Pierre Gressèns
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View article: A Minimally Invasive, Scalable and Reproducible Neonatal Rat Model of Severe Focal Brain Injury
A Minimally Invasive, Scalable and Reproducible Neonatal Rat Model of Severe Focal Brain Injury Open
Background Neonatal brain injuries such as stroke cause focal ischemic lesions that often result in lifelong neurological disabilities, as treatment options are limited. To speed up the discovery of potential therapies, early-phase screeni…
View article: Oropouche virus infects human neural progenitor cells and alters the growth of brain organoids
Oropouche virus infects human neural progenitor cells and alters the growth of brain organoids Open
Summary Oropouche virus (OROV), is the etiologic agent of Oropouche fever (OROF), an emerging zoonotic disease that has been prevalent in South and Central America since the 1960s. Starting late 2023, the current outbreak has raised concer…
View article: Novel purine derivatives mitigate hypoxia ischemia related brain injury through agrin, zyxin and synaptotagmin proteins
Novel purine derivatives mitigate hypoxia ischemia related brain injury through agrin, zyxin and synaptotagmin proteins Open
View article: A Comprehensive Review of the Pathophysiology of Neonatal Stroke and a Critique of Current and Future Therapeutic Strategies
A Comprehensive Review of the Pathophysiology of Neonatal Stroke and a Critique of Current and Future Therapeutic Strategies Open
Within the first 28 days after birth, more than 1 in every 2500 newborns will suffer a stroke. The weekly-adjusted risk of stroke for a term-born infant is threefold higher than for a male smoker aged 50 to 59 years with hypertension and d…
View article: Glycosylation in neurodevelopment: What oncology teaches?
Glycosylation in neurodevelopment: What oncology teaches? Open
View article: Immunity in neuromodulation: probing neural and immune pathways in brain disorders
Immunity in neuromodulation: probing neural and immune pathways in brain disorders Open
View article: Sex dimorphism in brain cell death after hypoxia-ischemia in newborn piglets
Sex dimorphism in brain cell death after hypoxia-ischemia in newborn piglets Open
View article: Radial Microbrain (Micrencephaly) Is Caused by a Recurrent Variant in the <i>RTTN</i> Gene
Radial Microbrain (Micrencephaly) Is Caused by a Recurrent Variant in the <i>RTTN</i> Gene Open
ClinicalTrials.gov number: NCT01565005.
View article: A Closer Look at Dystonia with the Glycosylation
A Closer Look at Dystonia with the Glycosylation Open
View article: A biallelic variant in<i>GORASP1</i>causes a novel Golgipathy with glycosylation and mitotic defects
A biallelic variant in<i>GORASP1</i>causes a novel Golgipathy with glycosylation and mitotic defects Open
GRASP65 is a Golgi-associated peripheral protein encoded by the GORASP1 gene and required for Golgi cisternal stacking in vitro. A key role of GRASP65 in the regulation of cell division has also been suggested. However, depletion of GRASP6…
View article: Functional ultrasound (fUS) detects mild cerebral alterations using canonical correlation analysis denoising and dynamic functional connectivity analysis
Functional ultrasound (fUS) detects mild cerebral alterations using canonical correlation analysis denoising and dynamic functional connectivity analysis Open
Functional ultrasound (fUS) is a promising imaging method for evaluating brain function in animals and human neonates. fUS images local cerebral blood volume changes to map brain activity. One application of fUS imaging is the quantificati…
View article: Bisphenol A exposure during gestation and lactation in mice: Sex-specific consequences on oligodendrocytes and myelination
Bisphenol A exposure during gestation and lactation in mice: Sex-specific consequences on oligodendrocytes and myelination Open
Bisphenol A (BPA), a ubiquitous environmental endocrine disruptor, is suspected of disturbing brain development through largely unknown cellular and molecular mechanisms. In the central nervous system, oligodendrocytes are responsible for …
View article: Microglial Depletion, a New Tool in Neuroinflammatory Disorders: Comparison of Pharmacological Inhibitors of the <scp>CSF</scp>‐<scp>1R</scp>
Microglial Depletion, a New Tool in Neuroinflammatory Disorders: Comparison of Pharmacological Inhibitors of the <span>CSF</span>‐<span>1R</span> Open
A growing body of evidence highlights the importance of microglia, the resident immune cells of the CNS, and their pro‐inflammatory activation in the onset of many neurological diseases. Microglial proliferation, differentiation, and survi…
View article: Chronic Inflammation Offers Hints About Viable Therapeutic Targets for Preeclampsia and Potentially Related Offspring Sequelae
Chronic Inflammation Offers Hints About Viable Therapeutic Targets for Preeclampsia and Potentially Related Offspring Sequelae Open
The combination of hypertension with systemic inflammation during pregnancy is a hallmark of preeclampsia, but both processes also convey dynamic information about its antecedents and correlates (e.g., fetal growth restriction) and potenti…
View article: C-section and systemic inflammation synergize to disrupt the neonatal gut microbiota and brain development in a model of prematurity
C-section and systemic inflammation synergize to disrupt the neonatal gut microbiota and brain development in a model of prematurity Open
Infants born very preterm (below 28 weeks of gestation) are at high risk of developing neurodevelopmental disorders, such as intellectual deficiency, autism spectrum disorders, and attention deficit. Preterm birth often occurs in the conte…
View article: Human Umbilical Cord-Mesenchymal Stem Cells Promote Extracellular Matrix Remodeling in Microglia
Human Umbilical Cord-Mesenchymal Stem Cells Promote Extracellular Matrix Remodeling in Microglia Open
