Pieter Wesseling
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View article: PATH-75. Hetairos enables AI-based histopathological classification of CNS tumours
PATH-75. Hetairos enables AI-based histopathological classification of CNS tumours Open
Central nervous system (CNS) tumours encompass a diverse group of neoplasms with complex histological and molecular profiles. DNA methylation profiling has revolutionised their classification, enabling diagnosis at granular resolution. How…
View article: BIOM-09. PROGNOSTIC AND PREDICTIVE MARKERS FOR OUTCOME IN PATIENTS WITH IDHMT TUMORS TREATED IN THE EORTC CATNON TRIAL ON ADJUVANT AND/OR CONCURRENT TEMOZOLOMIDE IN ANAPLASTIC ASTROCYTOMA
BIOM-09. PROGNOSTIC AND PREDICTIVE MARKERS FOR OUTCOME IN PATIENTS WITH IDHMT TUMORS TREATED IN THE EORTC CATNON TRIAL ON ADJUVANT AND/OR CONCURRENT TEMOZOLOMIDE IN ANAPLASTIC ASTROCYTOMA Open
INTRODUCTION In a four-arm study, the CATNON trial investigated the role of concurrent and/or adjuvant temozolomide as addition to radiotherapy in anaplastic astrocytoma patients. The results of the final database lock in October 2024 conf…
View article: <scp>AOSNP</scp> ‐ <scp>ADAPTR</scp> resource level‐based recommendations on practical diagnostic strategies for <scp>WHO CNS5</scp> adult‐type diffuse gliomas
<span>AOSNP</span> ‐ <span>ADAPTR</span> resource level‐based recommendations on practical diagnostic strategies for <span>WHO CNS5</span> adult‐type diffuse gliomas Open
The fifth edition of the WHO classification of CNS Tumors (WHO CNS5) has revised the diagnostic and grading criteria for Adult‐type Diffuse Gliomas (ADGs) by integrating molecular parameters with histologic features. Conducting molecular t…
View article: TET CpG sequence context specific DNA demethylation shapes progression of IDH-mutant gliomas
TET CpG sequence context specific DNA demethylation shapes progression of IDH-mutant gliomas Open
Background Treatment decisions in IDH-mutant oligodendrogliomas are shaped by tumor aggressiveness, underscoring the need for objective grading of these malignant brain tumors. Material and Methods We collected 302 primary and recurrent re…
View article: P10.09.B SERPINB1 IMPROVES CLINICAL OUTCOME THROUGH INCREASING APOPTOSIS AND CHEMOSENSITIVITY IN MEDULLOBLASTOMA
P10.09.B SERPINB1 IMPROVES CLINICAL OUTCOME THROUGH INCREASING APOPTOSIS AND CHEMOSENSITIVITY IN MEDULLOBLASTOMA Open
BACKGROUND Medulloblastoma (MB) is one of the most prevalent pediatric brain malignancies and makes up ~20% of all primary brain tumors in children. Current treatment options are not curative for approximately 30% of patients and leave sur…
View article: P12.02.A UNRAVELLING THE CROSSTALK BETWEEN GLIOMA AND OLIGODENDROCYTES IN THE HUMAN BRAIN
P12.02.A UNRAVELLING THE CROSSTALK BETWEEN GLIOMA AND OLIGODENDROCYTES IN THE HUMAN BRAIN Open
BACKGROUND Gliomas are primary brain tumors that carry glial characteristics and that maintain an intricate relationship with surrounding brain tissue facilitating both tumor cell proliferation and migration. The infiltrative nature of adu…
View article: P08.09.A COMBINED TARGETING OF TIGIT/LAG-3/PD-L1 IMMUNE CHECKPOINTS POTENTIATES NK CELL-MEDIATED CYTOTOXICITY IN MEDULLOBLASTOMA ORGANOIDS
P08.09.A COMBINED TARGETING OF TIGIT/LAG-3/PD-L1 IMMUNE CHECKPOINTS POTENTIATES NK CELL-MEDIATED CYTOTOXICITY IN MEDULLOBLASTOMA ORGANOIDS Open
BACKGROUND Medulloblastoma (MB) is one of the most prevalent pediatric brain malignancies and makes up approximately 20% of all primary brain tumors in children. Current treatment options are not curative for about 30% of patients and leav…
View article: OS12.4.A AI-BASED HISTOPATHOLOGICAL CLASSIFICATION OF CENTRAL NERVOUS SYSTEM TUMOURS
OS12.4.A AI-BASED HISTOPATHOLOGICAL CLASSIFICATION OF CENTRAL NERVOUS SYSTEM TUMOURS Open
BACKGROUND DNA methylation profiling is central to CNS tumour diagnostics, providing molecular classification beyond conventional histopathology. However, its use is constrained by extended turnaround time, high costs and the need for spec…
View article: OS04.2.A FINAL CLINICAL AND MOLECULAR ANALYSIS OF THE EORTC RANDOMIZED PHASE III INTERGROUP CATNON TRIAL ON CONCURRENT AND ADJUVANT TEMOZOLOMIDE IN ANAPLASTIC GLIOMA WITHOUT 1P/19Q CODELETION.
