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View article: Extraction, Purification, Structure, and Bioactivities of Polysaccharides from Glehnia littoralis: A Review
Extraction, Purification, Structure, and Bioactivities of Polysaccharides from Glehnia littoralis: A Review Open
Ethnopharmacological relevance: Glehnia littoralis (GL) is a well-known traditional Chinese medicine used to clear the lungs and benefit the stomach. Glehnia littoralis polysaccharides (GLPs) constitute one of the primary active ingredient…
View article: Deep eutectic solvent extraction of chlorogenic acid from dandelion with ultrasonic-assisted: Process optimization, purification, and bioactivity
Deep eutectic solvent extraction of chlorogenic acid from dandelion with ultrasonic-assisted: Process optimization, purification, and bioactivity Open
View article: Conserved function of the HAUS6 calponin homology domain in anchoring augmin for microtubule branching
Conserved function of the HAUS6 calponin homology domain in anchoring augmin for microtubule branching Open
View article: The efficacy of Akkermansia muciniphila YGMCC2602-derived postbiotics in skin repair
The efficacy of Akkermansia muciniphila YGMCC2602-derived postbiotics in skin repair Open
View article: Mechanistic studies of small molecule ligands selective to RNA single G bulges
Mechanistic studies of small molecule ligands selective to RNA single G bulges Open
Small-molecule RNA binders have emerged as an important pharmacological modality. A profound understanding of the ligand selectivity, binding mode, and influential factors governing ligand engagement with RNA targets is the foundation for …
View article: Dissecting the Structural Organization, Recruitment and Activation Mechanisms of Centrosomal γ‐<scp>TuRCs</scp>
Dissecting the Structural Organization, Recruitment and Activation Mechanisms of Centrosomal γ‐<span>TuRCs</span> Open
Visualizing human centrosomes using cryo‐electron tomography revealed the native structure and molecular organization of γ‐tubulin ring complexes (γ‐TuRCs). γ‐TuRCs localized to two distinct centrosomal pools, one in the pericentriolar mat…
View article: Structural mechanisms for centrosomal recruitment and organization of the microtubule nucleator γ-TuRC
Structural mechanisms for centrosomal recruitment and organization of the microtubule nucleator γ-TuRC Open
The γ-tubulin ring complex (γ-TuRC) acts as a structural template for microtubule formation at centrosomes, associating with two main compartments: the pericentriolar material and the centriole lumen. In the pericentriolar material, the γ-…
View article: Lysine acetyltransferase 5 contributes to diabetic retinopathy by modulating autophagy through epigenetically regulating autophagy-related gene 7
Lysine acetyltransferase 5 contributes to diabetic retinopathy by modulating autophagy through epigenetically regulating autophagy-related gene 7 Open
Objective Diabetic retinopathy (DR) is a prevalent and serious complication among individuals with diabetes, significantly compromising their visual acuity and overall quality of life. Lysine acetyltransferase 5 (KAT5), an essential cataly…
View article: B-Lightning: using bait genes for marker gene hunting in single-cell data with complex heterogeneity
B-Lightning: using bait genes for marker gene hunting in single-cell data with complex heterogeneity Open
In single-cell studies, cells can be characterized with multiple sources of heterogeneity (SOH) such as cell type, developmental stage, cell cycle phase, activation state, and so on. In some studies, many nuisance SOH are of no interest, b…
View article: Marker gene fishing for single-cell data with complex heterogeneity
Marker gene fishing for single-cell data with complex heterogeneity Open
In single-cell studies, cells can be characterized with multiple sources of heterogeneity such as cell type, developmental stage, cell cycle phase, activation state, and so on. In some studies, many nuisance sources of heterogeneity (SOH) …
View article: Combined analysis of gut microbiota and metabolomics in high-fat model mice fed with Chlorella pyrenoidosa peptides
