Pierre Payoux
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View article: Inhibition of p38α MAPK increases short-term astrocyte reactivity: the exploratory VIP trial in early Alzheimer’s disease
Inhibition of p38α MAPK increases short-term astrocyte reactivity: the exploratory VIP trial in early Alzheimer’s disease Open
View article: Polygenic pathways shape white matter vulnerability to Alzheimer’s disease-related pathophysiological changes
Polygenic pathways shape white matter vulnerability to Alzheimer’s disease-related pathophysiological changes Open
View article: The evolution of spatial patterns of brain activity during development and their role in the functional specialization of brain networks
The evolution of spatial patterns of brain activity during development and their role in the functional specialization of brain networks Open
View article: Disease Progression in Multiple System Atrophy: The <scp>ASPIRE</scp> Multi‐Modal Biomarker Study
Disease Progression in Multiple System Atrophy: The <span>ASPIRE</span> Multi‐Modal Biomarker Study Open
Objective The objective of this study was to characterize changes in candidate biomarkers in early multiple system atrophy (MSA) and identify baseline predictors of faster progression. Methods This 1‐year, multicenter, prospective study as…
View article: The INSPIRE-T longitudinal observational study centered on intrinsic capacity: baseline data
The INSPIRE-T longitudinal observational study centered on intrinsic capacity: baseline data Open
Background The “INStitute for Prevention,” “healthy agIng,” and “medicine REjuvenative” “Translational” (INSPIRE-T) study is a 10-year observational study. The primary objective of which is to study trajectories of aging across lifespan fr…
View article: Utility, Costs and Cost‐Utility of Amyloid‐<scp>PET</scp> in the Diagnostic Process of Memory Clinic Patients: A Trial‐Based Economic Evaluation From <scp>AMYPAD</scp>‐<scp>DPMS</scp>
Utility, Costs and Cost‐Utility of Amyloid‐<span>PET</span> in the Diagnostic Process of Memory Clinic Patients: A Trial‐Based Economic Evaluation From <span>AMYPAD</span>‐<span>DPMS</span> Open
Background Amyloid positron emission tomography (PET) is instrumental in achieving an accurate diagnosis and may help to limit health‐seeking behavior. Currently, amyloid‐PET is not routinely used in clinical practice due to lack of eviden…
View article: Amyloid PET predicts atrophy in older adults without dementia: Results from the AMYPAD Prognostic & Natural History Study
Amyloid PET predicts atrophy in older adults without dementia: Results from the AMYPAD Prognostic & Natural History Study Open
The impact of amyloid-β (Aβ) accumulation on regional brain atrophy in preclinical Alzheimer’s disease (AD), and its interaction with risk factors like sex and APOE -ε4 carriership, remains unclear. In this study, we examined these associa…
View article: Early oxytocin treatment in infants with Prader–Willi syndrome is safe and is associated with better endocrine, metabolic and behavioral outcomes
Early oxytocin treatment in infants with Prader–Willi syndrome is safe and is associated with better endocrine, metabolic and behavioral outcomes Open
View article: Association between herpes simplex virus infection and Alzheimer’s disease biomarkers: analysis within the MAPT trial
Association between herpes simplex virus infection and Alzheimer’s disease biomarkers: analysis within the MAPT trial Open
In vitro and animal studies have suggested that inoculation with herpes simplex virus 1 (HSV-1) can lead to amyloid deposits, hyperphosphorylation of tau, and/or neuronal loss. Here, we studied the association between HSV-1 and Alzheimer’s…
View article: Amyloid PET predicts atrophy in older adults without dementia: Results from the AMYPAD Prognostic & Natural History study
