Pieter A. Doevendans
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View article: Generation and characterization of human induced pluripotent stem cell (iPSC) lines from two asymptomatic Greek carriers of the Phospholamban (PLN)-R14del pathogenic variant and a non-carrier relative
Generation and characterization of human induced pluripotent stem cell (iPSC) lines from two asymptomatic Greek carriers of the Phospholamban (PLN)-R14del pathogenic variant and a non-carrier relative Open
View article: Chronotherapy as a novel strategy to limit anthracycline-induced cardiotoxicity
Chronotherapy as a novel strategy to limit anthracycline-induced cardiotoxicity Open
Anthracycline cardiotoxicity is a severe chemotherapeutic side effect that can lead to heart failure in cancer patients and survivors. Chronomodulated chemotherapy is a promising preventive strategy that encompasses the adjustment of anthr…
View article: Activating a patient-relevant mutation of a genetically defined heart disease in a humanized pig model
Activating a patient-relevant mutation of a genetically defined heart disease in a humanized pig model Open
Complex diseases such as progressive cardiomyopathies are often insufficiently reflected in small animal and in vitro models. Large animal species such as pigs provide a valuable alternative, but constitutive genetic manipulation (cGM) has…
View article: Living myocardial slices retain patient-specific features: Insights into etiology and therapeutic history
Living myocardial slices retain patient-specific features: Insights into etiology and therapeutic history Open
View article: Insights into <scp>pegRNA</scp> design from editing of the cardiomyopathy‐associated phospholamban R14del mutation
Insights into <span>pegRNA</span> design from editing of the cardiomyopathy‐associated phospholamban R14del mutation Open
Prime editing (PE) represents a transformative genome‐editing technology and enables precise insertions, deletions, and base substitutions without introducing double‐strand breaks, thereby reducing undesired indels and off‐target effects. …
View article: First in Human Use of Non-invasive, Robot Assisted, High Intensity Focused Ultrasound Treatment of Femoral Atherosclerosis: A Safety and Feasibility Pilot Study
First in Human Use of Non-invasive, Robot Assisted, High Intensity Focused Ultrasound Treatment of Femoral Atherosclerosis: A Safety and Feasibility Pilot Study Open
HIFU treatment using a DMUA transducer appears safe and feasible for the treatment of selected patients with PAD localised in the femoral artery.
View article: Characterization of human living myocardial slices culture-induced adaptations: a translational perspective
Characterization of human living myocardial slices culture-induced adaptations: a translational perspective Open
View article: The miniECG: Enabling interpretable detection of amplitude and intraventricular conduction ECG-abnormalities with a novel ECG device
The miniECG: Enabling interpretable detection of amplitude and intraventricular conduction ECG-abnormalities with a novel ECG device Open
Background The miniECG, a smartphone-sized, multi-lead device, offers a simple and fast alternative to the 12-lead ECG. We aimed to demonstrate the potential of the miniECG to record and detect amplitude and intraventricular conduction ECG…
View article: Corrigendum: Cre-dependent Cas9-expressing pigs enable efficient in vivo genome editing
Corrigendum: Cre-dependent Cas9-expressing pigs enable efficient in vivo genome editing Open
View article: Dexrazoxane protects against doxorubicin‐induced cardiotoxicity in susceptible human living myocardial slices: A proof‐of‐concept study
Dexrazoxane protects against doxorubicin‐induced cardiotoxicity in susceptible human living myocardial slices: A proof‐of‐concept study Open
Background and Purpose The increasing number of cancer survivors has caused growing concern over chemotherapy‐induced cardiotoxicity. This study aimed to investigate a novel human model of cardiotoxicity and explore cardioprotection. Exper…
View article: Feasibility and safety of single-pulse ablation in 20 patients with atrial fibrillation
Feasibility and safety of single-pulse ablation in 20 patients with atrial fibrillation Open
Acute electrical PVI could be achieved safely and rapidly. Acute silent cerebral lesions were detected in 3 of 20 patients (15%) and may be caused by ablation or changes of therapeutic and diagnostic catheters over a single transseptal acc…
View article: First-in-Human Study of Noninvasive, Robot-Assisted High-Intensity Focused Ultrasound Treatment of Femoral Atherosclerosis: A Safety and Feasibility Study
First-in-Human Study of Noninvasive, Robot-Assisted High-Intensity Focused Ultrasound Treatment of Femoral Atherosclerosis: A Safety and Feasibility Study Open
View article: Living myocardial slices: walking the path towards standardization
Living myocardial slices: walking the path towards standardization Open
Cardiovascular disease remains a persistent global health burden, underscoring the necessity for effective therapeutic strategies. Despite significant advances, the ability to mechanistically study human disease and predict clinical outcom…
View article: The PLN Foundation is striving for a cure, but who owns the disease?
