Hsiang–Po Huang
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View article: Metabolomics-Based Liquid Biopsy for Predicting Clinically Significant Prostate Cancer
Metabolomics-Based Liquid Biopsy for Predicting Clinically Significant Prostate Cancer Open
Prostate cancer (PC) remains a major cause of cancer deaths in men. The serum biomarker prostate-specific antigen (PSA) lacks specificity in distinguishing clinically significant PC (sPC) from insignificant PC (isPC), leading to overdiagno…
View article: Optimizing Osimertinib for NSCLC: Targeting Resistance and Exploring Combination Therapeutics
Optimizing Osimertinib for NSCLC: Targeting Resistance and Exploring Combination Therapeutics Open
Non-small-cell lung cancer (NSCLC) is a leading cause of cancer-related deaths worldwide, with epidermal growth factor receptor (EGFR) mutations present in a substantial proportion of patients. Third-generation EGFR tyrosine kinase inhibit…
View article: Generation of a human induced pluripotent stem cell line NTUHi006-A from a polycystic ovarian syndrome patient
Generation of a human induced pluripotent stem cell line NTUHi006-A from a polycystic ovarian syndrome patient Open
Polycystic ovary syndrome (PCOS) is a common endocrine disorder related to multifactors and genetic polymorphisms. Here, we derived an induced pluripotent stem cell (hiPSC) line NTUHi006-A from a phenotype A (full-blown) PCOS patients with…
View article: The Innovative Role of Nuclear Receptor Interaction Protein in Orchestrating Invadosome Formation for Myoblast Fusion
The Innovative Role of Nuclear Receptor Interaction Protein in Orchestrating Invadosome Formation for Myoblast Fusion Open
Background Nuclear receptor interaction protein (NRIP) is versatile and engages with various proteins to execute its diverse biological function. NRIP deficiency was reported to cause small myofibre size in adult muscle regeneration, indic…
View article: Predicting Clinically Significant Prostate Cancer Using Urine Metabolomics via Liquid Chromatography Mass Spectrometry
Predicting Clinically Significant Prostate Cancer Using Urine Metabolomics via Liquid Chromatography Mass Spectrometry Open
Urinary metabolomic profiles with baseline clinical factors may accurately predict sPC in men with elevated risk before biopsy.
View article: Prediction of clinically significant prostate cancer through urine metabolomic signatures: A large-scale validated study
Prediction of clinically significant prostate cancer through urine metabolomic signatures: A large-scale validated study Open
Purpose Currently, there are no accurate markers for predicting potentially lethal prostate cancer (PC) before biopsy. This study aimed to develop urine tests to predict clinically significant PC (sPC) in men at risk. Methods Urine samples…
View article: Data from CD248 Regulates Wnt Signaling in Pericytes to Promote Angiogenesis and Tumor Growth in Lung Cancer
Data from CD248 Regulates Wnt Signaling in Pericytes to Promote Angiogenesis and Tumor Growth in Lung Cancer Open
The tumor microenvironment plays a central role in cancer initiation and progression. CD248 is expressed in tumor-associated stromal cells, particularly fibroblasts and pericytes. Exploring the function of CD248 has the potential to provid…
View article: Data from CD248 Regulates Wnt Signaling in Pericytes to Promote Angiogenesis and Tumor Growth in Lung Cancer
Data from CD248 Regulates Wnt Signaling in Pericytes to Promote Angiogenesis and Tumor Growth in Lung Cancer Open
The tumor microenvironment plays a central role in cancer initiation and progression. CD248 is expressed in tumor-associated stromal cells, particularly fibroblasts and pericytes. Exploring the function of CD248 has the potential to provid…
View article: Supplementary Data from CD248 Regulates Wnt Signaling in Pericytes to Promote Angiogenesis and Tumor Growth in Lung Cancer
Supplementary Data from CD248 Regulates Wnt Signaling in Pericytes to Promote Angiogenesis and Tumor Growth in Lung Cancer Open
Supplementary Data from CD248 Regulates Wnt Signaling in Pericytes to Promote Angiogenesis and Tumor Growth in Lung Cancer
View article: Supplementary Data from CD248 Regulates Wnt Signaling in Pericytes to Promote Angiogenesis and Tumor Growth in Lung Cancer
Supplementary Data from CD248 Regulates Wnt Signaling in Pericytes to Promote Angiogenesis and Tumor Growth in Lung Cancer Open
Supplementary Data from CD248 Regulates Wnt Signaling in Pericytes to Promote Angiogenesis and Tumor Growth in Lung Cancer
View article: Supplementary Figures S1-S5 from Androgen-Induced TMPRSS2 Activates Matriptase and Promotes Extracellular Matrix Degradation, Prostate Cancer Cell Invasion, Tumor Growth, and Metastasis
Supplementary Figures S1-S5 from Androgen-Induced TMPRSS2 Activates Matriptase and Promotes Extracellular Matrix Degradation, Prostate Cancer Cell Invasion, Tumor Growth, and Metastasis Open
Supplementary Figures S1-S5. Identification of TMPRSS2 as a mediator of androgen-induced prostate cancer cell invasion (S1); TMPRSS2 induced matriptase activation in prostate cancer cells (S2); TMPRSS2 promoted matriptase activation and th…
View article: Supplementary Figure Legend from Androgen-Induced TMPRSS2 Activates Matriptase and Promotes Extracellular Matrix Degradation, Prostate Cancer Cell Invasion, Tumor Growth, and Metastasis
Supplementary Figure Legend from Androgen-Induced TMPRSS2 Activates Matriptase and Promotes Extracellular Matrix Degradation, Prostate Cancer Cell Invasion, Tumor Growth, and Metastasis Open
Supplementary Figure Legend. Legend for Supplementary Figures S1-S5.
