Piotr Gruca
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View article: Ventral hippocampal autophagy and mitophagy dynamics shape behavioral responses to chronic mild stress in adult male rats
Ventral hippocampal autophagy and mitophagy dynamics shape behavioral responses to chronic mild stress in adult male rats Open
View article: Efficacy of Venlafaxine and Deep Brain Stimulation Against the Effects of Hippocampal Lesion with Ibotenic Acid in Animals Exposed to the Chronic Mild Stress Model of Depression
Efficacy of Venlafaxine and Deep Brain Stimulation Against the Effects of Hippocampal Lesion with Ibotenic Acid in Animals Exposed to the Chronic Mild Stress Model of Depression Open
Introduction: Dysfunction of the pathway between the ventral hippocampus (vHPC) and medial prefrontal cortex (mPFC) may be responsible for the weaker or lack of efficacy of antidepressant drugs in patients suffering from treatment-resistan…
View article: Exposure to an acute stress impaired the metabolic plasticity of resilient rats by enhancing fatty acid β-oxidation in the ventral hippocampus
Exposure to an acute stress impaired the metabolic plasticity of resilient rats by enhancing fatty acid β-oxidation in the ventral hippocampus Open
View article: Elevated Expression of HSP72 in the Prefrontal Cortex and Hippocampus of Rats Subjected to Chronic Mild Stress and Treated with Imipramine
Elevated Expression of HSP72 in the Prefrontal Cortex and Hippocampus of Rats Subjected to Chronic Mild Stress and Treated with Imipramine Open
The HSP70 and HSP90 family members belong to molecular chaperones that exhibit protective functions during the cellular response to stressful agents. We investigated whether the exposure of rats to chronic mild stress (CMS), a validated mo…
View article: Elevated Expression of HSP72 in the Prefrontal Cortex and Hippocampus of Rats Subjected to Chronic Mild Stress and Treated with Imipramine
Elevated Expression of HSP72 in the Prefrontal Cortex and Hippocampus of Rats Subjected to Chronic Mild Stress and Treated with Imipramine Open
The HSP70 and HSP90 family members belong to molecular chaperones that exhibit protective functions during the cellular response to stressful agents. We investigated whether the exposure of rats to chronic mild stress (CMS), a validated mo…
View article: INVOLVEMENT OF THE VHPC-PFC PATHWAY IN THE EFFECTIVENESS OF VARIOUS THERAPEUTIC INTERVENTIONS IN AN ANIMAL MODEL OF DEPRESSION AND TREATMENT-RESISTANT DEPRESSION: BEHAVIOURAL AND ELECTROPHYSIOLOGICAL STUDIES.
INVOLVEMENT OF THE VHPC-PFC PATHWAY IN THE EFFECTIVENESS OF VARIOUS THERAPEUTIC INTERVENTIONS IN AN ANIMAL MODEL OF DEPRESSION AND TREATMENT-RESISTANT DEPRESSION: BEHAVIOURAL AND ELECTROPHYSIOLOGICAL STUDIES. Open
View article: Venlafaxine’s effect on resilience to stress is associated with a shift in the balance between glucose and fatty acid utilization
Venlafaxine’s effect on resilience to stress is associated with a shift in the balance between glucose and fatty acid utilization Open
View article: The 5-HT1A receptor biased agonists, NLX-204 and NLX-101, display ketamine-like RAAD and anti-TRD activities in rat CMS models
The 5-HT1A receptor biased agonists, NLX-204 and NLX-101, display ketamine-like RAAD and anti-TRD activities in rat CMS models Open
Objectives NLX-101 and NLX-204 are highly selective serotonin 5-HT 1A ‘biased’ agonists, displaying potent and efficacious antidepressant-like activity upon acute administration in models such as the forced swim test. Methods we compared t…
View article: Chronic N-Acetyl-Cysteine Treatment Enhances the Expression of the Immediate Early Gene Nr4a1 in Response to an Acute Challenge in Male Rats: Comparison with the Antidepressant Venlafaxine
Chronic N-Acetyl-Cysteine Treatment Enhances the Expression of the Immediate Early Gene Nr4a1 in Response to an Acute Challenge in Male Rats: Comparison with the Antidepressant Venlafaxine Open
Despite several antidepressant treatments being available in clinics, they are not effective in all patients. In recent years, N-acetylcysteine (NAC) has been explored as adjunctive therapy for many psychiatric disorders, including depress…
View article: Ketamine and the 5-HT1A receptor biased agonists, NLX-204 and NLX-101, share common cortical efficacious rapid acting antidepressant mechanisms in rat cms depression model
Ketamine and the 5-HT1A receptor biased agonists, NLX-204 and NLX-101, share common cortical efficacious rapid acting antidepressant mechanisms in rat cms depression model Open