The PLN Foundation is striving for a cure, but who owns the disease? Open
View article: Upstream and Downstream Cardiovascular Changes in Rheumatic Mitral Stenosis: An Update
Upstream and Downstream Cardiovascular Changes in Rheumatic Mitral Stenosis: An Update Open
Rheumatic heart disease (RHD) and its complications are major health problems worldwide, especially in developing countries, owing to their high prevalence. Mitral stenosis (MS) is one of the most common lesions in RHD, either isolated or …
View article: Candidate Biomarkers YES1, Troponin I, Lactate, and Ammonia for Evaluation of Cardiac Function Post Hypothermic Oxygenated Perfusion
Candidate Biomarkers YES1, Troponin I, Lactate, and Ammonia for Evaluation of Cardiac Function Post Hypothermic Oxygenated Perfusion Open
Hypothermic oxygenated perfusion (HOPE) is a promising method for donor heart preservation, but the hypothermic conditions reduce metabolic activity, making cardiac evaluation challenging, and necessitating prognostic biomarkers to monitor…
View article: Massive expansion and cryopreservation of functional human induced pluripotent stem cell-derived cardiomyocytes
Massive expansion and cryopreservation of functional human induced pluripotent stem cell-derived cardiomyocytes Open
View article: Low Attainment of Treatment Targets for Cardiovascular Risk Factors in Indonesian Adults With Established Coronary Artery Disease
Low Attainment of Treatment Targets for Cardiovascular Risk Factors in Indonesian Adults With Established Coronary Artery Disease Open
Rationale Established coronary artery disease (CAD) patients are at increased risk for recurrence of cardiovascular events and mortality due to non‐attainment of recommended risk factor control targets. Objective We aimed to evaluate the a…
View article: Altered circadian rhythmicity of the QT interval predicts mortality in a large real-world academic hospital population
Altered circadian rhythmicity of the QT interval predicts mortality in a large real-world academic hospital population Open
Using heterogeneous, real-world hospital data of more than 100,000 patients, circadian rhythmicity proved to be an independent determinant of the QT interval. Both increased and diminished QT rhythmicity was shown to be a predictor of all-…
View article: Generation and characterization of novel induced pluripotent stem cell (iPSC) lines derived from three symptomatic carriers of a pathogenic MYH11 variant and two non-carrier relatives
Generation and characterization of novel induced pluripotent stem cell (iPSC) lines derived from three symptomatic carriers of a pathogenic MYH11 variant and two non-carrier relatives Open
View article: Past Trends and Future Directions of Cardiac Regenerative Medicine – A Systematic Analysis of Clinical Trial Registries
Past Trends and Future Directions of Cardiac Regenerative Medicine – A Systematic Analysis of Clinical Trial Registries Open
View article: On the detection of acute coronary occlusion with the miniECG
On the detection of acute coronary occlusion with the miniECG Open
View article: Percutaneous pulmonary valve implantation guided by three-dimensional rotational angiography
Percutaneous pulmonary valve implantation guided by three-dimensional rotational angiography Open
The use of rotational angiography for the guidance of PPVI results in a high success rate, low number of complications with the use of a low amount of radiation.
View article: On the design and development of a handheld electrocardiogram device in a clinical setting
On the design and development of a handheld electrocardiogram device in a clinical setting Open
Cardiovascular diseases (CVDs) are a global burden that requires attention. For the detection and diagnosis of CVDs, the 12-lead ECG is a key tool. With technological advancements, ECG devices are becoming smaller and available for home us…
View article: Healthcare professionals’ perspective on the acceptance of gene therapy
Healthcare professionals’ perspective on the acceptance of gene therapy Open
View article: Modeling doxorubicin-induced cardiotoxicity with human myocardial tissue slices: insights on genetic susceptibility and cardioprotection
Modeling doxorubicin-induced cardiotoxicity with human myocardial tissue slices: insights on genetic susceptibility and cardioprotection Open
Funding Acknowledgements Type of funding sources: Public grant(s) – National budget only. Main funding source(s): PSIDER and HARVEY (ZonMW) Introduction Cardiotoxicity poses a significant challenge in drug development, often leading to the…
View article: Short- and long term preservation of cardiac tissue-engineered constructs
Short- and long term preservation of cardiac tissue-engineered constructs Open
Funding Acknowledgements Type of funding sources: Public grant(s) – EU funding. Main funding source(s): This research was financially supported by the Gravitation Program ‘‘Materials Driven Regeneration,’’ funded by the Netherlands Organiz…
View article: Left Ventricle Myocardial Work Correlated with Functional Capacity in Severe Rheumatic Mitral Stenosis with Preserved Left Ventricular Ejection Fraction
Left Ventricle Myocardial Work Correlated with Functional Capacity in Severe Rheumatic Mitral Stenosis with Preserved Left Ventricular Ejection Fraction Open
Background and Aims: Functional capacity is reduced in mitral stenosis (MS) patients. Previous studies showed a correlation between left atrial strain and functional capacity in this population. However, currently, no left ventricle (LV) e…
View article: Stress hyperglycemia and poor outcomes in patients with ST-elevation myocardial infarction: a systematic review and meta-analysis
Stress hyperglycemia and poor outcomes in patients with ST-elevation myocardial infarction: a systematic review and meta-analysis Open
Background Hyperglycemia, characterized by elevated blood glucose levels, is frequently observed in patients with acute coronary syndrome, including ST-elevation myocardial infarction (STEMI). There are conflicting sources regarding the re…
View article: In-hospital mortality of patients with acute coronary syndrome (ACS) after implementation of national health insurance (NHI) in Indonesia
In-hospital mortality of patients with acute coronary syndrome (ACS) after implementation of national health insurance (NHI) in Indonesia Open
Background The National Health Insurance (NHI) was implemented in Indonesia in 2014, and cardiovascular diseases are one of the diseases that have overburdened the healthcare system. However, data concerning the relationship between NHI an…