Ping Li
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View article: The role of mitochondrial-associated endoplasmic reticulum membranes (MAMs) in diabetic microvascular complications: a review
The role of mitochondrial-associated endoplasmic reticulum membranes (MAMs) in diabetic microvascular complications: a review Open
Diabetic vascular complications include macrovascular lesions and microvascular lesions. Diabetic microvascular complications (DMC) are mainly manifested by microvascular endothelial dysfunction, basement membrane thickening, capillary per…
View article: SUMOylation and NEDDylation in kidney diseases
SUMOylation and NEDDylation in kidney diseases Open
Kidney disease poses a serious threat to human health and life, while the lack of specific therapeutic targets hinders the treatment of kidney disease. Emerging evidence shows that post-translational modifications (PTMs), particularly SUMO…
View article: Gastroesophageal reflux disease and risk of atrial fibrillation/flutter: Implications for heart failure progression
Gastroesophageal reflux disease and risk of atrial fibrillation/flutter: Implications for heart failure progression Open
Aims While observational studies suggest an association between gastroesophageal reflux disease (GERD) and atrial fibrillation/flutter (AF/AFL), the causal relationship and mechanisms remain undefined. This study employed Mendelian randomi…
View article: Differential Effects of High Methionine Diet on Biochemical Parameters in Normal and Diabetic Rat Models
Differential Effects of High Methionine Diet on Biochemical Parameters in Normal and Diabetic Rat Models Open
This study investigated the organ-specific effects of a high-methionine (HM) diet in streptozotocin (STZ)-induced diabetic rats, focusing on hepatic and renal metabolic adaptations. Male Wistar rats were divided into four groups (n=8/group…
View article: Taxonomic and Biogeographic Misconceptions in Qinling Lenok ( <i>Brachymystax tsinlingensis</i> ): Reassessing Zhou et al. (2025) Species Distribution Models
Taxonomic and Biogeographic Misconceptions in Qinling Lenok ( <i>Brachymystax tsinlingensis</i> ): Reassessing Zhou et al. (2025) Species Distribution Models Open
The Qinling Lenok ( Brachymystax tsinlingensis ), an endangered teleost fish species endemic to China's Qinling Mountains, faces critical conservation challenges under climate change. Zhou et al. applied Maximum Entropy (MaxEnt) model to p…
View article: Rhubarb: Traditional Uses, Phytochemistry, Multiomics-Based Novel Pharmacological and Toxicological Mechanisms
Rhubarb: Traditional Uses, Phytochemistry, Multiomics-Based Novel Pharmacological and Toxicological Mechanisms Open
Traditional Chinese medicines (TCMs) are practiced in clinical and healthcare settings and are widely employed as essential therapies for intervening diverse refractory illnesses. Rhubarb, which is prescribed as the root and rhizome of …
View article: Genetic factors associated with dyslipidemia, T2DM and DKD: a cross-sectional study on FXR gene polymorphisms
Genetic factors associated with dyslipidemia, T2DM and DKD: a cross-sectional study on FXR gene polymorphisms Open
Aim: Genetic factors play a critical role in the development and progression of type 2 diabetes (T2DM) and diabetic kidney disease (DKD). Recent studies have reported associations between single nucleotide polymorphisms (SNPs) in the farne…
View article: Sirtuin 3 in diabetic kidney disease: mechanisms and pharmacotherapy
Sirtuin 3 in diabetic kidney disease: mechanisms and pharmacotherapy Open
Diabetic kidney disease (DKD) is a microvascular complication of diabetes and a major cause of kidney failure; current treatment methods still need improvement. Sirtuin 3 (SIRT3) is an NAD+-dependent protein deacetylase located in the mito…
View article: The aggregate index of systemic inflammation is positively correlated with the risk of all-cause mortality in sepsis-associated acute kidney injury
The aggregate index of systemic inflammation is positively correlated with the risk of all-cause mortality in sepsis-associated acute kidney injury Open
View article: Correction: Adverse effects of finerenone in patients with heart failure: a systematic review and meta-analysis
Correction: Adverse effects of finerenone in patients with heart failure: a systematic review and meta-analysis Open
[This corrects the article DOI: 10.3389/fcvm.2025.1601552.].
