Pinglin Lai
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View article: USP18 confers protection against allergic asthma by suppressing CCL8 production in alveolar type II epithelial cells
USP18 confers protection against allergic asthma by suppressing CCL8 production in alveolar type II epithelial cells Open
Overall, these findings reveal a previously unrecognized role for USP18 in regulating CCL8 production during asthma progression, highlighting USP18 and CCL8 as potential therapeutic targets for asthma treatment.
View article: Beige Adipocytes Promote Triple‐Negative Breast Cancer Cell Migration and Malignancy Through <scp>BMP4</scp> Signaling
Beige Adipocytes Promote Triple‐Negative Breast Cancer Cell Migration and Malignancy Through <span>BMP4</span> Signaling Open
Breast cancer remains a leading cause of cancer‐related mortality among women, with adipocyte–breast cancer interactions playing a critical role in cancer progression. Mammary gland fat contains both white and brown‐like adipocytes. While …
View article: Tree shrew as a new animal model for musculoskeletal disorders and aging
Tree shrew as a new animal model for musculoskeletal disorders and aging Open
Intervertebral disc degeneration (IDD), osteoarthritis (OA), and osteoporosis (OP) are common musculoskeletal disorders (MSDs) with similar age-related risk factors, representing the leading causes of disability. However, successful therap…
View article: Mecp2 Fine-tunes Quiescence Exit by Targeting Nuclear Receptors
Mecp2 Fine-tunes Quiescence Exit by Targeting Nuclear Receptors Open
Quiescence (G0) maintenance and exit are crucial for tissue homeostasis and regeneration in mammals. Here, we show that methyl-CpG binding protein 2 (Mecp2) expression is cell cycle-dependent and negatively regulates quiescence exit in cul…
View article: Author response: Mecp2 Fine-tunes Quiescence Exit by Targeting Nuclear Receptors
Author response: Mecp2 Fine-tunes Quiescence Exit by Targeting Nuclear Receptors Open
Quiescence (G0) maintenance and exit are crucial for tissue homeostasis and regeneration in mammals. Here, we show that methyl-CpG binding protein 2 (Mecp2) expression is cell cycle-dependent and negatively regulates quiescence exit in cul…
View article: ANGPTL4 binds to the leptin receptor to regulate ectopic bone formation
ANGPTL4 binds to the leptin receptor to regulate ectopic bone formation Open
Leptin protein was thought to be unique to leptin receptor (LepR), but the phenotypes of mice with mutation in LepR [ db/db (diabetes)] and leptin [ ob/ob (obese)] are not identical, and the cause remains unclear. Here, we show that db/db …
View article: Mecp2 fine-tunes quiescence exit by targeting nuclear receptors
Mecp2 fine-tunes quiescence exit by targeting nuclear receptors Open
Quiescence (G0) maintenance and exit are crucial for tissue homeostasis and regeneration in mammals. Here, we show that methyl-CpG binding protein 2 (Mecp2) expression is cell cycle-dependent and negatively regulates quiescence exit in cul…
View article: Tuberous sclerosis complex 1 targeted depletion in macrophages promotes osteogenesis by modulating secretion of Oncostatin M in the inflammatory stage of bone healing
Tuberous sclerosis complex 1 targeted depletion in macrophages promotes osteogenesis by modulating secretion of Oncostatin M in the inflammatory stage of bone healing Open
In bone healing, earlier bone formation benefits bone repair. The first process of repair following bone injury involves the interaction between macrophage polarization and osteogenic activation of osteoblast linage cells, but the radical …
View article: Mecp2 Fine-tunes Quiescence Exit by Targeting Nuclear Receptors
Mecp2 Fine-tunes Quiescence Exit by Targeting Nuclear Receptors Open