OS04.2.A FINAL CLINICAL AND MOLECULAR ANALYSIS OF THE EORTC RANDOMIZED PHASE III INTERGROUP CATNON TRIAL ON CONCURRENT AND ADJUVANT TEMOZOLOMIDE IN ANAPLASTIC GLIOMA WITHOUT 1P/19Q CODELETION. Open
BACKGROUND The 1st and 2 interim analyses of the CATNON trial on anaplastic glioma (NCT00626990) showed benefit from adjuvant (adj) temozolomide (TMZ) on overall survival (OS) in patients with IDH mutant (mt) tumors, but no benefit of conc…
View article: How ‘Sturgeon’ guides the surgeon
How ‘Sturgeon’ guides the surgeon Open
For pediatric patients with central nervous system (CNS) tumors, primary treatment often involves neurosurgical tumor resection. Accurate diagnosis is crucial to perform the best-suited extent of resection. Since two years, Sturgeon, an AI…
View article: <scp>cIMPACT</scp>‐<scp>NOW</scp> update 11: Proposal on adaptation of diagnostic criteria for <scp>IDH</scp>‐ and <scp>H3</scp>‐wildtype diffuse high‐grade gliomas and for posterior fossa ependymal tumors
<span>cIMPACT</span>‐<span>NOW</span> update 11: Proposal on adaptation of diagnostic criteria for <span>IDH</span>‐ and <span>H3</span>‐wildtype diffuse high‐grade gliomas and for posterior fossa ependymal tumors Open
The Consortium to Inform Molecular and Practical Approaches to Central Nervous System Tumor Taxonomy (cIMPACT‐NOW) updates provide guidelines for the diagnosis of central nervous system (CNS) tumors and suggestions for future World Health …
View article: F.7 Chromosome 1p loss and 1q gain are highly prognostic and can inform WHO grading of meningioma
F.7 Chromosome 1p loss and 1q gain are highly prognostic and can inform WHO grading of meningioma Open
Background: The WHO grade of meningioma was updated in 2021 to include homozygous deletions of CDKN2A/B and TERT promotor mutations. Previous work including the recent cIMPACT-NOW statement have discussed the potential value of including c…
View article: <scp>cIMPACT</scp>‐<scp>NOW</scp> update 10: Recommendations for defining new types for central nervous system tumor classification
<span>cIMPACT</span>‐<span>NOW</span> update 10: Recommendations for defining new types for central nervous system tumor classification Open
View article: Unraveling mutagenic processes influencing the tumor mutational patterns of individuals with constitutional mismatch repair deficiency
Unraveling mutagenic processes influencing the tumor mutational patterns of individuals with constitutional mismatch repair deficiency Open
View article: Corrigendum to “Implementation of paediatric precision oncology into clinical practice: The individualized therapies for children with cancer program ‘iTHER’” [Eur J Cancer 175 (2022) 311–325]
Corrigendum to “Implementation of paediatric precision oncology into clinical practice: The individualized therapies for children with cancer program ‘iTHER’” [Eur J Cancer 175 (2022) 311–325] Open
View article: IDH-mutant astrocytomas with primitive neuronal component have a distinct methylation profile and a higher risk of leptomeningeal spread
IDH-mutant astrocytomas with primitive neuronal component have a distinct methylation profile and a higher risk of leptomeningeal spread Open
View article: Gemistocytic tumor cells programmed for glial scarring characterize T cell confinement in IDH-mutant astrocytoma
Gemistocytic tumor cells programmed for glial scarring characterize T cell confinement in IDH-mutant astrocytoma Open
Isocitrate dehydrogenase 1/2 mutant (IDHmt) astrocytoma is considered a T cell-deprived tumor, yet little is known regarding the phenotypes underlying T cell exclusion. Using bulk, single nucleus and spatial RNA and protein profiling, we d…
View article: AI-based histopathological classification of central nervous system tumours
AI-based histopathological classification of central nervous system tumours Open
DNA methylation analysis has become an essential diagnostic assay for classifying tumours of the central nervous system (CNS). However, this test requires additional resources and time compared to conventional histopathological diagnosis u…
View article: cIMPACT-NOW update 9: Recommendations on utilization of genome-wide DNA methylation profiling for central nervous system tumor diagnostics
cIMPACT-NOW update 9: Recommendations on utilization of genome-wide DNA methylation profiling for central nervous system tumor diagnostics Open
Genome-wide DNA methylation signatures correlate with and distinguish central nervous system (CNS) tumor types. Since the publication of the initial CNS tumor DNA methylation classifier in 2018, this platform has been increasingly used as …
View article: European standard clinical practice recommendations for paediatric high-grade gliomas
European standard clinical practice recommendations for paediatric high-grade gliomas Open
View article: VGLL fusions define a new class of intraparenchymal central nervous system schwannoma
VGLL fusions define a new class of intraparenchymal central nervous system schwannoma Open
Background Intracerebral schwannomas are rare tumors resembling their peripheral nerve sheath counterparts but localized in the central nervous system (CNS). They are not classified as a separate tumor type in the 2021 World Health Organiz…
View article: M&M: an RNA-seq based pan-cancer classifier for paediatric tumours
M&M: an RNA-seq based pan-cancer classifier for paediatric tumours Open
Financial support was provided by the Foundation Children Cancer Free (KiKa core funding) and Adessium Foundation.