View article: Supplementary Figures S1-S5 from Androgen-Induced TMPRSS2 Activates Matriptase and Promotes Extracellular Matrix Degradation, Prostate Cancer Cell Invasion, Tumor Growth, and Metastasis
Supplementary Figures S1-S5 from Androgen-Induced TMPRSS2 Activates Matriptase and Promotes Extracellular Matrix Degradation, Prostate Cancer Cell Invasion, Tumor Growth, and Metastasis Open
Supplementary Figures S1-S5. Identification of TMPRSS2 as a mediator of androgen-induced prostate cancer cell invasion (S1); TMPRSS2 induced matriptase activation in prostate cancer cells (S2); TMPRSS2 promoted matriptase activation and th…
View article: Supplementary Tables S1-S4 from Androgen-Induced TMPRSS2 Activates Matriptase and Promotes Extracellular Matrix Degradation, Prostate Cancer Cell Invasion, Tumor Growth, and Metastasis
Supplementary Tables S1-S4 from Androgen-Induced TMPRSS2 Activates Matriptase and Promotes Extracellular Matrix Degradation, Prostate Cancer Cell Invasion, Tumor Growth, and Metastasis Open
Supplementary Tables S1-S4. Oligonucleotide primers used in this study (S1); Antibodies used in this study (S2); List of proteins identified from the conditioned media by LC-MS/MS analysis (S3); List of protein identities in the 160-kDa ba…
View article: Data from Androgen-Induced TMPRSS2 Activates Matriptase and Promotes Extracellular Matrix Degradation, Prostate Cancer Cell Invasion, Tumor Growth, and Metastasis
Data from Androgen-Induced TMPRSS2 Activates Matriptase and Promotes Extracellular Matrix Degradation, Prostate Cancer Cell Invasion, Tumor Growth, and Metastasis Open
Dysregulation of androgen signaling and pericellular proteolysis is necessary for prostate cancer progression, but the links between them are still obscure. In this study, we show how the membrane-anchored serine protease TMPRSS2 stimulate…
View article: Supplementary Methods and Reference from Androgen-Induced TMPRSS2 Activates Matriptase and Promotes Extracellular Matrix Degradation, Prostate Cancer Cell Invasion, Tumor Growth, and Metastasis
Supplementary Methods and Reference from Androgen-Induced TMPRSS2 Activates Matriptase and Promotes Extracellular Matrix Degradation, Prostate Cancer Cell Invasion, Tumor Growth, and Metastasis Open
Supplementary Methods and Reference. Description of additional methods and procedures used in the study. Also includes Supplementary Reference.
