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View article: Multifocal cancer is associated with better survival than solitary cancer in non-Hispanic White patients with thyroid carcinoma
Multifocal cancer is associated with better survival than solitary cancer in non-Hispanic White patients with thyroid carcinoma Open
Multifocal thyroid carcinoma is associated with better CSS and OS than solitary cancer in NHW patients.
View article: Expression and prognosis of cellular senescence genes in head and neck squamous cell carcinoma
Expression and prognosis of cellular senescence genes in head and neck squamous cell carcinoma Open
Background Cellular senescence refers to cells entering a relatively stable state of cell cycle arrest, which is a barrier that tumor cells must cross to achieve immortalization and plays an extremely important role in preventing the occur…
View article: Nicotine-induced CHRNA5 activation modulates CES1 expression, impacting head and neck squamous cell carcinoma recurrence and metastasis via MEK/ERK pathway
Nicotine-induced CHRNA5 activation modulates CES1 expression, impacting head and neck squamous cell carcinoma recurrence and metastasis via MEK/ERK pathway Open
The mucosal epithelium of the head and neck region (including the oral cavity, nasal cavity, pharynx, nasopharynx, and larynx) is the primary site exposed to tobacco smoke, and its presence of nicotinic acetylcholine receptors (nAChRs) has…
View article: Histone modifications in head and neck squamous cell carcinoma
Histone modifications in head and neck squamous cell carcinoma Open
Head and neck cancer is the main cause of cancer death worldwide, with squamous cell carcinoma (HNSCC) being the second most frequent subtype. HNSCC poses significant health threats due to its high incidence and poor prognosis, underscorin…
View article: Phase noise matching in resonant metasurfaces for intrinsic sensing stability
Phase noise matching in resonant metasurfaces for intrinsic sensing stability Open
Interferometry offers a precise means of interrogating resonances in dielectric and plasmonic metasurfaces, surpassing spectrometer-imposed resolution limits. However, interferometry implementations often face complexity or instability iss…
View article: N4-acetylcytidine-dependent GLMP mRNA stabilization by NAT10 promotes head and neck squamous cell carcinoma metastasis and remodels tumor microenvironment through MAPK/ERK signaling pathway
N4-acetylcytidine-dependent GLMP mRNA stabilization by NAT10 promotes head and neck squamous cell carcinoma metastasis and remodels tumor microenvironment through MAPK/ERK signaling pathway Open
N4-acetylcytidine (ac4C) is a post-transcriptional RNA modification that regulates in various important biological processes. However, its role in human cancer, especially lymph node metastasis, remains largely unknown. Here, we demonstrat…
View article: Interaction between Genetic Risks and Socioeconomic Factors on Thyroid Cancer: Evidence from 0.5 Million UK Biobank Participants
Interaction between Genetic Risks and Socioeconomic Factors on Thyroid Cancer: Evidence from 0.5 Million UK Biobank Participants Open
Background: There is a research gap between genetic predisposition, socioeconomic factors, and their interactions on thyroid tumorigenesis. Methods: Individual and genetic data were obtained from UK Biobank. Logistic regression models were…
View article: Expression and prognosis of cellular senescence genes in head and neck squamous cell carcinoma
Expression and prognosis of cellular senescence genes in head and neck squamous cell carcinoma Open
Background: Cellular senescence refers to cells entering a relatively stable state of cell cycle arrest, which is a barrier that tumor cells must cross to achieve immortalization and plays an extremely important role in preventing the occu…
View article: Prognosis and immunotherapy response in head and neck squamous cell carcinoma could be predicted by a signature based on three genes, as revealed by an integrated analysis of single-cell and bulk RNA-sequencing data
Prognosis and immunotherapy response in head and neck squamous cell carcinoma could be predicted by a signature based on three genes, as revealed by an integrated analysis of single-cell and bulk RNA-sequencing data Open
Background: The microenvironment of head and neck squamous cell carcinoma (HNSC) is made up of cancer and non-cancerous cells, and their interactions have profound effects on anti-tumor immunity. However, a thorough understanding of the ge…
View article: Exosomes Derived from Adipose Mesenchymal Stem Cells Carrying miRNA-22-3p Promote Schwann Cells Proliferation and Migration through Downregulation of PTEN
Exosomes Derived from Adipose Mesenchymal Stem Cells Carrying miRNA-22-3p Promote Schwann Cells Proliferation and Migration through Downregulation of PTEN Open
Peripheral nerve injury (PNI) is often resulting from trauma, which leads to severe and permanently disability. Schwann cells are critical for facilitating the regeneration process after PNI. Adipose-derived mesenchymal stem cells (ADSCs) …
View article: Prevalence and Characteristics of Erectile Dysfunction in Obstructive Sleep Apnea Patients
Prevalence and Characteristics of Erectile Dysfunction in Obstructive Sleep Apnea Patients Open
Background Obstructive sleep apnea (OSA) is a common and severe social problem. Erectile dysfunction (ED) is an important health concern. The prevalence of OSA with ED is increasing, which significantly affects the quality of life and work…
View article: Extensive hearing loss induced by low‐frequency noise exposure
Extensive hearing loss induced by low‐frequency noise exposure Open
Background With little attention given to low‐frequency traffic noise and our understanding that cochlear function may be highly susceptible to low‐frequency noise, there is an urgent need to determine traffic noise‐induced hearing loss (N…
View article: The RNA N6-Methyladenosine Demethylase FTO Promotes Head and Neck Squamous Cell Carcinoma Proliferation and Migration by Increasing CTNNB1
The RNA N6-Methyladenosine Demethylase FTO Promotes Head and Neck Squamous Cell Carcinoma Proliferation and Migration by Increasing CTNNB1 Open
FTO promotes head and neck squamous cell carcinoma proliferation and migration by increasing CTNNB1 in an m6A-dependent manner.
