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View article: Developing and validating a clinical prediction model to predict epilepsy-related emergency department attendance, hospital admission, or death: A cohort study protocol
Developing and validating a clinical prediction model to predict epilepsy-related emergency department attendance, hospital admission, or death: A cohort study protocol Open
Introduction This retrospective open cohort study develops and externally validates a clinical prediction model (CPM) to predict the joint risk of two important outcomes occurring within the next year in people with epilepsy (PWE). These a…
View article: Evaluating the impact of a parent champion model on bronchiolitis hospitalisation rates: a difference in differences study
Evaluating the impact of a parent champion model on bronchiolitis hospitalisation rates: a difference in differences study Open
Background Bronchiolitis and its outcomes have strong socioeconomic determinants. In Liverpool, a city with high deprivation and above-average bronchiolitis hospitalisations, we implemented the Respiratory Parent Champions in the Community…
View article: Increased 30-day mortality associated with weekend emergency admission for alcohol-related liver disease in England: a record-linkage study using the Clinical Practice Research Datalink
Increased 30-day mortality associated with weekend emergency admission for alcohol-related liver disease in England: a record-linkage study using the Clinical Practice Research Datalink Open
Objective Deficiencies have been highlighted in acute hospital care for alcohol-related liver disease (ARLD). Such problems may be worse at weekends (WEs). Increased 30-day mortality for WE admissions has been reported for several acute co…
View article: An automation framework for clinical codelist development validated with UK data from patients with multiple long-term conditions
An automation framework for clinical codelist development validated with UK data from patients with multiple long-term conditions Open
Background Codelists play a crucial role in ensuring accurate and standardized communication within healthcare. However, preparation of high-quality codelists is a rigorous and time-consuming process. The literature focuses on transparency…
View article: Developing an artificial intelligence-assisted tool that identifies patients with multimorbidity and complex polypharmacy to improve the process of medication reviews: a qualitative exploration of user requirements (Preprint)
Developing an artificial intelligence-assisted tool that identifies patients with multimorbidity and complex polypharmacy to improve the process of medication reviews: a qualitative exploration of user requirements (Preprint) Open
View article: An Automation Framework for Clinical Codelist Development Validated with UK Data from Patients with Multiple Long-term Conditions
An Automation Framework for Clinical Codelist Development Validated with UK Data from Patients with Multiple Long-term Conditions Open
Background Codelists play a crucial role in ensuring accurate and standardized communication within healthcare. However, preparation of high-quality codelists is a rigorous and time-consuming process. The literature focuses on transparency…
View article: A qualitative exploration of barriers to efficient and effective structured medication reviews in primary care: Findings from the DynAIRx study
A qualitative exploration of barriers to efficient and effective structured medication reviews in primary care: Findings from the DynAIRx study Open
Introduction Structured medication reviews (SMRs), introduced in the United Kingdom (UK) in 2020, aim to enhance shared decision-making in medication optimisation, particularly for patients with multimorbidity and polypharmacy. Despite its…
View article: An international study to investigate and optimise the safety of discontinuing valproate in young men and women with epilepsy: Protocol
An international study to investigate and optimise the safety of discontinuing valproate in young men and women with epilepsy: Protocol Open
Valproate is the most effective treatment for idiopathic generalised epilepsy. Currently, its use is restricted in women of childbearing potential owing to high teratogenicity. Recent evidence extended this risk to men’s offspring, prompti…
View article: Risk of Type 2 Diabetes, MASLD and Cardiovascular Disease in People Living With Polycystic Ovary Syndrome
Risk of Type 2 Diabetes, MASLD and Cardiovascular Disease in People Living With Polycystic Ovary Syndrome Open
