Piotr J. Balwierz
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View article: Multiomic atlas with functional stratification and developmental dynamics of zebrafish cis-regulatory elements
Multiomic atlas with functional stratification and developmental dynamics of zebrafish cis-regulatory elements Open
View article: Identification of downstream effectors of retinoic acid specifying the zebrafish pancreas by integrative genomics
Identification of downstream effectors of retinoic acid specifying the zebrafish pancreas by integrative genomics Open
View article: Integrated annotation and analysis of genomic features reveal new types of functional elements and large-scale epigenetic phenomena in the developing zebrafish
Integrated annotation and analysis of genomic features reveal new types of functional elements and large-scale epigenetic phenomena in the developing zebrafish Open
Zebrafish, a popular model for embryonic development and for modelling human diseases, has so far lacked a systematic functional annotation programme akin to those in other animal models. To address this, we formed the international DANIO-…
View article: Identification of Downstream Effectors of Retinoic Acid Specifying the Zebrafish Pancreas by Integrative Genomics.
Identification of Downstream Effectors of Retinoic Acid Specifying the Zebrafish Pancreas by Integrative Genomics. Open
Retinoic acid (RA) is a key signal for the specification of the pancreas. Still, the gene regulatory cascade triggered by RA in the endoderm remains poorly characterized. In this study, we investigated this regulatory network in zebrafish …
View article: Identification of novel potential interaction partners of UDP-galactose (SLC35A2), UDP-N-acetylglucosamine (SLC35A3) and an orphan (SLC35A4) nucleotide sugar transporters
Identification of novel potential interaction partners of UDP-galactose (SLC35A2), UDP-N-acetylglucosamine (SLC35A3) and an orphan (SLC35A4) nucleotide sugar transporters Open
Nucleotide sugar transporters (NSTs) are ER and Golgi-resident members of the solute carrier 35 (SLC35) family which supply substrates for glycosylation by exchanging lumenal nucleotide monophosphates for cytosolic nucleotide sugars. Defec…
View article: Germ cell differentiation requires Tdrd7-dependent chromatin and transcriptome reprogramming marked by germ plasm relocalization
Germ cell differentiation requires Tdrd7-dependent chromatin and transcriptome reprogramming marked by germ plasm relocalization Open
In many animal models, primordial germ cell (PGC) development depends on maternally deposited germ plasm, which prevents somatic cell fate. Here, we show that PGCs respond to regulatory information from the germ plasm in two distinct phase…
View article: Germ plasm localisation dynamics mark distinct phases of transcriptional and post-transcriptional regulation control in primordial germ cells
Germ plasm localisation dynamics mark distinct phases of transcriptional and post-transcriptional regulation control in primordial germ cells Open
SUMMARY In many animal models, primordial germ cell (PGC) development depends on maternally-deposited germ plasm to avoid somatic cell fate. Here, we show that PGCs respond to regulatory information from the germ plasm in two distinct phas…
View article: Dual-initiation promoters with intertwined canonical and TCT/TOP transcription start sites diversify transcript processing
Dual-initiation promoters with intertwined canonical and TCT/TOP transcription start sites diversify transcript processing Open
View article: Amphioxus functional genomics and the origins of vertebrate gene regulation
Amphioxus functional genomics and the origins of vertebrate gene regulation Open
View article: ISMARA: Completely automated inference of gene regulatory networks from high-throughput data
ISMARA: Completely automated inference of gene regulatory networks from high-throughput data Open
As the costs of high-throughput measurement technologies continue to fall, experimental approaches in biomedicine are increasingly data intensive and the advent of big data is justifiably seen as holding the promise to transform medicine. …
View article: ISMARA: Completely automated inference of gene regulatory networks from high-throughput data
ISMARA: Completely automated inference of gene regulatory networks from high-throughput data Open
As the costs of high-throughput measurement technologies continue to fall, experimental approaches in biomedicine are increasingly data intensive and the advent of big data is justifiably seen as holding the promise to transform medicine. …