Pirkka V. Kirjavainen
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View article: Perinatal Factors and Inhalant and Food Atopic Sensitization at the Age of Five
Perinatal Factors and Inhalant and Food Atopic Sensitization at the Age of Five Open
View article: The Janus face of <i>Bifidobacterium</i> in the development of atopic eczema: A role for compositional maturation
The Janus face of <i>Bifidobacterium</i> in the development of atopic eczema: A role for compositional maturation Open
Background Atopic eczema often develops in the first year of life, when the composition of the gut microbiota is most plastic as illustrated by the decrease in bifidobacteria after weaning. This may provide the opportunity for microbial st…
View article: Earlier pregnancies in nulliparous women with current father and lower risks for preeclampsia and low-birth weight newborns
Earlier pregnancies in nulliparous women with current father and lower risks for preeclampsia and low-birth weight newborns Open
New paternity has been related to placenta-associated complications in pregnancy. We evaluated whether a lack of earlier pregnancies or deliveries with a current father are associated with the pregnancy, prenatal, and early neonatal outcom…
View article: Microbial exposure at birth and the development of behavioral temperament during the first three years of childhood
Microbial exposure at birth and the development of behavioral temperament during the first three years of childhood Open
We investigated cross-sectional and longitudinal associations between neonate microbial exposure and emerging behavioral temperament measures at the ages of 1, 2, and 3 years. Infants and mothers ( n = 335 ) were extracted from the Kuopio …
View article: Maternal exercise during pregnancy is associated with reduced risk of asthma in the child: A prospective birth cohort study
Maternal exercise during pregnancy is associated with reduced risk of asthma in the child: A prospective birth cohort study Open
The study has been financially supported by grants from the Academy of Finland (no. 349427), the Emil Aaltonen Foundation, the Finnish Cultural Foundation, the Yrjö Jahnsson Foundation, the Juho Vainio Foundation (no. 202200461), the Kuopi…
View article: Impaired skin barrier and allergic sensitization in 16-year-old adolescents
Impaired skin barrier and allergic sensitization in 16-year-old adolescents Open
Background Transepidermal water loss (TEWL) has been used to measure skin barrier function and has been associated with atopic dermatitis and allergic diseases in infancy. However, few studies have assessed the association between TEWL and…
View article: Maternal caffeine intake during pregnancy and the risk of delivering a small for gestational age baby: Kuopio Birth Cohort
Maternal caffeine intake during pregnancy and the risk of delivering a small for gestational age baby: Kuopio Birth Cohort Open
View article: Maternal caffeine, coffee and cola drink intake and the risk of gestational diabetes – Kuopio Birth Cohort
Maternal caffeine, coffee and cola drink intake and the risk of gestational diabetes – Kuopio Birth Cohort Open
Caffeine intake during the first trimester of pregnancy was not associated with the risk of GDM but a minor non-significant decrease was seen with moderate coffee intake. Although the average consumption of cola drinks was low in the KuBiC…
View article: Vulvovaginal yeast infections, gestational diabetes and pregnancy outcome
Vulvovaginal yeast infections, gestational diabetes and pregnancy outcome Open
View article: Determinants of bacterial and fungal microbiota in Finnish home dust: Impact of environmental biodiversity, pets, and occupants
Determinants of bacterial and fungal microbiota in Finnish home dust: Impact of environmental biodiversity, pets, and occupants Open
The indoors is where many humans spend most of their time, and are strongly exposed to indoor microbiota, which may have multifaceted effects on health. Therefore, a comprehensive understanding of the determinants of indoor microbiota is n…
View article: Continuous Rather Than Solely Early Farm Exposure Protects From Hay Fever Development
Continuous Rather Than Solely Early Farm Exposure Protects From Hay Fever Development Open
While early life events determine the risk of subsequent hay fever, continuous exposure is necessary to achieve protection. These findings argue against the notion that only early life exposures set long-lasting trajectories.
