Pierre LeVan
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View article: The glymphatic system and glioblastoma
The glymphatic system and glioblastoma Open
The discovery of the glymphatic system and meningeal lymphatic vessels revolutionized the understanding of brain waste clearance. These findings challenged the long-held notion of central nervous system (CNS) immune privilege and provided …
View article: Brain physiological pulsations are linked to sleep architecture and cognitive performance in older adults
Brain physiological pulsations are linked to sleep architecture and cognitive performance in older adults Open
This study uniquely demonstrates that brain physiological pulsations measured non-invasively with MREG are significantly associated with sleep architecture and cognitive performance in older adults. These findings underscore the potential …
View article: Hubs and interaction: the brain’s meta-loop
Hubs and interaction: the brain’s meta-loop Open
We must reconcile the needs of the internal world and the demands of the external world to make decisions relevant to homeostasis, well-being, and flexible behavior. Engagement with the internal (eg interoceptive) world is linked to medial…
View article: Probing hippocampal stimulation in experimental temporal lobe epilepsy with functional MRI
Probing hippocampal stimulation in experimental temporal lobe epilepsy with functional MRI Open
Electrical neurostimulation is currently used to manage epilepsy, but the most effective approach for minimizing seizure occurrence is uncertain. While functional MRI (fMRI) can reveal which brain areas are affected by stimulation, simulta…
View article: The hemodynamic response to co‐occurring interictal epileptiform discharges and high‐frequency oscillations localizes the seizure‐onset zone
The hemodynamic response to co‐occurring interictal epileptiform discharges and high‐frequency oscillations localizes the seizure‐onset zone Open
Objective To use intracranial electroencephalography (EEG) to characterize functional magnetic resonance imaging (fMRI) activation maps associated with high‐frequency oscillations (HFOs) (80–250 Hz) and examine their proximity to HFO‐ and …
View article: Mesial temporal lobe spiking reveals distinct patterns of <scp>blood oxygen level‐dependent functional magnetic resonance imaging</scp> activation using simultaneous intracranial electroencephalography–functional magnetic resonance imaging
Mesial temporal lobe spiking reveals distinct patterns of <span>blood oxygen level‐dependent functional magnetic resonance imaging</span> activation using simultaneous intracranial electroencephalography–functional magnetic resonance imaging Open
Objective Temporal lobe epilepsy (TLE) has a high probability of becoming drug resistant and is frequently considered for surgical intervention. However, 30% of TLE cases have nonlesional magnetic resonance imaging (MRI) scans, which is as…
View article: Mapping interictal discharges using intracranial EEG-fMRI to predict postsurgical outcomes
Mapping interictal discharges using intracranial EEG-fMRI to predict postsurgical outcomes Open
Various subjective and objective methods have been proposed to identify which interictal epileptiform discharge (IED)-related EEG-functional MRI (fMRI) results are more likely to delineate seizure-generating tissue in patients with drug-re…
View article: In situ theranostic platform combining highly localized magnetic fluid hyperthermia, magnetic particle imaging, and thermometry in 3D
In situ theranostic platform combining highly localized magnetic fluid hyperthermia, magnetic particle imaging, and thermometry in 3D Open
Theranostic platforms, combining diagnostic and therapeutic approaches within one system, have garnered interest in augmenting invasive surgical, chemical, and ionizing interventions. Magnetic particle imaging (MPI) offers a quite recent a…
View article: Probing hippocampal stimulation in experimental temporal lobe epilepsy with functional MRI
Probing hippocampal stimulation in experimental temporal lobe epilepsy with functional MRI Open
Background Electrical neurostimulation is a potentially effective therapy in epilepsy but the optimal approach is not yet clear. The parameter space is wide and the effects of different stimulations are not immediately obvious. Functional …
View article: Thermal threshold for localized Blood-Brain-Barrier disruption