View article: Immunosenescence-Related Gene MAFF is Involved in Immune Regulation and Malignant Progression in Pancreatic Adenocarcinoma
Immunosenescence-Related Gene MAFF is Involved in Immune Regulation and Malignant Progression in Pancreatic Adenocarcinoma Open
Immunosenescence has lately become a focal point in oncology investigations. Nevertheless, its significance in pancreatic adenocarcinoma (PAAD) remains to be elucidated. This research sought to examine the predictive value and treatment im…
View article: Yellow serofluid-inclusion enhanced anaerobic preservation of whole plant maize for subsequently reducing potential methane emission during in vitro ruminal fermentation
Yellow serofluid-inclusion enhanced anaerobic preservation of whole plant maize for subsequently reducing potential methane emission during in vitro ruminal fermentation Open
Yellow serofluid, a wine industry by-product, may alter microbial communities, enhance fermentation, and reduce methane emissions from ruminal fermentation. However, the effect of yellow serofluids on silage fermentation and subsequent met…
View article: Tryptophan metabolism as a target in gut microbiota, ageing and kidney disease
Tryptophan metabolism as a target in gut microbiota, ageing and kidney disease Open
Aromatic amino acid tryptophan metabolism, particularly three main metabolism pathways including kynurenine, serotonin and indole-derived pathways are under the direct or indirect modulation of host-microbiota crosstalk in human physiology…
View article: SPAG6 Promotes Multiple Myeloma Through Activation of the MAPK/ERK Signaling Pathway
SPAG6 Promotes Multiple Myeloma Through Activation of the MAPK/ERK Signaling Pathway Open
Background Sperm - associated antigen 6 (SPAG6), a member of the cancer/testis antigen (CTA) family, has been linked to multiple hematologic malignancies. Nevertheless, its role in multiple myeloma (MM) remains unclear. Methods Bioinformat…
View article: SChLAP1 regulates the metastasis and apoptosis of prostate cancer partly via miR-101
SChLAP1 regulates the metastasis and apoptosis of prostate cancer partly via miR-101 Open
SChLAP1 promotes PC progression by regulating metastasis and apoptosis via the miR-101-5p axis. The SChLAP1/miR-101-5p signaling pathway represents a novel diagnostic and therapeutic target, with potential implications for improving progno…
View article: Adverse effects of finerenone in patients with heart failure: a systematic review and meta-analysis
Adverse effects of finerenone in patients with heart failure: a systematic review and meta-analysis Open
Background Finerenone has been shown to improve outcomes in patients with heart failure (HF), encompassing those with reduced (HFrEF), mildly reduced (HFmrEF), or preserved ejection fraction (HFpEF). However, its clinical use is accompanie…
View article: Regulation of autophagy by the PI3K-AKT pathway in Astragalus membranaceus -Cornus officinalis to ameliorate diabetic nephropathy
Regulation of autophagy by the PI3K-AKT pathway in Astragalus membranaceus -Cornus officinalis to ameliorate diabetic nephropathy Open
Aims and background Autophagy plays an increasingly significant role in diabetic nephropathy (DN), but the mechanism by which autophagy participates in DN injury is not well understood. Our previous studies have shown that Astragalus membr…
View article: Comparison of the clinical and prognostic characteristics of patients with different pathological types in acromegaly
Comparison of the clinical and prognostic characteristics of patients with different pathological types in acromegaly Open
Context Acromegaly is caused by somatotroph tumors. Recently, the WHO recommended the use of transcription factors (TFs) together with pituitary hormones to accurately classify the subtypes. Objective This study aims to evaluate difference…
View article: CLL cell-derived exosomes alter the immune and hematopoietic systems
CLL cell-derived exosomes alter the immune and hematopoietic systems Open
View article: Multi-omic analyses reveal aberrant DNA methylation patterns and the associated biomarkers of nasopharyngeal carcinoma and its cancer stem cells
Multi-omic analyses reveal aberrant DNA methylation patterns and the associated biomarkers of nasopharyngeal carcinoma and its cancer stem cells Open
