Pingping Shang
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View article: Method for simultaneous determination of three cooling agents in aerosols by GC–MS
Method for simultaneous determination of three cooling agents in aerosols by GC–MS Open
A cooling sensation is primarily elicited by cooling agents through activation of cold-sensitive receptors such as TRPM8 and TRPA1. Coolants are widely used as functional additives in various industries including food, personal care, pharm…
View article: Bionic Breathing-type Airway Exposure System for Inhalation Exposure Studies
Bionic Breathing-type Airway Exposure System for Inhalation Exposure Studies Open
We developed an advanced bionic breathing-type airway exposure platform to address the anatomical and physiological limitations of conventional inhalation toxicology models. This system integrates four key technological innovations: a biom…
View article: Development and application of a stepwise-assembled modular biomimetic lung chip for analyzing formaldehyde-induced cellular ferroptosis
Development and application of a stepwise-assembled modular biomimetic lung chip for analyzing formaldehyde-induced cellular ferroptosis Open
Formaldehyde poses a significant threat to human health, yet its toxicity assessment is limited by current detection methods. This study developed a modular biomimetic lung chip which consists of gas concentration gradient generator module…
View article: NLRP3 inflammasome-mediated disruption of mitochondrial homeostasis in alveolar macrophages contributes to ozone-induced acute lung inflammatory injury
NLRP3 inflammasome-mediated disruption of mitochondrial homeostasis in alveolar macrophages contributes to ozone-induced acute lung inflammatory injury Open
Ozone (O 3), a prevalent atmospheric pollutant, can induce lung injury. However, the molecular mechanisms of O 3-induced acute lung inflammatory injury remain unclear. In this study, we investigate the abnormal changes in and molecular mec…
View article: Engineered Macrophage Membrane‐Coated S100A9‐siRNA for Ameliorating Myocardial Ischemia‐Reperfusion Injury
Engineered Macrophage Membrane‐Coated S100A9‐siRNA for Ameliorating Myocardial Ischemia‐Reperfusion Injury Open
Despite the widespread adoption of emergency coronary reperfusion therapy, reperfusion‐induced myocardial injury remains a challenging issue in clinical practice. Following myocardial reperfusion, S100A8/A9 molecules are considered pivotal…
View article: Low expression of Lnc-ENST00000535078 inhibits the migration, invasion, and enhances apoptosis of CTPE-induced malignantly transformed BEAS-2B cells.
Low expression of Lnc-ENST00000535078 inhibits the migration, invasion, and enhances apoptosis of CTPE-induced malignantly transformed BEAS-2B cells. Open
Long non-coding RNA (LncRNA) plays an important role in malignant transformation of cells. This study aimed to explore the role of Lnc-ENST00000535078 in the malignant transformation of immortalized human bronchial epithelial cells (BEAS-2…
View article: SGLT2 inhibitors for patients with heart failure with preserved ejection fraction in China: a cost-effectiveness study
SGLT2 inhibitors for patients with heart failure with preserved ejection fraction in China: a cost-effectiveness study Open
Background: The potential benefits of intervention with empagliflozin or dapagliflozin for patients with heart failure with preserved ejection fraction (HFpEF) were first demonstrated in the EMPEROR-Preserved and DELIVER studies. However, …
View article: SENP2-mediated SERCA2a deSUMOylation increases calcium overload in cardiomyocytes to aggravate myocardial ischemia/reperfusion injury
SENP2-mediated SERCA2a deSUMOylation increases calcium overload in cardiomyocytes to aggravate myocardial ischemia/reperfusion injury Open
Background: Sarcoplasmic reticulum calcium ATPase 2a (SERCA2a) is a key protein that maintains myocardial Ca 2+ homeostasis. The present study aimed to investigate the mechanism underlying the SERCA2a-SUMOylation (small ubiquitin-like modi…
View article: Data from Enhanced Antitumor Effects by Chemical Modified IGb3 Analogues
Data from Enhanced Antitumor Effects by Chemical Modified IGb3 Analogues Open
Certain glycolipid antigens for natural killer T (NKT) cells can direct the overall cytokine balance of the immune response. However, the molecular mechanism of Th1- or Th2-biased cytokine secretion by NKT cells is still unknown. Previousl…
View article: Supplementary Figure Legends from Enhanced Antitumor Effects by Chemical Modified IGb3 Analogues
Supplementary Figure Legends from Enhanced Antitumor Effects by Chemical Modified IGb3 Analogues Open
Supplementary Figure Legends from Enhanced Antitumor Effects by Chemical Modified IGb3 Analogues
View article: Supplementary Figure 1 from Enhanced Antitumor Effects by Chemical Modified IGb3 Analogues
Supplementary Figure 1 from Enhanced Antitumor Effects by Chemical Modified IGb3 Analogues Open
Supplementary Figure 1 from Enhanced Antitumor Effects by Chemical Modified IGb3 Analogues
View article: Supplementary Figure 2 from Enhanced Antitumor Effects by Chemical Modified IGb3 Analogues
Supplementary Figure 2 from Enhanced Antitumor Effects by Chemical Modified IGb3 Analogues Open
Supplementary Figure 2 from Enhanced Antitumor Effects by Chemical Modified IGb3 Analogues
View article: Supplementary Figure 1 from Enhanced Antitumor Effects by Chemical Modified IGb3 Analogues
Supplementary Figure 1 from Enhanced Antitumor Effects by Chemical Modified IGb3 Analogues Open
Supplementary Figure 1 from Enhanced Antitumor Effects by Chemical Modified IGb3 Analogues
