Piotr Fichna
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View article: Selected parameters of epidermal barrier in juveniles with type 1 diabetes correspond with the severity of diabetes – an observational study
Selected parameters of epidermal barrier in juveniles with type 1 diabetes correspond with the severity of diabetes – an observational study Open
Background Our study aimed to evaluate the epidermal barrier function in children with type 1 diabetes. To the author’s knowledge, no studies have been conducted on epidermal barrier parameters, including TEWL and measurement of epidermal …
View article: The effects of diabetes on attention function: a comparative analysis of children and adolescents with type 1 diabetes and their healthy peers
The effects of diabetes on attention function: a comparative analysis of children and adolescents with type 1 diabetes and their healthy peers Open
Introduction Managing type 1 diabetes (T1D) is complex and requires frequent glucose monitoring, insulin dosing, and lifestyle adjustments to attain appropriate metabolic control. These self-management tasks demand intact cognitive and exe…
View article: Increasing trend of childhood type 1 diabetes incidence: 20-year observation from Greater Poland Province, Poland
Increasing trend of childhood type 1 diabetes incidence: 20-year observation from Greater Poland Province, Poland Open
View article: Non-invasive detection of early microvascular changes in juveniles with type 1 diabetes
Non-invasive detection of early microvascular changes in juveniles with type 1 diabetes Open
Aims/Hypothesis The study aimed to assess the usefulness of capillaroscopy and photoplethysmography in the search for early vascular anomalies in children with type 1 diabetes. Methods One hundred sixty children and adolescents aged 6–18, …
View article: Changes of androgen and corticosterone metabolites excretion and conversion in cystic fibrosis
Changes of androgen and corticosterone metabolites excretion and conversion in cystic fibrosis Open
Cystic fibrosis (CF) is a life-threatening inherited disease related to a mutation in the CFTR gene, that leads to serious health complications such as chronic pulmonary infections, pancreatic insufficiency, dysfunction of the sweat glands…
View article: Expanding the Role of Continuous Glucose Monitoring in Modern Diabetes Care Beyond Type 1 Disease
Expanding the Role of Continuous Glucose Monitoring in Modern Diabetes Care Beyond Type 1 Disease Open
Application of continuous glucose monitoring (CGM) has moved diabetes care from a reactive to a proactive process, in which a person with diabetes can prevent episodes of hypoglycemia or hyperglycemia, rather than taking action only once l…
View article: Genetic variants and risk of endocrine autoimmunity in relatives of patients with Addison’s disease
Genetic variants and risk of endocrine autoimmunity in relatives of patients with Addison’s disease Open
Since individuals with Addison’s disease (AD) present considerable co-occurrence of additional autoimmune conditions, clustering of autoimmunity was also predicted among their relatives. The study was aimed to assess circulating autoantibo…
View article: Alteration in glucocorticoids secretion and metabolism in patients affected by cystic fibrosis
Alteration in glucocorticoids secretion and metabolism in patients affected by cystic fibrosis Open
Cystic fibrosis (CF) is an inherited syndrome associated with a mutation in a cystic fibrosis transmembrane conductance regulator gene, composed of exocrine gland dysfunction involving multiple systems that may result in chronic respirator…
View article: Ambulatory Glucose Profile (AGP) Report in Daily Care of Patients with Diabetes: Practical Tips and Recommendations
Ambulatory Glucose Profile (AGP) Report in Daily Care of Patients with Diabetes: Practical Tips and Recommendations Open
The ambulatory glucose profile (AGP) is now established as the standardised, practical one-page report for graphically presenting a summary of glycaemic control status in patients with diabetes who use continuous glucose monitoring (CGM) s…
View article: Above 40% of Polish children and young adults with type 1 diabetes achieve international <scp>HbA1c</scp> target ‐ results of a nationwide cross‐sectional evaluation of glycemic control: The <scp>PolPeDiab HbA1c</scp> study
Above 40% of Polish children and young adults with type 1 diabetes achieve international <span>HbA1c</span> target ‐ results of a nationwide cross‐sectional evaluation of glycemic control: The <span>PolPeDiab HbA1c</span> study Open
In Polish children and young adults with T1D glycemic control expressed as HbA1c is promising in the light of ISPAD guidelines. Our results confirm the known associations between better glycemic control and the use of new technologies and …
View article: Novel methods of continuous glucose monitoring and telehealth in the improvement of diabetes care: a narrative review
Novel methods of continuous glucose monitoring and telehealth in the improvement of diabetes care: a narrative review Open