Quiescence (G0) maintenance and exit are crucial for tissue homeostasis and regeneration in mammals. Here, we show that methyl-CpG binding protein 2 (Mecp2) expression is cell cycle-dependent and negatively regulates quiescence exit in cul…
View article: Supplementary Methods, Tables 1 - 5, Figures 1 - 10 from Inhibition of Endometrial Cancer by n-3 Polyunsaturated Fatty Acids in Preclinical Models
Supplementary Methods, Tables 1 - 5, Figures 1 - 10 from Inhibition of Endometrial Cancer by n-3 Polyunsaturated Fatty Acids in Preclinical Models Open
PDF file - 1140K, Supplementary material and methods: including Cell proliferation assay, Colony formation assay, Cell viability assay, Western blot analysis, Gas chromatography analysis of fatty acids compositions Supplementary Tables (in…
View article: Data from Inhibition of Endometrial Cancer by n-3 Polyunsaturated Fatty Acids in Preclinical Models
Data from Inhibition of Endometrial Cancer by n-3 Polyunsaturated Fatty Acids in Preclinical Models Open
Although preclinical and epidemiologic studies have shown the importance of n-3 polyunsaturated fatty acids (PUFA) in the prevention of hormone-responsive cancers such as breast cancer, evidence of the association between n-3 PUFAs and end…
View article: Data from Inhibition of Endometrial Cancer by n-3 Polyunsaturated Fatty Acids in Preclinical Models
Data from Inhibition of Endometrial Cancer by n-3 Polyunsaturated Fatty Acids in Preclinical Models Open
Although preclinical and epidemiologic studies have shown the importance of n-3 polyunsaturated fatty acids (PUFA) in the prevention of hormone-responsive cancers such as breast cancer, evidence of the association between n-3 PUFAs and end…
View article: Supplementary Methods, Tables 1 - 5, Figures 1 - 10 from Inhibition of Endometrial Cancer by n-3 Polyunsaturated Fatty Acids in Preclinical Models
Supplementary Methods, Tables 1 - 5, Figures 1 - 10 from Inhibition of Endometrial Cancer by n-3 Polyunsaturated Fatty Acids in Preclinical Models Open
PDF file - 1140K, Supplementary material and methods: including Cell proliferation assay, Colony formation assay, Cell viability assay, Western blot analysis, Gas chromatography analysis of fatty acids compositions Supplementary Tables (in…
View article: Supplementary Methods from miR-483-5p Promotes Invasion and Metastasis of Lung Adenocarcinoma by Targeting RhoGDI1 and ALCAM
Supplementary Methods from miR-483-5p Promotes Invasion and Metastasis of Lung Adenocarcinoma by Targeting RhoGDI1 and ALCAM Open
PDF file - 184KB
View article: Data from miR-483-5p Promotes Invasion and Metastasis of Lung Adenocarcinoma by Targeting RhoGDI1 and ALCAM
Data from miR-483-5p Promotes Invasion and Metastasis of Lung Adenocarcinoma by Targeting RhoGDI1 and ALCAM Open
The nodal regulatory properties of microRNAs (miRNA) in metastatic cancer may offer new targets for therapeutic control. Here, we report that upregulation of miR-483-5p is correlated with the progression of human lung adenocarcinoma. miR-4…
View article: Supplementary Methods from miR-483-5p Promotes Invasion and Metastasis of Lung Adenocarcinoma by Targeting RhoGDI1 and ALCAM
Supplementary Methods from miR-483-5p Promotes Invasion and Metastasis of Lung Adenocarcinoma by Targeting RhoGDI1 and ALCAM Open
PDF file - 184KB
View article: Supplementary Figures 1 - 5 from miR-483-5p Promotes Invasion and Metastasis of Lung Adenocarcinoma by Targeting RhoGDI1 and ALCAM
Supplementary Figures 1 - 5 from miR-483-5p Promotes Invasion and Metastasis of Lung Adenocarcinoma by Targeting RhoGDI1 and ALCAM Open
PDF file - 488KB, Supplementary Figure 1. Upregulation of miR-483-5p is correlated with the progression of human lung adenocarcinoma. Supplementary Figure 2. miR-483-5p did not affect lung tumor growth in vitro and in vivo. Supplementary F…
