Pierre Seners
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View article: Neutrophil Activation 24 Hours After an Endovascular Therapy–Treated Acute Ischemic Stroke Is Associated With 3‐Month Clinical Outcome
Neutrophil Activation 24 Hours After an Endovascular Therapy–Treated Acute Ischemic Stroke Is Associated With 3‐Month Clinical Outcome Open
View article: Hemorrhagic transformation during inter-hospital transfer for thrombectomy: Incidence, associated factors, and relationship with outcome
Hemorrhagic transformation during inter-hospital transfer for thrombectomy: Incidence, associated factors, and relationship with outcome Open
Background: Patients with acute ischemic stroke with a large vessel occlusion (AIS-LVO) admitted to primary stroke centers (PSC) often require inter-hospital transfer to a comprehensive stroke center (CSC) for endovascular therapy (EVT). W…
View article: Intravenous Thrombolysis Use before Inter‐Facility Transfer for Thrombectomy: Association with Efficacy and Safety Outcomes
Intravenous Thrombolysis Use before Inter‐Facility Transfer for Thrombectomy: Association with Efficacy and Safety Outcomes Open
Objective Patients with acute ischemic stroke and large vessel occlusion (LVO) often require transfer from primary stroke centers (PSCs) to thrombectomy‐capable centers. This study assessed the efficacy and safety of intravenous thrombolys…
View article: Impact of Helicopter Transfer on Recanalization and Outcomes in Anterior Large Vessel Occlusion Strokes
Impact of Helicopter Transfer on Recanalization and Outcomes in Anterior Large Vessel Occlusion Strokes Open
BACKGROUND: For patients with acute ischemic stroke due to a large vessel occlusion admitted in primary stroke centers, helicopter transfer to comprehensive stroke centers is often used to expedite access to mechanical thrombectomy. Some s…
View article: Acute ischemic stroke patient factors associated with poor outcomes in patients with favorable collaterals and successful thrombectomy
Acute ischemic stroke patient factors associated with poor outcomes in patients with favorable collaterals and successful thrombectomy Open
View article: Reliability of CT, DECT, and MRI for the diagnosis of hemorrhagic transformation after thrombectomy
Reliability of CT, DECT, and MRI for the diagnosis of hemorrhagic transformation after thrombectomy Open
Introduction: Computed Tomography (CT) is the main modality used for the diagnosis and classification of hemorrhagic transformation (HT) after thrombectomy, however its reliability has shown limitations. Dual-energy CT (DECT) and magnetic …
View article: Endovascular treatment for isolated cervical internal carotid artery occlusion: ETIICA study
Endovascular treatment for isolated cervical internal carotid artery occlusion: ETIICA study Open
Introduction: Evidence regarding the benefit of endovascular therapy (EVT) in patients with acute ischemic stroke (AIS) due to isolated cervical internal carotid artery occlusion (c-ICA-O) is lacking. We assessed the outcomes and safety of…
View article: Recanalization Outcomes and Procedural Complications in Patients With Acute Ischemic Stroke and COVID-19 Receiving Endovascular Treatment
Recanalization Outcomes and Procedural Complications in Patients With Acute Ischemic Stroke and COVID-19 Receiving Endovascular Treatment Open
View article: Drip and ship in patients with acute ischemic stroke: a narrative review
Drip and ship in patients with acute ischemic stroke: a narrative review Open
Acute ischemic stroke (AIS) is a leading cause of long-term disability and mortality worldwide, necessitating the rapid implementation of time-sensitive reperfusion therapies to improve outcomes. The “drip and ship” (DS) model, in which in…
View article: Hypoperfusion intensity ratio to differentiate between stroke etiologies in patients with a large vessel occlusion
Hypoperfusion intensity ratio to differentiate between stroke etiologies in patients with a large vessel occlusion Open
Background: Collateral circulation plays a key role in acute ischemic stroke. We sought to determine the association between the arterial collateral status, estimated by the Hypoperfusion Intensity Ratio (HIR) on perfusion MRI, and stroke …
View article: Interfacility Transfer for Thrombectomy: A Promising Therapeutic Window
Interfacility Transfer for Thrombectomy: A Promising Therapeutic Window Open
