Explanipedia

Tumor Growth Kinetics and the Biological Cost of Treatment Delay in Oral Cancer Open

Arjun Singh, Abhishek Mahajan, Rathan Shetty, Samarpita Mohanty, Anuj Kumar , et al. · 2025

This prospective cohort study quantified the biological impact of treatment delay in oral squamous cell carcinoma (OSCC) through tumour kinetics. Between July 2020 and December 2023, 483 patients with treatment-naïve OSCC, Mumbai, underwen…

Targeted literature review and assessment of evidence in microvillus inclusion disease (MVID) Open

Antonella Diamanti, Merit M. Tabbers, Christos Tzivinikos, Mohamad Miqdady, Antonino Morabito , et al. · 2025

309P Automation of cancer case abstraction in the hospital-based cancer registry at Tata Memorial Centre (TMC), Mumbai using Onco-Insight software Open

Allen S. W. Oak, Sandhya Cheulkar, K. Sivaranjini, Esha Dashmukhe, P. Gode , et al. · 2025

An Expert Opinion on Hyaluronic Acid Fillers for Indian Facial Aesthetics: Insights From a Pre-meeting Questionnaire and Ad-Board Discussion Open

Rajat Kandhari, Chiranjiv Chhabra, Jagadish Sakhiya, Maya Vedamurthy, Ishad Aggarwal , et al. · 2025

Indian clinical practice consensus guidelines for the management of oropharyngeal cancer – Update 2024 Open

Vanita Noronha, Govind Babu, HS Darling, Pankaj Chaturvedi, Moni Abraham Kuriakose , et al. · 2025

Oropharyngeal cancer typically presents at a nonmetastatic stage and is mostly treated with curative intent. Although surgical options are available, they are often associated with significant functional and cosmetic morbidity, leading to …

Indian clinical practice consensus guidelines for the management of locoregional laryngeal cancer – Update 2024 Open

Manish Singhal, K Govind Babu, HS Darling, Pankaj Chaturvedi, Moni Abraham Kuriakose , et al. · 2025

Laryngeal cancer typically presents at an early stage, and most patients are treated with curative intent. Due to the functional and cosmetic morbidities associated with surgical approaches, nonsurgical modalities are increasingly favored.…

Indian clinical practice consensus guidelines for the management of recurrent, persistent, or metastatic squamous cell carcinoma of head-and-neck – Update 2024 Open

Vanita Noronha, K. Govind Babu, HS Darling, Pankaj Chaturvedi, Moni Abraham Kuriakose , et al. · 2025

Head-and-neck squamous cell carcinoma (HNSCC) remains a significant public health concern, particularly in India, where its incidence is disproportionately high due to risk factors such as tobacco and alcohol use. The updated guidelines fo…

Reply to: Beyond the Numbers: Inflammation as the Missing Link in Decayed, Missing, Filled Teeth–Based Buccal Mucosa Cancer Risk Models Open

Grace Sarah George, Rajesh Dikshit, Anil K. Chaturvedi, Pankaj Chaturvedi, Sharayu Mhatre · 2025

Indian clinical practice consensus guidelines for the management of locoregional hypopharyngeal cancer – Update 2024 Open

HS Darling, K Govind Babu, Vanita Noronha, Pankaj Chaturvedi, Moni Abraham Kuriakose , et al. · 2025

Hypopharyngeal cancer usually presents at the locally advanced stage and is relatively uncommon. Early diagnosis is difficult because of recesses and spaces around the larynx, which delay presentation until local progression or neck metast…

Management of Total Laryngectomy with Tracheoesophageal Prosthesis in a School Teacher: A 10-Year Case Report Open

Dhanush, Aseem Mishra, Pankaj Chaturvedi, Sunayana R Sarkar · 2025

Voice rehabilitation following total laryngectomy is essential for restoring communication and improving long-term quality of life. Tracheoesophageal puncture (TEP) with voice prosthesis is considered the gold standard method for post-lary…

Cancer Incidence and Mortality Across 43 Cancer Registries in India Open

Prashant Mathur, Krishnan Sathishkumar, Priyanka Das, Stephen Santhappan, Jayasankar Sankarapillai , et al. · 2025

Importance Cancer is a significant global health concern, with India ranking second in Asia and third in the world in terms of cancer incidence. Regular monitoring and updates on cancer statistics are vital for assessing the impact and bur…

NAMS task force report on oral cancer Open

Mahesh Verma, Om Prakash Kharbanda, Ravi Mehrotra, Vinay K. Hazarey, Shiv Kumar Sarin , et al. · 2025