View article: Supplementary Tables 1 - 4 from miR-483-5p Promotes Invasion and Metastasis of Lung Adenocarcinoma by Targeting RhoGDI1 and ALCAM
Supplementary Tables 1 - 4 from miR-483-5p Promotes Invasion and Metastasis of Lung Adenocarcinoma by Targeting RhoGDI1 and ALCAM Open
PDF file - 204KB, Supplementary Table 1. Clinicopathologic characteristics of lung adenocarcinoma patients. Supplementary Table 2. Correlation between the clinicopathological features and expression of miR-483-5p. Supplementary Table 3. Co…
View article: Data from miR-483-5p Promotes Invasion and Metastasis of Lung Adenocarcinoma by Targeting RhoGDI1 and ALCAM
Data from miR-483-5p Promotes Invasion and Metastasis of Lung Adenocarcinoma by Targeting RhoGDI1 and ALCAM Open
The nodal regulatory properties of microRNAs (miRNA) in metastatic cancer may offer new targets for therapeutic control. Here, we report that upregulation of miR-483-5p is correlated with the progression of human lung adenocarcinoma. miR-4…
View article: Supplementary Tables 1 - 4 from miR-483-5p Promotes Invasion and Metastasis of Lung Adenocarcinoma by Targeting RhoGDI1 and ALCAM
Supplementary Tables 1 - 4 from miR-483-5p Promotes Invasion and Metastasis of Lung Adenocarcinoma by Targeting RhoGDI1 and ALCAM Open
PDF file - 204KB, Supplementary Table 1. Clinicopathologic characteristics of lung adenocarcinoma patients. Supplementary Table 2. Correlation between the clinicopathological features and expression of miR-483-5p. Supplementary Table 3. Co…
View article: Supplementary Figures 1 - 5 from miR-483-5p Promotes Invasion and Metastasis of Lung Adenocarcinoma by Targeting RhoGDI1 and ALCAM
Supplementary Figures 1 - 5 from miR-483-5p Promotes Invasion and Metastasis of Lung Adenocarcinoma by Targeting RhoGDI1 and ALCAM Open
PDF file - 488KB, Supplementary Figure 1. Upregulation of miR-483-5p is correlated with the progression of human lung adenocarcinoma. Supplementary Figure 2. miR-483-5p did not affect lung tumor growth in vitro and in vivo. Supplementary F…
View article: Exosome Release Delays Senescence by Disposing of Obsolete Biomolecules
Exosome Release Delays Senescence by Disposing of Obsolete Biomolecules Open
Accumulation of obsolete biomolecules can accelerate cell senescence and organism aging. The two efficient intracellular systems, namely the ubiquitin‐proteasome system and the autophagy‐lysosome system, play important roles in dealing wit…
View article: Bindarit Reduces Bone Loss in Ovariectomized Mice by Inhibiting <scp>CCL2</scp> and <scp>CCL7</scp> Expression <i>via</i> the <scp>NF‐κB</scp> Signaling Pathway
Bindarit Reduces Bone Loss in Ovariectomized Mice by Inhibiting <span>CCL2</span> and <span>CCL7</span> Expression <i>via</i> the <span>NF‐κB</span> Signaling Pathway Open
Objective To investigate the changes in proinflammatory cytokines and chemokines, namely, C‐C motif ligand (CCL) 2 and CCL7, in postmenopausal osteoporosis (PMOP) and to develop a new drug, bindarit (Bnd), for PMOP in an ovariectomized (OV…
View article: DNMT1 is a negative regulator of osteogenesis
DNMT1 is a negative regulator of osteogenesis Open
The role and underlying mechanisms of DNA methylation in osteogenesis/chondrogenesis remain poorly understood. We here reveal DNA methyltransferase 1 (DNMT1), which is responsible for copying DNA methylation onto the newly synthesized DNA …
View article: Tsc1 regulates tight junction independent of mTORC1
Tsc1 regulates tight junction independent of mTORC1 Open
Significance The epithelium barrier is vital for sealing body surface and alimentary spaces, preventing paracellular material diffusion and pathogen invasion. We describe here that tuberous sclerosis complex 1 (Tsc1) controls tight junctio…