View article: High BMI, silicone oil tamponade, and recurrent vitreous hemorrhage predict poor visual outcomes after pars plana vitrectomy in proliferative diabetic retinopathy
High BMI, silicone oil tamponade, and recurrent vitreous hemorrhage predict poor visual outcomes after pars plana vitrectomy in proliferative diabetic retinopathy Open
View article: The value of peripheral blood inflammation markers in risk assessment and prediction of lung cancer
The value of peripheral blood inflammation markers in risk assessment and prediction of lung cancer Open
Our findings suggest that peripheral blood inflammation markers, particularly the NLR, may have potential utility in risk assessment and prediction for NSCLC. These markers warrant further investigation to explore their potential role in e…
View article: Colonoscopy Uptake in First-Degree Relatives of CRC Patients: Challenges and Intervention Strategies
Colonoscopy Uptake in First-Degree Relatives of CRC Patients: Challenges and Intervention Strategies Open
This study provides references for domestic research on the willingness of first-degree relatives for colonoscopy, provide new ideas for formulating intervention methods more suitable for first-degree relatives for colonoscopy, and promote…
View article: Decoding the anti-tumor mechanisms of Caulis Polygoni Multiflori against triple-negative breast cancer: A multi-omics approach combining network pharmacology, molecular docking, and experimental validation
Decoding the anti-tumor mechanisms of Caulis Polygoni Multiflori against triple-negative breast cancer: A multi-omics approach combining network pharmacology, molecular docking, and experimental validation Open
View article: Lipidomics-based natural products for chronic kidney disease treatment
Lipidomics-based natural products for chronic kidney disease treatment Open
View article: Decreased Serum Adipose Triglyceride Lipase Level Is Associated With Renal Function Impairment in Patients With Type 2 Diabetes.
Decreased Serum Adipose Triglyceride Lipase Level Is Associated With Renal Function Impairment in Patients With Type 2 Diabetes. Open
Background: Diagnosing diabetic kidney disease (DKD) remains a significant challenge. Research has increasingly focused on kidney injury resulting from lipid metabolism disorders. Adipose triglyceride lipase (ATGL), a pivotal enzyme…
View article: Objective Evaluation of the Prognostic Value of Common Nutritional Indicators in Patients with Different Inflammatory States after Radical Gastrectomy for Gastric Cancer: A Real-world Study Running Head：Nutritional Indicators in Inflammatory State
Objective Evaluation of the Prognostic Value of Common Nutritional Indicators in Patients with Different Inflammatory States after Radical Gastrectomy for Gastric Cancer: A Real-world Study Running Head：Nutritional Indicators in Inflammatory State Open
Background and aim: Few studies have investigated the prognostic significance of nutritional indicators in patients with various inflammatory states. Methods Patients who underwent radical gastrectomy for TNM stages I–III gastric cancer we…
View article: New insights into SUMOylation and NEDDylation in fibrosis
New insights into SUMOylation and NEDDylation in fibrosis Open
Fibrosis is the outcome of any abnormal tissue repair process that results in normal tissue replacement with scar tissue, leading to persistent tissue damage and cellular injury. During the process of fibrosis, many cytokines and chemokine…
View article: Evaluation and prediction of surface water pollution in China based on improved entropy-weighted TOPSIS algorithm and metabolism GM (1,1) grey model
Evaluation and prediction of surface water pollution in China based on improved entropy-weighted TOPSIS algorithm and metabolism GM (1,1) grey model Open
View article: Research hotspots and future trends in lipid metabolism in chronic kidney disease: a bibliometric and visualization analysis from 2004 to 2023
Research hotspots and future trends in lipid metabolism in chronic kidney disease: a bibliometric and visualization analysis from 2004 to 2023 Open
Background Disorders of lipid metabolism play a key role in the initiation and progression of chronic kidney disease (CKD). Recently, research on lipid metabolism in CKD has rapidly increased worldwide. However, comprehensive bibliometric …