Piush J. Mandhane
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View article: Phthalates, bisphenols, and childhood allergic Phenotypes: Findings from two birth cohort studies
Phthalates, bisphenols, and childhood allergic Phenotypes: Findings from two birth cohort studies Open
Phthalates and bisphenols may contribute to childhood allergic outcomes, but whether these are differentially associated with atopic or non-atopic phenotypes is uncertain. We investigated whether early-life exposure to these chemicals diff…
View article: Biological sex impacts immune cell proportions and epigenetic profiles in the developing pediatric immune system
Biological sex impacts immune cell proportions and epigenetic profiles in the developing pediatric immune system Open
Age- and sex-related differences in immune cell compositions and immune outcomes have been identified across the life course, but a comprehensive and nuanced characterization of these changes during the rapid developmental window of early …
View article: Examining associations between human milk fatty acids, oligosaccharides, and early infant cognitive, language and motor development in the CHILD cohort study
Examining associations between human milk fatty acids, oligosaccharides, and early infant cognitive, language and motor development in the CHILD cohort study Open
Introduction Human milk fatty acids and human milk oligosaccharides (HMOs) are milk components inconsistently associated with neurodevelopment. The objective of this research is to examine the link between fatty acids, HMOs and neurodevelo…
View article: Risk for Sleep-Disordered Breathing Among Children and Adolescents With Perinatal Stroke and the Impact on Mental Health, Quality of Life, and Caregivers
Risk for Sleep-Disordered Breathing Among Children and Adolescents With Perinatal Stroke and the Impact on Mental Health, Quality of Life, and Caregivers Open
View article: Exposure to maternal human milk components interacts with infant polygenic risk to predict childhood atopy
Exposure to maternal human milk components interacts with infant polygenic risk to predict childhood atopy Open
Although human milk (HM) is known to benefit infant health, how its many bioactive components (e.g., microbiota (HMM), oligosaccharides (HMOs), and fatty acids (HMFAs)) influence the risk of childhood atopy remains poorly understood. Our s…
View article: Infant Acid‐Suppressant Medication, <scp> <i>C. difficile</i> </scp> Colonisation, and Childhood Body Mass Index in a Canadian Cohort
Infant Acid‐Suppressant Medication, <span> <i>C. difficile</i> </span> Colonisation, and Childhood Body Mass Index in a Canadian Cohort Open
Aim To determine relationships between paediatric use of acid‐suppressive medications (ASMs) (proton pump inhibitors (PPI) and histamine‐2 receptor antagonists (H2RA)) and preschool body mass index (BMI) and mediation by C. difficile colon…
View article: Human milk IgA promotes normal immune development by limiting Th17-inducing <i>Erysipelatoclostridium ramosum</i> in the infant gut
Human milk IgA promotes normal immune development by limiting Th17-inducing <i>Erysipelatoclostridium ramosum</i> in the infant gut Open
The gut microbiota is highly dynamic during the first year of life and plays a crucial role in immune development. Breastfeeding is known to support infant health, but the contributions of the numerous breastmilk components to gut microbio…
View article: Breastfeeding limits the adverse impact of socioeconomic status on child health by modifying the infant gut microbiome
Breastfeeding limits the adverse impact of socioeconomic status on child health by modifying the infant gut microbiome Open
Lower familial socioeconomic status (SES) is linked to increased childhood disease risk. Since SES has no inherent biological basis, identifying how it becomes physiologically embedded is essential for equitable intervention. Using data fr…
View article: Associations of dietary patterns and obesity development in school‐aged children: results from the <scp>CHILD</scp> Cohort Study
Associations of dietary patterns and obesity development in school‐aged children: results from the <span>CHILD</span> Cohort Study Open
Objective We aimed to understand data‐driven dietary patterns in Canadian preschoolers and their impact on obesity development among male and female individuals. Methods In the prospective, population‐based Canadian pregnancy cohort, the C…
View article: RAMEN: Dissecting individual, additive and interactive gene-environment contributions to DNA methylome variability in cord blood
RAMEN: Dissecting individual, additive and interactive gene-environment contributions to DNA methylome variability in cord blood Open
DNA methylation (DNAme) is the most commonly studied epigenetic mark in human populations. DNAme has gained attention in the Developmental Origins of Health and Disease field due to its gene expression regulation and potential long-term st…