Combined analysis of gut microbiota and metabolomics in high-fat model mice fed with Chlorella pyrenoidosa peptides Open
Chlorella pyrenoidosa peptides (SISISVAGGGR, T1) can effectively alleviate obesity and related metabolic disorders in high-fat mice. However, their lipid-lowering mechanism is still unclear. This research endeavor sought to delve into the …
View article: HS-GC-IMS Analysis of Volatile Organic Compounds in Six Spicy Spices and Their Effects on Ulcerative Colitis
HS-GC-IMS Analysis of Volatile Organic Compounds in Six Spicy Spices and Their Effects on Ulcerative Colitis Open
The volatile organic compounds of six spices, including black pepper, dried ginger, cinnamon, fennel, clove, and zanthoxylum, were analyzed by gas chromatography–ion mobility spectrometry (HS-GC-IMS) combined with principal component analy…
View article: World Federation of Acupuncture-Moxibustion Societies (WFAS) Clinical Practice Guideline on Acupuncture and Moxibustion: Migraine recommendation summaries
World Federation of Acupuncture-Moxibustion Societies (WFAS) Clinical Practice Guideline on Acupuncture and Moxibustion: Migraine recommendation summaries Open
Clinical Practice Guideline on Acupuncture and Moxibustion: Migraine (WFAS 007.9-2023) is a clinical practice guideline officially released by the World Federation of Acupuncture-Moxibustion Societies (WFAS) on October 9, 2023, and is the …
View article: Dinuclear gold-catalyzed divergent dechlorinative radical borylation of gem-dichloroalkanes
Dinuclear gold-catalyzed divergent dechlorinative radical borylation of gem-dichloroalkanes Open
The enormous and widespread use of organoboronic acids has prompted the development of innovative synthetic methodologies to meet the demands on structural diversity and functional group tolerance. The existing photoinduced defunctionaliza…
View article: γ-TuRC asymmetry induces local protofilament mismatch at the RanGTP-stimulated microtubule minus end
γ-TuRC asymmetry induces local protofilament mismatch at the RanGTP-stimulated microtubule minus end Open
View article: Efficient Access to β-Branched Noncanonical Amino Acids via Transaminase-Catalyzed Dynamic Kinetic Resolutions Driven by a Lysine Amine Donor
Efficient Access to β-Branched Noncanonical Amino Acids via Transaminase-Catalyzed Dynamic Kinetic Resolutions Driven by a Lysine Amine Donor Open
Transaminases are choice biocatalysts for the synthesis of chiral primary amines, including amino acids bearing contiguous stereocenters. In this study, we employ lysine as a “smart” amine donor in transaminase-catalyzed dynamic kinetic re…
View article: ALIX and TSG101 are essential for cellular entry and replication of two porcine alphacoronaviruses
ALIX and TSG101 are essential for cellular entry and replication of two porcine alphacoronaviruses Open
Alphacoronaviruses are the primary coronaviruses responsible for causing severe economic losses in the pig industry with the potential to cause human outbreaks. Currently, extensive studies have reported the essential role of endosomal sor…
View article: Discovery of the Potent and Selective ATR Inhibitor Camonsertib (RP-3500)
Discovery of the Potent and Selective ATR Inhibitor Camonsertib (RP-3500) Open
ATR is a key kinase in the DNA-damage response (DDR) that is synthetic lethal with several other DDR proteins, making it an attractive target for the treatment of genetically selected solid tumors. Herein we describe the discovery of a nov…
View article: Stereoselective benzylic C(sp <sup>3</sup> )–H alkenylation enabled by metallaphotoredox catalysis
Stereoselective benzylic C(sp <sup>3</sup> )–H alkenylation enabled by metallaphotoredox catalysis Open
We report a site- and stereoselective benzylic C(sp 3 )–H alkenylation utilizing metallaphotoredox catalysis. In addition, enantioselective benzylic C(sp 3 )–H alkenylation can successfully produce highly enantioenriched tetrasubstituted o…
View article: Oxazaborolidine Catalyzed Asymmetric 1,4-Addition of Diarylphosphine Oxides to Α,Β-Unsaturated N-Acylindoles and N-Acylpyrroles
Oxazaborolidine Catalyzed Asymmetric 1,4-Addition of Diarylphosphine Oxides to Α,Β-Unsaturated N-Acylindoles and N-Acylpyrroles Open
View article: Photoinduced copper-catalyzed C–N coupling with trifluoromethylated arenes
