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View article: Diagnostic Value of the “Insular Knife‐Cut” Sign in Patients With Suspected Herpes Simplex Virus Encephalitis
Diagnostic Value of the “Insular Knife‐Cut” Sign in Patients With Suspected Herpes Simplex Virus Encephalitis Open
Background The “insular knife‐cut” sign is a sharp demarcation between hyperintense insular lesions on fluid‐attenuated inversion recovery axial images and the basal ganglia, detected on brain MRI. This sign has been associated with herpes…
View article: Clinical Characterization and Long-Term Outcome in Children and Adults With Anti-AMPA Receptor Encephalitis
Clinical Characterization and Long-Term Outcome in Children and Adults With Anti-AMPA Receptor Encephalitis Open
Children and adults with anti-AMPAR encephalitis show distinct clinical-radiologic features. At long-term follow-up, 68% of patients, all adults, have neurologic sequelae, with failure to respond to first-line immunotherapy being associate…
View article: Serum Autoantibody Titers and Neurofilament Light Chain Levels in CASPR2/LGI1 Encephalitis
Serum Autoantibody Titers and Neurofilament Light Chain Levels in CASPR2/LGI1 Encephalitis Open
Measuring LGI1 and CASPR2-IgG titers in AE could help to confirm the disease stage and define relapses but has no prognostic implications. Serum NfL at onset could be used to identify patients at higher risk of cognitive sequelae that migh…
View article: Assessing Commercial Tissue-Based Assays for Autoimmune Neurologic Disorders (II)
Assessing Commercial Tissue-Based Assays for Autoimmune Neurologic Disorders (II) Open
The diagnostic performance of EUROIMMUN IIF-TBA in detecting NSAbs in autoimmune encephalitis is suboptimal. NMDAR antibodies, among the most common NSAbs, can be missed in 50% of cases. This commercial TBA should not be used alone as a sc…
View article: Assessing Commercial Tissue-Based Assays for Autoimmune Neurologic Disorders (I)
Assessing Commercial Tissue-Based Assays for Autoimmune Neurologic Disorders (I) Open
The performance of commercial IIF-TBAs for IC-Abs detection is suboptimal, exhibiting high false-negative rates of 25%-35%. Therefore, commercial TBAs should not be used alone for IC-Abs screening, but alongside more sensitive techniques, …
View article: Conformational Antibodies to Proteolipid Protein-1 and Its Peripheral Isoform DM20 in Patients With CNS Autoimmune Demyelinating Disorders
Conformational Antibodies to Proteolipid Protein-1 and Its Peripheral Isoform DM20 in Patients With CNS Autoimmune Demyelinating Disorders Open
View article: Safety and efficacy of chronic weekly rozanolixizumab in generalized myasthenia gravis: the randomized open-label extension MG0004 study
Safety and efficacy of chronic weekly rozanolixizumab in generalized myasthenia gravis: the randomized open-label extension MG0004 study Open
View article: Retrograde Amnesia in LGI1 and CASPR2 Limbic Encephalitis: Two Case Reports and a Systematic Literature Review
Retrograde Amnesia in LGI1 and CASPR2 Limbic Encephalitis: Two Case Reports and a Systematic Literature Review Open
Background Both anterograde and retrograde amnesia can typically co‐occur in limbic autoimmune encephalitis (LAE), including the forms associated with antibodies to CASPR2/LGI1, two protein complexed with the voltage‐gated potassium channe…
View article: Conformational Antibodies to Proteolipid Protein-1 and Its Peripheral Isoform DM20 in Patients With CNS Autoimmune Demyelinating Disorders
Conformational Antibodies to Proteolipid Protein-1 and Its Peripheral Isoform DM20 in Patients With CNS Autoimmune Demyelinating Disorders Open
Conformational PLP1-IgG predominantly identify patients with non-MS ADDs. They should be tested mainly in those with CNS + PNS ADD, coherently with DM20-IgG coreactivity. PLP1-IgG could also be investigated as disease modifiers and prognos…
View article: Autoimmune encephalitis: what the radiologist needs to know
Autoimmune encephalitis: what the radiologist needs to know Open
Autoimmune encephalitis is a relatively novel nosological entity characterized by an immune-mediated damage of the central nervous system. While originally described as a paraneoplastic inflammatory phenomenon affecting limbic structures, …
View article: Visual System Involvement in Glial Fibrillary Acidic Protein Astrocytopathy
Visual System Involvement in Glial Fibrillary Acidic Protein Astrocytopathy Open
Visual system involvement in GFAP astrocytopathy is common and heterogeneous, ranging from asymptomatic bilateral optic disc edema to severe bilateral loss of vision, but optic neuritis is rare. GFAP CSF antibody testing should be consider…
