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View article: High Copy Number Variations Correlate with a Pro-Tumoral Microenvironment and Worse Prognosis in Acral Lentiginous Melanoma
High Copy Number Variations Correlate with a Pro-Tumoral Microenvironment and Worse Prognosis in Acral Lentiginous Melanoma Open
Acral lentiginous melanoma (ALM) is a rare melanoma subtype primarily located in acral regions. However, ALMs exhibit a distinctive genetic profile characterized by a high number of copy number variations (CNVs) and limited point mutations…
View article: Protocol to characterize the melanoma tumor immune microenvironment in mice from single cell to flow cytometry analysis
Protocol to characterize the melanoma tumor immune microenvironment in mice from single cell to flow cytometry analysis Open
Here, we present a protocol to study and describe immune cells that surround or infiltrate tumor cells or get through the body of a melanoma syngeneic mice model. We describe steps for creating and establishing the syngeneic mouse model, e…
View article: <i>ARID1A</i> ‐deficient cells require HDAC6 for progression of endometrial carcinoma
<i>ARID1A</i> ‐deficient cells require HDAC6 for progression of endometrial carcinoma Open
AT‐rich interactive domain‐containing protein 1A (ARID1A) loss‐of‐function mutation accompanied by a loss of ARID1A protein expression is frequently observed in endometrial carcinomas. However, the molecular mechanisms linking these geneti…
View article: BRAFV600E Mutant Allele Frequency (MAF) Influences Melanoma Clinicopathologic Characteristics
BRAFV600E Mutant Allele Frequency (MAF) Influences Melanoma Clinicopathologic Characteristics Open
Background: Cutaneous melanoma shows high variability regarding clinicopathological presentation, evolution and prognosis. Methods: Next generation sequencing was performed to analyze hotspot mutations in different areas of primary melanom…
View article: T-Type Calcium Channels: A Potential Novel Target in Melanoma
T-Type Calcium Channels: A Potential Novel Target in Melanoma Open
T-type calcium channels (TTCCs) are overexpressed in several cancers. In this review, we summarize the recent advances and new insights into TTCC biology, tumor progression, and prognosis biomarker and therapeutic potential in the melanoma…
View article: In vitro Cell Migration, Invasion, and Adhesion Assays: From Cell Imaging to Data Analysis
In vitro Cell Migration, Invasion, and Adhesion Assays: From Cell Imaging to Data Analysis Open
Cell migration is a key procedure involved in many biological processes including embryological development, tissue formation, immune defense or inflammation, and cancer progression. How physical, chemical, and molecular aspects can affect…