Currently, most acute ischemic stroke patients presenting with a large vessel occlusion are first evaluated at a nonthrombectomy-capable center before transfer to a comprehensive stroke center that performs thrombectomy. Interfacility tran…
View article: Blood–brain barrier profile pretreatment is associated with hemorrhagic transformation after endovascular reperfusion
Blood–brain barrier profile pretreatment is associated with hemorrhagic transformation after endovascular reperfusion Open
Background While advances in endovascular thrombectomy (EVT) have led to high reperfusion rates, most patients treated with EVT do not avoid disability. Post‐reperfusion hemorrhagic transformation (HT) is a potential target for improving o…
View article: Poor venous outflow is associated with hyperintense acute reperfusion marker on follow-up MRI in patients with acute ischemic stroke with a large vessel occlusion
Poor venous outflow is associated with hyperintense acute reperfusion marker on follow-up MRI in patients with acute ischemic stroke with a large vessel occlusion Open
Background Hyperintense acute reperfusion marker (HARM) refers to delayed enhancement in the subarachnoid or subpial space on post-contrast fluid attenuated inversion recovery (FLAIR) images. HARM is a measure of blood–brain barrier breakd…
View article: Perfusion imaging for delayed cerebral ischemia detection in patients following ruptured aneurysmal subarachnoid hemorrhage: Interrater reliability assessment
Perfusion imaging for delayed cerebral ischemia detection in patients following ruptured aneurysmal subarachnoid hemorrhage: Interrater reliability assessment Open
Background Delayed cerebral ischemia (DCI) following aneurysmal subarachnoid hemorrhage (aSAH) is associated with adverse neurological outcomes. Early and accurate diagnosis of DCI is crucial to prevent cerebral infarction. This study aime…
View article: Exploring the Limits of Endovascular Therapy for Large Core Patients: Where Do We Need More Data?
Exploring the Limits of Endovascular Therapy for Large Core Patients: Where Do We Need More Data? Open
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View article: Incidence and predictors of intracranial hemorrhage after intravenous thrombolysis with tenecteplase
Incidence and predictors of intracranial hemorrhage after intravenous thrombolysis with tenecteplase Open
Background: Despite its increasing use, there are limited data on the risk of intracranial hemorrhage (ICH) after intravenous thrombolysis with tenecteplase in the setting of acute ischemic stroke. Our aim was to investigate the incidence …
View article: Arterial Recanalization During Interhospital Transfer for Thrombectomy
Arterial Recanalization During Interhospital Transfer for Thrombectomy Open
BACKGROUND: Patients with acute ischemic stroke harboring a large vessel occlusion admitted to nonendovascular-capable centers often require interhospital transfer for thrombectomy. We evaluated the incidence and predictors of arterial rec…
View article: Clinical change during inter-hospital transfer for thrombectomy: Incidence, associated factors, and relationship with outcome
Clinical change during inter-hospital transfer for thrombectomy: Incidence, associated factors, and relationship with outcome Open
Background: Patients with acute ischemic stroke with a large vessel occlusion (LVO) admitted to non endovascular-capable centers often require inter-hospital transfer for thrombectomy. We aimed to describe the incidence of substantial clin…
View article: Inter‐hospital transfer for thrombectomy: transfer time is brain
Inter‐hospital transfer for thrombectomy: transfer time is brain Open
Background and purpose Patients with acute ischaemic stroke and a large vessel occlusion who present to a non‐endovascular‐capable centre often require inter‐hospital transfer for thrombectomy. Whether the inter‐hospital transfer time is a…
View article: The Management of Persistent Distal Occlusions after Mechanical Thrombectomy and Thrombolysis: An Inter- and Intrarater Agreement Study
The Management of Persistent Distal Occlusions after Mechanical Thrombectomy and Thrombolysis: An Inter- and Intrarater Agreement Study Open
Individuals did not agree regarding the best management of patients with persistent distal occlusion after mechanical thrombectomy and IV thrombolysis. There is sufficient uncertainty to justify a dedicated randomized trial.
