Explanipedia

Renal and Cardiovascular Outcomes in Renal Transplant Candidates According to Coronary Status Open

Louis Giovachini, Pierre Galichon, P Charleux, Iyad Rifai, Lilith Faucheux , et al. · 2025

Background To date, there is no consensus regarding coronary artery disease (CAD) screening strategy among renal transplant candidates. This study sought to evaluate the association between the coronary status at waitlisting for renal tran…

Epigenetic signatures on plasma cell-free DNA to detect kidney allograft rejection in a non-invasive way: development of a 10-plex digital PCR assay Open

Yoan Velut, Geoffroy Poulet, Thomas Bersez, P. D. Boyer, Coraline Maujean , et al. · 2025

Feasibility and Prognostic Value of Stress Cardiovascular Magnetic Resonance in Patients With End-Stage Renal Disease Open

Iyad Rifai, S. Ourahma, Thomas Broussaud, Pierre Galichon, Nadjia Kachenoura , et al. · 2025

In ESRD patients, stress CMR is feasible, safe, and adds significant prognostic value for MACE beyond traditional risk factors by characterizing patterns of microvascular and macrovascular disease.

Neuropilin‐1 regulates renin synthesis in juxtaglomerular cells Open

Yunzhu Shen, Kenza Lotenberg, Jérémy Zaworski, Katharina A.E. Broeker, Florence Vasseur , et al. · 2024

Renin is the key enzyme of the systemic renin–angiotensin–aldosterone system, which plays an essential role in regulating blood pressure and maintaining electrolyte and extracellular volume homeostasis. Renin is mainly produced and secrete…

Energy depletion by cell proliferation sensitizes the kidney epithelial cells to injury Open

Pierre Galichon, Morgane Lannoy, Li Li, Justine Serre, Sophie Vandermeersch , et al. · 2024

ATP depletion is a hallmark of acute kidney injury. Proliferation is instrumental to kidney repair. We show that ATP levels vary during the cell cycle and that proliferation sensitizes renal epithelial cells to superimposed injuries in vit…

Protective Role of the Podocyte IL-15 / STAT5 Pathway in Focal Segmental Glomerulosclerosis Open

Aïssata Niasse, Kévin Louis, Olivia Lenoir, Chloé Schwarz, Xiaoli Xu , et al. · 2024

Effect of Cardiac Arrest in Brain-dead Donors on Kidney Graft Function Open

Quentin Dubourg, Émilie Savoye, Sarah Drouin, Camille Legeai, Benoı̂t Barrou , et al. · 2023

Background. Cardiac arrest (CA) causes renal ischemia in one-third of brain-dead kidney donors before procurement. We hypothesized that the graft function depends on the time interval between CA and organ procurement. Methods. We conducted…

Immunoadsorption-Based HLA Desensitization in Patients Awaiting Deceased Donor Kidney Transplantation: An Interventional, Non-Randomised, Single Cohort Study Open

Côme Bureau, Cédric Rafat, Jean‐Luc Taupin, Stéphanie Malard, Laurent Mesnard , et al. · 2023

Whether immunoadsorption (IADS) as part of desensitization protocols could facilitate deceased donor kidney transplantation (KT) in highly sensitized (HS) patients remains to be proven. We retrospectively analyzed our IADS based desensitiz…

Pulmonary hypertension without heart failure causes cardiorenal syndrome in a porcine model Open

Arthur Orieux, Chloé Samson, Laurence Piéroni, Sarah Drouin, Simon Dang Van , et al. · 2023

Cardiorenal syndromes type 1 and 2 are complex disorders in which cardiac dysfunction leads to kidney dysfunction. However, the mechanisms remain incompletely explained, during pulmonary hypertension in particular. The objective of this st…

#3828 KINETICS OF THE DE NOVO NAD/NADH PATHWAY FROM AKI TO CKD Open

Justine Serre, Alexandre Bras, Franck Merlier, Chloé Samson, Sandrine Placier , et al. · 2023

Background and Aims Mitochondrial dysfunction and energy metabolism deficiency are part of the acute kidney injury (AKI) pathophysiology. In particular, recent studies highlighted the role of nicotinamide adenine dinucleotide (NAD) product…

ATP/ADP biosensor organoids for drug nephrotoxicity assessment Open

Koichiro Susa, Kenichi Kobayashi, Pierre Galichon, Takuya Matsumoto, Akitoshi Tamura , et al. · 2023

Drug nephrotoxicity is a common healthcare problem in hospitalized patients and a major limitation during drug development. Multi-segmented kidney organoids derived from human pluripotent stem cells may complement traditional cell culture …

Protective Role of Podocytic IL-15 / STAT5 Pathway in Experimental Focal and Segmental Glomerulosclerosis Open

Aïssata Niasse, Kévin Louis, Olivia Lenoir, Chloé Schwarz, Xiaoli Xu , et al. · 2022

During glomerular diseases, podocyte-specific pathways can modulate the intensity of the lesions and prognosis. The therapeutic targeting of these pathways could thus improve the management and prognosis of chronic kidney diseases. The Jan…

Predictive factors of glomerular filtration rate loss associated with living kidney donation: a single-center retrospective study Open

Arthur Orieux, A Bouchet, Alice Doreille, Liliana Pâslaru, Marine Livrozet , et al. · 2022

Modeling injury and repair in kidney organoids reveals that homologous recombination governs tubular intrinsic repair Open

Navin Gupta, Takuya Matsumoto, Ken Hiratsuka, Edgar Garcia Saiz, Chengcheng Zhang , et al. · 2022

