Po‐Liang Lu
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View article: Efficacy of same-day initiation of antiretroviral therapy with coformulated bictegravir, emtricitabine, and tenofovir alafenamide: Week 48 results of a single-arm, open-label, multicenter clinical trial
Efficacy of same-day initiation of antiretroviral therapy with coformulated bictegravir, emtricitabine, and tenofovir alafenamide: Week 48 results of a single-arm, open-label, multicenter clinical trial Open
Initiation of BIC/FTC/TAF on the same day of HIV diagnosis is feasible, safe, and efficacious in achieving virologic suppression and engagement in care.
View article: Quality of Life and Treatment Satisfaction in People with HIV Switching to Bictegravir/Emtricitabine/Tenofovir Alafenamide: Pooled Analysis from Observational Cohort Studies
Quality of Life and Treatment Satisfaction in People with HIV Switching to Bictegravir/Emtricitabine/Tenofovir Alafenamide: Pooled Analysis from Observational Cohort Studies Open
ClinicalTrials.gov identifiers NCT03580668 (Canada study) and NCT04009057 (Israel study); EudraCT trial identifier, EUPAS22185 (Europe study). Video abstract available for this article. Quality of life and treatment satisfaction in people …
View article: Gaps in the HIV self-testing cascade among people with HIV in Taiwan: Usage patterns, barriers, and public health implications
Gaps in the HIV self-testing cascade among people with HIV in Taiwan: Usage patterns, barriers, and public health implications Open
High attrition in the HIV-ST cascade, due to low awareness, and delays in confirmatory testing, driven by fear of negative consequences, undermine its public health impact. Optimizing its utility requires dual strategies: targeted campaign…
View article: Evaluation of thermal desorption–electrospray ionization mass spectrometry for characterization of Mycobacterium tuberculosis: Comparison with MIRU-VNTR and whole-genome sequencing
Evaluation of thermal desorption–electrospray ionization mass spectrometry for characterization of Mycobacterium tuberculosis: Comparison with MIRU-VNTR and whole-genome sequencing Open
Although TD-ESI/MS does not generate similar results from MTB molecular typing, it shows potential for identifying specific spectral signatures. The technique may be useful in future investigations into phenotypic diversity and other clini…
View article: Clinical insights into mixed <i>Candida</i> and bacterial bloodstream infections: a retrospective cohort study
Clinical insights into mixed <i>Candida</i> and bacterial bloodstream infections: a retrospective cohort study Open
Mixed bloodstream infections (BSIs) involving Candida and other bacterial pathogens present significant diagnostic and therapeutic challenges. The incidence of these co-infections has been increasing. However, the limited literature on thi…
View article: Enzyme-linked immunosorbent STI assays: development, current status and future perspective
Enzyme-linked immunosorbent STI assays: development, current status and future perspective Open
Sexually transmitted infections (STIs) continue to pose major public health challenges globally, with millions of new cases reported annually. The asymptomatic characteristic of many STIs makes accurate and cost-effective diagnostic method…
View article: Longitudinal molecular epidemiology of ceftriaxone-resistant enterobacterales in intra-abdominal and urinary tract infections: A decade-long SMART surveillance study in Taiwan (2009–2019)
Longitudinal molecular epidemiology of ceftriaxone-resistant enterobacterales in intra-abdominal and urinary tract infections: A decade-long SMART surveillance study in Taiwan (2009–2019) Open
A high prevalence and diversity of AmpC genes were observed in E. coli and K. pneumoniae. The limited activity of ertapenem and ceftolozane/tazobactam suggests that the molecular mechanisms underlying ceftriaxone-resistant Enterobacterales…
View article: A comparative analysis of HbA1c, glycated albumin, and fasting plasma glucose for glycemic assessment in people living with HIV
A comparative analysis of HbA1c, glycated albumin, and fasting plasma glucose for glycemic assessment in people living with HIV Open
HbA1c or GA alone do not reliably capture glycemic abnormalities in PLWH. A lower GA cut-off (12.42 %) for prediabetes improves sensitivity but remains suboptimal. A combined approach incorporating FPG is recommended to enhance prediabetes…
View article: Real-world viral effectiveness of two-drug versus three-drug regimens for HIV in Taiwan: Impact of adherence and treatment selection
Real-world viral effectiveness of two-drug versus three-drug regimens for HIV in Taiwan: Impact of adherence and treatment selection Open
Adherence, not regimen type, is the key factor affecting viral suppression. Nevertheless, the findings should be cautiously interpreted because of potential bias and small subgroup sizes. Further prospective studies should evaluate the com…
View article: <i>In Silico</i> Design of Antimicrobial Peptides against Carbapenem-Resistant <i>Acinetobacter baumannii</i> Infections with Enhanced Activity by Nanoformulation
