Pochuen Shieh
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View article: Association of<i>Matrix Metalloproteinase-1</i>Promoter Genotypes With Endometriosis Risk
Association of<i>Matrix Metalloproteinase-1</i>Promoter Genotypes With Endometriosis Risk Open
The 1G allele of MMP-1 rs1799750 is associated with reduced susceptibility to endometriosis in the Taiwanese population. These results highlight the potential of MMP-1 rs1799750 polymorphism as a protective genetic marker, warranting furth…
View article: Kuei-Lu-Er-Xian-Jiao extract enhances BMP-2 production in osteoblasts
Kuei-Lu-Er-Xian-Jiao extract enhances BMP-2 production in osteoblasts Open
View article: Metformin induces autophagy of cisplatin-resistant human gastric cancer cells in addition to apoptosis
Metformin induces autophagy of cisplatin-resistant human gastric cancer cells in addition to apoptosis Open
Metformin has been used to treat cases of type 2 diabetes mellitus, and mounting studies have shown that metformin can act alone or in synergy with other anticancer agents to achieve anti-cancer efficacies on various types of tumors. Howev…
View article: A New Pharmacological Vitreolysis through the Supplement of Mixed Fruit Enzymes for Patients with Ocular Floaters or Vitreous Hemorrhage-Induced Floaters
A New Pharmacological Vitreolysis through the Supplement of Mixed Fruit Enzymes for Patients with Ocular Floaters or Vitreous Hemorrhage-Induced Floaters Open
Purpose: Ocular floaters caused by vitreous degeneration or blood clots may interfere with various visual functions. Our study investigated the pharmacologic effects of oral supplementation of mixed fruit enzymes (MFEs) for treating sponta…
View article: CCDC 2068900: Experimental Crystal Structure Determination
CCDC 2068900: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Improvement of Presbyopia Using a Mixture of Traditional Chinese Herbal Medicines, Including Cassiae Semen, Wolfberry, and Dendrobium huoshanense
Improvement of Presbyopia Using a Mixture of Traditional Chinese Herbal Medicines, Including Cassiae Semen, Wolfberry, and Dendrobium huoshanense Open
Background. Presbyopia is a primary cause of a decline in near vision. In this study, we developed a new mixed herbal medicine to retard presbyopic progression and increase the amplitude of accommodation (AA), which is beneficial for near …
View article: CCDC 2067965: Experimental Crystal Structure Determination
CCDC 2067965: Experimental Crystal Structure Determination Open
View article: Transparent scientific reporting is imperative during the pandemic
Transparent scientific reporting is imperative during the pandemic Open
The coronavirus pandemic has exposed not only the lack of preparation to combat the deadly disease, but also the nature of response by governments worldwide. This article analyses how some governments suppress science reporting in the Asia…
View article: Liraglutide Activates Glucagon-Like Peptide 1 Receptor to Attenuate Hyperglycemia through Endogenous Beta-Endorphin in Diabetic Rats
Liraglutide Activates Glucagon-Like Peptide 1 Receptor to Attenuate Hyperglycemia through Endogenous Beta-Endorphin in Diabetic Rats Open
Liraglutide, an acylated analog of glucagon-like peptide 1 (GLP-1), could improve glycemic control in diabetes. Moreover, endogenous opioid peptides play a role in blood sugar regulation. Since GLP-1 receptors are also expressed in extra-p…
View article: Oral Treatment of Central Serous Chorioretinopathy Patients Using Propranolol Tablets
Oral Treatment of Central Serous Chorioretinopathy Patients Using Propranolol Tablets Open
Purpose: To evaluate the pharmacological effects of propranolol treatment of patients with central serous chorioretinopathy (CSCR) over 4 months. Results: Among the 89 male and 31 female patients, the mean BCVA decreased to 0.42 ± 0.08 log…
View article: Treatment of Symptomatic Vitreous Opacities with Pharmacologic Vitreolysis Using a Mixure of Bromelain, Papain and Ficin Supplement
Treatment of Symptomatic Vitreous Opacities with Pharmacologic Vitreolysis Using a Mixure of Bromelain, Papain and Ficin Supplement Open
Methods: Our research was scheduled in Southern Taiwan between April 2017 and December 2017. A total of 280 patients presenting 280 eyes were enrolled and received a series of ocular examinations. Each of our specially designed capsules co…
View article: Combination of a Self-Regulation Module and Mobile Application to Enhance Treatment Outcome for Patients with Acne
Combination of a Self-Regulation Module and Mobile Application to Enhance Treatment Outcome for Patients with Acne Open
Background and Objectives: Acne, an inflammatory disorder of the pilosebaceous unit associated with both physiological and psychological morbidities, should be considered a chronic disease. The application of self-regulation theory and the…
View article: Queries on the COVID‐19 quick publishing ethics
Queries on the COVID‐19 quick publishing ethics Open
The Editorial titled "COVID19: Why justice and transparency in hospital triage policies are paramount" by Schuklenk, which appeared in Bioethics, is striking, as it features the importance of honesty and openness in research ethics.1 Ethic…
View article: Action of Chlorzoxazone on Ca2+ Movement and Viability in Human Oral Cancer Cells
Action of Chlorzoxazone on Ca2+ Movement and Viability in Human Oral Cancer Cells Open
Chlorzoxazone is a skeletal muscle relaxant. However, the effect of chlorzoxazone on intracellular Ca 2+ concentrations ([Ca 2+ ] i ) in oral cancer cells is unclear. This study examined whether chlorzoxazone altered Ca 2+ signaling and ce…
View article: Kaempferol inhibits angiogenic ability by targeting VEGF receptor-2 and downregulating the PI3K/AKT, MEK and ERK pathways in VEGF-stimulated human umbilical vein endothelial cells
Kaempferol inhibits angiogenic ability by targeting VEGF receptor-2 and downregulating the PI3K/AKT, MEK and ERK pathways in VEGF-stimulated human umbilical vein endothelial cells Open
Anti-angiogenesis is one of the most general clinical obstacles in cancer chemotherapy. Kaempferol is a flavonoid phytochemical found in many fruits and vegetables. Our previous study revealed that kaempferol triggered apoptosis in human u…
View article: Kuei-Lu-Er-Xian-Jiao extract enhances BMP-2 production in osteoblasts
Kuei-Lu-Er-Xian-Jiao extract enhances BMP-2 production in osteoblasts Open
Osteoporosis is a common skeletal disorder, resulting from an imbalance in bone resorption relative to formation. Bone morphogenetic protein (BMP) is a key regulator in bone formation and osteoblastic differentiation. Hence, compounds that…