Wenbin Zhang
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View article: Nano-functionalized probiotic treats atherosclerosis via inhibiting intestinal microbiota-TMA-TMAO axis
Nano-functionalized probiotic treats atherosclerosis via inhibiting intestinal microbiota-TMA-TMAO axis Open
Many patients are suffering from atherosclerosis without typical risk factors, which can cause severe cardiovascular complications. Trimethylamine N-oxide (TMAO), derived from gut microbes, is a key unconventional contributor to the develo…
View article: Alternative Pathway for Methyl Supply through the Coupling of SHMT1 and PEMT to Maintain Astrocytic Homeostasis in Parkinson's Disease
Alternative Pathway for Methyl Supply through the Coupling of SHMT1 and PEMT to Maintain Astrocytic Homeostasis in Parkinson's Disease Open
Serine Hydroxymethyltransferase 1 (SHMT1) plays a pivotal role in one‐carbon metabolism, facilitating the production of SAM. In this study, dysregulation of one‐carbon metabolism is reported in both Parkinson's disease (PD) patients and an…
View article: Generative AI in depth: A survey of recent advances, model variants, and real-world applications
Generative AI in depth: A survey of recent advances, model variants, and real-world applications Open
In recent years, deep learning based generative models, particularly Generative Adversarial Networks (GANs), Variational Autoencoders (VAEs), and Diffusion Models (DMs), have been instrumental in generating diverse, high-quality content ac…
View article: Clinical effects and safety of proximal femur bionic nail versus proximal femoral nail anti-rotation and InterTAN for the treatment of intertrochanteric femoral fracture: a systematic review and meta-analysis
Clinical effects and safety of proximal femur bionic nail versus proximal femoral nail anti-rotation and InterTAN for the treatment of intertrochanteric femoral fracture: a systematic review and meta-analysis Open
Objective To compare the clinical effects and safety of the proximal femur bionic nail (PFBN) with those of proximal femoral nail anti-rotation (PFNA) and InterTAN for the treatment of intertrochanteric femoral fracture (IFF). Methods Stud…
View article: Formation Mechanism of Characteristic Flavor Substances in 3-Year-Old Diannan Small-Ear Pig Ham: Lipidomics and Flavoromics Study
Formation Mechanism of Characteristic Flavor Substances in 3-Year-Old Diannan Small-Ear Pig Ham: Lipidomics and Flavoromics Study Open
Diannan small-ear pig (DSP) ham is known for exceptional flavor. However, the composition of flavor components and the mechanisms underlying flavor development remain unclear. In this study, we employed lipidomics, flavoromics, and ultra-h…
View article: AMCR: A Framework for Assessing and Mitigating Copyright Risks in Generative Models
AMCR: A Framework for Assessing and Mitigating Copyright Risks in Generative Models Open
Generative models have achieved impressive results in text to image tasks, significantly advancing visual content creation. However, this progress comes at a cost, as such models rely heavily on large-scale training data and may unintentio…
View article: Cardiac tumors: clinical presentation, diagnosis, treatment, and results
Cardiac tumors: clinical presentation, diagnosis, treatment, and results Open
Cardiac tumors are a heterogeneous group of diseases that include primary and metastatic tumors. Among primary tumors, benign tumors account for the majority, and the incidence of malignant tumors is low. In contrast, the incidence of meta…
View article: Case Report: Child with Menkes syndrome complicated by bladder diverticula
Case Report: Child with Menkes syndrome complicated by bladder diverticula Open
Background Menkes syndrome is a rare X-linked genetic disorder of copper metabolism caused by variants in the ATP7A gene. It is characterized by developmental delay, hair abnormalities, hypotonia, and organ dysfunction. Bladder diverticula…
View article: Predictors for quantitative flow ratio loss in patients with de novo coronary artery disease treated with drug-coated balloons
Predictors for quantitative flow ratio loss in patients with de novo coronary artery disease treated with drug-coated balloons Open
Drug-Coated Balloons (DCB) have been widely used in interventional treatment for coronary artery de novo lesions. However, DCB treatment still have a certain proportion of target vessel restenosis (TLR) and adverse follow-up events. Quanti…
View article: Accelerating Virtual Directed Evolution of Proteins via Reinforcement Learning
Accelerating Virtual Directed Evolution of Proteins via Reinforcement Learning Open
With the advancement of machine learning methods, the protein fitness landscape can be predicted, providing reliable guidance in the selection of advantageous mutations for the directed evolution of proteins. However, the potential multipl…
View article: Analysis of Risk Factors for Contrast-Induced Acute Kidney Injury after PCI in Elderly Patients with Mild to Moderate Renal Insufficiency
Analysis of Risk Factors for Contrast-Induced Acute Kidney Injury after PCI in Elderly Patients with Mild to Moderate Renal Insufficiency Open
Background Contrast-induced acute Kidney Injury (CI-AKI) is a significant complication that can occur after percutaneous coronary intervention (PCI), particularly in patients with pre-existing renal insufficiency. The study was carried out…
View article: Dimethyl malonate alleviates obstructive nephropathy by enhancing renal metabolism and inhibiting kidney oxidative stress and inflammation
Dimethyl malonate alleviates obstructive nephropathy by enhancing renal metabolism and inhibiting kidney oxidative stress and inflammation Open
Introduction Obstructive nephropathy is a leading cause of renal injury and fibrosis. Mitochondrial dysfunction represents a hallmark of obstructive nephropathy, a condition that leads to metabolic aberrations, succinate accumulation, reac…