View article: Visual system involvement in GFAP astrocytopathy: two case reports and a systematic literature review
Visual system involvement in GFAP astrocytopathy: two case reports and a systematic literature review Open
The database contains information regarding patients with GFAP astrocytopathy reported in the literature included in the revew, including demographic, clinical presentation and course, neuroradiological data, laboratory data, treatment and…
View article: Visual system involvement in GFAP astrocytopathy: two case reports and a systematic literature review
Visual system involvement in GFAP astrocytopathy: two case reports and a systematic literature review Open
The database contains information regarding patients with GFAP astrocytopathy reported in the literature included in the revew, including demographic, clinical presentation and course, neuroradiological data, laboratory data, treatment and…
View article: Comparison of Fixed and Live Cell-Based Assay for the Detection of AChR and MuSK Antibodies in Myasthenia Gravis
Comparison of Fixed and Live Cell-Based Assay for the Detection of AChR and MuSK Antibodies in Myasthenia Gravis Open
Fixed CBA represents a valuable alternative to RIA for AChR and MuSK Ab detection in patients with MG and could be considered as a first-step diagnostic test. Live CBA can be useful in the serologic evaluation of RIA- and fixed CBA-negativ…
View article: COVID-19 and Guillain-Barré syndrome: A single-center prospective case series with a 1-year follow-up
COVID-19 and Guillain-Barré syndrome: A single-center prospective case series with a 1-year follow-up Open
Single reports of Guillain-Barré syndrome (GBS) have been reported worldwide during the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. While case reports are likely to be biased toward uncommon clinical presentation…
View article: Movement disorders associated with neuronal antibodies: a data-driven approach
Movement disorders associated with neuronal antibodies: a data-driven approach Open
View article: Dual IGF1R/IR inhibitors in combination with GD2-CAR T-cells display a potent anti-tumor activity in diffuse midline glioma H3K27M-mutant
Dual IGF1R/IR inhibitors in combination with GD2-CAR T-cells display a potent anti-tumor activity in diffuse midline glioma H3K27M-mutant Open
Background Diffuse midline gliomas (DMG) H3K27M-mutant, including diffuse intrinsic pontine glioma (DIPG), are pediatric brain tumors associated with grim prognosis. Although GD2-CAR T-cells demonstrated significant anti-tumor activity aga…
View article: DATABASE_MGCOVID
DATABASE_MGCOVID Open
The database contains information collected from a retrospective telephonic survey and from outpatient chart revision in patients with myastenia gravis (MG) followed up at our institution that provided informed consent. In detail, we colle…
View article: DATABASE_MGCOVID
DATABASE_MGCOVID Open
The database contains information collected from a retrospective telephonic survey and from outpatient chart revision in patients with myastenia gravis (MG) followed up at our institution that provided informed consent. In detail, we colle…
View article: COVID‐19 in patients with myasthenia gravis: Epidemiology and disease course
COVID‐19 in patients with myasthenia gravis: Epidemiology and disease course Open
Introduction/Aims Coronavirus disease 2019 (COVID‐19), a disease caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection, has become a global pandemic. Patients with myasthenia gravis (MG), often treated with immun…
View article: <i>RFC1</i> expansions are a common cause of idiopathic sensory neuropathy
<i>RFC1</i> expansions are a common cause of idiopathic sensory neuropathy Open
After extensive evaluation, one-third of patients affected by polyneuropathy remain undiagnosed and are labelled as having chronic idiopathic axonal polyneuropathy, which refers to a sensory or sensory-motor, axonal, slowly progressive neu…
View article: Acute myelopathies associated to SARS-CoV-2 infection: Viral or immune-mediated damage?
Acute myelopathies associated to SARS-CoV-2 infection: Viral or immune-mediated damage? Open
View article: IMMU-13. DUAL IGF1R/IR INHIBITOR IN COMBINATION WITH GD2-CAR T-CELLS AS A POTENT THERAPEUTIC STRATEGY FOR H3K27M-MUTANT DIFFUSE MIDLINE GLIOMAS
IMMU-13. DUAL IGF1R/IR INHIBITOR IN COMBINATION WITH GD2-CAR T-CELLS AS A POTENT THERAPEUTIC STRATEGY FOR H3K27M-MUTANT DIFFUSE MIDLINE GLIOMAS Open
Diffuse midline gliomas (DMG) are aggressive paediatric brain tumors for which there is no effective treatment. Recent pre-clinical studies suggest that adoptive transfer of chimeric antigen receptor (CAR) T-cells targeting the disialogang…