Kidneys have the capacity for intrinsic repair, preserving kidney architecture with return to a basal state after tubular injury. When injury is overwhelming or repetitive, however, that capacity is exceeded and incomplete repair results i…

Overview of Traditional and Environmental Factors Related to Bone Health Open

Juan Carlos Rubio-Gutiérrez, Pablo Méndez‐Hernández, Yann Guéguen, Pierre Galichon, Marcela Tamayo‐Ortiz , et al. · 2022

Peritoneal Tuberculosis Open

Ruben Azencot, Philippe Rouvier, Pierre Galichon · 2022

Effect of Cardiac Arrest in Brain-Dead Donors on Kidney Graft Function Open

Quentin Dubourg, Émilie Savoye, Sarah Drouin, Camille Legeai, Benoı̂t Barrou , et al. · 2022

Cell stress response impairs de novo NAD+ biosynthesis in the kidney Open

Yohan Bignon, Anna Maria Rinaldi, Zahia Nadour, Virginie Poindessous, Ivan Nemazanyy , et al. · 2021

The biosynthetic routes leading to de novo nicotinamide adenine dinucleotide (NAD+) production are involved in acute kidney injury (AKI), with a critical role for quinolinate phosphoribosyl transferase (QPRT), a bottleneck enzyme of de nov…

Anaesthesia-Induced Transcriptomic Changes in the Context of Renal Ischemia Uncovered by the Use of a Novel Clamping Device Open

Charles Verney, David Legouis, Sandrine Placier, Tiffany Migeon, Philippe Bonnin , et al. · 2021

Ischemia is a common cause of acute kidney injury worldwide, frequently occurring in patients undergoing cardiac surgery or admitted to the intensive care unit (ICU). Thus, ischemia-reperfusion injury (IRI) remains one of the main experime…

Immediate Impact of Induction Treatment on Postvaccination SARS-CoV-2 Serology in Kidney Transplant Recipients Open

Inna Mohamadou, J. Nkok, Pierre Galichon, M. Cazenave, Nadia Arzouk , et al. · 2021

International audience

Orphan nuclear receptor COUP‐TFII enhances myofibroblast glycolysis leading to kidney fibrosis Open

Li Li, Pierre Galichon, Xiaoyan Xiao, Ana C Figueroa‐Ramirez, Diana Tamayo , et al. · 2021

KIM-1 mediates fatty acid uptake by renal tubular cells to promote progressive diabetic kidney disease Open

Yutaro Mori, Amrendra K. Ajay, Jae‐Hyung Chang, Shan Mou, Huiping Zhao , et al. · 2021

SARS-CoV-2 Renal Impairment in Critical Care: An Observational Study of 42 Cases (Kidney COVID) Open

Antoine-Marie Molina Barragan, Emmanuel Pardo, Pierre Galichon, Nicolas Hantala, Anne-Charlotte Gianinazzi , et al. · 2021

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection leads to 5% to 16% hospitalization in intensive care units (ICU) and is associated with 23% to 75% of kidney impairments, including acute kidney injury (AKI). The c…

SARS-COV2 Renal Impairment in Critical Care: A Retrospective Study of 42 Cases - Kid COVID Study Open

Antoine-Marie Molina Barragan, Emmanuel Pardo, Pierre Galichon, Nicolas Hantala, Anne-Charlotte Gianinazzi , et al. · 2020

BackgroundThe new coronavirus (SARS-CoV-2) infection leads to 5% to 16% hospitalization in Intensive Care Units (ICU) and is associated with 23% to 75% of kidney impairments, including acute kidney injury (AKI), as a major prognosis factor…

Author Correction: Altered proximal tubular cell glucose metabolism during acute kidney injury is associated with mortality Open

David Legouis, Sven-Erick Ricksten, Anna Faivre, Thomas Verissimo, Karim Gariani , et al. · 2020

Home dialysis machine use for emergency dialysis during the COVID-19 pandemic Open

Cyril Mousseaux, Valentin Mayet, Anselme Poda, Chloé Schwarz, Samir Saheb , et al. · 2020

Altered proximal tubular cell glucose metabolism during acute kidney injury is associated with mortality Open

David Legouis, Sven-Erick Ricksten, Anna Faivre, Thomas Verissimo, Karim Gariani , et al. · 2020

Orphan nuclear receptor COUP-TFII drives the myofibroblast metabolic shift leading to fibrosis Open

Li Li, Pierre Galichon, Xiaoyan Xiao, Ana C Figueroa‐Ramirez, Diana Tamayo , et al. · 2020

Recent studies demonstrated that metabolic disturbance, such as augmented glycolysis, contributes to fibrosis. The molecular regulation of this metabolic perturbation in fibrosis, however, has been elusive. COUP-TFII (also known as NR2F2) …

Kidney epithelial proliferation impairs cell viability via energy depletion Open

Pierre Galichon, Morgane Lannoy, Li Li, Sophie Vandermeersch, David Legouis , et al. · 2020

Both proliferative and anti-proliferative pathways are induced after acute kidney injury. The consequences of proliferation on energy homeostasis and cell viability are unknown. We hypothesized that proliferation regulation is an important…

Microvasculature partial endothelial mesenchymal transition in early posttransplant biopsy with acute tubular necrosis identifies poor recovery renal allografts Open

Yi-Chun Xu-Dubois, Pedram Ahmadpoor, Isabelle Brochériou, Kévin Louis, Nadia Arzouk Snanoudj , et al. · 2020

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