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View article: UBR5 forms ligand-dependent complexes on chromatin to regulate nuclear hormone receptor stability
UBR5 forms ligand-dependent complexes on chromatin to regulate nuclear hormone receptor stability Open
Nuclear hormone receptors (NRs) are ligand-binding transcription factors that are widely targeted therapeutically. Agonist binding triggers NR activation and subsequent degradation by unknown ligand-dependent ubiquitin ligase machinery. NR…
View article: A deep dive into degrader-induced protein-protein interfaces
A deep dive into degrader-induced protein-protein interfaces Open
Targeted protein degradation (TPD) relies on a comprehensive understanding of interfaces between hijacked E3 ligases and their substrates. In vitro techniques often do not capture the interaction dynamics. Recently, Hanzl et al. introduced…