Explanipedia

Computation-aided design of rod-shaped nanoparticles for tumoral targeting Open

Jinhyung Lee, Wuxia Zhang, Thanh Danh Nguyen, Libo Zhou, Justin Amengual , et al. · 2025

Various nanomaterials have been developed for drug delivery, but the vast majority are spherical nanoparticles (50-500 nm in diameter). This limits their ability to target and infiltrate hard-to-penetrate tissues, such as certain solid tum…

Giant, non-perturbative tuning of light-matter interaction of embedded quantum dots in semiconducting matrices Open

Ming-Chung Wu, Kai‐Chi Hsiao, Chu-Liang Fu, Ting‐Han Lin, Yin‐Hsuan Chang , et al. · 2025

Embedding quantum dots (QDs) in a solid-state matrix represents a promising hybrid platform that offers great flexibility and tunability. However, the lack of clear underlying designing principle and presence of large design space make the…

Nanoscale “Chessboard” Pattern Lamellae in a Supramolecular Perylene-Diimide Polydiacetylene System Open

Ian J. Martin, Francis K. Masese, Kuo‐Chih Shih, Mu‐Ping Nieh, Rajeswari M. Kasi · 2025

The rational design of ordered chromogenic supramolecular polymeric systems is critical for the advancement of next-generation stimuli-responsive, optical, and semiconducting materials. Previously, we reported the design of a stimuli-respo…

Automated structural analysis of small angle scattering data from common nanoparticles via machine learning Open

Graham Roberts, Mu‐Ping Nieh, W. K. Anson, Qian Yang · 2025

A data-efficient and trustworthy machine learning approach is developed for automated inverse analysis of small angle scattering data.

Correction: Influence of shape on crystal structure and optical properties of heterocyclic conjugated molecules Open

Elisa Guzmán, Yu Yan, P. Müller, Justin Amengual, Chung‐Hao Liu , et al. · 2025

Correction for ‘Influence of shape on crystal structure and optical properties of heterocyclic conjugated molecules’ by Elisa Guzmán et al. , J. Mater. Chem. C , 2025, 13 , 954–962, https://doi.org/10.1039/D4TC03509G.

Automated Structure Analysis of Small Angle Scattering Data via Machine Learning Open

Graham Roberts, Mu‐Ping Nieh, W. K. Anson, Qian Yang · 2024

Billions of dollars have been invested in recent years to build up national scattering facilities around the world with more advanced configurations and faster data collection for small angle scattering (SAS), a technique that enables in-s…

Automated Structure Analysis of Small Angle Scattering Data via Machine Learning Open

Graham Roberts, Mu‐Ping Nieh, W. K. Anson, Qian Yang · 2024

Billions of dollars have been invested in recent years to build up national scattering facilities around the world with more advanced configurations and faster data collection for small angle scattering (SAS), a technique that enables in-s…

Influence of shape on crystal structure and optical properties of heterocyclic conjugated molecules Open

Elisa Guzmán, Yu Yan, Péter Müller, Justin Amengual, Mu‐Ping Nieh , et al. · 2024

Multi-ring, thiophene based heterocycles participate in discrete non-covalent interactions that dictate crystal packing of conjugated molecules, which also form a variety of polymorphs with different optical properties.

Block Sequence Effects on the Self-Assembly Behaviors of Polypeptide-Based Penta-Block Copolymer Hydrogels Open

Ke-Hsin Wang, Chung‐Hao Liu, Dun-Heng Tan, Mu‐Ping Nieh, Wei‐Fang Su · 2024

Peptide-based hydrogels have great potential for applications in tissue engineering, drug delivery, and so on. We systematically synthesize, characterize, and investigate the self-assembly behaviors of a series of polypeptide-based penta-b…

Computation-aided Design of Rod-Shaped Janus Base Nanopieces for Improved Tissue Penetration and Therapeutics Delivery Open

Jinhyung Lee, Wuxia Zhang, Thanh Danh Nguyen, Libo Zhou, Justin Amengual , et al. · 2024

Despite the development of various drug delivery technologies, there remains a significant need for vehicles that can improve targeting and biodistribution in “hard-to-penetrate” tissues. Some solid tumors, for example, are particularly ch…

