Pingyang Han
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View article: Systemic lupus erythematosus in a patient with 22q11.2 deletion syndrome: A case report and review of the literature
Systemic lupus erythematosus in a patient with 22q11.2 deletion syndrome: A case report and review of the literature Open
22q11.2 deletion syndrome (MIM: 192430/188400, ORPHA: 567) is the most common chromosomal microdeletion disorder, caused by a hemizygous microdeletion of 2.5 million base pairs on chromosome 22. There is a known association between 22q11.2…
View article: The value of the neutrophil to lymphocyte ratio and PLT count for the diagnosis and prediction of COVID-19 severity
The value of the neutrophil to lymphocyte ratio and PLT count for the diagnosis and prediction of COVID-19 severity Open
Background COVID-19 and influenza A can cause severe respiratory illness. Differentiating between the two diseases and identifying critically ill patients in times of epidemics become a challenge for frontline medical staff. We sought to i…
View article: Risk of Hepatitis B Virus Reactivation in Patients with Resolved Infection on Therapy with Corticosteroids and Conventional Synthesis Immunosuppressants for Kidney Disease: A Single-Center Analysis of 258 Patients
Risk of Hepatitis B Virus Reactivation in Patients with Resolved Infection on Therapy with Corticosteroids and Conventional Synthesis Immunosuppressants for Kidney Disease: A Single-Center Analysis of 258 Patients Open
Among patients with a previously resolved hepatitis B virus infection on therapy with corticosteroids and conventional synthesis immunosuppressants for kidney disease, hepatitis B virus reactivation was not common and severe, suggesting th…
View article: Risk of hepatitis B virus reactivation in patients with resolved infection on therapy with corticosteroids and conventional synthesis immunosuppressants for kidney disease — a single-centre analysis of 258 patients
Risk of hepatitis B virus reactivation in patients with resolved infection on therapy with corticosteroids and conventional synthesis immunosuppressants for kidney disease — a single-centre analysis of 258 patients Open
Background The risk of hepatitis B virus (HBV) reactivation in patients with a previously resolved HBV (prHBV) infection on therapy with corticosteroids and conventional synthesis immunosuppressants (csISs) for kidney disease has not been …
View article: A Cohort Study of Liver Involvement in Patients With Adult-Onset Still's Disease: Prevalence, Characteristics and Impact on Prognosis
A Cohort Study of Liver Involvement in Patients With Adult-Onset Still's Disease: Prevalence, Characteristics and Impact on Prognosis Open
Objective: Adult-onset Still's disease (AOSD) is a systemic disorder commonly accompanied by liver involvement. This study aims to illustrate the detailed information of liver abnormalities in patients with AOSD and evaluate the impact on …
View article: Idiopathic multicentric Castleman disease with pulmonary and cutaneous lesions treated with tocilizumab: A case report
Idiopathic multicentric Castleman disease with pulmonary and cutaneous lesions treated with tocilizumab: A case report Open
iMCD with lung parenchyma and skin involvement is a rare condition that requires clinicians' attention and awareness for early diagnosis.
View article: Daily zeaxanthin supplementation prevents atrophy of the retinal pigment epithelium (RPE) in a mouse model of mitochondrial oxidative stress
Daily zeaxanthin supplementation prevents atrophy of the retinal pigment epithelium (RPE) in a mouse model of mitochondrial oxidative stress Open
Oxidative damage is implicated in the pathogenesis of age-related macular degeneration (AMD). The dry form of AMD (geographic atrophy) is characterized by loss of RPE, photoreceptors, and macular pigments. The cumulative effects of oxidati…
View article: Timing of Antioxidant Gene Therapy: Implications for Treating Dry AMD
Timing of Antioxidant Gene Therapy: Implications for Treating Dry AMD Open
We conclude that antioxidant gene therapy may be effective in preventing the detrimental effects of oxidative stress, but may not be beneficial once substantial tissue damage has occurred.
View article: Early Sub-retinal Delivery of AAV1-Sod2 Protects the Retina in a Mouse Model of Progressive Retinal Degeneration.
Early Sub-retinal Delivery of AAV1-Sod2 Protects the Retina in a Mouse Model of Progressive Retinal Degeneration. Open
View article: The 5HT1a Agonist Xaliproden Exhibits Anti-oxidant and Anti-inflammatory Properties and Protects the Retina in a Mouse Model of Geographic Atrophy
The 5HT1a Agonist Xaliproden Exhibits Anti-oxidant and Anti-inflammatory Properties and Protects the Retina in a Mouse Model of Geographic Atrophy Open
View article: Repurposing an orally available drug for the treatment of geographic atrophy.
Repurposing an orally available drug for the treatment of geographic atrophy. Open
Xaliproden protected RPE cells from oxidative and inflammatory insults and protected the mouse RPE and retina from RPE atrophy in the face of excess mitochondrial oxidative stress. These results suggest that this drug, which had a reasonab…