Erica L. Plummer
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View article: Gut microbiota composition in preterm infants with and without necrotizing enterocolitis: a systematic review and narrative synthesis
Gut microbiota composition in preterm infants with and without necrotizing enterocolitis: a systematic review and narrative synthesis Open
Necrotizing enterocolitis (NEC) is a devastating gastrointestinal disorder in preterm infants with a high mortality rate. The aetiology of NEC appears to be multifaceted; however, gut microbiota dysbiosis likely plays a significant role. T…
View article: Sequencing of <i>Mycoplasma genitalium</i> genomes using a tiling amplicon method on the Nanopore MinION
Sequencing of <i>Mycoplasma genitalium</i> genomes using a tiling amplicon method on the Nanopore MinION Open
Mycoplasma genitalium is challenging to work with and new methods are needed to study this bacterium directly in clinical samples. This study designed and validated a proof-of-concept polymerase chain reaction (PCR)-based ‘tiling’ methodol…
View article: Gut microbiota composition in preterm infants with and without necrotizing enterocolitis: A systematic review and narrative synthesis
Gut microbiota composition in preterm infants with and without necrotizing enterocolitis: A systematic review and narrative synthesis Open
Aim Necrotizing enterocolitis (NEC) is a devastating gastrointestinal disorder in preterm infants with a high mortality rate. The etiology of NEC appears to be multifaceted; however, gut microbiota dysbiosis likely plays a significant role…
View article: Factors that contribute to the success of primary isolation of Mycoplasma genitalium from clinical samples
Factors that contribute to the success of primary isolation of Mycoplasma genitalium from clinical samples Open
Introduction. Mycoplasma genitalium , a small and slow-growing bacterium, has gained notoriety due to rapidly increasing rates of antibiotic resistance. Gap Statement. M. genitalium is difficult to culture, limiting efforts to understand i…
View article: Efficacy and tolerability of the combination of minocycline and metronidazole for macrolide-resistant <i>Mycoplasma genitalium</i>
Efficacy and tolerability of the combination of minocycline and metronidazole for macrolide-resistant <i>Mycoplasma genitalium</i> Open
Background and objectives Curing Mycoplasma genitalium is challenging in the context of rising antimicrobial resistance and limited therapeutic options. There is an urgent need for globally relevant and effective treatment options using re…
View article: Evolving patterns of macrolide and fluoroquinolone resistance in Mycoplasma genitalium: an updated systematic review and meta-analysis
Evolving patterns of macrolide and fluoroquinolone resistance in Mycoplasma genitalium: an updated systematic review and meta-analysis Open
Australian Research Council.
View article: Getting Everyone on Board to Break the Cycle of Bacterial Vaginosis (BV) Recurrence: A Qualitative Study of Partner Treatment for BV
Getting Everyone on Board to Break the Cycle of Bacterial Vaginosis (BV) Recurrence: A Qualitative Study of Partner Treatment for BV Open
These findings suggest that the widescale adoption of MPT for BV will require multilevel approaches to address gaps in the awareness of BV with sensitivity to the relational, social, and structural context of delivering care.
View article: Diversity of Mycoplasma genitalium strains in Australia: relationship with sexual networks and antimicrobial resistance
Diversity of Mycoplasma genitalium strains in Australia: relationship with sexual networks and antimicrobial resistance Open
Purpose Molecular typing can identify relationships between M. genitalium strains and antimicrobial resistance and demographic data. We examined the association of mgpB sequence types (STs) with sex/sexual orientation, antimicrobial resist…
View article: Trends in infections detected in women with cervicitis over a decade
Trends in infections detected in women with cervicitis over a decade Open
Objectives There is a growing body of evidence that in the absence of Chlamydia trachomatis and/or Neisseria gonorrhoeae, Mycoplasma genitalium and bacterial vaginosis (BV) are associated with cervicitis. We aimed to describe infections de…
View article: The genital tract microbiota of IVF patients and oocyte donors: a comparative analysis
The genital tract microbiota of IVF patients and oocyte donors: a comparative analysis Open
Recent studies have observed an association between genital tract microbiota and reproductive outcomes in patients undergoing in vitro fertilization (IVF). This finding could be caused by ascending dysbiosis from the vagina to the endometr…
View article: Vaginal anaerobes are associated with cervicitis: A case-control study
Vaginal anaerobes are associated with cervicitis: A case-control study Open
We report a positive association between non-optimal vaginal microbiota composition and STI-negative cervicitis. Specific anaerobic BV-associated bacteria may represent infectious causes of cervicitis.
View article: Systematic Review and Meta-analysis of the Association Between<i>Mycoplasma Genitalium</i>and Pelvic Inflammatory Disease (PID)
Systematic Review and Meta-analysis of the Association Between<i>Mycoplasma Genitalium</i>and Pelvic Inflammatory Disease (PID) Open
Background Differences in opinion concerning the contribution of Mycoplasma genitalium to pelvic inflammatory disease (PID) has resulted in inconsistencies across global testing and treatment guidelines. We conducted a systematic review an…
View article: Economic evaluation alongside a clinical trial of near-to-patient testing for sexually transmitted infections
Economic evaluation alongside a clinical trial of near-to-patient testing for sexually transmitted infections Open
We found that NPT is cost-saving compared with standard clinical care for individuals with STI symptoms and sexual contacts of CT, NG, and MG.
View article: Near-to-patient-testing to inform targeted antibiotic use for sexually transmitted infections in a public sexual health clinic: the NEPTUNE cohort study
Near-to-patient-testing to inform targeted antibiotic use for sexually transmitted infections in a public sexual health clinic: the NEPTUNE cohort study Open
ARC ITRP Hub-grant; NHMRC.