<i>In Silico</i> Design of Antimicrobial Peptides against Carbapenem-Resistant <i>Acinetobacter baumannii</i> Infections with Enhanced Activity by Nanoformulation Open
Carbapenem-resistant Acinetobacter baumannii (CRAB) has emerged as a critical public health menace. Its resistance to last-resort antibiotics highlights the urgent need for innovative treatment approaches. Antimicrobial peptides (AMPs) are…
View article: <i>In vitro</i> activity of isavuconazole, ravuconazole, and comparison of the Sensititre YeastOne and CLSI broth microdilution methods against clinical isolates of <i>Trichosporon</i> species
<i>In vitro</i> activity of isavuconazole, ravuconazole, and comparison of the Sensititre YeastOne and CLSI broth microdilution methods against clinical isolates of <i>Trichosporon</i> species Open
This study aimed to evaluate the in vitro activity of isavuconazole and ravuconazole against clinical Trichosporon isolates. Additionally, we assessed the performance of the Sensititre YeastOne (SYO) assay compared to the reference Clinica…
View article: Prevalence and treatment outcomes of latent tuberculosis infection among older patients with chronic obstructive pulmonary disease in an area with intermediate tuberculosis burden
Prevalence and treatment outcomes of latent tuberculosis infection among older patients with chronic obstructive pulmonary disease in an area with intermediate tuberculosis burden Open
ABSTRACTChronic obstructive pulmonary disease (COPD) and aging both increase the risk of tuberculosis (TB), an important infectious disease in human. Exploring the burden and predictors of latent tuberculosis infection (LTBI) and treatment…
View article: Do Hospitalized Adult Patients with Acute Pharyngotonsillitis Need Empiric Antibiotics? The Impact on Antimicrobial Stewardship
Do Hospitalized Adult Patients with Acute Pharyngotonsillitis Need Empiric Antibiotics? The Impact on Antimicrobial Stewardship Open
Acute pharyngotonsillitis is a common reason to visit primary care providers. Group A Streptococcal (GAS) pharyngitis is the most common bacterial infection which needs antibiotic treatment. GAS accounts for only 10–15% of adult acute phar…
View article: Real-world use and treatment outcomes of ceftazidime-avibactam in gram-negative bacterial infection in Taiwan: A multicenter retrospective study
Real-world use and treatment outcomes of ceftazidime-avibactam in gram-negative bacterial infection in Taiwan: A multicenter retrospective study Open
Most patients receiving CAZ-AVI as targeted therapy in Taiwan with characteristics of older age, high SOFA scores, and high CCI scores. Receiving immunomodulators, higher SOFA score, and Enterobacter spp. infections were the significant fa…
View article: Prevalence of Naturally Occurring HIV-1 Capsid Inhibitor Resistance–Related Mutations in Antiretroviral Therapy–Naïve and –Experienced Individuals in Taiwan
Prevalence of Naturally Occurring HIV-1 Capsid Inhibitor Resistance–Related Mutations in Antiretroviral Therapy–Naïve and –Experienced Individuals in Taiwan Open
Background It is generally believed that HIV-1 capsid inhibitor–naïve populations are susceptible to capsid inhibitors. Moreover, conventional HIV-1 resistance genotyping does not include the CA region, leading to limited surveillance data…
View article: Implementation of 2% Chlorhexidine Bathing to Reduce Healthcare-Associated Infections Among Patients in the Intensive Care Unit
Implementation of 2% Chlorhexidine Bathing to Reduce Healthcare-Associated Infections Among Patients in the Intensive Care Unit Open
Healthcare-associated infections (HAIs) significantly increase morbidity, mortality, length of hospital stays, and costs, particularly among ICU patients. Despite standard interventions, catheter-associated urinary tract infections (CAUTI)…
View article: Implementation of 2% Chlorhexidine Bathing to Reduce Healthcare Associated Infections among Patients in the Intensive Care Unit
Implementation of 2% Chlorhexidine Bathing to Reduce Healthcare Associated Infections among Patients in the Intensive Care Unit Open
Healthcare-associated infections (HAI) significantly increase morbidity, mortality, length of hospital stays, and costs, particularly among ICU patients. Despite standard interventions, catheter-associated urinary tract infections (CAUTI) …
View article: Development of the novel gene chip and restriction fragment length polymorphism (RFLP) methods for rapid detection of Mycobacterium tuberculosis complex in broth culture
Development of the novel gene chip and restriction fragment length polymorphism (RFLP) methods for rapid detection of Mycobacterium tuberculosis complex in broth culture Open
Our novel gene chip and RFLP methods are effective for rapid highly-reliable and cost-effective M. tuberculosis detection in MGIT specimens. Both gene chip and RFLP methods are suitable for resource-limited settings, offering an economical…
View article: Characteristics and Prevalence of Vancomycin-variable Enterococcus faecium bacteremia in southern Taiwan
