Piyali Ganguli
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View article: Context-dependent effects of CDKN2A and other 9p21 gene losses during the evolution of esophageal cancer
Context-dependent effects of CDKN2A and other 9p21 gene losses during the evolution of esophageal cancer Open
View article: Metabolic reprogramming and signalling cross-talks in tumour–immune interaction: a system-level exploration
Metabolic reprogramming and signalling cross-talks in tumour–immune interaction: a system-level exploration Open
Tumour-immune microenvironment (TIME) is pivotal in tumour progression and immunoediting. Within TIME, immune cells undergo metabolic adjustments impacting nutrient supply and the anti-tumour immune response. Metabolic reprogramming emerge…
View article: Context-dependent effects of<i>CDKN2A</i>and other 9p21 gene losses during the evolution of oesophageal cancer
Context-dependent effects of<i>CDKN2A</i>and other 9p21 gene losses during the evolution of oesophageal cancer Open
CDKN2A is a tumour suppressor located in chromosome 9p21 and frequently lost in Barrett’s oesophagus (BO) and oesophageal adenocarcinoma (OAC). How CDKN2A and other 9p21 gene co-deletions affect OAC evolution remains understudied. We explo…
View article: The transcriptional landscape of endogenous retroelements delineates esophageal adenocarcinoma subtypes
The transcriptional landscape of endogenous retroelements delineates esophageal adenocarcinoma subtypes Open
Most cancer types exhibit aberrant transcriptional activity, including derepression of retrotransposable elements (RTEs). However, the degree, specificity and potential consequences of RTE transcriptional activation may differ substantiall…
View article: PRESGENE: A web server for PRediction of ESsential GENE using integrative machine learning strategies
PRESGENE: A web server for PRediction of ESsential GENE using integrative machine learning strategies Open
Study of essential genes in disease-causing organisms has wide application in the prediction of therapeutic targets and exploring different clinical strategies. Predicting gene essentiality for large set of genes in non-model, less explore…
View article: Somatic variation in normal tissues: friend or foe of cancer early detection?
Somatic variation in normal tissues: friend or foe of cancer early detection? Open
View article: Somatic Variation in Normal Tissues: Friend or Foe of Cancer Early Detection?
Somatic Variation in Normal Tissues: Friend or Foe of Cancer Early Detection? Open
Seemingly normal tissues progressively become populated by mutant clones over time. Most of these clones bear mutations in well-known cancer genes but only rarely do they transform into cancer. This poses questions on what triggers cancer …
View article: Study of Combinatorial Drug Synergy of Novel Acridone Derivatives With Temozolomide Using in-silico and in-vitro Methods in the Treatment of Drug-Resistant Glioma
Study of Combinatorial Drug Synergy of Novel Acridone Derivatives With Temozolomide Using in-silico and in-vitro Methods in the Treatment of Drug-Resistant Glioma Open
Drug resistance is one of the critical challenges faced in the treatment of Glioma. There are only limited drugs available in the treatment of Glioma and among them Temozolomide (TMZ) has shown some effectiveness in treating Glioma patient…
View article: Essential gene prediction using limited gene essentiality information–An integrative semi-supervised machine learning strategy
Essential gene prediction using limited gene essentiality information–An integrative semi-supervised machine learning strategy Open
Essential gene prediction helps to find minimal genes indispensable for the survival of any organism. Machine learning (ML) algorithms have been useful for the prediction of gene essentiality. However, currently available ML pipelines perf…
View article: Temporal Analysis of COVID - 19 Pandemic in India and R0 prediction
Temporal Analysis of COVID - 19 Pandemic in India and R0 prediction Open
India now ranks 3rd in the list of countries affected due to the COVID-19 pandemic. With more than 0.7 million confirmed COVID–19 cases and a gradual withdrawal of nation-wide lockdown, it is expected India may see a further sur…
View article: On the Temporal Analysis of COVID-19 Pandemic and Prediction of R0
On the Temporal Analysis of COVID-19 Pandemic and Prediction of R0 Open
The COVID-19 pandemic has affected millions of people and claimed numerous lives already. As of now, there are no available treatments and it has become both imperative and challenging to forecast the COVID-19 cases, which will help to des…
View article: On the Temporal Analysis of COVID-19 Pandemic and Prediction of R <sub>0</sub>
On the Temporal Analysis of COVID-19 Pandemic and Prediction of R <sub>0</sub> Open
View article: Exploring immuno-regulatory mechanisms in the tumor microenvironment: Model and design of protocols for cancer remission
Exploring immuno-regulatory mechanisms in the tumor microenvironment: Model and design of protocols for cancer remission Open
The tumor microenvironment comprising of the immune cells and cytokines acts as the 'soil' that nourishes a developing tumor. Lack of a comprehensive study of the interactions of this tumor microenvironment with the heterogeneous sub-popul…
View article: BIOPYDB: A Dynamic Human Cell Specific Biochemical Pathway Database with Advanced Computational Analyses Platform
BIOPYDB: A Dynamic Human Cell Specific Biochemical Pathway Database with Advanced Computational Analyses Platform Open
BIOPYDB: BIOchemical PathwaY DataBase is developed as a manually curated, readily updatable, dynamic resource of human cell specific pathway information along with integrated computational platform to perform various pathway analyses. Pres…
View article: Integrative Approaches to Understand the Mastery in Manipulation of Host Cytokine Networks by Protozoan Parasites with Emphasis on Plasmodium and Leishmania Species
Integrative Approaches to Understand the Mastery in Manipulation of Host Cytokine Networks by Protozoan Parasites with Emphasis on Plasmodium and Leishmania Species Open
Diseases by protozoan pathogens pose a significant public health concern, particularly in tropical and subtropical countries, where these are responsible for significant morbidity and mortality. Protozoan pathogens tend to establish chroni…
View article: Identification of Th1/Th2 regulatory switch to promote healing response during leishmaniasis: a computational approach
Identification of Th1/Th2 regulatory switch to promote healing response during leishmaniasis: a computational approach Open
Leishmania devices its survival strategy by suppressing the host's immune functions. The antigen molecules produced by Leishmania interferes with the host's cell signaling cascades and consequently changes the protein express…