View article: Comparative Analysis of Sulfuric Acid Alkylation Technologies Based on a Reaction Kinetic Model
Comparative Analysis of Sulfuric Acid Alkylation Technologies Based on a Reaction Kinetic Model Open
As a core component of transportation fuels, clean gasoline plays a vital role in environmental protection. Alkylate, with its nearly zero sulfur, aromatic, and olefin contents, coupled with its superior research octane number, serves as a…
View article: Sweet spot mapping and structural connectivity in subthalamic stimulation: predicting neuropsychiatric outcomes in Parkinson’s disease
Sweet spot mapping and structural connectivity in subthalamic stimulation: predicting neuropsychiatric outcomes in Parkinson’s disease Open
Objective STN-DBS is an effective treatment for Parkinson’s disease (PD), improving motor symptoms, but its impact on non-motor symptoms, such as anxiety and depression, remain unclear. This study investigates the relationship between elec…
View article: Robot-Assisted Extraction of Impacted Mandibular Tooth: A Clinical Report
Robot-Assisted Extraction of Impacted Mandibular Tooth: A Clinical Report Open
Background: This clinical report presents the use of a minimally invasive, robot-assisted windowing surgery for the extraction of a median impacted mandibular tooth. The report highlights the precision and safety afforded by robotic assist…
View article: Application of the BOPPPS-CBL model in emergency chest pain management teaching for resident physicians: a randomized comparison
Application of the BOPPPS-CBL model in emergency chest pain management teaching for resident physicians: a randomized comparison Open
The BOPPPS-CBL model could be an effective teaching method in emergency chest pain management teaching for resident physicians.
View article: Biomimetic peroxisome targets myocardial injury and promotes heart repair and regeneration
Biomimetic peroxisome targets myocardial injury and promotes heart repair and regeneration Open
Heart ischemic injury predominately causes mitochondrial dysfunction, leading to the accumulation of ROS and lactate. The ROS-associated DNA damage response (DDR) contributes to myocardial cell cycle arrest and the inhibition of proliferat…
View article: Dentate nucleus deep brain stimulation for spinocerebellar ataxia: results of a six-month follow-up
Dentate nucleus deep brain stimulation for spinocerebellar ataxia: results of a six-month follow-up Open
Spinocerebellar ataxia (SCA) is a genetically heterogeneous neurodegenerative disorder lacking effective treatments currently. While noninvasive cerebellum neuromodulation showed positive results, invasive techniques like deep brain stimul…
View article: The prognostic association of triglyceride-glucose index and its derived indicators with stable coronary artery disease patients undergoing percutaneous coronary intervention
The prognostic association of triglyceride-glucose index and its derived indicators with stable coronary artery disease patients undergoing percutaneous coronary intervention Open
Aims Research on the triglyceride-glucose (TyG) index in patients with stable coronary artery disease (SCAD) remains relatively limited. Therefore, this study aims to investigate the association of the TyG index and its derived indicators,…
View article: Global, regional, national epidemiology and trends of Parkinson’s disease from 1990 to 2021: findings from the Global Burden of Disease Study 2021
Global, regional, national epidemiology and trends of Parkinson’s disease from 1990 to 2021: findings from the Global Burden of Disease Study 2021 Open
Aims In light of the escalating global incidence of Parkinson’s disease and the dearth of therapeutic interventions that can alter the disease’s course, there exists an urgent necessity to comprehensively elucidate and quantify the disease…
View article: Nano-engineered probiotic treats atherosclerosis via inhibiting intestinal microbiota-TMA-TMAO axis
Nano-engineered probiotic treats atherosclerosis via inhibiting intestinal microbiota-TMA-TMAO axis Open
Considerable numbers of patient are suffering from atherosclerosis without typical risk factors, which can cause severe cardiovascular complication but is lack of practical treatment. Thereinto, trimethylamine N -oxide (TMAO), originated f…
View article: Terpene mixtures and metabolic syndrome in the US general population: exploring the mediating role of insulin resistance
Terpene mixtures and metabolic syndrome in the US general population: exploring the mediating role of insulin resistance Open
Serum terpenes were positively associated with MetS, which might be partially mediated by the mechanism of IR.
View article: Exploring the Utility of the Reynolds and Framingham Risk Stratification Models in Predicting the Presence and Severity of Coronary Artery Disease in Chinese Patients
Exploring the Utility of the Reynolds and Framingham Risk Stratification Models in Predicting the Presence and Severity of Coronary Artery Disease in Chinese Patients Open
Coronary artery disease (CAD) is one of the leading causes of mortality and morbidity worldwide. Thus, a simple and practical method to identify it is urgently needed. This study aims to explore the correlation between the Reynolds and Fra…
View article: SARM1 Activation Promotes Axonal Degeneration Via a Two-Step Liquid-to-Solid Phase Transition
SARM1 Activation Promotes Axonal Degeneration Via a Two-Step Liquid-to-Solid Phase Transition Open
SARM1 protein plays a central role in axonal degeneration, a key process in many neurodegenerative diseases and nerve injuries. It mediates this by depleting axonal NAD+ through its NADase activity, catalyzed by the TIR domain. Normally, t…