Standard markers of glycaemic control, such as glycated haemoglobin (HbA1c) and self-measurement of blood glucose (SMBG), have proven insufficient. HbAc1 is an averaged measurement that does not give information about glucose variability. …
View article: Polymorphism in BACH2 gene is a marker of polyglandular autoimmunity
Polymorphism in BACH2 gene is a marker of polyglandular autoimmunity Open
View article: STAT4 sequence variant and elevated gene expression are associated with type 1 diabetes in Polish children
STAT4 sequence variant and elevated gene expression are associated with type 1 diabetes in Polish children Open
The study confirms an association of STAT4 rs7574865 with T1D in Polish patients, and provides an evidence for its relationship with an earlier disease onset and concomitant thyroid autoimmunity. STAT4 expression appears elevated in T1D, e…
View article: Upregulation of <i>FOXO3</i> in New‐Onset Type 1 Diabetes Mellitus
Upregulation of <i>FOXO3</i> in New‐Onset Type 1 Diabetes Mellitus Open
Forkhead box O (FOXO) transcription factors have been implicated in the development and differentiation of the immune cells. FOXO3 plays a crucial role in physiologic and pathologic immune response. FOXO3, cooperatively with FOXO1, control…
View article: Ketoacidosis at diagnosis of type 1 diabetes in children and adolescents from Wielkopolska province in Poland: prevalence, risk factors and clinical presentation
Ketoacidosis at diagnosis of type 1 diabetes in children and adolescents from Wielkopolska province in Poland: prevalence, risk factors and clinical presentation Open
Background. Diabetic ketoacidosis (DKA) is a life- -threatening condition frequently present at type 1 diabetes diagnosis (T1D). Younger children are at greater risk of developing this acute complication. It is alarming due to worldwide ri…
View article: Overexpression of miR-652-5p in new onset type 1 diabetes
Overexpression of miR-652-5p in new onset type 1 diabetes Open
Introduction. MicroRNAs (miRNAs) are small noncoding RNA regulating gene expression at the posttranscriptional level. miRNAs have emerged as an important regulators of central and peripheral immune tolerance, therefore study the RNA molecu…
View article: Enlargement of foveal avascular zone in diabetic children without diabetic retinopathy shown by OCT angiography.
Enlargement of foveal avascular zone in diabetic children without diabetic retinopathy shown by OCT angiography. Open
View article: Elevated serum RANTES chemokine in autoimmune Addison’s disease
Elevated serum RANTES chemokine in autoimmune Addison’s disease Open
INTRODUCTION Regulated on activation, normal T‑cell expressed and secreted chemokine (RANTES), the product of the CCL5 gene, is involved in trafficking immune cells into the inflammation site. It acts as coactivator of T cells and promotes…
View article: Autoantibodies against zinc transporter 8 are related to age and metabolic state in patients with newly diagnosed autoimmune diabetes
Autoantibodies against zinc transporter 8 are related to age and metabolic state in patients with newly diagnosed autoimmune diabetes Open
View article: Glikokortykosteroidy a czynność komórek beta
Glikokortykosteroidy a czynność komórek beta Open
Glucocorticoids (GCs) play a pivotal role in carbohydrate metabolism. They counteract insulin by decreasing peripheral glucose uptake and stimulating hepatic gluconeogenesis, although they are best known for inducing insulin resistance (IR…
View article: Lack of association of the HSD11B1 gene polymorphisms with obesity and other traits of metabolic syndrome in children and adolescents
Lack of association of the HSD11B1 gene polymorphisms with obesity and other traits of metabolic syndrome in children and adolescents Open
Introduction. Obesity and its related disorders, clustered into metabolic syndrome (MetS), are increasingly diagnosed in children and adolescents. Clinical features, which define MetS are also encountered in patients with glucocorticoid ex…
View article: Assessment of the Usefulness of Multiplex Real-Time PCR Tests in the Diagnostic and Therapeutic Process of Pneumonia in Hospitalized Children: A Single-Center Experience
Assessment of the Usefulness of Multiplex Real-Time PCR Tests in the Diagnostic and Therapeutic Process of Pneumonia in Hospitalized Children: A Single-Center Experience Open
The aim of the study was assessment of the usefulness of multiplex real-time PCR tests in the diagnostic and therapeutic process in children hospitalized due to pneumonia and burdened with comorbidities. Methods . The study group included …
View article: MAVS is not a Likely Susceptibility Locus for Addison’s Disease and Type 1 Diabetes
MAVS is not a Likely Susceptibility Locus for Addison’s Disease and Type 1 Diabetes Open
Mitochondrial antiviral signaling (MAVS) protein is an intracellular adaptor molecule, downstream of viral sensors, retinoid acid-inducible gene I (RIG-I)-like receptors (RLRs). Impaired antiviral cell signaling might contribute to autoimm…
View article: Compliance in diabetes — target or way to success?