Human mesenchymal stem cells modulate the immune response and are good candidates for cell therapy in neuroinflammatory brain disorders affecting both adult and premature infants. Recent evidence indicates that through their secretome, mes…
View article: Neonatal inflammation impairs developmentally-associated microglia and promotes a highly reactive microglial subset
Neonatal inflammation impairs developmentally-associated microglia and promotes a highly reactive microglial subset Open
Microglia and border-associated macrophages play critical roles in both immunity and neurodevelopment. The disruption of microglial development trajectories by neonatal inflammation is an important issue in research on neurodevelopmental d…
View article: Dysregulation of FLVCR1a-dependent mitochondrial calcium handling in neural progenitors causes congenital hydrocephalus
Dysregulation of FLVCR1a-dependent mitochondrial calcium handling in neural progenitors causes congenital hydrocephalus Open
Congenital hydrocephalus (CH), occurring in approximately 1/1,000 live births, represents an important clinical challenge due to the limited knowledge of underlying molecular mechanisms. The discovery of novel CH genes is thus essential to…
View article: Consensus definition and diagnostic criteria for neonatal encephalopathy—study protocol for a real-time modified delphi study
Consensus definition and diagnostic criteria for neonatal encephalopathy—study protocol for a real-time modified delphi study Open
Background ‘Neonatal encephalopathy’ (NE) describes a group of conditions in term infants presenting in the earliest days after birth with disturbed neurological function of cerebral origin. NE is aetiologically heterogenous; one cause is …
View article: Neuroglobin overexpression in cerebellar neurons of Harlequin mice improves mitochondrial homeostasis and reduces ataxic behavior
Neuroglobin overexpression in cerebellar neurons of Harlequin mice improves mitochondrial homeostasis and reduces ataxic behavior Open
Neuroglobin, a member of the globin superfamily, is abundant in the brain, retina, and cerebellum of mammals and localizes to mitochondria. The protein exhibits neuroprotective capacities by participating in electron transfer, oxygen suppl…
View article: Neuroinflammatory markers at school age in preterm born children with neurodevelopmental impairments
Neuroinflammatory markers at school age in preterm born children with neurodevelopmental impairments Open
View article: Mcph1, mutated in primary microcephaly, is also crucial for erythropoiesis
Mcph1, mutated in primary microcephaly, is also crucial for erythropoiesis Open
View article: Preterm birth: A neuroinflammatory origin for metabolic diseases?
Preterm birth: A neuroinflammatory origin for metabolic diseases? Open
Preterm birth and its related complications have become more and more common as neonatal medicine advances. The concept of "developmental origins of health and disease" has raised awareness of adverse perinatal events in the development of…
View article: Long-term disruption of glucose homeostasis in a rodent model of preterm birth
Long-term disruption of glucose homeostasis in a rodent model of preterm birth Open
Around 1 of every 10 babies is born preterm, and the incidence of preterm birth has been rising. The long-term consequences of preterm survivors are not fully understood. Preterm birth is proven to be associated with metabolic diseases and…
View article: No neuroprotective effect of therapeutic hypothermia following lipopolysaccharide-sensitized hypoxia-ischemia: a newborn piglet study
No neuroprotective effect of therapeutic hypothermia following lipopolysaccharide-sensitized hypoxia-ischemia: a newborn piglet study Open
Introduction Therapeutic hypothermia is the only proven neuroprotective treatment for hypoxic-ischemic encephalopathy. However, studies have questioned whether therapeutic hypothermia may benefit newborns subjected to infection or inflamma…
View article: Key roles of glial cells in the encephalopathy of prematurity
Key roles of glial cells in the encephalopathy of prematurity Open
Across the globe, approximately one in 10 babies are born preterm, that is, before 37 weeks of a typical 40 weeks of gestation. Up to 50% of preterm born infants develop brain injury, encephalopathy of prematurity (EoP), that substantially…
View article: C-section and systemic inflammation synergize to disrupt the neonatal gut microbiota and brain development in a model of prematurity
C-section and systemic inflammation synergize to disrupt the neonatal gut microbiota and brain development in a model of prematurity Open
Infants born very preterm (below 28 weeks of gestation) are at high risk of developing neurodevelopmental disorders, such as intellectual deficiency, autism spectrum disorders, and attention deficit. Preterm birth often occurs in the conte…
View article: Molecular and Cellular Insights: A Focus on Glycans and the HNK1 Epitope in Autism Spectrum Disorder
Molecular and Cellular Insights: A Focus on Glycans and the HNK1 Epitope in Autism Spectrum Disorder Open
Autism Spectrum Disorder (ASD) is a synaptic disorder with a GABA/glutamate imbalance in the perineuronal nets and structural abnormalities such as increased dendritic spines and decreased long distance connections. Specific pregnancy diso…
View article: G protein-coupled receptor 17 is regulated by WNT pathway during oligodendrocyte precursor cell differentiation
G protein-coupled receptor 17 is regulated by WNT pathway during oligodendrocyte precursor cell differentiation Open
G protein-coupled receptor 17 (GPR17) and the WNT pathway are critical players of oligodendrocyte (OL) differentiation acting as essential timers in developing brain to achieve fully-myelinating cells. However, whether and how these two sy…
View article: Author Correction: CBP-HSF2 structural and functional interplay in Rubinstein-Taybi neurodevelopmental disorder
Author Correction: CBP-HSF2 structural and functional interplay in Rubinstein-Taybi neurodevelopmental disorder Open