Pieter Baatsen
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View article: Lipid vesicle formation by encapsulation of SMALPs in surfactant-stabilised droplets
Lipid vesicle formation by encapsulation of SMALPs in surfactant-stabilised droplets Open
Understanding the intricate functions of membrane proteins is pivotal in cell biology and drug discovery. The composition of the cell membrane is highly complex, with different types of membrane proteins and lipid species. Hence, studying …
View article: Lipid vesicle formation by encapsulation of SMALPs in surfactant-stabilised droplets
Lipid vesicle formation by encapsulation of SMALPs in surfactant-stabilised droplets Open
Understanding the intricate functions of membrane proteins is pivotal in cell biology and drug discovery. The composition of the cell membrane is highly complex, with different types of membrane proteins and a huge variety of lipid species…
View article: Cdk5-dependent rapid formation and stabilization of dendritic spines by corticotropin-releasing factor
Cdk5-dependent rapid formation and stabilization of dendritic spines by corticotropin-releasing factor Open
View article: Heterozygous mutations in the C-terminal domain of COPA underlie a complex autoinflammatory syndrome
Heterozygous mutations in the C-terminal domain of COPA underlie a complex autoinflammatory syndrome Open
Mutations in the N-terminal WD40 domain of coatomer protein complex subunit α (COPA) cause a type I interferonopathy, typically characterized by alveolar hemorrhage, arthritis, and nephritis. We described 3 heterozygous mutations in the C-…
View article: Lipid Vesicle Formation by Encapsulation of SMALP in Surfactant-Stabilised Droplets
Lipid Vesicle Formation by Encapsulation of SMALP in Surfactant-Stabilised Droplets Open
View article: Improvement of Endothelial Cell-Polycaprolactone Interaction through Surface Modification via Aminolysis, Hydrolysis, and a Combined Approach
Improvement of Endothelial Cell-Polycaprolactone Interaction through Surface Modification via Aminolysis, Hydrolysis, and a Combined Approach Open
Polycaprolactone (PCL) is a promising material for the fabrication of alternatives to autologous grafts used in coronary bypass surgery. PCL biodegrades over time, allowing cells to infiltrate the polymeric matrix, replacing the biodegradi…
View article: Pericyte loss initiates microvascular dysfunction in the development of diastolic dysfunction
Pericyte loss initiates microvascular dysfunction in the development of diastolic dysfunction Open
Aims Microvascular dysfunction has been proposed to drive heart failure with preserved ejection fraction (HFpEF), but the initiating molecular and cellular events are largely unknown. Our objective was to determine when microvascular alter…
View article: A nanoparticle platform for combined mucosal healing and immunomodulation in inflammatory bowel disease treatment
A nanoparticle platform for combined mucosal healing and immunomodulation in inflammatory bowel disease treatment Open
View article: Author Correction: Reverse engineering synthetic antiviral amyloids
Author Correction: Reverse engineering synthetic antiviral amyloids Open
View article: Extracellular matrix flow guides emergent in-vitro morphogenesis
Extracellular matrix flow guides emergent in-vitro morphogenesis Open
Morphogenesis of vertebrate embryos requires extracellular matrix (ECM) in multiple developmental contexts1. Symmetry-breaking events in initially homogenous tissues trigger collective cellular dynamics which follow fluid-like b…
View article: Carbon nanotubes as a nitric oxide nano-reservoir improved the controlled release profile in 3D printed biodegradable vascular grafts
Carbon nanotubes as a nitric oxide nano-reservoir improved the controlled release profile in 3D printed biodegradable vascular grafts Open
Small diameter vascular grafts (SDVGs) are associated with a high failure rate due to poor endothelialization. The incorporation of a nitric oxide (NO) releasing system improves biocompatibility by using the NO effect to promote endothelia…
View article: FUS-ALS hiPSC-derived astrocytes impair human motor units through both gain-of-toxicity and loss-of-support mechanisms
FUS-ALS hiPSC-derived astrocytes impair human motor units through both gain-of-toxicity and loss-of-support mechanisms Open
View article: Neutrophils Protect Against <i>Staphylococcus aureus</i> Endocarditis Progression Independent of Extracellular Trap Release
Neutrophils Protect Against <i>Staphylococcus aureus</i> Endocarditis Progression Independent of Extracellular Trap Release Open
Background: Infective endocarditis (IE) is characterized by an infected thrombus at the heart valves. How bacteria bypass the immune system and cause these thrombi remains unclear. Neutrophils releasing NETs (neutrophil extracellular traps…
View article: Extracellular matrix flow guides in-vitro epithelial morphogenesis
Extracellular matrix flow guides in-vitro epithelial morphogenesis Open
Changes in spatial localization of the extracellular matrix (ECM) are necessary for establishing morphogenesis in multiple developmental contexts. Both ECM motion and tissue deformation require multicellular scale coordination, however the…
View article: Vascular and Liver Homeostasis in Juvenile Mice Require Endothelial Cyclic AMP-Dependent Protein Kinase A
Vascular and Liver Homeostasis in Juvenile Mice Require Endothelial Cyclic AMP-Dependent Protein Kinase A Open
During vascular development, endothelial cAMP-dependent protein kinase A (PKA) regulates angiogenesis by controlling the number of tip cells, and PKA inhibition leads to excessive angiogenesis. Whether this role of endothelial PKA is restr…
View article: The membrane-active polyaminoisoprenyl compound NV716 re-sensitizes Pseudomonas aeruginosa to antibiotics and reduces bacterial virulence
The membrane-active polyaminoisoprenyl compound NV716 re-sensitizes Pseudomonas aeruginosa to antibiotics and reduces bacterial virulence Open
View article: Modularity of RBC hitchhiking with polymeric nanoparticles: testing the limits of non-covalent adsorption
Modularity of RBC hitchhiking with polymeric nanoparticles: testing the limits of non-covalent adsorption Open
Red blood cell (RBC) hitchhiking has great potential in enhancing drug therapy, by improving targeting and reducing rapid clearance of nanoparticles (NPs). However, to improve the potential for clinical translation of RBC hitchhiking, a mo…
View article: Perturbation of Alphavirus and Flavivirus Infectivity by Components of the Bacterial Cell Wall
Perturbation of Alphavirus and Flavivirus Infectivity by Components of the Bacterial Cell Wall Open
During the past decades, the world has experienced a vast increase in epidemics of alphavirus and flavivirus infections. These viruses can cause severe diseases, such as hemorrhagic fever, encephalitis, and arthritis.
