Pierre Moretti
YOU?
Author Swipe
View article: Alternative splicing for tuneable expression of protein subunits at desired ratios
Alternative splicing for tuneable expression of protein subunits at desired ratios Open
The controlled expression of two or more proteins at a defined and stable ratio remains a substantial challenge, particularly in the bi- and multispecific antibody field. Achieving an optimal ratio of protein subunits can facilitate the as…
View article: SPLICELECT™: an adaptable cell surface display technology based on alternative splicing allowing the qualitative and quantitative prediction of secreted product at a single-cell level
SPLICELECT™: an adaptable cell surface display technology based on alternative splicing allowing the qualitative and quantitative prediction of secreted product at a single-cell level Open
We describe a mammalian expression construct (SPLICELECT™) that allows the redirection of a proportion of a secreted protein onto the cell surface using alternative splicing: whereas the majority of the RNA is spliced into a transcript enc…
View article: Antibody disulfide bond reduction during process development: Insights using a scale-down model process
Antibody disulfide bond reduction during process development: Insights using a scale-down model process Open
View article: Use of a new genetic element to improve expression level of cell lines for recombinant protein production
Use of a new genetic element to improve expression level of cell lines for recombinant protein production Open