Amyloid PET predicts atrophy in older adults without dementia: Results from the AMYPAD Prognostic & Natural History study Open
The impact of amyloid-β (Aβ) accumulation on regional brain atrophy in preclinical Alzheimer's disease (AD), and its interaction with risk factors like sex and APOE-ε4 carriership, remains unclear. In this study, we examined these associat…
View article: Image‐derived phenotypes in the AMYPAD Prognostic and Natural History Study
Image‐derived phenotypes in the AMYPAD Prognostic and Natural History Study Open
Background The Amyloid Imaging to Prevent Alzheimer’s Disease (AMYPAD) Prognostic & Natural History Study (PNHS) is a prospective longitudinal PET cohort of over 1,500 non‐demented individuals from 10 parent cohorts across Europe. We provi…
View article: Image‐derived phenotypes in the AMYPAD Prognostic and Natural History Study
Image‐derived phenotypes in the AMYPAD Prognostic and Natural History Study Open
Background The Amyloid Imaging to Prevent Alzheimer’s Disease (AMYPAD) Prognostic & Natural History Study (PNHS) is a prospective longitudinal PET cohort of over 1,500 non‐demented individuals from 10 parent cohorts across Europe. We provi…
View article: NMDA Receptors: Distribution, Role, and Insights into Neuropsychiatric Disorders
NMDA Receptors: Distribution, Role, and Insights into Neuropsychiatric Disorders Open
Background: N-methyl-D-aspartate receptors (NMDARs) are members of the ionotropic glutamate receptor family. These ligand-gated channels are entwined with numerous fundamental neurological functions within the central nervous system (CNS),…
View article: Association of Vascular Risk Factors and Cerebrovascular Pathology With Alzheimer Disease Pathologic Changes in Individuals Without Dementia
Association of Vascular Risk Factors and Cerebrovascular Pathology With Alzheimer Disease Pathologic Changes in Individuals Without Dementia Open
In a large nondemented population, our findings suggest that cSVD is a mediator of the relationship between VRFs and CSF Aβ1-42 and affects downstream neurodegeneration and cognitive impairment. We provide evidence of VRFs indir…
View article: Alzheimer's disease genetic pathways impact cerebrospinal fluid biomarkers and imaging endophenotypes in non‐demented individuals
Alzheimer's disease genetic pathways impact cerebrospinal fluid biomarkers and imaging endophenotypes in non‐demented individuals Open
INTRODUCTION Unraveling how Alzheimer's disease (AD) genetic risk is related to neuropathological heterogeneity, and whether this occurs through specific biological pathways, is a key step toward precision medicine. METHODS We computed pat…
View article: Early oxytocin treatment in infants with Prader-Willi is safe and is associated with better endocrine metabolic and behavior outcomes.
Early oxytocin treatment in infants with Prader-Willi is safe and is associated with better endocrine metabolic and behavior outcomes. Open
Background: Oxytocin (OT) plays an important role in modulating behavior social interactions and feeding. Prader-Willi syndrome (PWS), a rare genetic neurodevelopmental disorder, is a model of hypothalamic disorder including OT dysfunction…
View article: Adaptive Strategies of Single-Sided Deaf Cochlear-Implant Users Revealed Through Resting State Activity: an Auditory PET Brain Imaging Study
Adaptive Strategies of Single-Sided Deaf Cochlear-Implant Users Revealed Through Resting State Activity: an Auditory PET Brain Imaging Study Open
View article: PET Study of Microglial Activation in Kleine-Levin Syndrome
PET Study of Microglial Activation in Kleine-Levin Syndrome Open
Our findings do not support the presence of neuroinflammation in KLS. Further research is needed to identify relevant biomarkers in KLS.
