Pierre Stallforth
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View article: Global profiling of polyketide synthases in facultative multicellular eukaryotes
Global profiling of polyketide synthases in facultative multicellular eukaryotes Open
Polyketides represent a structurally diverse class of natural products with a wide range of biological functions, including antimicrobial activity, defense responses, developmental regulation, pigmentation, and intercellular and intracellu…
View article: Inhibitor fluorination pattern tunes chemically induced protein dimerization
Inhibitor fluorination pattern tunes chemically induced protein dimerization Open
Chemically induced dimerization of proteins is a powerful approach to regulate biomolecular functions through small molecule ligands acting as “molecular glues”. Here, we demonstrate that simple, thienopyrimidinone scaffold-based inhibitor…
View article: Pangenome Analysis of the Plant Pathogen <i>Pseudomonas syringae</i> Reveals Unique Natural Products for Niche Adaptation
Pangenome Analysis of the Plant Pathogen <i>Pseudomonas syringae</i> Reveals Unique Natural Products for Niche Adaptation Open
Pseudomonas syringae is a soil‐dwelling bacterium that exhibits remarkable niche adaptability, and it is known for its devastating impact as a plant pathogen. This bacterium has an outstanding capability to produce a wide array of biologic…
View article: Pangenome Analysis of the Plant Pathogen <i>Pseudomonas syringae</i> Reveals Unique Natural Products for Niche Adaptation
Pangenome Analysis of the Plant Pathogen <i>Pseudomonas syringae</i> Reveals Unique Natural Products for Niche Adaptation Open
Pseudomonas syringae is a soil‐dwelling bacterium that exhibits remarkable niche adaptability, and it is known for its devastating impact as a plant pathogen. This bacterium has an outstanding capability to produce a wide array of biologic…
View article: A chemical radar allows bacteria to detect and kill predators
A chemical radar allows bacteria to detect and kill predators Open
Amoebal predation exerts a strong evolutionary selection pressure on bacteria, thus driving the development of effective predator-defense strategies. However, little is known about the molecular interplay between bacteria and predators, pa…
View article: Strategic Acyl Carrier Protein Engineering Enables Functional Type II Polyketide Synthase Reconstitution In Vitro
Strategic Acyl Carrier Protein Engineering Enables Functional Type II Polyketide Synthase Reconstitution In Vitro Open
Microbial polyketides represent a structurally diverse class of secondary metabolites with medicinally relevant properties. Aromatic polyketides are produced by type II polyketide synthase (PKS) systems, each minimally composed of a ketosy…
View article: Microbial dynamics and <i>Pseudomonas</i> natural product production in milk and dairy products
Microbial dynamics and <i>Pseudomonas</i> natural product production in milk and dairy products Open
This review focuses on the role of microorganisms and their natural products in milk and dairy products.
View article: Pleiotropic regulation of bacterial toxin production and Allee effect govern microbial predator–prey interactions
Pleiotropic regulation of bacterial toxin production and Allee effect govern microbial predator–prey interactions Open
Bacteria are social organisms, which are constantly exposed to predation by nematodes or amoebae. To counteract these predation pressures, bacteria have evolved a variety of potent antipredator strategies. Bacteria of the genus Pseudomonas…
View article: Metamorphosis of a unicellular green alga in the presence of acetate and a spatially structured three‐dimensional environment
Metamorphosis of a unicellular green alga in the presence of acetate and a spatially structured three‐dimensional environment Open
Summary Photosynthetic protists, named microalgae, are key players in global primary production. The green microalga Chlamydomonas reinhardtii is a well‐studied model organism. In nature, it dwells in acetate‐rich paddy rice soil, which is…
View article: Naturstoffe aus der Vergangenheit
Naturstoffe aus der Vergangenheit Open
Low molecular weight compounds biosynthesized by microorganisms, commonly known as natural products, are indispensable in modern medicine. They serve as the basis for many antibiotics, immunomodulators, and anti cancer agents. The new rese…
View article: Pleiotropic regulation of bacterial toxin production and Allee effect govern microbial predator–prey interactions
Pleiotropic regulation of bacterial toxin production and Allee effect govern microbial predator–prey interactions Open
Bacteria are social organisms, which are constantly exposed to predation by nematodes or amoebae. To counteract these predation pressures, bacteria have evolved a variety of potent antipredator strategies. Bacteria of the genus Pseudomonas…
View article: Accessing microbial natural products of the past
Accessing microbial natural products of the past Open
Microbial natural products—low molecular weight compounds biosynthesized by microorganisms—form the foundation of important modern therapeutics, including antibiotics, immunomodulators, and anti-cancer agents. This perspective discusses an…
View article: Bifurcate evolution of quinone synthetases in basidiomycetes
Bifurcate evolution of quinone synthetases in basidiomycetes Open
Background The terphenylquinones represent an ecologically remarkable class of basidiomycete natural products as they serve as central precursors of pigments and compounds that impact on microbial consortia by modulating bacterial biofilms…
View article: Ecological Niche-Inspired Genome Mining Leads to the Discovery of Crop-Protecting Nonribosomal Lipopeptides Featuring a Transient Amino Acid Building Block
Ecological Niche-Inspired Genome Mining Leads to the Discovery of Crop-Protecting Nonribosomal Lipopeptides Featuring a Transient Amino Acid Building Block Open
Investigating the ecological context of microbial predator-prey interactions enables the identification of microorganisms, which produce multiple secondary metabolites to evade predation or to kill the predator. In addition, genome mining …
View article: Nonribosomal peptides protect <i>Pseudomonas nunensis</i> 4A2e from amoebal and nematodal predation
Nonribosomal peptides protect <i>Pseudomonas nunensis</i> 4A2e from amoebal and nematodal predation Open
Genome mining of the environmental bacterial isolate Pseudomonas nunensis 4A2e led to the discovery of three novel lipopeptides. Ecology-inspired bioassays highlight their importance in protecting the producing organism against various pre…
View article: Correction: Tyrosine bioconjugation with hypervalent iodine
Correction: Tyrosine bioconjugation with hypervalent iodine Open
Correction for ‘Tyrosine bioconjugation with hypervalent iodine’ by Nina Declas et al. , Chem. Sci. , 2022, 13 , 12808–12817, https://doi.org/10.1039/D2SC04558C.
