Explanipedia

The Advantage of Targeted Next-Generation Sequencing over qPCR in Testing for Druggable EGFR Variants in Non-Small-Cell Lung Cancer Open

Adam Szpechciński, Joanna Moes-Sosnowska, Paulina Skronska, Urszula Lechowicz, Magdalena Pelc , et al. · 2024

The emergence of targeted therapies in non-small-cell lung cancer (NSCLC), including inhibitors of epidermal growth factor receptor (EGFR) tyrosine kinase, has increased the need for robust companion diagnostic tests. Nowadays, detection o…

FGFR1–4 RNA-Based Gene Alteration and Expression Analysis in Squamous Non-Small Cell Lung Cancer Open

Joanna Moes-Sosnowska, Monika Skupińska, Urszula Lechowicz, Ewa Szczepulska‐Wójcik, Paulina Skronska , et al. · 2022

While fibroblast growth factor receptors (FGFRs) are involved in several biological pathways and FGFR inhibitors may be useful in the treatment of squamous non-small cell lung cancer (Sq-NSCLC), FGFR aberrations are not well characterized …

Detection of EGFR mutations in liquid biopsy samples using allele-specific quantitative PCR: A comparative real-world evaluation of two popular diagnostic systems Open

Adam Szpechciński, Maciej Bryl, Piotr Wójcik, Grzegorz Czyżewicz, Emil Wojda , et al. · 2021

Cobas was superior to therascreen for detection of plasma EGFR mutations in advanced NSCLC. Plasma cfDNA EGFR mutation analysis is complex; therefore, the diagnostic accuracy of commercially available assays should be validated.

Validation of Lung EpiCheck, a novel methylation-based blood assay, for the detection of lung cancer in European and Chinese high-risk individuals Open

Mina Gaga, Joanna Chorostowska‐Wynimko, Ildikó Horváth, Martin C. Tammemägi, David Shitrit , et al. · 2020

Aim Lung cancer screening reduces mortality. We aim to validate the performance of Lung EpiCheck, a six-marker panel methylation-based plasma test, in the detection of lung cancer in European and Chinese samples. Methods A case–control Eur…

Primary mediastinal neoplasms: a report of 1,005 cases from a single institution Open

Małgorzata Szołkowska, Ewa Szczepulska‐Wójcik, Beata Maksymiuk, Barbara Burakowska, Sebastian Winiarski , et al. · 2019

PMNs are rare conditions thus awareness of basic epidemiology may be very helpful for final diagnosis.

The expression of circulating miR-504 in plasma is associated with EGFR mutation status in non-small-cell lung carcinoma patients Open

Adam Szpechciński, Mateusz Florczuk, Katarzyna Duk, Aneta Zdral, Stefan Rudziński , et al. · 2019

Wpływ skojarzonego leczenia cisplatyną podawaną doosierdziowo oraz kolchicyną doustnie na poprawę wyników leczenia wysięku osierdziowego w przebiegu raka nerki z przerzutami Open

Małgorzata Dybowska, Monika Szturmowicz, Paweł Kuca, Barbara Kazanecka, Janusz Burakowski , et al. · 2019

Wstęp: Wysięk do worka osierdziowego o etiologii nowotworowej (NPE) stanowi częstą przyczynę zachorowalności i umieralności u chorych onkologicznych. Często przebiega w postaci tamponady serca wymagającej pilnego odbarczenia: perikardiocen…

Wpływ skojarzonego leczenia cisplatyną podawaną doosierdziowo oraz kolchicyną doustnie na poprawę wyników leczenia wysięku osierdziowego w przebiegu raka nerki z przerzutami Open

Małgorzata Dybowska, Monika Szturmowicz, Paweł Kuca, Barbara Kazanecka, Janusz Burakowski , et al. · 2019

Wstęp: Wysięk do worka osierdziowego o etiologii nowotworowej (NPE) stanowi częstą przyczynę zachorowalności i umieralności u chorych onkologicznych. Często przebiega w postaci tamponady serca wymagającej pilnego odbarczenia: perikardiocen…

Pericardiocentesis Vs Subxyphoid Pericardiotomy - Comparison Of Efficacy And Safety Open

Małgorzata Dybowska, Witold Tomkowski, Monika Szturmowicz, Paweł Kuca, Janusz Burakowski , et al. · 2018