Background Polycystic ovary syndrome (PCOS) is associated with adverse clinical outcomes that may differ according to PCOS phenotype. Methods Using UK Biobank data, we compared the incidence of type 2 diabetes (T2D), metabolic dysfunction …
View article: An international study to investigate and optimise the safety of discontinuing valproate in young men and women with epilepsy: protocol
An international study to investigate and optimise the safety of discontinuing valproate in young men and women with epilepsy: protocol Open
Valproate is the most effective treatment for idiopathic generalised epilepsy. Currently, its use is restricted in women of childbearing potential owing to high teratogenicity. Recent evidence extended this risk to men’s offspring, prompti…
View article: A qualitative exploration of barriers to efficient and effective Structured Medication Reviews in Primary Care: Findings from the DynAIRx study
A qualitative exploration of barriers to efficient and effective Structured Medication Reviews in Primary Care: Findings from the DynAIRx study Open
Introduction Structured medication reviews (SMRs), introduced in the United Kingdom (UK) in 2020, aim to enhance shared decision-making in medication optimisation, particularly for patients with multimorbidity and polypharmacy. Despite its…
View article: Risk of Type 2 Diabetes, Metabolic Dysfunction Associated Steatotic Liver Disease and Cardiovascular Disease in People Living with Polycystic Ovary Syndrome According to Disease Phenotype: An Analysis of Prospective Cohort and Multi-Organ Imaging Data from the UK Biobank
Risk of Type 2 Diabetes, Metabolic Dysfunction Associated Steatotic Liver Disease and Cardiovascular Disease in People Living with Polycystic Ovary Syndrome According to Disease Phenotype: An Analysis of Prospective Cohort and Multi-Organ Imaging Data from the UK Biobank Open
View article: The predictive accuracy of cardiovascular disease risk prediction tools in inflammatory arthritis and psoriasis: an observational validation study using the Clinical Practice Research Datalink
The predictive accuracy of cardiovascular disease risk prediction tools in inflammatory arthritis and psoriasis: an observational validation study using the Clinical Practice Research Datalink Open
Objectives Cardiovascular risk prediction tools developed for the general population often underperform for individuals with RA, and their predictive accuracy are unclear for other inflammatory conditions that also have increased cardiovas…
View article: Developing and validating a clinical prediction model to predict epilepsy-related hospital admission or death within the next year using administrative healthcare data: a population-based cohort study protocol
Developing and validating a clinical prediction model to predict epilepsy-related hospital admission or death within the next year using administrative healthcare data: a population-based cohort study protocol Open
Introduction This retrospective open cohort study develops and externally validates a clinical prediction model (CPM) to predict the joint risk of two important outcomes occurring within the next year in people with epilepsy (PWE): A) seiz…
View article: Autocrine activation of MAPK signaling mediates intrinsic tolerance to androgen deprivation in LY6D prostate cancer cells
Autocrine activation of MAPK signaling mediates intrinsic tolerance to androgen deprivation in LY6D prostate cancer cells Open
View article: P61 Regional inequalities in multimorbidity within England between 2004 and 2019: a descriptive epidemiology study using the clinical practice research datalink
P61 Regional inequalities in multimorbidity within England between 2004 and 2019: a descriptive epidemiology study using the clinical practice research datalink Open
Background An estimated 25% of GP patients within the UK have multimorbidity (two or more chronic conditions), a large proportion of which is attributable to non-communicable diseases, many of them preventable. There are known regional ine…
View article: Inequalities in incident and prevalent multimorbidity in England, 2004–19: a population-based, descriptive study
Inequalities in incident and prevalent multimorbidity in England, 2004–19: a population-based, descriptive study Open
View article: Autocrine Activation of MAPK-Signaling Mediates Intrinsic Tolerance to Androgen Deprivation in LY6D Prostate Cancer Cells
Autocrine Activation of MAPK-Signaling Mediates Intrinsic Tolerance to Androgen Deprivation in LY6D Prostate Cancer Cells Open