Characteristics and Prevalence of Vancomycin-variable Enterococcus faecium bacteremia in southern Taiwan Open
The prevalence of VVE was high among E. faecium isolates with vancomycin-susceptible phenotypes in southern Taiwan. Although the current study revealed that VVE bacteremia was not associated with poor clinical outcome, further multicenter …
View article: Phylogeographic Analysis of <i>Mycobacterium kansasii</i> Isolates from Patients with <i>M. kansasii</i> Lung Disease in Industrialized City, Taiwan
Phylogeographic Analysis of <i>Mycobacterium kansasii</i> Isolates from Patients with <i>M. kansasii</i> Lung Disease in Industrialized City, Taiwan Open
Little is known about environmental transmission of Mycobacterium kansasii. We retrospectively investigated potential environmental acquisition, primarily water sources, of M. kansasii among 216 patients with pulmonary disease from an indu…
View article: Multicenter study on clinical outcomes and poor prognostic factors in patients with Klebsiella pneumoniae bacteremia receiving cefoperazone/sulbactam treatment
Multicenter study on clinical outcomes and poor prognostic factors in patients with Klebsiella pneumoniae bacteremia receiving cefoperazone/sulbactam treatment Open
Background Infections caused by Klebsiella pneumoniae are common and result in high mortality rates. In vitro studies demonstrated the potency of cefoperazone/sulbactam (CPZ/SUL) against Klebsiella pneumoniae . However, the clinical effica…
View article: One-month daily and three-month weekly rifapentine plus isoniazid are comparable in completion rate and safety for latent tuberculosis infection in non-HIV Population: a randomized controlled trial
One-month daily and three-month weekly rifapentine plus isoniazid are comparable in completion rate and safety for latent tuberculosis infection in non-HIV Population: a randomized controlled trial Open
In non-HIV population, the incidence rate of SDR under 1HP is not lower than 3HP. Notably, urticaria, rather than flu-like syndrome, was the predominant SDR associated 1HP. The findings of this study underscore the feasibility of 1HP regim…
View article: Sputum bacterial microbiota signature as a surrogate for predicting disease progression of nontuberculous mycobacterial lung disease
Sputum bacterial microbiota signature as a surrogate for predicting disease progression of nontuberculous mycobacterial lung disease Open
Identification of the composition of sputum bacterial microbiome facilitates prediction of the course of NTM-LD, and maybe used to develop precision treatment involving modulating the respiratory microbiome composition to ameliorate NTM-LD.
View article: Epidemiology and antimicrobial susceptibility profiles of Enterobacterales causing bloodstream infections before and during COVID-19 pandemic: Results of the Study for Monitoring Antimicrobial Resistance Trends (SMART) in Taiwan, 2018–2021
Epidemiology and antimicrobial susceptibility profiles of Enterobacterales causing bloodstream infections before and during COVID-19 pandemic: Results of the Study for Monitoring Antimicrobial Resistance Trends (SMART) in Taiwan, 2018–2021 Open
The COVID-19 pandemic appears to be associated with a general decrease in antimicrobial susceptibility rates among Enterobacterales causing BSIs in Taiwan. Continuous surveillance is crucial to monitor antimicrobial resistance during the p…
View article: Enhancing indicator condition–guided HIV testing in Taiwan: a nationwide case–control study from 2009 to 2015
Enhancing indicator condition–guided HIV testing in Taiwan: a nationwide case–control study from 2009 to 2015 Open
Background Although indicator condition (IC)-guided HIV testing (IC-HIVT) is effective at facilitating timely HIV diagnosis, research on IC categories and the related HIV risk in Taiwan is limited. To improve the adoption and spread of IC-…
View article: Multicenter study on clinical outcomes and risk factors in patients with Klebsiella pneumoniae bacteremia receiving cefoperazone/sulbactam treatment
Multicenter study on clinical outcomes and risk factors in patients with Klebsiella pneumoniae bacteremia receiving cefoperazone/sulbactam treatment Open
Background Infections caused by Klebsiella pneumoniae are common and result in high mortality rates. In vitro studies demonstrated the potency of cefoperazone/sulbactam (CPZ/SUL) against Klebsiella pneumoniae . However, the clinical effica…
View article: Trends and the associated factors of optimal immunological response and virological response in late anti-retroviral therapy initiation HIV cases in Taiwan from 2009 to 2020
Trends and the associated factors of optimal immunological response and virological response in late anti-retroviral therapy initiation HIV cases in Taiwan from 2009 to 2020 Open
Our study identified several modifiable factors for optimal IR (rapid cART initiation and INSTI-based regimen initiation) and for optimal VR (STR initiation) among late initiators, which may guide early treatment modifications to reduce th…