Background:-Comparison of safety and effectiveness of pericardiocentesis versus subxyphoid pericardiotomy in patients with large pericardial effusion (PE) defined as more than 2 cm fluids behind the posterior wall of left ventricle measure…

PERICARDIOCENTESIS VS SUBXYPHOID PERICARDIOTOMY - COMPARISON OF EFFICACY AND SAFETY Open

Małgorzata Dybowska, Witold Tomkowski, Monika Szturmowicz, Paweł Kuca, Janusz Burakowski , et al. · 2018

17Sep 2018 PERICARDIOCENTESIS VS SUBXYPHOID PERICARDIOTOMY - COMPARISON OF EFFICACY AND SAFETY Małgorzata Dybowska , Witold Tomkowski , Monika Szturmowicz , Paweł Kuca , Janusz Burakowski , Franciszek Grzegorczyk , Cezary Czajka , Juliusz …

Malignant pleural mesothelioma: main topics of American Society of Clinical Oncology clinical practice guidelines for diagnosis and treatment Open

Małgorzata Szołkowska, Katarzyna Błasińska‐Przerwa, Magdalena Knetki‐Wróblewska, Piotr Rudziński, Renata Langfort · 2018

Malignant pleural mesothelioma (MPM) is a rare, asbestos-related neoplasm with a poor prognosis. Men are more often affected than women and the incidence in males in the US is 1.5/100,000/year (according to data in the SEER database), in T…

Cryptogenic organizing pneumonia—Results of treatment with clarithromycin versus corticosteroids—Observational study Open

Elżbieta Radzikowska, Elżbieta Wiatr, Renata Langfort, Iwona Bestry, Agnieszka Skoczylas , et al. · 2017

CAM can be used to treat COP patients in whom the pulmonary function parameters are within normal limits. Such therapy is shorter, better tolerated, and associated with fewer adverse events and relapses than is PRE. However, the therapy is…

Stage I non-small-cell lung cancer: long-term results of lobectomy versus sublobar resection from the Polish National Lung Cancer Registry† Open

Robert Dziedzic, Wojciech Żurek, Tomasz Marjański, Piotr Rudziński, Tadeusz Orłowski , et al. · 2017

Wedge resection was associated with significantly lower 3-year and 5-year survival rates compared to the other methods of resection. There was no significant difference in 3-year or 5-year survival rates between lobectomy and segmentectomy…

Clinical presentation and characteristics of 25 adult cases of pulmonary sequestration Open

Mateusz Polaczek, Inga Barańska, Małgorzata Szołkowska, Jacek Zych, Piotr Rudziński , et al. · 2017

Surgical treatment of symptomatic cases of PS is characterized by slightly longer post-surgical hospital stay and higher risk of surgical complications. Fungal infections are the most likely to occur in PS.

AB029. PS01.11. Thymomas are the potential candidates for the immune checkpoint inhibitors therapy Open

Małgorzata Szołkowska, Ewa Szczepulska‐Wójcik, Beata Maksymiuk, Sebastian Winiarski, Piotr Rudziński , et al. · 2017

Background: A robust development of targeted therapy including immunotherapy with checkpoint inhibitors for a lung carcinoma occurred in the last years. The immunotherapy is the most effective in the group of patients with a high expressio…

P2.01-004 The Methylation Profiling of Multiple Tumor Suppressor Genes in Plasma Cell-Free DNA of Patients with NSCLC vs Benign Tumors Open

Mateusz Florczuk, Adam Szpechciński, Monika Goś, Renata Langfort, Michał Komorowski , et al. · 2017

Results of surgical treatment and impact on T staging of non-small-cell lung cancer adjacent lobe invasion Open

Dariusz Dziedzic, Piotr Rudziński, Renata Langfort, Tadeusz Orłowski · 2016

In our study, a tumour with ALI (T-ALI) represented a separate stage of cancer between T2 and T3. The survival rate in the T-ALI-A group was significantly poorer than that in the T-ALI-D group. Overall treatment results were similar for st…

Atypical Image of Pulmonary Alveolar Proteinosis—A Case Report Open

Justyna Fijołek, Elżbieta Wiatr, Lucyna Opoka, Piotr Rudziński, Małgorzata Nierebińska , et al. · 2015

Pulmonary alveolar proteinosis is a very rare interstitial lung disease caused by abnormal intra-alveolar surfactant accumulation. Usually, it appears as a “crazy-paving” pattern on high-resolution computed tomography. The image is so typi…

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