Pieter A. Leermakers
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View article: Novel RRAGD Variants in Autosomal Dominant Kidney Hypomagnesemia and Therapeutic Perspectives
Novel RRAGD Variants in Autosomal Dominant Kidney Hypomagnesemia and Therapeutic Perspectives Open
To date, 37 patients with ADKH-RRAGD have been identified. Kidney tubulopathy is the most prominent feature within the phenotypic spectrum of ADKH-RRAGD. Molecularly, constitutive activation of noncanonical mTORC1 is present in most RRA…
View article: Characterization of intestine-specific TRPM6 knockout C57BL/6 J mice: effects of short-term omeprazole treatment
Characterization of intestine-specific TRPM6 knockout C57BL/6 J mice: effects of short-term omeprazole treatment Open
The transient receptor potential melastatin type 6 (TRPM6) is a divalent cation channel pivotal for gatekeeping Mg 2+ balance. Disturbance in Mg 2+ balance has been associated with the chronic use of proton pump inhibitors (PPIs) such as o…
View article: Alterations in the molecular control of mitochondrial turnover in COPD lung and airway epithelial cells
Alterations in the molecular control of mitochondrial turnover in COPD lung and airway epithelial cells Open
View article: Impact of sub-acute acrolein inhalation on the molecular regulation of mitochondrial metabolism in rat lung
Impact of sub-acute acrolein inhalation on the molecular regulation of mitochondrial metabolism in rat lung Open
Nowadays, mitochondria are recognized as key players in the pathogenesis of a variety of smoking-associated lung diseases. Acrolein, a component of cigarette smoke, is a known driver of biological mechanisms underlying smoking-induced resp…
View article: Butyrate reduces cellular magnesium absorption independently of metabolic regulation in Caco-2 human colon cells
Butyrate reduces cellular magnesium absorption independently of metabolic regulation in Caco-2 human colon cells Open
View article: Acrolein inhalation acutely affects the regulation of mitochondrial metabolism in rat lung
Acrolein inhalation acutely affects the regulation of mitochondrial metabolism in rat lung Open
Exposure of the airways to cigarette smoke (CS) is the primary risk factor for developing several lung diseases such as Chronic Obstructive Pulmonary Disease (COPD). CS consists of a complex mixture of over 6000 chemicals including the hig…
View article: Placental Mitochondrial Abnormalities in Preeclampsia
Placental Mitochondrial Abnormalities in Preeclampsia Open
View article: Hypoxia-induced mitochondrial abnormalities in cells of the placenta
Hypoxia-induced mitochondrial abnormalities in cells of the placenta Open
Introduction Impaired utero-placental perfusion is a well-known feature of early preeclampsia and is associated with placental hypoxia and oxidative stress. Although aberrations at the level of the mitochondrion have been implicated in PE …
View article: Depletion of ATP Limits Membrane Excitability of Skeletal Muscle by Increasing Both ClC1-Open Probability and Membrane Conductance
Depletion of ATP Limits Membrane Excitability of Skeletal Muscle by Increasing Both ClC1-Open Probability and Membrane Conductance Open
Activation of skeletal muscle contractions require that action potentials can be excited and propagated along the muscle fibers. Recent studies have revealed that muscle fiber excitability is regulated during repeated firing of action pote…
View article: Iron deficiency‐induced loss of skeletal muscle mitochondrial proteins and respiratory capacity; the role of mitophagy and secretion of mitochondria‐containing vesicles
Iron deficiency‐induced loss of skeletal muscle mitochondrial proteins and respiratory capacity; the role of mitophagy and secretion of mitochondria‐containing vesicles Open
Iron homeostasis is essential for mitochondrial function, and iron deficiency has been associated with skeletal muscle weakness and decreased exercise capacity in patients with different chronic disorders. We hypothesized that iron deficie…
View article: Pulmonary inflammation-induced alterations in key regulators of mitophagy and mitochondrial biogenesis in murine skeletal muscle
Pulmonary inflammation-induced alterations in key regulators of mitophagy and mitochondrial biogenesis in murine skeletal muscle Open
Background Both mitophagy, a selective mechanism for clearance of mitochondria, and mitochondrial biogenesis are key processes determining mitochondrial content and oxidative capacity of the musculature. Abnormalities in these processes co…
View article: Skeletal muscle unloading results in increased mitophagy and decreased mitochondrial biogenesis regulation
Skeletal muscle unloading results in increased mitophagy and decreased mitochondrial biogenesis regulation Open
Introduction Physical inactivity significantly contributes to loss of muscle mass and performance in bed‐bound patients. Loss of skeletal muscle mitochondrial content has been well‐established in muscle unloading models, but the underlying…
View article: Distinct skeletal muscle molecular responses to pulmonary rehabilitation in chronic obstructive pulmonary disease: a cluster analysis
Distinct skeletal muscle molecular responses to pulmonary rehabilitation in chronic obstructive pulmonary disease: a cluster analysis Open
Background Pulmonary rehabilitation (PR) is a cornerstone in the management of chronic obstructive pulmonary disease (COPD), targeting skeletal muscle to improve functional performance. However, there is substantial inter‐individual variab…
View article: Molecular signalling towards mitochondrial breakdown is enhanced in skeletal muscle of patients with chronic obstructive pulmonary disease (COPD)
Molecular signalling towards mitochondrial breakdown is enhanced in skeletal muscle of patients with chronic obstructive pulmonary disease (COPD) Open
Loss of skeletal muscle mitochondrial oxidative capacity is well-established in patients with COPD, but the role of mitochondrial breakdown herein is largely unexplored. Currently, we studied if mitochondrial breakdown signalling is increa…
View article: Coordinated regulation of skeletal muscle mass and metabolic plasticity during recovery from disuse
Coordinated regulation of skeletal muscle mass and metabolic plasticity during recovery from disuse Open
Skeletal muscle regeneration after disuse is essential for muscle maintenance and involves the regulation of both mass‐ and metabolic plasticity–related processes. However, the relation between these processes during recovery from disuse r…
View article: Increased Myogenic and Protein Turnover Signaling in Skeletal Muscle of Chronic Obstructive Pulmonary Disease Patients With Sarcopenia
Increased Myogenic and Protein Turnover Signaling in Skeletal Muscle of Chronic Obstructive Pulmonary Disease Patients With Sarcopenia Open
View article: Skeletal muscle mitophagy in chronic disease
Skeletal muscle mitophagy in chronic disease Open
Based on available evidence, we propose that enhanced mitophagy is involved in chronic disease-induced loss of muscle oxidative capacity. Clearly more research is required to confirm this role and to establish to what extent mitophagy is p…