EXECUTIVE SUMMARY Oral cancer is the term described as cancers occurring in the mouthparts that include lips, cheeks, sinuses, tongue, hard and soft palate, or the base of the mouth extending up to the oropharynx. Globally, oral cancer ran…

Rethinking Radiation Therapy for Perineural Invasion in Oral Cancer: Does More Coverage Improve Outcomes? Open

Sarbani Ghosh Laskar, Anuj Kumar, Ashwini Adhau, Shwetabh Sinha, Samarpita Mohanty , et al. · 2025

Introduction Perineural invasion (PNI) in oral squamous cell carcinoma (OSCC) is linked to aggressive tumour behaviour and poorer survival outcomes. Adjuvant radiotherapy (RT) is recommended for PNI‐positive OSCC, but optimal RT target vol…

Adjuvant External Beam Radiotherapy in Differentiated Thyroid Cancers: An Audit of Clinical Practice, Adapting to New Evidence Open

Sarbani Ghosh Laskar, Samarpita Mohanty, Shwetabh Sinha, Anuj Kumar, Gouri Pantvaidya , et al. · 2025

Introduction There is limited evidence on the role of adjuvant external beam radiotherapy in differentiated thyroid cancer (DTC). Methods We conducted a retrospective study of patients with DTC treated with adjuvant Intensity Modulated rad…

Epidemiology of adolescent and young adult cancer and associated disparities in cancer pattern and care in India: findings from Varanasi’s population-based cancer registry, 2017–2019 Open

Divya Khanna, R.A. Vishwakarma, Anand N Sharma, Atul Budukh, Rahul K. Verma , et al. · 2025

Introduction Adolescents and Young Adults (AYAs) aged 15–39 represent a unique oncology demographic due to their distinct developmental needs. However, there is limited data on cancer burden and care disparities among the Indian AYAs. This…

Association of Decayed, Missing, Filled Teeth Score With the Risk for Buccal Mucosa Cancer, Stratified on Tobacco and Alcohol Use: A Multicenter Case-Control Study From India Open

Grace Sarah George, Arjun Singh, Romi Moirangthem, Aniket Patil, Gayathri B. Pullat , et al. · 2025

PURPOSE Buccal mucosa cancer (BMC), the most prevalent oral cancer (OC) site, is a multifactorial disease. With relatively high prevalence of periodontal diseases because of poor oral hygiene practices, oral health indicators remain an are…

Ocular syphilis in antibiotic era Open

P. Das, Pankaj Chaturvedi, Ranjit Goenka, Gautam K. Singh, Anuj Bhatnagar , et al. · 2025

Syphilis is a sexually transmitted multisystem disease caused by Treponema pallidum . Although easily treatable in early stages, if unrecognized, the disease usually progresses through its natural stages (i.e., primary, secondary, early la…

Comparison of Clinical and Pathological T Staging in Gingivobuccal Complex Cancers—A Retrospective Analysis Open

Poonam Joshi, V. V. Sameema, Roy S, Arjun Singh, Asawari Patil , et al. · 2025

Accurate staging of gingivobuccal complex (GBC) cancers is critical for treatment planning and prognosis. Discrepancies between clinical T staging (cT) and pathological T staging (pT) may lead to over or undertreatment. This study examines…

Genomic Characterization of Papillary Thyroid Cancer Reveals Germline Mutations Associated With Congenital Hypothyroidism Open

Vaishakhi Trivedi, Harsha Gowda, Disha Poojary, Vanita Noronha, Munita Bal , et al. · 2025

PURPOSE Thyroid dyshormonogenesis, a form of congenital hypothyroidism, is characterized by defects in thyroid hormone synthesis genes, affecting both children and adults. However, the potential link between such genetic defects and the de…

A Genome-wide Association study of Buccal Mucosa Cancer in India and Multi-ancestry Meta-analysis Identifies Novel Risk Loci and Gene-environment Interactions Open

Sharayu Mhatre, Diptavo Dutta, Anand Iyer, Shruti Gholap, Aseem Mishra , et al. · 2025

Genome-wide association studies (GWAS) of oral cancers (OC) to date have focused predominantly on European Ancestry (EA) populations. India faces an excess burden of OC, but the most common site of occurrence is the cancer of the buccal mu…

Patterns of Failure in Head and Neck Carcinoma of Unknown Primary: Insights from a Tobacco-Associated Cancer Cohort Open

