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View article: IL-23 Promotes a Coordinated B Cell Germinal Center Program for Class-Switch Recombination to IgG2b in BXD2 Mice
IL-23 Promotes a Coordinated B Cell Germinal Center Program for Class-Switch Recombination to IgG2b in BXD2 Mice Open
IL-23 promotes autoimmune disease, including Th17 CD4 T cell development and autoantibody production. In this study, we show that a deficiency of the p19 component of IL-23 in the autoimmune BXD2 (BXD2-p19−/−) mouse leads to a shift of the…
View article: 192 Disparities of B-cell type I interferon production and responses in SLE
192 Disparities of B-cell type I interferon production and responses in SLE Open
Background Dysregulated responses to type I interferons (IFNs) is a hallmark of autoreactive B-cell development in SLE. This study investigated the source of IFN, the major type I IFN responsive B cells, and the disparities associated with…
View article: Cutting Edge: Intracellular IFN-β and Distinct Type I IFN Expression Patterns in Circulating Systemic Lupus Erythematosus B Cells
Cutting Edge: Intracellular IFN-β and Distinct Type I IFN Expression Patterns in Circulating Systemic Lupus Erythematosus B Cells Open
In systemic lupus erythematosus (SLE), type I IFNs promote induction of type I IFN–stimulated genes (ISG) and can drive B cells to produce autoantibodies. Little is known about the expression of distinct type I IFNs in lupus, particularly …
View article: II-05 B cells from SLE patients have increased endogenous production of IFNβ which is stimulated by BCR signaling and is required for survival of autoreactive B cells
II-05 B cells from SLE patients have increased endogenous production of IFNβ which is stimulated by BCR signaling and is required for survival of autoreactive B cells Open
Background Increased type I interferon (IFN) has been shown to affect survival and activation of B cells in SLE. This study investigated novel mechanisms of endogenous production and autocrine activity of IFNβ in SLE B cells at the single-…
View article: AA-05 B cell intrinsic IFNβ is associated with autoantibodies and active renal disease in SLE
AA-05 B cell intrinsic IFNβ is associated with autoantibodies and active renal disease in SLE Open
Background Dysregulated responses to type I interferons (IFNs) is a hallmark of autoreactive B cell development in SLE patients. High sera levels of type I IFN protein were recently shown to occur in the absence of increased circulating pD…
View article: Cutting Edge: Endogenous IFN-β Regulates Survival and Development of Transitional B Cells
Cutting Edge: Endogenous IFN-β Regulates Survival and Development of Transitional B Cells Open
The transitional stage of B cell development is a formative stage in the spleen where autoreactive specificities are censored as B cells gain immune competence, but the intrinsic and extrinsic factors regulating survival of transitional st…
View article: Interferon-induced mechanosensing defects impede apoptotic cell clearance in lupus
Interferon-induced mechanosensing defects impede apoptotic cell clearance in lupus Open
Systemic lupus erythematosus (SLE) is a severe autoimmune disease that is associated with increased circulating apoptotic cell autoantigens (AC-Ags) as well as increased type I IFN signaling. Here, we describe a pathogenic mechanism in whi…
View article: General Approach for Tetramer-Based Identification of Autoantigen-Reactive B Cells: Characterization of La- and snRNP-Reactive B Cells in Autoimmune BXD2 Mice
General Approach for Tetramer-Based Identification of Autoantigen-Reactive B Cells: Characterization of La- and snRNP-Reactive B Cells in Autoimmune BXD2 Mice Open
Autoreactive B cells are associated with the development of several autoimmune diseases, including systemic lupus erythematosus and rheumatoid arthritis. The low frequency of these cells represents a major barrier to their analysis. Ag tet…