View article: Yellow polyketide pigment suppresses premature hatching in social amoeba
Yellow polyketide pigment suppresses premature hatching in social amoeba Open
Low-molecular-weight natural products from microbes are indispensable in the development of potent drugs. However, their biological roles within an ecological context often remain elusive. Here, we shed light on natural products from eukar…
View article: Raw data for the article "Tyrosine Bioconjugation with Hypervalent Iodine"
Raw data for the article "Tyrosine Bioconjugation with Hypervalent Iodine" Open
Raw NMR, IR and MS data and further information on fluorescence experiments and cell uptake studies for the article "Tyrosine Bioconjugation with Hypervalent Iodine" published in Chemical Science, DOI: https://doi.org/10.1039/D2SC04558C Th…
View article: Raw data for the article "Tyrosine Bioconjugation with Hypervalent Iodine"
Raw data for the article "Tyrosine Bioconjugation with Hypervalent Iodine" Open
Raw NMR, IR and MS data and further information on fluorescence experiments and cell uptake studies for the article "Tyrosine Bioconjugation with Hypervalent Iodine" published in Chemical Science, DOI: https://doi.org/10.1039/D2SC04558C Th…
View article: Tyrosine Bioconjugation with Hypervalent Iodine
Tyrosine Bioconjugation with Hypervalent Iodine Open
Hypervalent iodine reagents have recently emerged as powerful tools for late-stage peptide and protein functionalization. Herein we report a tyrosine bioconjugation methodology for the introduction of hypervalent iodine onto biomolecules u…
View article: The potential of amoeba-based processes for natural product syntheses
The potential of amoeba-based processes for natural product syntheses Open
The identification of novel platform organisms for the production and discovery of small molecules is of high interest for the pharmaceutical industry. In particular, the structural complexity of most natural products with therapeutic pote…
View article: Total Synthesis and Structure Correction of the Cyclic Lipodepsipeptide Orfamide A
Total Synthesis and Structure Correction of the Cyclic Lipodepsipeptide Orfamide A Open
A total synthesis of the cyclic lipodepsipeptide natural product orfamide A was achieved. By developing a synthesis format using an aminoacid ester building block and SPPS protocol adaptation, a focused library of target compounds was obta…
View article: Metabolomics dataset - Dictyostelium discoideum fruiting bodies, AX2 wildtype and pks5 inactivation mutant
Metabolomics dataset - Dictyostelium discoideum fruiting bodies, AX2 wildtype and pks5 inactivation mutant Open
Fruiting body extracts of pks5- mutant and WT were subjected to high resolution (HR-)LCMS analysis. Raw LC-MS data was split into groups for negative and positive ionization mode and converted to mzXML file format in centroid mode with MSC…
View article: Tyrosine bioconjugation with hypervalent iodine
Tyrosine bioconjugation with hypervalent iodine Open
A tyrosine bioconjugation for the introduction of hypervalent iodine onto biomolecules is described. The transformation was applied to peptides and proteins and was used to modify native streptavidin to enable thiol-mediated cellular uptak…
View article: Total Synthesis and Bioactivity Mapping of Geodiamolide H
Total Synthesis and Bioactivity Mapping of Geodiamolide H Open
The first total synthesis of the actin‐stabilizing marine natural product geodiamolide H was achieved. Solid‐phase based peptide assembly paired with scalable stereoselective syntheses of polyketide building blocks and an optimized esterif…
View article: Lipopeptide-mediated bacterial interaction enables cooperative predator defense
Lipopeptide-mediated bacterial interaction enables cooperative predator defense Open
Significance Natural products are important mediators in interacting microbial communities. Here, we show that bacteria can defend themselves against a common predator by teaming up. This form of cooperative defense relies on the productio…