View article: Effect of Asymptomatic and Symptomatic COVID-19 on Acute Ischemic Stroke Revascularization Outcomes
Effect of Asymptomatic and Symptomatic COVID-19 on Acute Ischemic Stroke Revascularization Outcomes Open
BACKGROUND: The association of COVID-19 with higher bleeding risk and worse outcomes in acute ischemic stroke (AIS) undergoing revascularization may be related to the presence of infection symptoms. We aimed to assess the safety and outcom…
View article: Dynamic evolution of infarct volumes at MRI in ischemic stroke due to large vessel occlusion
Dynamic evolution of infarct volumes at MRI in ischemic stroke due to large vessel occlusion Open
Background and Objectives The typical infarct volume trajectories in stroke patients, categorized as slow or fast progressors, remain largely unknown. This study aimed to reveal the characteristic spatiotemporal evolutions of infarct volum…
View article: Does imaging of the ischemic penumbra have value in acute ischemic stroke with large vessel occlusion?
Does imaging of the ischemic penumbra have value in acute ischemic stroke with large vessel occlusion? Open
Purpose of review In this review, we summarize current evidence regarding potential benefits and limitations of using perfusion imaging to estimate presence and extent of irreversibly injured ischemic brain tissue (‘core’) and severely isc…
View article: Brain edema growth after thrombectomy is associated with comprehensive collateral blood flow
Brain edema growth after thrombectomy is associated with comprehensive collateral blood flow Open
Background We determined whether a comprehensive assessment of cerebral collateral blood flow is associated with ischemic lesion edema growth in patients successfully treated by thrombectomy. Methods This was a multicenter retrospective st…
View article: Intravenous thrombolysis with tenecteplase versus alteplase combined with endovascular treatment of anterior circulation tandem occlusions: A pooled analysis of ETIS and TETRIS
Intravenous thrombolysis with tenecteplase versus alteplase combined with endovascular treatment of anterior circulation tandem occlusions: A pooled analysis of ETIS and TETRIS Open
Background: Tandem occlusions are a singular large vessel occlusion entity involving specific endovascular and perioperative antithrombotic management. In this context, data on safety and efficacy of prior intravenous thrombolysis (IVT) wi…
View article: Factors Associated With Fast Early Infarct Growth in Patients With Acute Ischemic Stroke With a Large Vessel Occlusion
Factors Associated With Fast Early Infarct Growth in Patients With Acute Ischemic Stroke With a Large Vessel Occlusion Open
The HIR is the primary factor associated with fast infarct progression, regardless of imaging modality. These results have implication for neuroprotection trial design, as well as informing triage decisions at primary stroke centers.
View article: Larger ischemic cores and poor collaterals among large vessel occlusions presenting in the late evening
Larger ischemic cores and poor collaterals among large vessel occlusions presenting in the late evening Open
View article: Thrombectomy in Stroke With a Large Vessel Occlusion and Mild Symptoms: “Striving to Better, Oft We Mar What’s Well?”
Thrombectomy in Stroke With a Large Vessel Occlusion and Mild Symptoms: “Striving to Better, Oft We Mar What’s Well?” Open
View article: Relevance of National Institutes of Health Stroke Scale subitems for best revascularization therapy in minor stroke patients with large vessel occlusion: An observational multicentric study
Relevance of National Institutes of Health Stroke Scale subitems for best revascularization therapy in minor stroke patients with large vessel occlusion: An observational multicentric study Open
Background and purpose The best management of acute ischemic stroke patients with a minor stroke and large vessel occlusion is still uncertain. Specific clinical and radiological data may help to select patients who would benefit from endo…
View article: Successful Thrombectomy Improves Functional Outcome in Tandem Occlusions with a Large Ischemic Core
Successful Thrombectomy Improves Functional Outcome in Tandem Occlusions with a Large Ischemic Core Open