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View article: Potential function of hepatic Niemann–Pick C1-like 1: cholesterol homeostasis regulation of the canalicular lipid bilayer membrane
Potential function of hepatic Niemann–Pick C1-like 1: cholesterol homeostasis regulation of the canalicular lipid bilayer membrane Open
Niemann–Pick C1-like 1 (NPC1L1) is distributed in the human liver and intestine but only slightly expressed in the mouse liver. While it is well established that intestinal NPC1L1 is crucial for the absorption of exogenous cholesterol, the…
View article: Effect of hepatic NPC1L1 on cholesterol gallstone disease and its mechanism
Effect of hepatic NPC1L1 on cholesterol gallstone disease and its mechanism Open
Cholesterol gallstone disease (CGD) is associated with bile cholesterol supersaturation. The Niemann-Pick C1-like 1 (NPC1L1), the inhibitory target of ezetimibe (EZE), is a critical sterol transporter of cholesterol absorption. Intestinal …
View article: Tumor-Infiltrating Lymphocyte-Based Risk Score for Predicting Prognosis in Gastric Cancer
Tumor-Infiltrating Lymphocyte-Based Risk Score for Predicting Prognosis in Gastric Cancer Open
Tumor-infiltrating lymphocytes (TILs) in gastric cancer are closely related to clinical prognosis; however, little is known regarding the immune microenvironment in this disease. Thus, RNA-sequencing data from gastric cancer patients were …
View article: <i>N</i><sup>6</sup>-methyladenosine (m<sup>6</sup>A) RNA methylation signature as a predictor of stomach adenocarcinoma outcomes and its association with immune checkpoint molecules
<i>N</i><sup>6</sup>-methyladenosine (m<sup>6</sup>A) RNA methylation signature as a predictor of stomach adenocarcinoma outcomes and its association with immune checkpoint molecules Open
Objective Although N 6 -methyladenosine (m 6 A) RNA methylation is the most common mRNA modification process, few studies have examined the role of m 6 A in stomach adenocarcinomas (STADs). Methods In this retrospective study, we analyzed …