View article: Preservation of Fluorescence Signal and Imaging Optimization for Integrated Light and Electron Microscopy
Preservation of Fluorescence Signal and Imaging Optimization for Integrated Light and Electron Microscopy Open
Life science research often needs to define where molecules are located within the complex environment of a cell or tissue. Genetically encoded fluorescent proteins and or fluorescence affinity-labeling are the go-to methods. Although rece…
View article: Generation of Human Motor Units with Functional Neuromuscular Junctions in Microfluidic Devices
Generation of Human Motor Units with Functional Neuromuscular Junctions in Microfluidic Devices Open
Neuromuscular junctions (NMJs) are specialized synapses between the axon of the lower motor neuron and the muscle facilitating the engagement of muscle contraction. In motor neuron disorders, such as amyotrophic lateral sclerosis (ALS) and…
View article: Generation of Human Motor Units with Functional Neuromuscular Junctions in Microfluidic Devices
Generation of Human Motor Units with Functional Neuromuscular Junctions in Microfluidic Devices Open
Neuromuscular junctions (NMJs) are specialized synapses between the axon of the lower motor neuron and the muscle facilitating the engagement of muscle contraction. In motor neuron disorders, such as amyotrophic lateral sclerosis (ALS) and…
View article: Renal and Extra Renal Manifestations in Adult Zebrafish Model of Cystinosis
Renal and Extra Renal Manifestations in Adult Zebrafish Model of Cystinosis Open
Cystinosis is a rare, incurable, autosomal recessive disease caused by mutations in the CTNS gene. This gene encodes the lysosomal cystine transporter cystinosin, leading to lysosomal cystine accumulation in all cells of the body, with kid…
View article: Fetal hematopoietic stem cell homing is controlled by VEGF regulating the integrity and oxidative status of the stromal-vascular bone marrow niches
Fetal hematopoietic stem cell homing is controlled by VEGF regulating the integrity and oxidative status of the stromal-vascular bone marrow niches Open
View article: A workflow for streamlined acquisition and correlation of serial regions of interest in array tomography
A workflow for streamlined acquisition and correlation of serial regions of interest in array tomography Open
View article: Corticotropin-releasing factor induces functional and structural synaptic remodelling in acute stress
Corticotropin-releasing factor induces functional and structural synaptic remodelling in acute stress Open
View article: A prion-like protein regulator of seed germination undergoes hydration-dependent phase separation
A prion-like protein regulator of seed germination undergoes hydration-dependent phase separation Open
View article: Corticotropin-Releasing Factor Induces Functional And Structural Synaptic Remodelling In Acute Stress
Corticotropin-Releasing Factor Induces Functional And Structural Synaptic Remodelling In Acute Stress Open
Biological responses to internal and external stress factors involve highly conserved mechanisms, using a tightly coordinated interplay of many factors. Corticotropin-releasing factor (CRF) plays a central role in organizing these lifesavi…
View article: Perturbation of alphavirus and flavivirus infectivity by components of the bacterial cell wall
Perturbation of alphavirus and flavivirus infectivity by components of the bacterial cell wall Open
The impact of the host microbiota on arbovirus infections is currently not well understood. Arboviruses are viruses transmitted through the bites of infected arthropods, predominantly mosquitoes or ticks. The first site of arbovirus inocul…
View article: Human motor units in microfluidic devices are impaired by FUS mutations and improved by HDAC6 inhibition
Human motor units in microfluidic devices are impaired by FUS mutations and improved by HDAC6 inhibition Open
Neuromuscular junctions (NMJs) ensure communication between motor neurons (MNs) and muscle; however, in MN disorders, such as amyotrophic lateral sclerosis (ALS), NMJs degenerate resulting in muscle atrophy. The aim of this study was to es…
View article: PU.1 drives specification of pluripotent stem cell-derived endothelial cells to LSEC-like cells
PU.1 drives specification of pluripotent stem cell-derived endothelial cells to LSEC-like cells Open