View article: Measuring Diet Intake in Adolescents: Relative Validation of an Artificial Intelligence Enhanced, Image Assisted Mobile Application in the CHILD Cohort Study
Measuring Diet Intake in Adolescents: Relative Validation of an Artificial Intelligence Enhanced, Image Assisted Mobile Application in the CHILD Cohort Study Open
View article: Advancing Pediatric and Longitudinal DNA Methylation Studies with CellsPickMe, an Integrated Blood Cell Deconvolution Method
Advancing Pediatric and Longitudinal DNA Methylation Studies with CellsPickMe, an Integrated Blood Cell Deconvolution Method Open
Prospective birth cohorts offer the potential to interrogate the relation between early life environment and embedded biological processes such as DNA methylation (DNAme). These association studies are frequently conducted in the context o…
View article: Early life predictors of child development at kindergarten: a structural equation model using a longitudinal cohort
Early life predictors of child development at kindergarten: a structural equation model using a longitudinal cohort Open
Introduction Early child development sets the stage for lifelong health. Identifying early life factors related to child development can help guide programs and policies to bolster child health and wellbeing. The objective of this research…
View article: Secretory IgA modifies the association between early-life gut microbiota trajectories and childhood nonatopic wheeze
Secretory IgA modifies the association between early-life gut microbiota trajectories and childhood nonatopic wheeze Open
Aims Wheezing in childhood is common and evidence is accumulating for the role of the gut microbiome in the development of atopic wheeze. Changes to the early-life gut microbiota and secretory IgA (SIgA) production have been linked to chil…
View article: Ultraprocessed Food Consumption and Obesity Development in Canadian Children
Ultraprocessed Food Consumption and Obesity Development in Canadian Children Open
Importance Ultraprocessed foods (UPF), characterized as shelf-stable but nutritionally imbalanced foods, pose a public health crisis worldwide. In adults, UPF consumption is associated with increased obesity risk, but findings among childr…
View article: Exploring the potential mediating role of systemic antibiotics in the association between early-life lower respiratory tract infections and asthma at age 5 in the CHILD study
Exploring the potential mediating role of systemic antibiotics in the association between early-life lower respiratory tract infections and asthma at age 5 in the CHILD study Open
Objective Lower respiratory tract infections (LRTIs) in early life are one of the strongest risk factors for childhood asthma and are often treated with systemic antibiotics (IV or oral). We aimed to explore the association between early-l…
View article: Gut microbiota metabolites, secretory immunoglobulin A and Bayley-III cognitive scores in children from the CHILD Cohort Study
Gut microbiota metabolites, secretory immunoglobulin A and Bayley-III cognitive scores in children from the CHILD Cohort Study Open
Our study contributes to growing evidence that neurodevelopment is influenced by the infant gut microbiota and that it might involve SIgA level, but larger studies are required.
View article: Pets and related allergens modify the association between early life DEHP exposure and respiratory outcomes in children
Pets and related allergens modify the association between early life DEHP exposure and respiratory outcomes in children Open
Early-life exposure to pets and related biological agents may modify the associations between phthalates and asthma and wheeze in children. Heterogeneity in single exposure studies could be a result of differences in co-exposures among stu…
View article: Biological sex impacts immune cell proportions and epigenetic profiles in the developing pediatric immune system
Biological sex impacts immune cell proportions and epigenetic profiles in the developing pediatric immune system Open
Age- and sex-related differences in immune cell compositions and immune outcomes have been identified in adult and aging populations, but a comprehensive and nuanced characterization of these changes during the rapid developmental window o…
View article: Early Life Predictors of Child Development at Kindergarten: A Structural Equation Model using a Longitudinal Cohort
Early Life Predictors of Child Development at Kindergarten: A Structural Equation Model using a Longitudinal Cohort Open
Introduction Early child development sets the stage for lifelong health. Identifying early life factors related to child development can help guide programs and policies to bolster child health and wellbeing. The objective of this research…
View article: Impact of postpartum hospital length of stay on infant gut microbiota: a comprehensive analysis of vaginal and caesarean birth
Impact of postpartum hospital length of stay on infant gut microbiota: a comprehensive analysis of vaginal and caesarean birth Open
Prolonged hospital stay after birth is associated with infant gut dysbiosis.