Thermal threshold for localized Blood-Brain-Barrier disruption Open
The Blood-Brain Barrier is the gatekeeper of the CNS. It effectively shields the brain from blood-borne harm but simultaneously represents a significant challenge for treating neurological diseases. Altering its permeability enables increa…
View article: Thermal threshold for localized Blood-Brain-Barrier disruption
Thermal threshold for localized Blood-Brain-Barrier disruption Open
The Blood-Brain Barrier is the gatekeeper of the CNS. It effectively shields the brain from blood-borne harm but simultaneously represents a significant challenge for treating neurological diseases. Altering its permeability enables increa…
View article: In situ theranostic platform uniting highly localized magnetic fluid hyperthermia, magnetic particle imaging, and thermometry in 3D
In situ theranostic platform uniting highly localized magnetic fluid hyperthermia, magnetic particle imaging, and thermometry in 3D Open
In all of medical profession a broad field of research is dedicated to seek less invasive and low-risk forms of therapy with the ultimate goal of non-invasive therapy, particularly in neoplasmic diseases. Theranostic platforms, combining d…
View article: Increased interictal synchronicity of respiratory related brain pulsations in epilepsy
Increased interictal synchronicity of respiratory related brain pulsations in epilepsy Open
Respiratory brain pulsations have recently been shown to drive electrophysiological brain activity in patients with epilepsy. Furthermore, functional neuroimaging indicates that respiratory brain pulsations have increased variability and a…
View article: Aphasia recovery by language training using a brain–computer interface: a proof-of-concept study
Aphasia recovery by language training using a brain–computer interface: a proof-of-concept study Open
Aphasia, the impairment to understand or produce language, is a frequent disorder after stroke with devastating effects. Conventional speech and language therapy include each formal intervention for improving language and communication abi…
View article: Holo-Hilbert Spectral-based Noise Removal Method for EEG High-Frequency Bands
Holo-Hilbert Spectral-based Noise Removal Method for EEG High-Frequency Bands Open
Simultaneous EEG-fMRI is a growing and promising field, as it has great potential to further our understanding of the spatiotemporal dynamics of brain function in health and disease. In particular, there is much interest in understanding t…
View article: Trading off spatio‐temporal properties in 3D high‐speed fMRI using interleaved stack‐of‐spirals trajectories
Trading off spatio‐temporal properties in 3D high‐speed fMRI using interleaved stack‐of‐spirals trajectories Open
Purpose Highly undersampled acquisitions have been proposed to push the limits of temporal resolution in functional MRI. This contribution is aimed at identifying parameter sets that let the user trade‐off between ultra‐high temporal resol…
View article: Improving the sensitivity of spin‐echo fMRI at 3T by highly accelerated acquisitions
Improving the sensitivity of spin‐echo fMRI at 3T by highly accelerated acquisitions Open
Purpose Spin‐echo (SE) functional MRI (fMRI) can be highly advantageous compared to gradient‐echo (GE) fMRI with respect to magnetic field‐inhomogeneity artifacts. However, at 3T, the majority of blood oxygenation level‐dependent (BOLD) fM…
View article: The variability of functional MRI brain signal increases in Alzheimer's disease at cardiorespiratory frequencies
The variability of functional MRI brain signal increases in Alzheimer's disease at cardiorespiratory frequencies Open
Biomarkers sensitive to prodromal or early pathophysiological changes in Alzheimer’s disease (AD) symptoms could improve disease detection and enable timely interventions. Changes in brain hemodynamics may be associated with the main clini…
View article: 15 Years MR-encephalography
15 Years MR-encephalography Open
Objective This review article gives an account of the development of the MR-encephalography (MREG) method, which started as a mere ‘Gedankenexperiment’ in 2005 and gradually developed into a method for ultrafast measurement of physiologica…
View article: The neuronal associations of respiratory-volume variability in the resting state
The neuronal associations of respiratory-volume variability in the resting state Open