Antivesiculation and Complete Unbinding of Tail-Tethered Lipids Open

Kuo‐Chih Shih, Geoffray Leriche, Chung‐Hao Liu, Jibao He, Vijay T. John , et al. · 2024

We report the effect of tail-tethering on vesiculation and complete unbinding of bilayered membranes. Amphiphilic molecules of a bolalipid, resembling the tail-tethered molecular structure of archaeal lipids, with two identical zwitterioni…

Fluorinated polymer zwitterions on gold nanoparticles: patterned catalyst surfaces guide interfacial transport and electrochemical CO2 reduction Open

Qiang Luo, Joseph Tapia, Le Zhou, Chung‐Hao Liu, Maham Liaqat , et al. · 2024

We report the use of fluorinated polymer zwitterions to build hybrid systems for efficient CO 2 electroreduction.

Strongly coupled plasmonic metal nanoparticles with reversible pH-responsiveness and highly reproducible SERS in solution Open

Zichao Wei, Audrey Vandergriff, Chung‐Hao Liu, Maham Liaqat, Mu‐Ping Nieh , et al. · 2023

We report a facile method to prepare polymer-grafted plasmonic metal nanoparticles (NPs) that exhibit pH-responsive surface-enhanced Raman scattering (SERS).

Correlating structural changes in thermoresponsive hydrogels to the optical response of embedded plasmonic nanoparticles Open

Kamila Zygadlo, Chung‐Hao Liu, Emmanuel Reynoso Bernardo, Huayue Ai, Mu‐Ping Nieh , et al. · 2023

Hybrid sensors rely on correlation of the optical and structural response. Thermal response of AuNR-hydrogel nanocomposites is examined by DLS, optical spectroscopy and NMR, revealing differences in collapse between the composite core and …

Next-generation poly-L-histidine formulations for miRNA mimic delivery Open

Vishal Kasina, Aniket Wahane, Chung‐Hao Liu, Lin Yang, Mu‐Ping Nieh , et al. · 2023

Many diseases, especially cancer, are caused by the abnormal expression of non-coding microRNAs (miRNAs), which regulate gene expression, leading to the development of miRNA-based therapeutics. Synthetic miRNA inhibitors have shown promisi…

Effect of Diphenyl Content on Viscoelasticity of Poly(dimethyl-co-diphenyl)siloxane Melt and Network Open

Weikang Xian, Chung‐Hao Liu, Behrad Kangarlou, Shing‐Yun Chang, Chao Wu , et al. · 2023

Polydimethylsiloxane (PDMS) is one of the most widely used polymeric materials for sealants, adhesives, lubricants, and thermal as well as electrical insulation. At low temperatures, however, PDMS is subject to crystallization that can cau…

Hydrophobic pockets built in polymer micelles enhance the reactivity of Cu2+ions Open

Zichao Wei, Chung‐Hao Liu, Qiang Luo, Srinivas Thanneeru, Alfredo M. Angeles‐Boza , et al. · 2023

We report the hydrophobicity-enhanced reactivity of Cu 2+ ions as an ester hydrolase.

Facile polymerization in a bicellar template to produce polymer nano-rings Open

Chung‐Hao Liu, Catherine Cheu, J. G. Barker, Lin Yang, Mu‐Ping Nieh · 2022

Effect of Drug-To-Lipid Ratio on Nanodisc-Based Tenofovir Drug Delivery to The Brain for HIV-1 Infection Open

Caroline R Garcia, Armin Tahmasbi Rad, Farnoosh Saeedinejad, Arvind Manojkumar, Deepa Roy , et al. · 2022

Background: Combination antiretroviral therapy has significantly advanced HIV-1 infection treatment. However, HIV-1 remains persistent in the brain; the inaccessibility of the blood-brain barrier allows for persistent HIV-1 infectio…

Self-assembly of gold nanoparticles grafted with amphiphilic supramolecular block copolymers Open

Zichao Wei, Chung‐Hao Liu, Hanyi Duan, Qiang Luo, Margaret Huang , et al. · 2022

Restriction‐In‐Motion of Surface Ligands Enhances Photoluminescence of Quantum Dots—Experiment and Theory Open

