Pierre Rouget
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View article: Propofol and Sufentanil Titration with the Bispectral Index to Provide Anesthesia for Coronary Artery Surgery
Propofol and Sufentanil Titration with the Bispectral Index to Provide Anesthesia for Coronary Artery Surgery Open
Background To provide anesthesia for cardiac surgery, hypnotics and opioids are frequently titrated on variables such as mean arterial pressure and heart rate. In this study conducted in patients scheduled to undergo coronary artery bypass…
View article: Purification, Molecular Cloning, and Functional Expression of the Human Nicodinamide-Adenine Dinucleotide Phosphate-Regulated Thyroid Hormone-Binding Protein
Purification, Molecular Cloning, and Functional Expression of the Human Nicodinamide-Adenine Dinucleotide Phosphate-Regulated Thyroid Hormone-Binding Protein Open
The kidney and several other thyroid hormone-responsive tissues contain a NADP-regulated thyroid hormone (TH)-binding protein (THBP), with an apparent molecular mass of 36 kDa on SDS-PAGE, responsible for most of the intracellular high-aff…
View article: Identification of a neural-specific cDNA, NPDC-1, able to down-regulate cell proliferation and to suppress transformation.
Identification of a neural-specific cDNA, NPDC-1, able to down-regulate cell proliferation and to suppress transformation. Open
Immortalized neural precursor cell lines carrying the polyoma large tumor (T) gene have been shown previously to retain a clear-cut contact inhibition of growth and to differentiate in vitro. In the present study, we have identified and is…
View article: Acute lymphoblastic leukemia with pre-B-cell characteristics
Acute lymphoblastic leukemia with pre-B-cell characteristics Open
Blast cells from 6 of 50 patients with acute lymphoblastic leukemia (ALL) displayed intracytoplasmic mu chains in the absence of detectable light chains and surface immunoglobulins. These cells also expressed lalike and common ALL antigens…
View article: Origin of polyoma virus-associated endonuclease
Origin of polyoma virus-associated endonuclease Open
Polyoma virus particles purified from infected cells, but not from the culture medium, exhibited an endonuclease activity distinct from the serum contaminant recently described. This endonuclease cleaved form I polyoma DNA once only per mo…
View article: Leucyl-tRNA Synthetase. Two Forms of the Enzyme : Role of Sulfhydryl Groups
Leucyl-tRNA Synthetase. Two Forms of the Enzyme : Role of Sulfhydryl Groups Open
The role of sulhydryl groups in the enzymatic properties of leucyl-tRNA synthetase was examined and related to the differences between two forms of the enzyme. The titration of sulfhydryl groups shows that two groups are masked in EIi. e t…
View article: Leucyl-tRNA Synthetase. Mechanism of Leucyl-tRNA Formation
Leucyl-tRNA Synthetase. Mechanism of Leucyl-tRNA Formation Open
The binding of ATP, leucine and tRNA to leucyl-tRNA synthestase and the properties of the complexes are examined. The results show that the binding of leucine to the enzyme is dependent on the presence of ATP and that the first step of leu…
View article: Leucyl tRNA Synthetase. Two Forms of the Enzyme: Relation between Structural and Catalytic Properties
Leucyl tRNA Synthetase. Two Forms of the Enzyme: Relation between Structural and Catalytic Properties Open
Two factors which are involved in an apparent interconversion between the two forms of leucyl-tRNA synthetase were separated. One of the factors, F1, is a protein of 200000 molecular weight and catalyzes the transformation of EII, i.e the …
View article: Reactions Sequence of Leucine Activation Catalysed by Leucyl-RNA Synthetase. 2. Formation of Complexes between the Enzyme and Substrates
Reactions Sequence of Leucine Activation Catalysed by Leucyl-RNA Synthetase. 2. Formation of Complexes between the Enzyme and Substrates Open
In order to obtain information on the sequence of reactions which participate in the activation of leucine, the formation of complexes between the leucyl-RNA synthetase and its substrates was examined. A leucyladenylate-enzyme complex able…
View article: Reactions Sequence of Leucine Activation Catalysed by Leucyl-RNA Synthetase. 1. Kinetic Studies
Reactions Sequence of Leucine Activation Catalysed by Leucyl-RNA Synthetase. 1. Kinetic Studies Open
The inhibition of the leucyl-RNA synthetase from Escherichia coli B by leucinol-AMP, leucinol and 6-N-hydroxyethyl-ATP was examined; Km and Ki values for the substrates and analogues were determined. It was shown that leucinol-AMP inhibits…