Explanipedia

Analysis of mRNA multimerisation (aggregation) using non-denaturing ion-pair reversed-phase HPLC Open

A. G. Webb, Emma N. Welbourne, Kate A. Loveday, Puran S. Bora, Zoltán Kis , et al. · 2025

mRNA-based technology has emerged as a new class of medicines with a wide range of applications, including viral vaccines, cancer vaccines, and therapeutics for the treatment of metabolic diseases and cardiovascular conditions. Impurities,…

Investigation of Black and Brown Rice as Inhibitors of Tyrosinase and Xanthine Oxidase Enzymes: An in vitro and in silico Investigation Open

Taranga Jyoti Baruah, Sanathoi Tongbram, Puran S. Bora, S. Priya, Langlen Meinam , et al. · 2024

Therapeutic Advancement of Adiponectin in Age-Related Macular Degeneration and Other Metabolic Disorders. Open

Anusha Singh, Nalini S. Bora, Puran S. Bora · 2024

Adiponectin (APN) has been thoroughly investigated for its role in various human disorders. It is fascinating to note that this peptide plays an essential role as a therapeutic agent to cure a plethora of disorders. Our aim is to elucidate…

Genetic Insights into Age-Related Macular Degeneration Open

Bhumika, Nalini S. Bora, Puran S. Bora · 2024

One of the major causes of vision impairment among elderly people in developed nations is age-related macular degeneration (AMD). The distinctive features of AMD are the accumulation of extracellular deposits called drusen and the gradual …

Linking Adiponectin and Its Receptors to Age-Related Macular Degeneration (AMD) Open

Mayank Choubey, Munichandra Babu Tirumalasetty, Nalini S. Bora, Puran S. Bora · 2023

In recent years, there has been a captivating focus of interest in elucidating the intricate crosstalk between adiponectin (APN), a versatile fat-associated adipokine and ocular pathologies. Unveiling the intricate relationship between adi…

Obesity Hormone Function in Aging Eyes: Linking Adiponectin and its Receptors to AMD Open

Mayank Choubey, Munichandra Babu Tirumalasetty, Nalini S. Bora, Puran S. Bora · 2023

In recent years, the interaction between adiponectin (APN), a versatile fat-associated adipokines, and eye disorders has become a captivating focus of interest. Unveiling the intricate relationship between APN and its receptors (AdipoRs) w…

Wet and Dry Age-Related Macular Degeneration Induced by Polyethylene Glycol Open

Reece Mitchell, Connor Logan, Valeriy V. Lyzogubov, Nalini S. Bora, Puran S. Bora · 2023

Age-related macular degeneration (AMD) is a leading cause of irreversible blindness world-wide. We recently reported that polyethylene glycol (PEG) can activate the alternative pathway of the complement system and induce choroidal neovascu…

New Discoveries in Retinal Cell Degeneration and Retinal Diseases Open

Puran S. Bora · 2023

Age-related macular degeneration (AMD) has two phenotypes: dry AMD and wet AMD [...]

Emerging Role of Adiponectin/AdipoRs Signaling in Choroidal Neovascularization, Age-Related Macular Degeneration, and Diabetic Retinopathy Open

Mayank Choubey, Puran S. Bora · 2023

Age-related macular degeneration (AMD), a leading cause of irreversible blindness in adults, may result in poor central vision, making it difficult to see, read, and drive. AMD is generally classified in either dry or wet types. Milder cas…

Role of Adiponectin Peptide I (APNp1) in Age-Related Macular Degeneration Open

Connor Logan, Valeriy V. Lyzogubov, Nalini S. Bora, Puran S. Bora · 2022

Age-related macular degeneration (AMD) is an eye disease that can cause central vision loss, particularly in the elderly population. There are 2 classes of AMD, wet-type and dry-type. Wet-type involves excess angiogenesis around the macula…

Issue Information Open

Wolfgang Miesbach, Dimitrios Farmakis, Anastasios Giakoumis, Lucja Swiatkowski Cannon, Michael Angastiniotis , et al. · 2020

Non-myeloablative matched sibling stem cell transplantation with the optional reinforced stem cell infusion for patients with hemoglobinopathies Application of comprehensive geriatric assessment in predicting early mortality among elder pa…

Pathomorphological studies of respiratory mannheimiosis in goats Open

Biswajit Dutta, SA Begum, Rishabh Sarmah, Karthikan Sadhasivam, Krishna Kalita , et al. · 2020

The study investigated an outbreak of respiratory mannheimiosis in goat maintained at the Goat Research station, AAU, Burnihat during September- October, 2019. Out of the total 215 nos. of animals at risk, 48 nos. were affected and 16 died…

Inhibitory role of transforming growth factor β2 in experimental autoimmune anterior uveitis Open

Bharati Matta, Puran S. Bora, Adam J. Neuhouser, Nalini S. Bora · 2019

TGF-β2 plays a critical role in regulation of intraocular inflammation in EAAU. Findings reported in this study improve our understanding of immunopathology of IAU and suggest that recombinant TGF-β2 may be a promising therapeutic agent fo…

Role of adiponectin as a modulator of testicular function during aging in mice Open

Mayank Choubey, Ashutosh Ranjan, Puran S. Bora, Fátima Baltazar, Luc J. Martin , et al. · 2018

The mechanisms by which testicular functions decline with aging remain largely speculative. Our recent finding showed the importance of adiponectin in the regulation of testicular functions, whereas its concentration declines during male i…

Direct actions of adiponectin on changes in reproductive, metabolic, and anti-oxidative enzymes status in the testis of adult mice Open

Mayank Choubey, Ashutosh Ranjan, Puran S. Bora, Fátima Baltazar, Amitabh Krishna · 2018

Obesity is a major health problem that is linked to decreased sperm count. It is hypothesized that an obesity-associated reduction in adiponectin secretion may be responsible for impairment of spermatogenesis. Therefore, the aim of the stu…

Conspectus on Indian Gymnacranthera and Myristica Open

Dipanwita Banik, Puran S. Bora, Vinay Kumar, R. L. Bezbaruah · 2017

Since, Sir J.D. Hooker's the Flora of British India, no comprehensive work on the family Myristicaceae R. Br., nom.cons. in India has been made but the family was treated with confusion in several regional floras, which were devoid of upda…

Table of Contents Open

Meagan W. Moore, Erica L. Herzog, Risako Fujikawa, Sei Higuchi, Masato Nakatsuji , et al. · 2016

The Complement Regulatory Protein CD46 Deficient Mouse Spontaneously Develops Dry-Type Age-Related Macular Degeneration–Like Phenotype Open

Valeriy V. Lyzogubov, Puran S. Bora, Xiaobo Wu, Leah E. Horn, Ryan de Roque , et al. · 2016

Puran S. Bora YOU? Author Swipe