Compliance in diabetes — target or way to success? Open
In medicine, the term "compliance" is associated with
\nmedical practice and guidance, especially in relation to
\nchronic diseases. Its definition has evolved with the development of modern medicine. In the last decade, the
\nrelationship…
View article: Positive autoantibodies to ZnT8 indicate elevated risk for additional autoimmune conditions in patients with Addison’s disease
Positive autoantibodies to ZnT8 indicate elevated risk for additional autoimmune conditions in patients with Addison’s disease Open
Autoimmune Addison's disease (AAD) associates with exceptional susceptibility to develop other autoimmune conditions, including type 1 diabetes (T1D), marked by positive serum autoantibodies to insulin (IAA), glutamic acid decarboxylase (G…
View article: Compliance w cukrzycy — cel czy droga do sukcesu?
Compliance w cukrzycy — cel czy droga do sukcesu? Open
Termin compliance wiąże się z prowadzeniem postępowania terapeutycznego, przede wszystkim w odniesieniu do chorób przewlekłych. Jego definicja ewoluowała jednak wraz z rozwojem współczesnej medycyny. W ostatniej dekadzie wizja relacji pomi…
View article: Polymorphisms of the Toll-Like Receptor-3 Gene in Autoimmune Adrenal Failure and Type 1 Diabetes in Polish Patients
Polymorphisms of the Toll-Like Receptor-3 Gene in Autoimmune Adrenal Failure and Type 1 Diabetes in Polish Patients Open
Infectious agents are plausible environmental triggers for autoimmunity in genetically susceptible individuals. Polymorphic variants of genes implicated in innate immunity may affect immune responses and hence promote auto-aggressive react…
View article: Lipokaina związana z żelatynazą neutrofilii i katepsyna L jako wczesne markery uszkodzenia nerek u dzieci z cukrzycą typu 1
Lipokaina związana z żelatynazą neutrofilii i katepsyna L jako wczesne markery uszkodzenia nerek u dzieci z cukrzycą typu 1 Open
Significant changes in the concentration of markers of early kidney injury: sNGAL, uNGAL, and uCathL, can occur in children with DM1 and normoalbuminuria. The changes of uNGAL and uCathL can be even found in children without GH and with op…
View article: Supplementary Material for: A Case of Wiedemann-Steiner Syndrome Associated with a 46,XY Disorder of Sexual Development and Gonadal Dysgenesis
Supplementary Material for: A Case of Wiedemann-Steiner Syndrome Associated with a 46,XY Disorder of Sexual Development and Gonadal Dysgenesis Open
We report the case of a female patient suffering from a 46,XY disorder of sexual development (DSD) with complete gonadal dysgenesis and Wiedemann-Steiner Syndrome (WDSTS). The coexistence of these 2 conditions has not yet been reported. Us…
View article: Type 1 diabetes in children and adolescents – a need for multi-professional team intervention
Type 1 diabetes in children and adolescents – a need for multi-professional team intervention Open
Type 1 diabetes is defined by absolute insulin deficiency caused by autoimmune-mediated pancreatic β-cell destruction and is one of the most frequently recognized chronic diseases among children.Its therapy consists of intensive insulin tr…