View article: Resilience to chronic mild stress-induced anhedonia preserves the ability of the ventral hippocampus to respond to an acute challenge
Resilience to chronic mild stress-induced anhedonia preserves the ability of the ventral hippocampus to respond to an acute challenge Open
View article: Exposure to chronic stress impairs the ability to cope with an acute challenge: Modulation by lurasidone treatment
Exposure to chronic stress impairs the ability to cope with an acute challenge: Modulation by lurasidone treatment Open
View article: Pro-cognitive effect of acute imipramine administration correlates with direct interaction of BDNF with its receptor, Trkβ
Pro-cognitive effect of acute imipramine administration correlates with direct interaction of BDNF with its receptor, Trkβ Open
View article: Optogenetic stimulation of medial prefrontal cortex excites GABAergic cells in the nucleus accumbens and hippocampus of Wistar-Kyoto rats exposed to chronic mild stress
Optogenetic stimulation of medial prefrontal cortex excites GABAergic cells in the nucleus accumbens and hippocampus of Wistar-Kyoto rats exposed to chronic mild stress Open
View article: Metabolomic signature and mitochondrial dynamics outline the difference between vulnerability and resilience to chronic stress
Metabolomic signature and mitochondrial dynamics outline the difference between vulnerability and resilience to chronic stress Open
View article: Resilience to chronic mild stress-induced anhedonia preserves the ability of the ventral hippocampus to respond to an acute challenge
Resilience to chronic mild stress-induced anhedonia preserves the ability of the ventral hippocampus to respond to an acute challenge Open
Stress is one of the main precipitating factors for psychiatric disorders and its effects may depend on its duration and intensity. Interestingly, the ability to react to stressful life events may alter the response to a subsequent novel s…
View article: Insufficiency of ventral hippocampus to medial prefrontal cortex transmission explains antidepressant non-response
Insufficiency of ventral hippocampus to medial prefrontal cortex transmission explains antidepressant non-response Open
Background: There is extensive evidence that antidepressant drugs restore normal brain function by repairing damage to ventral hippocampus (vHPC) and medial prefrontal cortex (mPFC). While the damage is more extensive in hippocampus, the e…
View article: The coupling of RACK1 with the beta isoform of the glucocorticoid receptor promotes resilience to chronic stress exposure
The coupling of RACK1 with the beta isoform of the glucocorticoid receptor promotes resilience to chronic stress exposure Open
View article: Stress Modifies the Expression of Glucocorticoid-Responsive Genes by Acting at Epigenetic Levels in the Rat Prefrontal Cortex: Modulatory Activity of Lurasidone
Stress Modifies the Expression of Glucocorticoid-Responsive Genes by Acting at Epigenetic Levels in the Rat Prefrontal Cortex: Modulatory Activity of Lurasidone Open
Epigenetics is one of the mechanisms by which environmental factors can alter brain function and may contribute to central nervous system disorders. Alterations of DNA methylation and miRNA expression can induce long-lasting changes in neu…
View article: The Effect of Chronic Mild Stress and Escitalopram on the Expression and Methylation Levels of Genes Involved in the Oxidative and Nitrosative Stresses as Well as Tryptophan Catabolites Pathway in the Blood and Brain Structures
The Effect of Chronic Mild Stress and Escitalopram on the Expression and Methylation Levels of Genes Involved in the Oxidative and Nitrosative Stresses as Well as Tryptophan Catabolites Pathway in the Blood and Brain Structures Open
Previous studies suggest that depression may be associated with reactive oxygen species overproduction and disorders of the tryptophan catabolites pathway. Moreover, one-third of patients do not respond to conventional pharmacotherapy. The…
View article: AMPA receptors mediate the pro-cognitive effects of electrical and optogenetic stimulation of the medial prefrontal cortex in antidepressant non-responsive Wistar–Kyoto rats
AMPA receptors mediate the pro-cognitive effects of electrical and optogenetic stimulation of the medial prefrontal cortex in antidepressant non-responsive Wistar–Kyoto rats Open
Background: The chronic mild stress (CMS) procedure is a widely used animal model of depression, and its application in Wistar–Kyoto (WKY) rats has been validated as a model of antidepressant-refractory depression. While not responding to …