View article: Cerebellum/liver index on baseline 18F-FDG PET/CT to improve prognostication in post-transplant lymphoproliferative disorders: a multicenter retrospective study
Cerebellum/liver index on baseline 18F-FDG PET/CT to improve prognostication in post-transplant lymphoproliferative disorders: a multicenter retrospective study Open
View article: Alzheimer's Disease and Small Vessel Disease Differentially Affect White Matter Microstructure
Alzheimer's Disease and Small Vessel Disease Differentially Affect White Matter Microstructure Open
Objective Alzheimer's disease (AD) and cerebral small vessel disease (cSVD), the two most common causes of dementia, are characterized by white matter (WM) alterations diverging from the physiological changes occurring in healthy aging. Di…
View article: Predictive Capacity of the Integrated Care for Older People Screening Tool for Intrinsic Capacity Impairments: Results From the INSPIRE-T Cohort
Predictive Capacity of the Integrated Care for Older People Screening Tool for Intrinsic Capacity Impairments: Results From the INSPIRE-T Cohort Open
Background The Integrated Care for Older People (ICOPE) approach was developed by the World Health Organization (WHO) aiming to shift the traditional focus of care based on diseases to a function- and person-centered approach, focused on m…
View article: Microglia Density and Its Association With Disease Duration, Severity, and Orexin Levels in Patients With Narcolepsy Type 1
Microglia Density and Its Association With Disease Duration, Severity, and Orexin Levels in Patients With Narcolepsy Type 1 Open
ClinicalTrials.org NCT03754348.
View article: Investigating reliable amyloid accumulation in Centiloids: Results from the AMYPAD Prognostic and Natural History Study
Investigating reliable amyloid accumulation in Centiloids: Results from the AMYPAD Prognostic and Natural History Study Open
INTRODUCTION To support clinical trial designs focused on early interventions, our study determined reliable early amyloid‐β (Aβ) accumulation based on Centiloids (CL) in pre‐dementia populations. METHODS A total of 1032 participants from …
View article: The Optic Nerve at Stake: Update on Environmental Factors Modulating Expression of Leber’s Hereditary Optic Neuropathy
The Optic Nerve at Stake: Update on Environmental Factors Modulating Expression of Leber’s Hereditary Optic Neuropathy Open
Optic neuropathies are characterized by the degeneration of the optic nerves and represent a considerable individual and societal burden. Notably, Leber’s hereditary optic neuropathy (LHON) is a devastating vision disease caused by mitocho…
View article: Neuroimmune activation is associated with neurological outcome in anoxic and traumatic coma
Neuroimmune activation is associated with neurological outcome in anoxic and traumatic coma Open
The pathophysiological underpinnings of critically disrupted brain connectomes resulting in coma are poorly understood. Inflammation is potentially an important but still undervalued factor. Here, we present a first-in-human prospective st…
View article: Association Between Years of Education and Amyloid Burden in Patients With Subjective Cognitive Decline, MCI, and Alzheimer Disease
Association Between Years of Education and Amyloid Burden in Patients With Subjective Cognitive Decline, MCI, and Alzheimer Disease Open
Education may represent a factor oppositely modulating subjective awareness in preclinical stages and objective severity of ongoing neuropathologic processes in clinical stages.
View article: Neuroimmune activation is associated with neurological outcome in anoxic and traumatic coma
Neuroimmune activation is associated with neurological outcome in anoxic and traumatic coma Open
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View article: Translocator Protein (Tspo) Genotype Does Not Change Cerebrospinal Fluid Levels of Neuro-Inflammation, Axonal and Synaptic Damage Markers in Early Alzheimer's Disease
Translocator Protein (Tspo) Genotype Does Not Change Cerebrospinal Fluid Levels of Neuro-Inflammation, Axonal and Synaptic Damage Markers in Early Alzheimer's Disease Open
View article: Translocator protein (TSPO) genotype does not change cerebrospinal fluid levels of glial activation, axonal and synaptic damage markers in early Alzheimer’s disease
Translocator protein (TSPO) genotype does not change cerebrospinal fluid levels of glial activation, axonal and synaptic damage markers in early Alzheimer’s disease Open
TSPO genotype is not associated with a change in glial activation, synaptic and axonal damage in early AD. Further studies with larger numbers of participants will be needed to confirm that the inclusion of specific TSPO genetic subgroups …
View article: The association between Aβ aggregation and age depends on APOE genotype: Findings from the AMYPAD cohort
The association between Aβ aggregation and age depends on APOE genotype: Findings from the AMYPAD cohort Open
Background The present study aimed to explore the association between Apolipoprotein E (APOE) genotype, the main genetic risk factor for sporadic Alzheimer’s Disease (AD), age, and cerebral β‐amyloid (Aβ) aggregation, the earliest patholog…