Justin M. Fang, Sayan Basu, Mingda Li, Kuo‐Chih Shih, Jun Wang , et al. · 2022

The relationship between emission and ligand restriction of a series of ZnSe/ZnS quantum dots (QDs) encapsulated in nanoparticles is investigated systematically via experiments and quantum theory. The QDs have a ZnSe core and a ZnS shell, …

Codelivery of Paclitaxel and Parthenolide in Discoidal Bicelles for a Synergistic Anticancer Effect: Structure Matters Open

Armin Tahmasbi Rad, Derek Hargrove, Leila Daneshmandi, Amanda K. Ramsdell, Xiuling Lü , et al. · 2021

Nanotechnology has long been used to improve the tumor targeting of chemotherapeutics. The structure of these nanocarriers greatly affects their efficacy and toxicity. Herein, structurally stable nanodiscoidal phospholipid bicelles, which …

Head on Comparison of Self‐ and Nano‐Assemblies of Gamma Peptide Nucleic Acid Amphiphiles Open

Shipra Malik, Vikas Kumar, Chung‐Hao Liu, Kuo‐Chih Shih, Susan Krueger , et al. · 2021

Peptide nucleic acids (PNAs) are nucleic acid analogs with hybridization properties and enzymatic stability superior to that of DNA. In addition to gene targeting applications, PNAs have garnered significant attention as bio‐polymers due t…

Flower-like Micelles of Polyethylene Oxide End-Capped with Cholesterol Open

Behrad Kangarlou, Rasika Dahanayake, Ian J. Martin, Dennis Ndaya, Chun‐Ming Wu , et al. · 2021

Nanostructures self-assembled from natural or biocompatible macromolecules attract increasing attention due to their potential in nanomedical and technological applications. Self-assembly and structural properties of flower-like micelles f…

Nanocomplex made up of antimicrobial metallo-supramolecules and model biomembranes – characterization and enhanced fluorescence Open

Chung‐Hao Liu, Heng Wang, Lin Yang, Yun Liu, Xiaopeng Li , et al. · 2021

Antimicrobial 3-D supramolecular hexagonal prisms can be entrapped by lipid discoidal bicelles, forming a well-defined nanocomplex. Such a nanocomplex emits the three-fold intensity compared to its solution form, making it a candidate for …

Aggregation‐Enhanced Photoluminescence and Photoacoustics of Atomically Precise Gold Nanoclusters in Lipid Nanodiscs (NANO2) Open

Armin Tahmasbi Rad, Yue Bao, Hyun‐Sook Jang, Yan Xia, Hari Sharma , et al. · 2020

The authors designed a structurally stable nano‐in‐nano (NANO 2 ) system highly capable of bioimaging via an aggregation‐enhanced NIR excited emission and photoacoustic response achieved based on atomically precise gold nanoclusters protec…

Multichannel hollow carbon fibers: Processing, structure, and properties Open

Narayan Shirolkar, Adam Maffe, Edward DiLoreto, Pedro J. Arias‐Monje, Mingxuan Lu , et al. · 2020

Refining internal bilayer structure of bicelles resolved by extended-q small angle X-ray scattering Open

Catherine Cheu, Lin Yang, Mu‐Ping Nieh · 2020

Bicelles Rich in both Sphingolipids and Cholesterol and Their Use in Studies of Membrane Proteins Open

J.M.S. Hutchison, Kuo‐Chih Shih, Holger A. Scheidt, Sarah M. Fantin, Kristine F. Parson , et al. · 2020

How the distinctive lipid composition of mammalian plasma membranes impacts membrane protein structure is largely unexplored, partly because of the dearth of isotropic model membrane systems that contain abundant sphingolipids and choleste…

DNA-Mediated Step-Growth Polymerization of Bottlebrush Macromonomers Open

Xueguang Lu, Hailin Fu, Kuo‐Chih Shih, Fei Jia, Yehui Sun , et al. · 2020

Herein, we report the DNA-mediated self-assembly of bivalent bottlebrush polymers, a process akin to the step-growth polymerization of small molecule monomers. In these "condensation reactions", the polymer serves as a steric guide to limi…

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