View article: Supplementary Figure Legends from Enhanced Antitumor Effects by Chemical Modified IGb3 Analogues
Supplementary Figure Legends from Enhanced Antitumor Effects by Chemical Modified IGb3 Analogues Open
Supplementary Figure Legends from Enhanced Antitumor Effects by Chemical Modified IGb3 Analogues
View article: Supplementary Figure 2 from Enhanced Antitumor Effects by Chemical Modified IGb3 Analogues
Supplementary Figure 2 from Enhanced Antitumor Effects by Chemical Modified IGb3 Analogues Open
Supplementary Figure 2 from Enhanced Antitumor Effects by Chemical Modified IGb3 Analogues
View article: Data from Enhanced Antitumor Effects by Chemical Modified IGb3 Analogues
Data from Enhanced Antitumor Effects by Chemical Modified IGb3 Analogues Open
Certain glycolipid antigens for natural killer T (NKT) cells can direct the overall cytokine balance of the immune response. However, the molecular mechanism of Th1- or Th2-biased cytokine secretion by NKT cells is still unknown. Previousl…
View article: Downregulation of microRNA-23a confers protection against myocardial ischemia/reperfusion injury by upregulating tissue factor pathway inhibitor 2 following luteolin pretreatment in rats
Downregulation of microRNA-23a confers protection against myocardial ischemia/reperfusion injury by upregulating tissue factor pathway inhibitor 2 following luteolin pretreatment in rats Open
To the Editor: Myocardial ischemia/reperfusion injury (MI/RI) often causes death, dysfunction, or damage to the cardiomyocytes, and thus more effective clinical treatments are required.[1] MicroRNAs (miRNAs) bind to target mRNAs to regulat…
View article: Design of a microfluidic lung chip and its application in assessing the toxicity of formaldehyde
Design of a microfluidic lung chip and its application in assessing the toxicity of formaldehyde Open
In this work, a microfluidic lung chip with membrane supporting cell growth that can produce multiple concentration gradients of gas and liquid is introduced. The chip is composed of a gas gradient layer in the upper part, a porous membran…
View article: MiR-223-3p attenuates the migration and invasion of NSCLC cells by regulating NLRP3
MiR-223-3p attenuates the migration and invasion of NSCLC cells by regulating NLRP3 Open
Lung cancer is the malignant tumor with high invasion and metastasis, which seriously threatens public health. Previous study showed that NLRP3 could promote the occurrence of lung tumors in B(a)P-induced mice. MicroRNAs are closely relate…
View article: Association between urinary polycyclic aromatic hydrocarbon metabolites and diabetes mellitus among the US population: a cross-sectional study
Association between urinary polycyclic aromatic hydrocarbon metabolites and diabetes mellitus among the US population: a cross-sectional study Open
Background The primary aim of this study is to examine the association between urinary polycyclic aromatic hydrocarbons (PAHs) and diabetes mellitus (DM) among the US population. Methods We used data from the National Health and Nutritiona…
View article: A Cross-Sectional Study of Electronic Cigarette Use Among Chinese Adult Populations in Four Cities of China. Part II. Puffing Topography
A Cross-Sectional Study of Electronic Cigarette Use Among Chinese Adult Populations in Four Cities of China. Part II. Puffing Topography Open
Summary With the rapid popularity and increasing numbers of E-cigarette (EC) users, debates on possible health risks and regulation of EC products have attracted attention in public. As a useful means to help assessing the risks of EC cons…
View article: A Cross-Sectional Study of Electronic Cigarette Use Among Chinese Adult Populations in Four Cities of China. Part I. Questionnaire Survey
A Cross-Sectional Study of Electronic Cigarette Use Among Chinese Adult Populations in Four Cities of China. Part I. Questionnaire Survey Open
Summary The use of electronic cigarettes (ECs) has grown exponentially over the past few years in China. To obtain the basic information of Chinese EC users, a questionnaire survey was performed to collect the data that describe characteri…
View article: Relationship Between Nicotine Dependence Scores and Nicotine, Cotinine, 3′-Hydroxycotinine and Nicotine Metabolite Ratio in Chinese Male Smokers
Relationship Between Nicotine Dependence Scores and Nicotine, Cotinine, 3′-Hydroxycotinine and Nicotine Metabolite Ratio in Chinese Male Smokers Open
Summary Smoking is mainly sustained by nicotine dependence (ND), which varies across ethnic groups principally due to genetic as well as environmental factors. The Fagerström Test for Nicotine Dependence (FTND) and biomarkers of tobacco ex…
View article: Glyburide Attenuates B(a)p and LPS-Induced Inflammation-Related Lung Tumorigenesis in Mice
Glyburide Attenuates B(a)p and LPS-Induced Inflammation-Related Lung Tumorigenesis in Mice Open
Background: Glyburide (Gly) serves as inhibitor of NLRP3 inflammasome, which is also one of the most common medication used in the treatment of type 2 diabetes. Although accumulating evidences suggest that Gly could affect cancer risk and …
View article: Preparation of PolyHIPE Scaffolds for 3D Cell Culture and the Application in Cytotoxicity Evaluation of Cigarette Smoke
Preparation of PolyHIPE Scaffolds for 3D Cell Culture and the Application in Cytotoxicity Evaluation of Cigarette Smoke Open
Polystyrene-based polyHIPE (polymerized high internal phase emulsion) materials were prepared by the copolymerization of styrene and divinylbenzene in the continuous phase of a HIPE. The resultant polyHIPE materials were found to have an o…