Photoinduced copper-catalyzed C–N coupling with trifluoromethylated arenes Open
Selective defluorinative functionalization of trifluoromethyl group (–CF 3 ) is an attractive synthetic route to the pharmaceutically privileged fluorine-containing moiety. Herein, we report a strategy based on photoexcited copper catalysi…
View article: Porcine enteric alphacoronavirus infection increases lipid droplet accumulation to facilitate the virus replication
Porcine enteric alphacoronavirus infection increases lipid droplet accumulation to facilitate the virus replication Open
Coronaviruses are widely transmissible between humans and animals, causing diseases of varying severity. Porcine enteric alphacoronavirus (PEAV) is a newly-discovered pathogenic porcine enteric coronavirus in recent years, which causes wat…
View article: #3527 NOVEL MODELS FOR THE PREDICTION OF NON-DIABETIC RENAL DISEASE IN TYPE 2 DIABETES MELLITUS
#3527 NOVEL MODELS FOR THE PREDICTION OF NON-DIABETIC RENAL DISEASE IN TYPE 2 DIABETES MELLITUS Open
Background and Aims Accurately distinguishing non-diabetic renal disease (NDRD) from patients with diabetic kidney disease (DKD) in absence of kidney biopsy remains big challenge. We aimed to develop and validate a prediction model to guid…
View article: Sulfated modification, basic characterization, antioxidant and anticoagulant potentials of polysaccharide from Sagittaria trifolia
Sulfated modification, basic characterization, antioxidant and anticoagulant potentials of polysaccharide from Sagittaria trifolia Open
To discover novel antioxidants and anticoagulants for the prevention and treatment of cardiovascular diseases remains ongoing concern. Sagittaria trifolia is a commonly consumed aquatic vegetable with highly nutritious value and wide plant…
View article: How Alginate Lyase Produces Quasi-Monodisperse Oligosaccharides: A Normal Mod-Based Docking and Molecular Dynamics Simulation Study
How Alginate Lyase Produces Quasi-Monodisperse Oligosaccharides: A Normal Mod-Based Docking and Molecular Dynamics Simulation Study Open
View article: Negative emotional granularity: Its mechanisms and related interventions
Negative emotional granularity: Its mechanisms and related interventions Open
情绪粒度可分为正性情绪粒度(positive emotional granularity) 和 负
View article: Characterization of aroma-active compounds in Dongli by quantitative descriptive analysis, gas chromatography-triple quadrupole tandem mass spectrometry, and gas chromatography-olfactometry
Characterization of aroma-active compounds in Dongli by quantitative descriptive analysis, gas chromatography-triple quadrupole tandem mass spectrometry, and gas chromatography-olfactometry Open
View article: Photoredox-Catalyzed Giese Reactions: Decarboxylative Additions to Cyclic Vinylogous Amides and Esters
Photoredox-Catalyzed Giese Reactions: Decarboxylative Additions to Cyclic Vinylogous Amides and Esters Open
An effective strategy has been developed for the photoredox-catalyzed decarboxylative addition of cyclic amino acids to both vinylogous amides and esters leading to uniquely substituted heterocycles. The additions take place exclusively tr…
View article: Protective Effect and Its Mechanism Analysis of Baihe Wuyao Decoction on Treatment of Type 1 Diabetes Mellitus and Associated Hepatic Injury
Protective Effect and Its Mechanism Analysis of Baihe Wuyao Decoction on Treatment of Type 1 Diabetes Mellitus and Associated Hepatic Injury Open
Objective: To investigate the protective effect of Baihe Wuyao decoction (BWD) on mice with type 1 diabetes mellitus (T1DM) and liver damage, and to reveal its underlying mechanism. Methods: Ten of 70 mice were randomly selected as the bla…
View article: Development of ProTx-II Analogues as Highly Selective Peptide Blockers of Na<sub>v</sub>1.7 for the Treatment of Pain
Development of ProTx-II Analogues as Highly Selective Peptide Blockers of Na<sub>v</sub>1.7 for the Treatment of Pain Open
Inhibitor cystine knot peptides, derived from venom, have evolved to block ion channel function but are often toxic when dosed at pharmacologically relevant levels in vivo. The article describes the design of analogues of ProTx-II t…