View article: The Impact of Chronic Mild Stress and Agomelatine Treatment on the Expression Level and Methylation Status of Genes Involved in Tryptophan Catabolic Pathway in PBMCs and Brain Structures
The Impact of Chronic Mild Stress and Agomelatine Treatment on the Expression Level and Methylation Status of Genes Involved in Tryptophan Catabolic Pathway in PBMCs and Brain Structures Open
Depression is the serious mental disorder. Previous studies suggest that the development mechanism of depression may be associated with disorders of the tryptophan catabolic pathway (TRYCAT). Thus, this study investigates the effect of ago…
View article: The effects of agomelatine and imipramine on liver cytochrome P450 during chronic mild stress (CMS) in the rat
The effects of agomelatine and imipramine on liver cytochrome P450 during chronic mild stress (CMS) in the rat Open
Background The aim of our research was to determine the effects of chronic treatment with the atypical antidepressant agomelatine on the expression and activity of liver cytochrome P450 (CYP) in the chronic mild stress (CMS) model of depre…
View article: The Changes of Expression and Methylation of Genes Involved in Oxidative Stress in Course of Chronic Mild Stress and Antidepressant Therapy with Agomelatine
The Changes of Expression and Methylation of Genes Involved in Oxidative Stress in Course of Chronic Mild Stress and Antidepressant Therapy with Agomelatine Open
Preclinical studies conducted so far suggest that oxidative stress processes may be associated with the mechanism of depression development. This study shows the effects of chronic administration of agomelatine on expression and the methyl…
View article: The Effect of Chronic Mild Stress and Venlafaxine on the Expression and Methylation Levels of Genes Involved in the Tryptophan Catabolites Pathway in the Blood and Brain Structures of Rats
The Effect of Chronic Mild Stress and Venlafaxine on the Expression and Methylation Levels of Genes Involved in the Tryptophan Catabolites Pathway in the Blood and Brain Structures of Rats Open
View article: Effects of venlafaxine on the expression level and methylation status of genes involved in oxidative stress in rats exposed to a chronic mild stress
Effects of venlafaxine on the expression level and methylation status of genes involved in oxidative stress in rats exposed to a chronic mild stress Open
Recent human and animal studies indicate that oxidative and nitrosative stress may play a role in the aetiology and pathogenesis of depression. This study investigates the effect of chronic administration of the serotonin‐norepinephrine re…
View article: Effect of lurasidone treatment on chronic mild stress-induced behavioural deficits in male rats: The potential role for glucocorticoid receptor signalling
Effect of lurasidone treatment on chronic mild stress-induced behavioural deficits in male rats: The potential role for glucocorticoid receptor signalling Open
Background: Stress represents one of the main precipitating factors for psychiatric diseases, characterised by an altered function of glucocorticoid receptors (GR), known to play a role in mood and cognitive function. We investigated the a…
View article: Resilient Phenotype in Chronic Mild Stress Paradigm Is Associated with Altered Expression Levels of miR-18a-5p and Serotonin 5-HT1a Receptor in Dorsal Part of the Hippocampus
Resilient Phenotype in Chronic Mild Stress Paradigm Is Associated with Altered Expression Levels of miR-18a-5p and Serotonin 5-HT1a Receptor in Dorsal Part of the Hippocampus Open
View article: S112. EFFECT OF CHRONIC LURASIDONE TREATMENT ON CHRONIC MILD STRESS-INDUCED BEHAVIORAL DEFICITS: THE POTENTIAL ROLE FOR GLUCOCORTICOID RECEPTOR SIGNALING
S112. EFFECT OF CHRONIC LURASIDONE TREATMENT ON CHRONIC MILD STRESS-INDUCED BEHAVIORAL DEFICITS: THE POTENTIAL ROLE FOR GLUCOCORTICOID RECEPTOR SIGNALING Open
BACKGROUND: Psychiatric diseases are characterized by an altered function of the hypothalamic-pituitary-adrenal axis. The activation of this system is also involved in learning and memory processes and its dysregulation may therefore contr…
View article: Negative Allosteric Modulators of mGlu7 Receptor as Putative Antipsychotic Drugs
Negative Allosteric Modulators of mGlu7 Receptor as Putative Antipsychotic Drugs Open
The data concerning antipsychotic-like activity of negative allosteric modulators (NAMs)/antagonists of mGlu7 receptors are limited. The only available ligands for this receptor are MMPIP and ADX71743. In the present studies, we…