View article: Efficacy of Sitafloxacin for <i>Mycoplasma genitalium</i> in an Era of Increasing Antimicrobial Resistance
Efficacy of Sitafloxacin for <i>Mycoplasma genitalium</i> in an Era of Increasing Antimicrobial Resistance Open
Antimicrobial resistance in Mycoplasma genitalium is rising globally and antimicrobial options are limited. We evaluated the efficacy of sitafloxacin regimens for macrolide-resistant M genitalium at Melbourne Sexual Health Centre, Australi…
View article: Efficacy of Minocycline for the Treatment of<i>Mycoplasma genitalium</i>
Efficacy of Minocycline for the Treatment of<i>Mycoplasma genitalium</i> Open
Background High levels of macrolide resistance and increasing fluoroquinolone resistance are making Mycoplasma genitalium increasingly difficult to treat. Minocycline is an alternative treatment for patients with macrolide-resistant M geni…
View article: <i>Prevotella</i> and <i>Gardnerella</i> Are Associated With Treatment Failure Following First-line Antibiotics for Bacterial Vaginosis
<i>Prevotella</i> and <i>Gardnerella</i> Are Associated With Treatment Failure Following First-line Antibiotics for Bacterial Vaginosis Open
Background Bacterial vaginosis (BV) is a common vaginal dysbiosis that often recurs following first-line antibiotics. We investigated if vaginal microbiota composition was associated with BV recurrence. Methods We analyzed samples and data…
View article: <i>gyrA</i> Mutations in <i>Mycoplasma genitalium</i> and Their Contribution to Moxifloxacin Failure: Time for the Next Generation of Resistance-Guided Therapy
<i>gyrA</i> Mutations in <i>Mycoplasma genitalium</i> and Their Contribution to Moxifloxacin Failure: Time for the Next Generation of Resistance-Guided Therapy Open
Background Although single nucleotide polymorphisms (SNPs) in Mycoplasma genitalium parC contribute to fluoroquinolone treatment failure, data are limited for the homologous gene, gyrA. This study investigated the prevalence of gyrA SNPs a…
View article: Comparison of Seegene AnyPlexTM II STI-7e with standard-of-care diagnostic methods for the detection of <i>Mycoplasma genitalium, Chlamydia trachomatis, Neisseria gonorrhoeae</i>, and <i>Trichomonas vaginalis</i>
Comparison of Seegene AnyPlexTM II STI-7e with standard-of-care diagnostic methods for the detection of <i>Mycoplasma genitalium, Chlamydia trachomatis, Neisseria gonorrhoeae</i>, and <i>Trichomonas vaginalis</i> Open
The AnyPlexTM II STI-7e panel assay (Seegene) detects seven sexually transmitted organisms (Chlamydia trachomatis, Neisseria gonorrhoeae, Mycoplasma genitalium, M. hominis, Ureaplasma urealyticum, U. parvum, and Trichomonas vaginalis). Thi…
View article: Time to healthcare seeking following the onset of symptoms among men and women attending a sexual health clinic in Melbourne, Australia
Time to healthcare seeking following the onset of symptoms among men and women attending a sexual health clinic in Melbourne, Australia Open
Background Timely diagnosis and treatment of sexually transmitted infections (STIs) underpin their control by reducing the duration of infectiousness. There are currently limited data exploring healthcare seeking among individuals with STI…
View article: The Urethral Microbiota of Men with and without Idiopathic Urethritis
The Urethral Microbiota of Men with and without Idiopathic Urethritis Open
Nongonococcal urethritis (NGU) is the commonest genital tract syndrome in men and is nearly universally presumptively treated with an antibiotic. Common causes of NGU include Chlamydia trachomatis and Mycoplasma genitalium , but in more th…
View article: Positivity and Risk Factors for Trichomonas vaginalis Among Women Attending a Sexual Health Clinic in Melbourne, 2006 to 2019
Positivity and Risk Factors for Trichomonas vaginalis Among Women Attending a Sexual Health Clinic in Melbourne, 2006 to 2019 Open
Background Trichomonas vaginalis is not a notifiable disease in Australia in most states, resulting in limited Australian epidemiological studies. This study aimed to examine the positivity of T. vaginalis in women attending the Melbourne …
View article: <i>parC</i> Variants in Mycoplasma genitalium: Trends over Time and Association with Moxifloxacin Failure
<i>parC</i> Variants in Mycoplasma genitalium: Trends over Time and Association with Moxifloxacin Failure Open
Prevalence, trends, and treatment outcome estimates were generated for parC variants in macrolide-resistant Mycoplasma genitalium . Among 539 cases, the most common amino acid change was S83I, which increased from 13% in 2012 to 2013, to 2…
View article: Impact of 16S rRNA Single Nucleotide Polymorphisms on Mycoplasma genitalium Organism Load with Doxycycline Treatment
Impact of 16S rRNA Single Nucleotide Polymorphisms on Mycoplasma genitalium Organism Load with Doxycycline Treatment Open
Doxycycline targets the 16S rRNA and is widely used for the treatment of sexually transmitted infections. While it is not highly effective at eradicating Mycoplasma genitalium infections, it can reduce organism load.
View article: The Impact of Mouthwash on the Oropharyngeal Microbiota of Men Who Have Sex with Men: a Substudy of the OMEGA Trial
The Impact of Mouthwash on the Oropharyngeal Microbiota of Men Who Have Sex with Men: a Substudy of the OMEGA Trial Open
Given the role of the oral microbiota in human health, it is important to understand if and how external factors influence its composition. Mouthwash use is common in some populations, and the use of antiseptic mouthwash has been proposed …