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View article: Long Non-Coding RNAs and RNA-Binding Proteins in Pancreatic Cancer Development and Progression
Long Non-Coding RNAs and RNA-Binding Proteins in Pancreatic Cancer Development and Progression Open
Pancreatic ductal adenocarcinoma (PDAC) is the most common type of pancreatic cancer and is responsible for about 467,000 cancer deaths annually. An oftentimes asymptomatic early phase of this disease results in a delayed diagnosis, and pa…
View article: NEAT1 promotes genome stability via m <sup>6</sup> A methylation-dependent regulation of CHD4
NEAT1 promotes genome stability via m <sup>6</sup> A methylation-dependent regulation of CHD4 Open
Long noncoding (lnc)RNAs emerge as regulators of genome stability. The nuclear-enriched abundant transcript 1 (NEAT1) is overexpressed in many tumors and is responsive to genotoxic stress. However, the mechanism that links NEAT1 to DNA dam…
View article: NEAT1 promotes genome stability via m6A methylation-dependent regulation of CHD4
NEAT1 promotes genome stability via m6A methylation-dependent regulation of CHD4 Open
Long non-coding (lnc)RNA emerge as regulators of genome stability. The nuclear enriched abundant transcript 1 ( NEAT1 ) locus encodes two lncRNA isoforms that modulate gene expression, growth and proliferation in mammals. Interestingly, NE…
View article: Quadruplex–Duplex Junction: A High‐Affinity Binding Site for Indoloquinoline Ligands
Quadruplex–Duplex Junction: A High‐Affinity Binding Site for Indoloquinoline Ligands Open
A parallel quadruplex derived from the Myc promoter sequence was extended by a stem‐loop duplex at either its 5′‐ or 3′‐terminus to mimic a quadruplex–duplex (Q–D) junction as a potential genomic target. High‐resolution structures of the h…