Polytimi Frangou
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View article: Neurogenetic phenotypes of learning-dependent plasticity for improved perceptual decisions
Neurogenetic phenotypes of learning-dependent plasticity for improved perceptual decisions Open
Genetics and experience are known to mold our cognitive development. Yet, the interactions between genetics and brain mechanisms that support learning and flexible behavior in the adult human brain remain largely unknown. Here, we test the…
View article: Microstructural and neurochemical plasticity mechanisms interact to enhance human perceptual decision-making
Microstructural and neurochemical plasticity mechanisms interact to enhance human perceptual decision-making Open
Experience and training are known to boost our skills and mold the brain’s organization and function. Yet, structural plasticity and functional neurotransmission are typically studied at different scales (large-scale networks, local circui…
View article: Where functional MRI stops, metabolism starts
Where functional MRI stops, metabolism starts Open
Combining techniques that track blood oxygenation and biochemicals during neuronal activity reveals how the brain computes perceived and unperceived stimuli.
View article: Neurochemical and functional interactions for improved perceptual decisions through training
Neurochemical and functional interactions for improved perceptual decisions through training Open
Combining multimodal brain imaging [magnetic resonance spectroscopy (MRS)-GABA, functional connectivity] with interventions [transcranial direct current stimulation (tDCS)], we demonstrate that glutamatergic excitation and functional inter…
View article: Brain stimulation boosts perceptual learning by altering sensory GABAergic plasticity and functional connectivity
Brain stimulation boosts perceptual learning by altering sensory GABAergic plasticity and functional connectivity Open
Interpreting cluttered scenes —a key skill for successfully interacting with our environment— relies on our ability to select relevant sensory signals while filtering out noise. Training is known to improve our ability to make these percep…
View article: Decision letter: Perception is associated with the brain’s metabolic response to sensory stimulation
Decision letter: Perception is associated with the brain’s metabolic response to sensory stimulation Open
Article Figures and data Abstract Editor's evaluation Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Processing of incoming…
View article: Functional Interactions between Sensory and Memory Networks for Adaptive Behavior
Functional Interactions between Sensory and Memory Networks for Adaptive Behavior Open
The brain’s capacity to adapt to sensory inputs is key for processing sensory information efficiently and interacting in new environments. Following repeated exposure to the same sensory input, brain activity in sensory areas is known to d…
View article: GABA and glutamate deficits from frontotemporal lobar degeneration are associated with disinhibition
GABA and glutamate deficits from frontotemporal lobar degeneration are associated with disinhibition Open
Behavioural disinhibition is a common feature of the syndromes associated with frontotemporal lobar degeneration (FTLD). It is associated with high morbidity and lacks proven symptomatic treatments. A potential therapeutic strategy is to c…
View article: GABA, not BOLD, reveals dissociable learning-dependent plasticity mechanisms in the human brain
GABA, not BOLD, reveals dissociable learning-dependent plasticity mechanisms in the human brain Open
Experience and training have been shown to facilitate our ability to extract and discriminate meaningful patterns from cluttered environments. Yet, the human brain mechanisms that mediate our ability to learn by suppressing noisy and irrel…
View article: Data supporting "GABA, not BOLD, reveals dissociable learning-dependent plasticity mechanisms in the human brain"
Data supporting "GABA, not BOLD, reveals dissociable learning-dependent plasticity mechanisms in the human brain" Open
Behavioural data. BOLD change measurements. GABA change measurements. Behavioural data under tDCs intervention.
View article: Author response: GABA, not BOLD, reveals dissociable learning-dependent plasticity mechanisms in the human brain
Author response: GABA, not BOLD, reveals dissociable learning-dependent plasticity mechanisms in the human brain Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Experience and training have …
View article: Inhibitory mechanisms for visual learning in the human brain
Inhibitory mechanisms for visual learning in the human brain Open
Identifying targets in cluttered scenes is critical for our interactions in complex environments. Our visual system is challenged to both detect elusive targets that we may want to avoid or chase and discriminate between targets that are h…