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View article: Androgens drive SLC1A5-dependent metabolic reprogramming in polycystic ovary syndrome
Androgens drive SLC1A5-dependent metabolic reprogramming in polycystic ovary syndrome Open
Polycystic ovary syndrome is the primary cause of female infertility. Growing evidence suggests that dysregulation of amino acid metabolism plays a significant role in the onset and progression. However, the underlying mechanism remains un…
View article: Safety and efficacy of rivastigmine and memantine combined for treatment of patients with Alzheimer’s disease: a retrospective study
Safety and efficacy of rivastigmine and memantine combined for treatment of patients with Alzheimer’s disease: a retrospective study Open
The combination of the two drugs was more effective in alleviating AD symptoms with comparable safety. It also showed an edge in suppressing pro-inflammatory cytokines and Tau in AD.
View article: High Estradiol Environment After IVF Causes Increased Risk of Glucose Metabolic Dysfunction in Offspring
High Estradiol Environment After IVF Causes Increased Risk of Glucose Metabolic Dysfunction in Offspring Open
Context Assisted reproductive technology (ART) is associated with increased metabolic risks in offspring. The effect of high maternal estradiol (E2) levels during early pregnancy on the glucose metabolism of offspring remains unclear. Obje…
View article: Efficacy of traditional Chinese medicines in the treatment of solar lentigo based on network pharmacology and experimental validation
Efficacy of traditional Chinese medicines in the treatment of solar lentigo based on network pharmacology and experimental validation Open
Background and Aims Solar lentigo is a prevalent skin condition that affects a significant number of individuals. Fortunately, certain traditional Chinese medicines and monomers (TCMM) have proven effective in addressing these concerns. In…
View article: Intrauterine hyperglycaemia during late gestation caused mitochondrial dysfunction in skeletal muscle of male offspring through CREB/PGC1A signaling
Intrauterine hyperglycaemia during late gestation caused mitochondrial dysfunction in skeletal muscle of male offspring through CREB/PGC1A signaling Open
Background Maternal diabetes mellitus can influence the development of offspring. Gestational diabetes mellitus (GDM) creates a short-term intrauterine hyperglycaemic environment in offspring, leading to glucose intolerance in later life, …
View article: RBFNN-Based Adaptive Integral Sliding Mode Feedback and Feedforward Control for a Lower Limb Exoskeleton Robot
RBFNN-Based Adaptive Integral Sliding Mode Feedback and Feedforward Control for a Lower Limb Exoskeleton Robot Open
In this paper, an adaptive trajectory tracking control method combining proportional–integral–derivative (PID) control, Radial Basis Function neural network (RBFNN)-based integral sliding mode control (ISMC), and feedforward control, i.e.,…
View article: Active Ingredients of Schisandra chinensis Fruit Oil and their Effect on Propionibacterium acnes-Induced Inflammation in HaCaT Cells
Active Ingredients of Schisandra chinensis Fruit Oil and their Effect on Propionibacterium acnes-Induced Inflammation in HaCaT Cells Open
Background: Propionibacterium acnes causes upregulation of inflammatory factors, such as cycloxygenase-2, prostaglandin E2, interleukin-1β, and tumor necrosis factor-alpha, increased levels of reactive oxygen species (ROS) and inward flow …
View article: Effect of lncRNA MALAT1 on the Granulosa Cell Proliferation and Pregnancy Outcome in Patients With PCOS
Effect of lncRNA MALAT1 on the Granulosa Cell Proliferation and Pregnancy Outcome in Patients With PCOS Open
Follicle arrest is one of the main characteristics of polycystic ovary syndrome (PCOS), the most common endocrinological disorder in reproductive-aged women. Increasing evidence proves that high anti-Mullerian hormone (AMH) levels may play…
View article: Pediatric and Adult Obesity Concern Female Health: A Mendelian Randomization Study
Pediatric and Adult Obesity Concern Female Health: A Mendelian Randomization Study Open
Purpose: Adulthood and childhood obesity are associated with female reproductive endocrinology and gynecological cancers. However, the causality of such association is yet to be identified. Independent of inverse bias and confounding, mend…
View article: Intergenerational neurocognitive effects of intrauterine hyperglycemia on male offspring
Intergenerational neurocognitive effects of intrauterine hyperglycemia on male offspring Open
Background Studies on human and animals suggest associations between gestational diabetes mellitus (GDM) with increased susceptibility to develop neurological disorders in offspring. However, researches have focused on the neurodevelopment…
View article: Requirements for confirmation of PCR-RFLP results of polymorphisms
Requirements for confirmation of PCR-RFLP results of polymorphisms Open
This is a Letter to the Editor and does not have an abstract.
View article: Basonuclin 1 deficiency causes testicular premature aging: BNC1 cooperates with TAF7L to regulate spermatogenesis
Basonuclin 1 deficiency causes testicular premature aging: BNC1 cooperates with TAF7L to regulate spermatogenesis Open
Basonuclin (BNC1) is expressed primarily in proliferative keratinocytes and gametogenic cells. However, its roles in spermatogenesis and testicular aging were not clear. Previously we discovered a heterozygous BNC1 truncation mutation in a…
View article: Construction of implantation failure related lncRNA-mRNA network and identification of lncRNA biomarkers for predicting endometrial receptivity
Construction of implantation failure related lncRNA-mRNA network and identification of lncRNA biomarkers for predicting endometrial receptivity Open
Insufficient endometrial receptivity is a major factor leading to implantation failure (IF), and the traditional way of morphological observation of endometrium cannot determine the condition of receptivity sufficiently. Considering that l…
View article: Maternal High Estradiol Exposure is Associated with Elevated Thyroxine and Pax8 in Mouse Offspring
Maternal High Estradiol Exposure is Associated with Elevated Thyroxine and Pax8 in Mouse Offspring Open
Our previous studies have shown that maternal high estradiol (E 2 ) environment increased the risk of thyroid dysfunction in offspring. However, the mechanism involved remains unexplored. To evaluate the thyroid function of offspring after…
View article: High Maternal Serum Estradiol Levels Induce Dyslipidemia in Human Newborns via a Hepatic HMGCR Estrogen Response Element
High Maternal Serum Estradiol Levels Induce Dyslipidemia in Human Newborns via a Hepatic HMGCR Estrogen Response Element Open
While the intrauterine environment is essential for the health of offspring, the impact of high maternal serum estradiol (E 2 ) on lipid metabolism in offspring and the mechanisms are unknown. We found that ovarian stimulation (OS) could r…
View article: Alternative splicing of the androgen receptor in polycystic ovary syndrome
Alternative splicing of the androgen receptor in polycystic ovary syndrome Open
Significance Excess androgens and abnormal follicle development, largely due to ovarian granulosa cell (GC) dysfunction, characterize polycystic ovary syndrome (PCOS), a common endocrinopathy of women predisposing to infertility. Thus, it …
View article: The Association between Polymorphism of INSR and Polycystic Ovary Syndrome: A Meta-Analysis
The Association between Polymorphism of INSR and Polycystic Ovary Syndrome: A Meta-Analysis Open
Polycystic ovary syndrome (PCOS) is the most common gynecological endocrine disorder. The genetic background is believed to play a crucial role in the pathogenesis of PCOS. In recent years, the role of insulin receptor (INSR) polymorphisms…