View article: Pathological diagnosis of central nervous system tumours in adults: what's new?
Pathological diagnosis of central nervous system tumours in adults: what's new? Open
In the course of the last decade, the pathological diagnosis of many tumours of the central nervous system (CNS) has transitioned from a purely histological to a combined histological and molecular approach, resulting in a more precise 'hi…
View article: European Association of Neuro-Oncology guideline on molecular testing of meningiomas for targeted therapy selection
European Association of Neuro-Oncology guideline on molecular testing of meningiomas for targeted therapy selection Open
Meningiomas are the most common primary intracranial tumors of adults. For meningiomas that progress or recur despite surgical resection and radiotherapy, additional treatment options are limited due to a lack of proven efficacy. Meningiom…
View article: Diffuse pediatric high-grade glioma of methylation-based RTK2A and RTK2B subclasses present distinct radiological and histomolecular features including Gliomatosis cerebri phenotype
Diffuse pediatric high-grade glioma of methylation-based RTK2A and RTK2B subclasses present distinct radiological and histomolecular features including Gliomatosis cerebri phenotype Open
Diffuse pediatric-type high-grade gliomas (pedHGG), H3- and IDH-wildtype, encompass three main DNA-methylation-based subtypes: pedHGG-MYCN, pedHGG-RTK1A/B/C, and pedHGG-RTK2A/B. Since their first description in 2017 tumors of pedHGG-RTK2A/…
View article: Large-scale segmentation model facilitates intraoperative histopathology by third harmonic generation microscopy
Large-scale segmentation model facilitates intraoperative histopathology by third harmonic generation microscopy Open
Histopathological assessment is the corner stone for tumor diagnosis in the clinic, but it is in its optimal form (using paraffin-embedded sections) not readily available during surgery. The intraoperative alternative, frozen section analy…
View article: Preoperative prediction of diffuse glioma type and grade in adults: a gadolinium-free MRI-based decision tree
Preoperative prediction of diffuse glioma type and grade in adults: a gadolinium-free MRI-based decision tree Open
View article: Updated EANO guideline on rational molecular testing of gliomas, glioneuronal, and neuronal tumors in adults for targeted therapy selection—Update 1
Updated EANO guideline on rational molecular testing of gliomas, glioneuronal, and neuronal tumors in adults for targeted therapy selection—Update 1 Open
The standard of care for adult patients with gliomas, glioneuronal, and neuronal tumors consists of combinations of surgery, radiotherapy, and chemotherapy. For many systemic cancers, targeted treatments are a major part of the standard tr…
View article: Glioblastoma, IDH-wildtype with primarily leptomeningeal localization diagnosed by nanopore sequencing of cell-free DNA from cerebrospinal fluid
Glioblastoma, IDH-wildtype with primarily leptomeningeal localization diagnosed by nanopore sequencing of cell-free DNA from cerebrospinal fluid Open
View article: cIMPACT-NOW update 8: Clarifications on molecular risk parameters and recommendations for WHO grading of meningiomas
cIMPACT-NOW update 8: Clarifications on molecular risk parameters and recommendations for WHO grading of meningiomas Open
Meningiomas are the most frequent primary intracranial tumors. Hence, they constitute a major share of diagnostic specimens in neuropathology practice. The 2021 WHO Classification of Central Nervous System Tumors (“CNS5”) has introduced th…