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View article: A brain‐derived tau oligomer polymorph is associated with cognitive resilience to Alzheimer's disease
A brain‐derived tau oligomer polymorph is associated with cognitive resilience to Alzheimer's disease Open
INTRODUCTION Misfolded tau can assemble into oligomers that adopt distinct conformations, referred to as polymorphs, each with unique biochemical and pathological properties. These tau polymorphs are thought to influence disease progressio…
View article: Cognitive integrity in Non‐Demented Individuals with Alzheimer’s Disease Neuropathology is associated with preservation and remodeling of dendritic spines
Cognitive integrity in Non‐Demented Individuals with Alzheimer’s Disease Neuropathology is associated with preservation and remodeling of dendritic spines Open
Background Alzheimer’s disease (AD) is the most prevalent neurodegenerative disorder leading to dementia. The existence of individuals who remain cognitively intact despite presenting histopathological signs of AD, here referred to as “Non…
View article: Cognitive integrity in Non‐Demented Individuals with Alzheimer's Neuropathology is associated with preservation and remodeling of dendritic spines
Cognitive integrity in Non‐Demented Individuals with Alzheimer's Neuropathology is associated with preservation and remodeling of dendritic spines Open
INTRODUCTION Individuals referred to as Non‐Demented with Alzheimer's Neuropathology (NDAN) exhibit cognitive resilience despite presenting Alzheimer's disease (AD) histopathological signs. Investigating the mechanisms behind this resilien…
View article: Calcineurin inhibition prevents synaptic plasticity deficit induced by brain-derived tau oligomers
Calcineurin inhibition prevents synaptic plasticity deficit induced by brain-derived tau oligomers Open
Compelling evidence suggests that cognitive decline in Alzheimer’s disease is associated with the accumulation and aggregation of tau protein, with the most toxic aggregates being in the form of oligomers. This underscores the necessity fo…
View article: Calcineurin inhibition prevents hippocampal synaptic plasticity impairment induced by brain‐derived tau oligomers via modulation of the transcriptome
Calcineurin inhibition prevents hippocampal synaptic plasticity impairment induced by brain‐derived tau oligomers via modulation of the transcriptome Open
Background Cognitive decline in Alzheimer’s disease (AD) strongly correlates with tau protein accumulation, with the most toxic species being in form of oligomers [1,2]. Due to the polymorphism of tau oligomers, isolating and testing brain…
View article: Preserved Autophagy in Cognitive Intact Non‐Demented Individuals with Alzheimer’s Neuropathology
Preserved Autophagy in Cognitive Intact Non‐Demented Individuals with Alzheimer’s Neuropathology Open
Background Alzheimer’s disease (AD) is a terminal neurodegenerative disease and the most common cause of dementia. Notably, some individuals, here referred to as Non‐Demented individuals with Alzheimer’s Neuropathology (NDAN) are cognitive…
View article: Preserved autophagy in cognitively intact non‐demented individuals with Alzheimer's neuropathology
Preserved autophagy in cognitively intact non‐demented individuals with Alzheimer's neuropathology Open
INTRODUCTION Growing evidence supports that dysfunctional autophagy, the major cell mechanism responsible for removing protein aggregates and a route of clearance for Tau in healthy neurons, is a major finding in demented Alzheimer's disea…
View article: Functional excitatory to inhibitory synaptic imbalance and loss of cognitive performance in people with Alzheimer’s disease neuropathologic change
Functional excitatory to inhibitory synaptic imbalance and loss of cognitive performance in people with Alzheimer’s disease neuropathologic change Open
Individuals at distinct stages of Alzheimer’s disease (AD) show abnormal electroencephalographic activity, which has been linked to network hyperexcitability and cognitive decline. However, whether pro-excitatory changes at the synaptic le…
View article: Increased excitatory to inhibitory synaptic ratio in parietal cortex samples from individuals with Alzheimer’s disease
Increased excitatory to inhibitory synaptic ratio in parietal cortex samples from individuals with Alzheimer’s disease Open
View article: Functional Integrity of Synapses in the Central Nervous System of Cognitively Intact Individuals with High Alzheimer’s Disease Neuropathology Is Associated with Absence of Synaptic Tau Oligomers
Functional Integrity of Synapses in the Central Nervous System of Cognitively Intact Individuals with High Alzheimer’s Disease Neuropathology Is Associated with Absence of Synaptic Tau Oligomers Open
Background: Certain individuals, here referred to as Non-Demented with Alzheimer Neuropathology (NDAN), do not show overt neurodegeneration (N-) and remain cognitively intact despite the presence of plaques (A+) and tangles (T+) that would…
View article: Preservation of global synaptic excitatory to inhibitory ratio during long postmortem intervals
Preservation of global synaptic excitatory to inhibitory ratio during long postmortem intervals Open
The study of postsynaptic excitation to inhibition (E/I ratio) imbalances in human brain diseases, is a highly relevant functional measurement poorly investigated due to postmortem degradation of synaptic receptors. We show that near-simul…
View article: NEUROINFLAMMATION AND SYNAPTIC IMBALANCE IN ALZHEIMER’S DISEASE
NEUROINFLAMMATION AND SYNAPTIC IMBALANCE IN ALZHEIMER’S DISEASE Open
View article: Anti-inflammatory and antioxidant effects of muscarinic acetylcholine receptor (mAChR) activation in the rat hippocampus
Anti-inflammatory and antioxidant effects of muscarinic acetylcholine receptor (mAChR) activation in the rat hippocampus Open
Recently we found that acute treatment with Oxotremorine (Oxo), a non-selective mAChRs agonist, up-regulates heat shock proteins and activates their transcription factor heat shock factor 1 in the rat hippocampus. Here we aimed to investig…
View article: Anti-inflammatory and cognitive effects of interferon-β1a (IFNβ1a) in a rat model of Alzheimer’s disease
Anti-inflammatory and cognitive effects of interferon-β1a (IFNβ1a) in a rat model of Alzheimer’s disease Open
View article: Anti-inflammatory and cognitive effects of interferon-β1a (IFNβ1a) in a rat model of Alzheimer's disease 11 Medical and Health Sciences 1109 Neurosciences
Anti-inflammatory and cognitive effects of interferon-β1a (IFNβ1a) in a rat model of Alzheimer's disease 11 Medical and Health Sciences 1109 Neurosciences Open
View article: Identification of peptidomimetics as novel chemical probes modulating fibroblast growth factor 14 (FGF14) and voltage-gated sodium channel 1.6 (Nav1.6) protein-protein interactions
Identification of peptidomimetics as novel chemical probes modulating fibroblast growth factor 14 (FGF14) and voltage-gated sodium channel 1.6 (Nav1.6) protein-protein interactions Open