The desire to enhance the sensitivity and specificity of resting-state (rs-fMRI) measures has prompted substantial recent research into removing noise components. Chief among contributions to noise in rs-fMRI are physiological processes, a…
View article: Analysis of accelerated 4D flow MRI in the murine aorta by radial acquisition and compressed sensing reconstruction
Analysis of accelerated 4D flow MRI in the murine aorta by radial acquisition and compressed sensing reconstruction Open
Preclinical 4D flow MRI remains challenging and is restricted for parallel imaging acceleration due to the limited number of available receive channels. A radial acquisition with combined parallel imaging and temporal compressed sensing re…
View article: Corrigendum: Histological Correlates of Diffusion-Weighted Magnetic Resonance Microscopy in a Mouse Model of Mesial Temporal Lobe Epilepsy
Corrigendum: Histological Correlates of Diffusion-Weighted Magnetic Resonance Microscopy in a Mouse Model of Mesial Temporal Lobe Epilepsy Open
In the published article, there were errors in affiliations 2 and 3. Instead of “Experimental Epilepsy Research, Department of Neurosurgery, Medical Center – University of Freiburg, Freiburg, Germany” and “Department Neurosurgery, Experime…
View article: Histological Correlates of Diffusion-Weighted Magnetic Resonance Microscopy in a Mouse Model of Mesial Temporal Lobe Epilepsy
Histological Correlates of Diffusion-Weighted Magnetic Resonance Microscopy in a Mouse Model of Mesial Temporal Lobe Epilepsy Open
Mesial temporal lobe epilepsy (MTLE) is the most common type of focal epilepsy. It is frequently associated with abnormal MRI findings, which are caused by underlying cellular, structural, and chemical changes at the micro-scale. In the cu…
View article: Time‐domain principal component reconstruction (tPCR): A more efficient and stable iterative reconstruction framework for non‐Cartesian functional MRI
Time‐domain principal component reconstruction (tPCR): A more efficient and stable iterative reconstruction framework for non‐Cartesian functional MRI Open
Purpose To improve the reconstruction efficiency (i.e., computational load) and stability of iterative reconstruction for non‐Cartesian fMRI when using high undersampling rates and/or in the presence of strong off‐resonance effects. Theory…
View article: Content-Free Awareness: EEG-fcMRI Correlates of Consciousness as Such in an Expert Meditator
Content-Free Awareness: EEG-fcMRI Correlates of Consciousness as Such in an Expert Meditator Open
The minimal neural correlate of the conscious state, regardless of the neural activity correlated with the ever-changing contents of experience, has still not been identified. Different attempts have been made, mainly by comparing the norm…
View article: Respiratory-related brain pulsations are increased in epilepsy—a two-centre functional MRI study
Respiratory-related brain pulsations are increased in epilepsy—a two-centre functional MRI study Open
Resting-state functional MRI has shown potential for detecting changes in cerebral blood oxygen level-dependent signal in patients with epilepsy, even in the absence of epileptiform activity. Furthermore, it has been suggested that coeffic…
View article: Design of a shim coil array matched to the human brain anatomy
Design of a shim coil array matched to the human brain anatomy Open
Purpose The purpose of this study is to introduce a novel design method of a shim coil array specifically optimized for whole brain shimming and to compare the performance of the resulting coils to conventional spherical harmonic shimming.…
View article: Altered physiological brain variation in drug‐resistant epilepsy
Altered physiological brain variation in drug‐resistant epilepsy Open
Introduction Functional magnetic resonance imaging ( fMRI ) combined with simultaneous electroencephalography ( EEG ‐ fMRI ) has become a major tool in mapping epilepsy sources. In the absence of detectable epileptiform activity, the resti…
View article: Sparse Estimation of Resting-State Effective Connectivity From fMRI Cross-Spectra
Sparse Estimation of Resting-State Effective Connectivity From fMRI Cross-Spectra Open
In functional magnetic resonance imaging (fMRI), functional connectivity is conventionally characterized by correlations between fMRI time series, which are intrinsically undirected measures of connectivity. Yet, some information about the…