View article: The Effects of Single Strains and Mixtures of Probiotic Bacteria on Immune Profile in Liver, Spleen, and Peripheral Blood
The Effects of Single Strains and Mixtures of Probiotic Bacteria on Immune Profile in Liver, Spleen, and Peripheral Blood Open
Probiotic bacteria have potential use as immunomodulators but comparative data on their immunological effects are very limited. The aim of this study was to characterize the effect of oral administration of probiotic strains, alone or as m…
View article: Bifidobacterium Species Colonization in Infancy: A Global Cross-Sectional Comparison by Population History of BreastFeeding
Bifidobacterium Species Colonization in Infancy: A Global Cross-Sectional Comparison by Population History of BreastFeeding Open
Bifidobacterium are a beneficial and dominant member of the breast-fed infant gut microbiome. However, the health benefits of Bifidobacterium are partially species dependent. Here we characterize the species and subspecies of Bifidobacteri…
View article: Interplay between natural environment, human microbiota and immune system: A scoping review of interventions and future perspectives towards allergy prevention
Interplay between natural environment, human microbiota and immune system: A scoping review of interventions and future perspectives towards allergy prevention Open
There is some evidence that the so-called biodiversity interventions have the potential to diversify human microbiota, at least over a short period. Adequately powered randomized controlled trials with long term follow-up are required to e…
View article: Excessive Unbalanced Meat Consumption in the First Year of Life Increases Asthma Risk in the PASTURE and LUKAS2 Birth Cohorts.
Excessive Unbalanced Meat Consumption in the First Year of Life Increases Asthma Risk in the PASTURE and LUKAS2 Birth Cohorts. Open
A higher diversity of food items introduced in the first year of life has been inversely related to subsequent development of asthma. In the current analysis, we applied latent class analysis (LCA) to systematically assess feeding patterns…
View article: Early age exposure to moisture and mould is related to FeNO at the age of 6 years.
Early age exposure to moisture and mould is related to FeNO at the age of 6 years. Open
Background: Exposure to indoor moisture damage and visible mold has been found to be associated with asthma and respiratory symptoms in several questionnaire- based studies by self- report. We aimed to define the prospective association be…
View article: Associations between dog keeping and indoor dust microbiota
Associations between dog keeping and indoor dust microbiota Open
View article: Microbial diversity in homes and the risk of allergic rhinitis and inhalant atopy in two European birth cohorts
Microbial diversity in homes and the risk of allergic rhinitis and inhalant atopy in two European birth cohorts Open
Our study suggests that a higher bacterial diversity may reduce the risk of allergic rhinitis later in childhood. The environment-dependent heterogeneity in the associations with inhalant atopy - visible here as inconsistent results betwee…
View article: Maturation of the gut microbiome during the first year of life contributes to the protective farm effect on childhood asthma
Maturation of the gut microbiome during the first year of life contributes to the protective farm effect on childhood asthma Open
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View article: Early life home microbiome and hyperactivity/inattention in school-age children
Early life home microbiome and hyperactivity/inattention in school-age children Open
View article: Indoor bacterial microbiota and development of asthma by 10.5 years of age
Indoor bacterial microbiota and development of asthma by 10.5 years of age Open
View article: TNF-α–induced protein 3 is a key player in childhood asthma development and environment-mediated protection
TNF-α–induced protein 3 is a key player in childhood asthma development and environment-mediated protection Open
View article: Author Correction: Farm-like indoor microbiota in non-farm homes protects children from asthma development
Author Correction: Farm-like indoor microbiota in non-farm homes protects children from asthma development Open
View article: Farm-like indoor microbiota in non-farm homes protects children from asthma development
Farm-like indoor microbiota in non-farm homes protects children from asthma development Open
View article: Population Duration of Breastfeeding and Prevalence of Bifidobacterium Longum Subspecies Infantis (OR01-01-19)
Population Duration of Breastfeeding and Prevalence of Bifidobacterium Longum Subspecies Infantis (OR01-01-19) Open
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Guest Editors Open
View article: Association between antibiotic treatment during pregnancy and infancy and the development of allergic diseases
Association between antibiotic treatment during pregnancy and infancy and the development of allergic diseases Open
Background Allergies are a serious public health issue, and prevalences are rising worldwide. The role of antibiotics in the development of allergies has repeatedly been discussed, as results remain inconsistent. The aim of this study was …
View article: Decreased plasma serotonin and other metabolite changes in healthy adults after consumption of wholegrain rye: an untargeted metabolomics study
Decreased plasma serotonin and other metabolite changes in healthy adults after consumption of wholegrain rye: an untargeted metabolomics study Open
View article: High levels of butyrate and propionate in early life are associated with protection against atopy
High levels of butyrate and propionate in early life are associated with protection against atopy Open
Background Dietary changes are suggested to play a role in the increasing prevalence of allergic diseases and asthma. Short‐chain fatty acids ( SCFA s) are metabolites present in certain foods and are produced by microbes in the gut follow…