic Aberrations Leading to MAPK Pathway Activation Mediate Oncogene-Induced Senescence in Sporadic Pilocytic Astrocytomas Open
Supplementary Figures S1-S3; Supplementary Tables S1-S2.
View article: Supplementary Data from Genetic Aberrations Leading to MAPK Pathway Activation Mediate Oncogene-Induced Senescence in Sporadic Pilocytic Astrocytomas
Supplementary Data from Genetic Aberrations Leading to MAPK Pathway Activation Mediate Oncogene-Induced Senescence in Sporadic Pilocytic Astrocytomas Open
Supplementary Figures S1-S3; Supplementary Tables S1-S2.
View article: Subtle magnetic resonance imaging differences in tegmental pilocytic astrocytomas as a caution against attempting gross-total resection: illustrative cases
Subtle magnetic resonance imaging differences in tegmental pilocytic astrocytomas as a caution against attempting gross-total resection: illustrative cases Open
BACKGROUND Although surgery within the tegmentum of the midbrain is challenging, resection of tegmental pilocytic astrocytomas (PAs) is a standard treatment because this has been shown to outperform chemotherapy and radiotherapy in terms o…
View article: GABAB receptor outward currents are transiently disclosed by the convulsant 4-aminopyridine in vitro
GABAB receptor outward currents are transiently disclosed by the convulsant 4-aminopyridine in vitro Open
The K+ channel blocker 4-aminopyridine (4AP) has been extensively used to investigate the mechanisms underlying neuronal network synchronization in both in vitro and in vivo animal models of focal epilepsy. 4AP-ind…
View article: K27M in canonical and noncanonical H3 variants occurs in distinct oligodendroglial cell lineages in brain midline gliomas
K27M in canonical and noncanonical H3 variants occurs in distinct oligodendroglial cell lineages in brain midline gliomas Open
View article: HGG-11. Clinical characteristics and clinical evolution of a large cohort of pediatric patients with primary central nervous system (CNS) tumors and tropomyosin receptor kinase (TRK) fusion.
HGG-11. Clinical characteristics and clinical evolution of a large cohort of pediatric patients with primary central nervous system (CNS) tumors and tropomyosin receptor kinase (TRK) fusion. Open
BACKGROUND: TRK fusions are detected in less than 3% of CNS tumors. Given their rarity, there are limited data on the clinical course of these patients. METHODS: We contacted 166 oncology centers worldwide to retrieve data on patients with…
View article: P.173 Evaluation of Arterial Spin Labeling (ASL) Perfusion Imaging in Poorly-Defined Focal Epilepsy in Children
P.173 Evaluation of Arterial Spin Labeling (ASL) Perfusion Imaging in Poorly-Defined Focal Epilepsy in Children Open
Background: Poorly-defined cases (PDCs) of focal epilepsy are cases with no/subtle MRI abnormalities or have abnormalities extending beyond the lesion visible on MRI. Here, we evaluated the utility of Arterial Spin Labeling (ASL) MRI perfu…
View article: Pelvic pseudocyst presenting with vaginal drainage of cerebrospinal fluid in an adolescent: A rare complication of ventriculoperitoneal shunt
Pelvic pseudocyst presenting with vaginal drainage of cerebrospinal fluid in an adolescent: A rare complication of ventriculoperitoneal shunt Open
The case report describes a 16-year-old female with a ventriculoperitoneal (VP) shunt due to congenital hydrocephalus. She presented with abdominal pain and vaginal leakage of cerebrospinal fluid (CSF). CT imaging demonstrated multiple int…
View article: Letter: The Risk of COVID-19 Infection During Neurosurgical Procedures: A Review of Severe Acute Respiratory Distress Syndrome Coronavirus 2 (SARS-CoV-2) Modes of Transmission and Proposed Neurosurgery-Specific Measures for Mitigation
Letter: The Risk of COVID-19 Infection During Neurosurgical Procedures: A Review of Severe Acute Respiratory Distress Syndrome Coronavirus 2 (SARS-CoV-2) Modes of Transmission and Proposed Neurosurgery-Specific Measures for Mitigation Open
To the Editor: The novel coronavirus disease of 2019 (COVID-19) is a disease caused by the severe acute respiratory distress syndrome coronavirus 2 (SARS-CoV-2). It was first reported in December 2019 as a series of cases of pneumonia with…
View article: Operative Time as the Predominant Risk Factor for Transfusion Requirements in Nonsyndromic Craniosynostosis Repair
Operative Time as the Predominant Risk Factor for Transfusion Requirements in Nonsyndromic Craniosynostosis Repair Open
Background: Despite recent advances in surgical, anesthetic, and safety protocols in the management of nonsyndromic craniosynostosis (NSC), significant rates of intraoperative blood loss continue to be reported by multiple centers. The pur…
View article: Stalled developmental programs at the root of pediatric brain tumors
Stalled developmental programs at the root of pediatric brain tumors Open
View article: Correction to: Efficacy of Dabrafenib for three children with brainstem BRAFV600E positive ganglioglioma
Correction to: Efficacy of Dabrafenib for three children with brainstem BRAFV600E positive ganglioglioma Open
View article: CJN volume 46 issue 5 Cover and Front matter
CJN volume 46 issue 5 Cover and Front matter Open
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View article: Hyperacute Infarct on Intraoperative Diffusion Imaging of Pediatric Brain Tumor Surgery
Hyperacute Infarct on Intraoperative Diffusion Imaging of Pediatric Brain Tumor Surgery Open
Background: Brain neoplasms are the second-most prevalent cancer of childhood for which surgical resection remains the main treatment. Intraoperative MRI is a useful tool to optimize brain tumor resection. It is, however, not known whether…
View article: PDCT-08. TRAMETINIB AND DABRAFENIB FOR REFRACTORY/INOPERABLE PEDIATRIC LOW GRADE GLIOMAS
PDCT-08. TRAMETINIB AND DABRAFENIB FOR REFRACTORY/INOPERABLE PEDIATRIC LOW GRADE GLIOMAS Open
BACKGROUND: Low grade gliomas (LGG) are the most common pediatric brain tumors and frequently harbor BRAF mutations or fusions. In cases of refractory and progressing LGG, BRAF and MEK inhibitors now offer an interesting therapeutic approa…
View article: Magnetic Resonance Myelography in Congenital Absence of the Cervical Pedicle
Magnetic Resonance Myelography in Congenital Absence of the Cervical Pedicle Open
Absence of the cervical pedicle is a very rare congenital anomaly, easily misrecognized as a unilateral facet dislocation in a setting of acute trauma or a neoplastic process like a nerve sheath tumor. Although correct diagnosis can be ach…