View article: Human milk feeding practices and serum immune profiles of one-year-old infants in the CHILD birth cohort study
Human milk feeding practices and serum immune profiles of one-year-old infants in the CHILD birth cohort study Open
View article: Association between maternal perinatal stress and depression and infant DNA methylation in the first year of life
Association between maternal perinatal stress and depression and infant DNA methylation in the first year of life Open
Maternal stress and depression during pregnancy and the first year of the infant's life affect a large percentage of mothers. Maternal stress and depression have been associated with adverse fetal and childhood outcomes as well as differen…
View article: From fetus to 8: the CHILD Cohort Study
From fetus to 8: the CHILD Cohort Study Open
The CHILD Cohort Study is an active multicenter, longitudinal, prospective, population pregnancy cohort study following Canadian infants from fetal life until adulthood. We hypothesized that early life physical and psychosocial environment…
View article: Human milk oligosaccharides are associated with maternal genetics and respiratory health of human milk-fed children
Human milk oligosaccharides are associated with maternal genetics and respiratory health of human milk-fed children Open
Breastfeeding provides many health benefits, but its impact on respiratory health remains unclear. This study addresses the complex and dynamic nature of the mother-milk-infant triad by investigating maternal genomic factors regulating hum…
View article: Author response: Maternal smoking DNA methylation risk score associated with health outcomes in offspring of European and South Asian ancestry
Author response: Maternal smoking DNA methylation risk score associated with health outcomes in offspring of European and South Asian ancestry Open
View article: Maternal smoking DNA methylation risk score associated with health outcomes in offspring of European and South Asian ancestry
Maternal smoking DNA methylation risk score associated with health outcomes in offspring of European and South Asian ancestry Open
Background: Maternal smoking has been linked to adverse health outcomes in newborns but the extent to which it impacts newborn health has not been quantified through an aggregated cord blood DNA methylation (DNAm) score. Here, we examine t…
View article: Author response: Maternal smoking DNA methylation risk score associated with health outcomes in offspring of European and South Asian ancestry
Author response: Maternal smoking DNA methylation risk score associated with health outcomes in offspring of European and South Asian ancestry Open
Maternal smoking has been linked to adverse health outcomes in newborns but the extent to which it impacts newborn health has not been quantified through an aggregated cord blood DNA methylation (DNAm) score. Here we examine the feasibilit…
View article: Maternal smoking DNA methylation risk score associated with health outcomes in offspring of European and South Asian ancestry
Maternal smoking DNA methylation risk score associated with health outcomes in offspring of European and South Asian ancestry Open
Maternal smoking has been linked to adverse health outcomes in newborns but the extent to which it impacts newborn health has not been quantified through an aggregated cord blood DNA methylation (DNAm) score. Here we examine the feasibilit…
View article: Don't Forget the Fathers! Preconception Paternal Adherence to a Prudent Diet Pattern: a Shield Against Accelerated Child Growth
Don't Forget the Fathers! Preconception Paternal Adherence to a Prudent Diet Pattern: a Shield Against Accelerated Child Growth Open
Objectives: Maternal dietary factors have been acknowledged to be associated with childhood obesity. However, the contribution of paternal diet has been understudied. We hypothesize that children of fathers adhering to a prudent diet patte…