View article: Integrated Data Analysis Implicates PLAU, SERPINE1, SPP1, and MMP1 as Prognostic Factors in Head and Neck Squamous Cell Carcinoma
Integrated Data Analysis Implicates PLAU, SERPINE1, SPP1, and MMP1 as Prognostic Factors in Head and Neck Squamous Cell Carcinoma Open
Aim: Head and neck squamous cell carcinoma (HNSCC) ranks seventh in incidence among the most common types of cancer worldwide.Although smoking and drinking are risk factors for HNSCC, the specific causes of, and molecular mechanisms underl…
View article: RNA methyltransferase NSUN2 promotes hypopharyngeal squamous cell carcinoma proliferation and migration by enhancing TEAD1 expression in an m5C-dependent manner
RNA methyltransferase NSUN2 promotes hypopharyngeal squamous cell carcinoma proliferation and migration by enhancing TEAD1 expression in an m5C-dependent manner Open
RNA methyltransferase NSUN2 is involved in cell proliferation and invasion in a variety of tumors. However, the expression, function, and mechanism of NSUN2 in hypopharyngeal squamous cell carcinoma (HPSCC) remains unknown. We used a bioin…
View article: Socioeconomic factors are associated with the prognosis of Thyroid Cancer
Socioeconomic factors are associated with the prognosis of Thyroid Cancer Open
Background: Thyroid adenomas/adenocarcinomas are the most common type of thyroid cancer. The impact of socioeconomic factors on the prognosis of thyroid cancer is unclear. Methods: Clinical information and socioeconomic factors were obtain…
View article: Identification of a prognostic 4-mRNA signature in laryngeal squamous cell carcinoma
Identification of a prognostic 4-mRNA signature in laryngeal squamous cell carcinoma Open
Background: Laryngeal squamous cell carcinoma (LSCC) is one of the most common malignancy in the respiratory tract and could reduce the quality of life seriously like dyspnea, dysphonia and dysphagia. Moreover, 5-year survival rate has dec…
View article: AGO2 involves the malignant phenotypes and FAK/PI3K/AKT signaling pathway in hypopharyngeal-derived FaDu cells
AGO2 involves the malignant phenotypes and FAK/PI3K/AKT signaling pathway in hypopharyngeal-derived FaDu cells Open
Argonaute 2 (AGO2) protein is usually overexpressed in various head and neck squamous cell carcinoma. However, the precise molecular mechanisms of AGO2 in hypopharyngeal cancer have not yet been clearly understood. Here we found the AGO2 e…
View article: Schwann cells promote the capability of neural stem cells to differentiate into neurons and secret neurotrophic factors
Schwann cells promote the capability of neural stem cells to differentiate into neurons and secret neurotrophic factors Open
The present study investigated whether co-culturing Schwann cells (SCs) with neural stem cells (NSCs) improves viability, direction of differentiation and secretion of brain-derived neurotrophic factor (BDNF) and glial cell-derived neurotr…
View article: Brain-derived and glial cell line-derived neurotrophic factor fusion protein immobilization to laminin
Brain-derived and glial cell line-derived neurotrophic factor fusion protein immobilization to laminin Open
Damage to the recurrent laryngeal nerve often causes hoarseness, dyspnea, dysphagia, and sometimes asphyxia due to vocal cord paralysis which result in a reduction of quality of life. Brain-derived neurotrophic factor (BDNF) and glial cell…
View article: <em>MiR-203</em> is involved in the laryngeal carcinoma pathogenesis via targeting VEGFA and Cox-2
<em>MiR-203</em> is involved in the laryngeal carcinoma pathogenesis via targeting VEGFA and Cox-2 Open
The development of laryngeal squamous cell carcinoma (LSCC) is a multistep process involving multiple factors. MicroRNAs, a group of important negative regulators of gene expression, have also been confirmed to be involved in the LSCC path…
View article: MiR-203 is involved in the laryngeal carcinoma pathogenesis via targeting VEGFA and Cox-2
MiR-203 is involved in the laryngeal carcinoma pathogenesis via targeting VEGFA and Cox-2 Open
Lin Xu,1 Bin Shen,2 Tingting Chen,3 Pin Dong2 1Department of Otolaryngology, Second Affiliated Hospital of Zhejiang University Medical College, Hangzhou, 2Department of Otolaryngology-Head & Neck Surgery, Shanghai Jiaotong Univers…
View article: Oxymatrine Downregulates<i>HPV16E7</i>Expression and Inhibits Cell Proliferation in Laryngeal Squamous Cell Carcinoma Hep-2 Cells In Vitro
Oxymatrine Downregulates<i>HPV16E7</i>Expression and Inhibits Cell Proliferation in Laryngeal Squamous Cell Carcinoma Hep-2 Cells In Vitro Open
Objective . To investigate the possible mechanisms of oxymatrine’s role in anti laryngeal squamous cell carcinoma. Methods . We examined the effects of oxymatrine on the proliferation, cell cycle phase distribution, apoptosis, and the prot…
View article: Effect of laminin-binding BDNF on induction of recurrent laryngeal nerve regeneration by miR-222 activation of mTOR signal pathway.
Effect of laminin-binding BDNF on induction of recurrent laryngeal nerve regeneration by miR-222 activation of mTOR signal pathway. Open
The present study revealed that LBD-BDNF promoted the recurrent laryngeal nerve regeneration in laryngeal nerve injured rabbits. The underlying mechanism was closely related to activation of p-mTOR by miR-222.