View article: Dynamics of multimorbidity in England between 2004 and 2019: a descriptive epidemiology study
Dynamics of multimorbidity in England between 2004 and 2019: a descriptive epidemiology study Open
Background An estimated 25% of GP patients within the UK have multimorbidity, a large proportion of which is attributable to non-communicable diseases, many of them preventable. The heterogeneity of existing study methodologies limits comp…
View article: OP29 Dynamics of multimorbidity in England between 2004 and 2019: a descriptive epidemiology study using the clinical practice research datalink
OP29 Dynamics of multimorbidity in England between 2004 and 2019: a descriptive epidemiology study using the clinical practice research datalink Open
Background An estimated 25% of GP patients within the UK have multimorbidity, a large proportion of which is attributable to non-communicable diseases, many of them preventable. The heterogeneity of existing study methodologies and definit…
View article: Profiling of Circulating Free DNA Using Targeted and Genome-wide Sequencing in Patients with SCLC
Profiling of Circulating Free DNA Using Targeted and Genome-wide Sequencing in Patients with SCLC Open
View article: Corrigendum: Mutational signatures of DNA mismatch repair deficiency in <i>C. elegans</i> and human cancers
Corrigendum: Mutational signatures of DNA mismatch repair deficiency in <i>C. elegans</i> and human cancers Open
View article: Hypoxia induces rapid changes to histone methylation reprogramming chromatin for the cellular response
Hypoxia induces rapid changes to histone methylation reprogramming chromatin for the cellular response Open
Molecular dioxygenases include JmjC-containing histone demethylases and PHD enzymes, but only PHDs are considered to be molecular oxygen sensors in cells. Although, it is known that hypoxia can alter chromatin, whether this is a direct eff…
View article: Mutational signatures of DNA mismatch repair deficiency in <i>C. elegans</i> and human cancers
Mutational signatures of DNA mismatch repair deficiency in <i>C. elegans</i> and human cancers Open
Throughout their lifetime, cells are subject to extrinsic and intrinsic mutational processes leaving behind characteristic signatures in the genome. DNA mismatch repair (MMR) deficiency leads to hypermutation and is found in different canc…
View article: The application of liquid biopsies in metastatic salivary gland cancer to identify candidate therapeutic targets
The application of liquid biopsies in metastatic salivary gland cancer to identify candidate therapeutic targets Open
View article: Mutational signatures of DNA mismatch repair deficiency in<i>C. elegans</i>and human cancers
Mutational signatures of DNA mismatch repair deficiency in<i>C. elegans</i>and human cancers Open
Throughout their lifetime cells are subject to extrinsic and intrinsic mutational processes leaving behind characteristic signatures in the genome. DNA mismatch repair (MMR) deficiency leads to hypermutation and is found in different cance…
View article: Examining the role of individual movement in promoting coexistence in a spatially explicit prisoner's dilemma
Examining the role of individual movement in promoting coexistence in a spatially explicit prisoner's dilemma Open
View article: Dynamical patterns of coexisting strategies in a hybrid discrete-continuum spatial evolutionary game model
Dynamical patterns of coexisting strategies in a hybrid discrete-continuum spatial evolutionary game model Open
We present a novel hybrid modelling framework that takes into account two aspects which have been largely neglected in previous models of spatial evolutionary games: random motion and chemotaxis. A stochastic individual-based model is used…
View article: Erratum: How many biological replicates are needed in an RNA-seq experiment and which differential expression tool should you use?
Erratum: How many biological replicates are needed in an RNA-seq experiment and which differential expression tool should you use? Open
View article: The Chromatin Remodelling Enzymes SNF2H and SNF2L Position Nucleosomes adjacent to CTCF and Other Transcription Factors
The Chromatin Remodelling Enzymes SNF2H and SNF2L Position Nucleosomes adjacent to CTCF and Other Transcription Factors Open
Within the genomes of metazoans, nucleosomes are highly organised adjacent to the binding sites for a subset of transcription factors. Here we have sought to investigate which chromatin remodelling enzymes are responsible for this. We find…