View article: Supplementary Tables S1-S4 from Androgen-Induced TMPRSS2 Activates Matriptase and Promotes Extracellular Matrix Degradation, Prostate Cancer Cell Invasion, Tumor Growth, and Metastasis
Supplementary Tables S1-S4 from Androgen-Induced TMPRSS2 Activates Matriptase and Promotes Extracellular Matrix Degradation, Prostate Cancer Cell Invasion, Tumor Growth, and Metastasis Open
Supplementary Tables S1-S4. Oligonucleotide primers used in this study (S1); Antibodies used in this study (S2); List of proteins identified from the conditioned media by LC-MS/MS analysis (S3); List of protein identities in the 160-kDa ba…
View article: Data from Androgen-Induced TMPRSS2 Activates Matriptase and Promotes Extracellular Matrix Degradation, Prostate Cancer Cell Invasion, Tumor Growth, and Metastasis
Data from Androgen-Induced TMPRSS2 Activates Matriptase and Promotes Extracellular Matrix Degradation, Prostate Cancer Cell Invasion, Tumor Growth, and Metastasis Open
Dysregulation of androgen signaling and pericellular proteolysis is necessary for prostate cancer progression, but the links between them are still obscure. In this study, we show how the membrane-anchored serine protease TMPRSS2 stimulate…
View article: Supplementary Figure Legend from Androgen-Induced TMPRSS2 Activates Matriptase and Promotes Extracellular Matrix Degradation, Prostate Cancer Cell Invasion, Tumor Growth, and Metastasis
Supplementary Figure Legend from Androgen-Induced TMPRSS2 Activates Matriptase and Promotes Extracellular Matrix Degradation, Prostate Cancer Cell Invasion, Tumor Growth, and Metastasis Open
Supplementary Figure Legend. Legend for Supplementary Figures S1-S5.
View article: Supplementary Methods and Reference from Androgen-Induced TMPRSS2 Activates Matriptase and Promotes Extracellular Matrix Degradation, Prostate Cancer Cell Invasion, Tumor Growth, and Metastasis
Supplementary Methods and Reference from Androgen-Induced TMPRSS2 Activates Matriptase and Promotes Extracellular Matrix Degradation, Prostate Cancer Cell Invasion, Tumor Growth, and Metastasis Open
Supplementary Methods and Reference. Description of additional methods and procedures used in the study. Also includes Supplementary Reference.
View article: An induced pluripotent stem cell-based model identifies molecular targets of vincristine neurotoxicity
An induced pluripotent stem cell-based model identifies molecular targets of vincristine neurotoxicity Open
To model peripheral nerve degeneration and investigate molecular mechanisms of neurodegeneration, we established a cell system of induced pluripotent stem cell (iPSC)-derived sensory neurons exposed to vincristine, a drug that frequently c…
View article: CD248 Regulates Wnt Signaling in Pericytes to Promote Angiogenesis and Tumor Growth in Lung Cancer
CD248 Regulates Wnt Signaling in Pericytes to Promote Angiogenesis and Tumor Growth in Lung Cancer Open
The tumor microenvironment plays a central role in cancer initiation and progression. CD248 is expressed in tumor-associated stromal cells, particularly fibroblasts and pericytes. Exploring the function of CD248 has the potential to provid…
View article: Neuronal splicing regulator RBFOX3 mediates seizures via regulating <i>Vamp1</i> expression preferentially in NPY-expressing GABAergic neurons
Neuronal splicing regulator RBFOX3 mediates seizures via regulating <i>Vamp1</i> expression preferentially in NPY-expressing GABAergic neurons Open
Epilepsy is a common neurological disorder, which has been linked to mutations or deletions of RNA binding protein, fox-1 homolog ( Caenorhabditis elegans ) 3 ( RBFOX3 )/ NeuN , a neuronal splicing regulator. However, the mechanism of seiz…
View article: RTL1/PEG11 imprinted in human and mouse brain mediates anxiety-like and social behaviors and regulates neuronal excitability in the locus coeruleus
RTL1/PEG11 imprinted in human and mouse brain mediates anxiety-like and social behaviors and regulates neuronal excitability in the locus coeruleus Open
RTL1/PEG11, which has been associated with anxiety disorders, is a retrotransposon-derived imprinted gene in the placenta. However, imprinting patterns and functions of RTL1 in the brain have not been well-investigated. We found Rtl1 was p…
View article: LMNB1, a potential marker for early prostate cancer progression.
LMNB1, a potential marker for early prostate cancer progression. Open
Although prostate cancer (PC) is the most common cancer among men in the Western world, there are no good biomarkers that can reliably differentiate between potentially aggressive and indolent PC. This leads to overtreatment, even for pati…
View article: Copy number variant hotspots in Han Taiwanese population induced pluripotent stem cell lines - lessons from establishing the Taiwan human disease iPSC Consortium Bank
Copy number variant hotspots in Han Taiwanese population induced pluripotent stem cell lines - lessons from establishing the Taiwan human disease iPSC Consortium Bank Open
Background The Taiwan Human Disease iPSC Service Consortium was established to accelerate Taiwan’s growing stem cell research initiatives and provide a platform for researchers interested in utilizing induced pluripotent stem cell (iPSC) t…