Sarbani Ghosh Laskar, Jifmi Jose Manjali, Ashwini Budrukkar, Monali Swain, Debanjali Dutta , et al. · 2025

We report the patterns of failure and survival with carcinoma of unknown primary of the head and neck (CUP-HN). This is a retrospective audit of CUP-HN patients treated with curative radiotherapy (RT) between January 2006 and December 2020…

Prevalence and associated factors of mammography uptake among the women aged 45 years and above: policy implications from the longitudinal ageing study in India wave I survey Open

Priyanka Sharma, Dipak Ranjan Das, Divya Khanna, Atul Budukh, Anita Khokhar , et al. · 2025

Low rates of mammography among women across the country, along with inter-state disparities, highlight inadequate coverage of early detection of breast cancer under National program. Increasing burden of breast cancer in all states undersc…

A Genome-Wide Association Study of Buccal Mucosa Cancer in India and Multi-Ancestry Meta-Analysis Identifies Novel Risk Loci and Gene-Environment Interactions Open

Sharayu Mhatre, Diptavo Dutta, Anand Iyer, Shruti Vishwas Golapkar, Aseem Mishra , et al. · 2025

A prospective study on diagnostic accuracy of technology‐enabled early detection of oral cancer and epidemiology of tobacco and other substances use in rural India Open

Divya Khanna, Aseem Mishra, Praveen Birur, Tulika Shruti, Keerthi Gurushanth , et al. · 2025

Background Lip and oral cavity cancer is leading cause of cancer mortality among Indian men. This study evaluated diagnostic accuracy of mobile health (mHealth) enabled screening for early detection of oral premalignant lesions or oral can…

Adjuvant Intensity Modulated Radiation Therapy With a Pedicled Flap Reconstruction in Oral Cavity Squamous Cell Carcinomas: Implications on Target Delineation Open

Sarbani Ghosh‐Laskar, Shwetabh Sinha, Pritha Roy, Rabi Das, Shivakumar Thiagarajan , et al. · 2024

Objectives To address controversies regarding target volume delineation for adjuvant intensity‐modulated radiation therapy for oral cavity squamous cell carcinoma with pedicled flap reconstruction and elective nodal irradiation (ENI). Mate…

Indian clinical practice consensus guidelines for the management of locoregional hypopharyngeal cancer - Update 2023 Open

HS Darling, K Govind Babu, Vanita Noronha, Pankaj Chaturvedi, Moni Abraham Kuriakose , et al. · 2024

Hypopharyngeal cancer usually presents at a locally advanced stage. Almost all patients are treated with a curative intent. As surgical approaches are functionally and cosmetically morbid, nonsurgical modalities are preferred. This review …

Indian clinical practice consensus guidelines for the management of oral cavity cancer - Update 2023 Open

HS Darling, K. Govind Babu, Vanita Noronha, Pankaj Chaturvedi, Moni Abraham Kuriakose , et al. · 2024

Oral cavity cancer (OCC) essentially presents at a non-metastatic stage. Almost all patients are treated with a curative intent. Surgical approaches are the mainstay of treatment accompanied by radiotherapy and chemotherapy where applicabl…

Indian clinical practice consensus guidelines for the management of nasopharyngeal cancer - Update 2023 Open

HS Darling, Vanita Noronha, Govind Babu, Pankaj Chaturvedi, Moni Abraham Kuriakose , et al. · 2024

Nasopharyngeal carcinoma (NPC) is a rare malignancy that poses significant treatment challenges, particularly in the context of curative intent. This updated guideline consolidates contemporary evidence and clinical practices tailored to t…

Indian clinical practice consensus guidelines for the management of recurrent, persistent, or metastatic squamous cell carcinoma of head-and-neck - Update 2023 Open

Vanita Noronha, K. Govind Babu, HS Darling, Pankaj Chaturvedi, Moni Abraham Kuriakose , et al. · 2024

Head-and-neck squamous cell carcinoma (HNSCC) remains a significant public health concern, particularly in India, where its incidence is disproportionately high due to risk factors such as tobacco and alcohol use. The updated guidelines fo…

Marginal Mandibulectomy in Oral Cavity Cancers — Classification and Indications Open

Sudhir Nair, Hitesh Singhavi, Vidula Mestry, Rathan Shetty, Poonam Joshi , et al. · 2024

Squamous cell carcinoma of the lip and oral cavity (OSCC) is a significant global health issue, particularly in low-income countries, with an estimated 390,000 cases detected annually. Although surgery remains the primary treatment option,…

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